Expression of enterotoxigenic Escherichia coli colonization factors in Vibrio cholerae

Vaccine

Volumn 24, Issue 20, 2006, Pages 4354-4368

  Favre, Didier ^a   Lüdi, Stefan ^b   Stoffel, Michael ^b   Frey, Joachim ^b   Horn, Michael P ^a   Dietrich, Guido ^a   Spreng, Simone ^a   Viret, Jean François ^a  

^a Berna Biotech AG   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

ETEC; Fimbriae expression; V. cholerae carrier

Indexed keywords

BACTERIAL ANTIGEN; COLONIZATION FACTOR ANTIGEN; ESCHERICHIA COLI ENTEROTOXIN; ESCHERICHIA COLI SURFACE ANTIGEN 3; ESCHERICHIA COLI SURFACE ANTIGEN 6; ESCHERICHIA COLI VACCINE; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; CHROMOSOME; CONTROLLED STUDY; ESCHERICHIA COLI; FIMBRIA; GENE DOSAGE; GENE LOCUS; MOUSE; NONHUMAN; OPERON; PRIORITY JOURNAL; REGULATOR GENE; THERMOREGULATION; UPREGULATION; VIBRIO CHOLERAE; WILD TYPE;

ANTIGENS, BACTERIAL; CHROMOSOMES, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENE DOSAGE; MICROSCOPY, ELECTRON; OPERON; PLASMIDS; VIBRIO CHOLERAE;

EID: 33646153264     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.02.052     Document Type: Article

References (79)

1. Steffen R., Castelli F., Dieter N.H., Rombo L., and Jane Z.N. Vaccination against enterotoxigenic Escherichia coli, a cause of travelers' diarrhea. J Travel Med 12 2 (2005) 102-107
2. Tacket C.O., Reid R.H., Boedeker E.C., Losonsky G., Nataro J.P., Bhagat H., et al. Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres. Vaccine 12 14 (1994) 1270-1274
3. Qadri F., Svennerholm A.-M., Faruque A.S.G., and Sack R.B. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin Microbiol Rev 18 3 (2005) 465-483
4. Nataro J.P., and Kaper J.B. Diarrheagenic Escherichia coli. Clin Microbiol Rev 11 1 (1998) 142-201
5. Boedeker E.C. Vaccines for enterotoxigenic Escherichia coli: current status. Curr Opin Gastroenterol 21 1 (2005) 15-19
6. Cassels F.J., and Wolf M.K. Colonization factors of diarrheagenic E. coli and their intestinal receptors. J Ind Microbiol 15 3 (1995) 214-226
7. Gaastra W., and Svennerholm A.M. Colonization factors of human enterotoxigenic Escherichia coli (ETEC). Trends Microbiol 4 11 (1996) 444-452
8. Sizemore D.R., Roland K.L., and Ryan U.S. Enterotoxigenic Escherichia coli virulence factors and vaccine approaches. Expert Rev Vaccines 3 5 (2004) 585-595
9. Torres A.G., Zhou X., and Kaper J.B. Adherence of diarrheagenic Escherichia coli strains to epithelial cells. Infect Immun 73 1 (2005) 18-29
10. Munson G.P., Holcomb L.G., and Scott J.R. Novel group of virulence activators within the AraC family that are not restricted to upstream binding sites. Infect Immun 69 1 (2001) 186-193
11. Savelkoul P.H., Willshaw G.A., McConnell M.M., Smith H.R., Hamers A.M., van der Zeijst B.A., et al. Expression of CFA/I fimbriae is positively regulated. Microb Pathog 8 2 (1990) 91-99
12. Caron J., Coffield L.M., and Scott J.R. A plasmid-encoded regulatory gene, rns, required for expression of the CS1 and CS2 adhesins of enterotoxigenic Escherichia coli. Proc Natl Acad Sci USA 86 3 (1989) 963-967
13. de Haan L.A., Willshaw G.A., van der Zeijst B.A., and Gaastra W. The nucleotide sequence of a regulatory gene present on a plasmid in an enterotoxigenic Escherichia coli strain of serotype O167:H5. FEMS Microbiol Lett 67 3 (1991) 341-346
14. Gallegos M.T., Schleif R., Bairoch A., Hofmann K., and Ramos J.L. Arac/XylS family of transcriptional regulators. Microbiol Mol Biol Rev 61 4 (1997) 393-410
15. Munson G.P., and Scott J.R. Binding site recognition by Rns, a virulence regulator in the AraC family. J Bacteriol 181 7 (1999) 2110-2117
16. Munson G.P., and Scott J.R. Rns, a virulence regulator within the AraC family, requires binding sites upstream and downstream of its own promoter to function as an activator. Mol Microbiol 36 6 (2000) 1391-1402
17. Murphree D., Froehlich B., and Scott J.R. Transcriptional control of genes encoding CS1 pili: negative regulation by a silencer and positive regulation by Rns. J Bacteriol 179 18 (1997) 5736-5743
18. Jordi B.J., Dagberg B., de Haan L.A., Hamers A.M., van der Zeijst B.A., Gaastra W., et al. The positive regulator CfaD overcomes the repression mediated by histone-like protein H-NS (H1) in the CFA/I fimbrial operon of Escherichia coli. EMBO J 11 7 (1992) 2627-2632
19. Jordi B.J., van der Zeijst B.A., and Gaastra W. Regions of the CFA/I promoter involved in the activation by the transcriptional activator CfaD and repression by the histone-like protein H-NS. Biochimie 76 10-11 (1994) 1052-1054
20. de Lorimier A.J., Byrd W., Hall E.R., Vaughan W.M., Tang D., Roberts Z.J., et al. Murine antibody response to intranasally administered enterotoxigenic Escherichia coli colonization factor CS6. Vaccine 21 19-20 (2003) 2548-2555
21. Katz D.E., DeLorimier A.J., Wolf M.K., Hall E.R., Cassels F.J., van Hamont J.E., et al. Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen. Vaccine 21 5-6 (2003) 341-346
22. Tacket C.O., and Levine M.M. Vaccines against enterotoxigenic Escherichia coli infections, part ii, live oral vaccines and subunits (purified fimbriae and toxin subunits) vaccines. In: Levine M.M., Woodrow G.C., Kaper J.B., and Cobon G.S. (Eds). New generation vaccines (1987), Marcel Dekker Inc., New York 875-883
23. Guerena-Burgueno F., Hall E.R., Taylor D.N., Cassels F.J., Scott D.A., Wolf M.K., et al. Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously. Infect Immun 70 4 (2002) 1874-1880
24. Yu J., Cassels F., Scharton-Kersten T., Hammond S.A., Hartman A., Angov E., et al. Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli. Infect Immun 70 3 (2002) 1056-1068
25. Lee J.Y., Yu J., Henderson D., and Langridge W.H. Plant-synthesized E. coli CFA/I fimbrial protein protects Caco-2 cells from bacterial attachment. Vaccine 23 2 (2004) 222-231
26. Tacket C.O. Plant-derived vaccines against diarrhoeal diseases. Expert Opin Biol Ther 4 5 (2004) 719-728
27. Lasaro M.O., Luiz W.B., Sbrogio-Almeida M.E., Nishimura L.S., Guth B.E., and Ferreira L.C. Combined vaccine regimen based on parenteral priming with a DNA vaccine and administration of an oral booster consisting of a recombinant Salmonella enterica serovar Typhimurium vaccine strain for immunization against infection with human-derived enterotoxigenic Escherichia coli strains. Infect Immun 72 11 (2004) 6480-6491
28. Lasaro M.O., Luiz W.B., Sbrogio-Almeida M.E., and Ferreira L.C. Prime-boost vaccine regimen confers protective immunity to human-derived enterotoxigenic Escherichia coli. Vaccine 23 19 (2005) 2430-2438
29. Cohen D., Orr N., Haim M., Ashkenazi S., Robin G., Green M.S., et al. Safety and immunogenicity of two different lots of the oral, killed enterotoxigenic Escherichia coli-cholera toxin B subunit vaccine in Israeli young adults. Infect Immun 68 8 (2000) 4492-4497
30. Jertborn M., Ahren C., Holmgren J., and Svennerholm A.M. Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine. Vaccine 16 2-3 (1998) 255-260
31. Qadri F., Wenneras C., Ahmed F., Asaduzzaman M., Saha D., Albert M.J., et al. Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi adults and children. Vaccine 18 24 (2000) 2704-2712
32. Savarino S.J., Hall E.R., Bassily S., Wierzba T.F., Youssef F.G., Peruski Jr. L.F., et al. Introductory evaluation of an oral, killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infants. Pediatr Infect Dis J 21 4 (2002) 322-330
33. Svennerholm A.M., Ahren C., and Jertborn M. Vaccines against enterotoxigenic Escherichia coli infections, part i, oral inactivated vaccines against enterotoxigenic Escherichia coli. In: Levine M.M., Woodrow G.C., Kaper J.B., and Cobon G.S. (Eds). New generation vaccines (1997), Marcel Dekker Inc., New York 875-883
34. Turner A.K., Terry T.D., Sack D.A., Londono-Arcila P., and Darsley M.J. Construction and characterization of genetically defined aro omp mutants of enterotoxigenic Escherichia coli and preliminary studies of safety and immunogenicity in humans. Infect Immun 69 8 (2001) 4969-4979
35. Wu S., Pascual D.W., Vancott J.L., McGhee J.R., Maneval Jr. D.R., Levine M.M., and Hone D.M. Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR. Infect Immun 63 12 (1995) 4933-4938
36. Giron J.A., Xu J.G., Gonzalez C.R., Hone D., Kaper J.B., and Levine M.M. Simultaneous expression of CFA/I and CS3 colonization factor antigens of enterotoxigenic Escherichia coli by delta aroC, delta aroD Salmonella typhi vaccine strain CVD 908. Vaccine 13 10 (1995) 939-946
37. Altboum Z., Barry E.M., Losonsky G., Galen J.E., and Levine M.M. Attenuated Shigella flexneri 2a Delta guaBA strain CVD 1204 expressing enterotoxigenic Escherichia coli (ETEC) CS2 and CS3 fimbriae as a live mucosal vaccine against Shigella and ETEC infection. Infect Immun 69 5 (2001) 3150-3158
38. Altboum Z., Levine M.M., Galen J.E., and Barry E.M. Genetic characterization and immunogenicity of coli surface antigen 4 from enterotoxigenic Escherichia coli when it is expressed in a Shigella live-vector strain. Infect Immun 71 3 (2003) 1352-1360
39. Barry E.M., Altboum Z., Losonsky G., and Levine M.M. Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains. Vaccine 21 5-6 (2003) 333-340
40. Koprowski H., Levine M.M., Anderson R.J., Losonsky G., Pizza M., and Barry E.M. Attenuated Shigella flexneri 2a vaccine strain CVD 1204 expressing colonization factor antigen I and mutant heat-labile enterotoxin of enterotoxigenic Escherichia coli. Infect Immun 68 9 (2000) 4884-4892
41. Noriega F.R., Losonsky G., Wang J.Y., Formal S.B., and Levine M.M. Further characterization of delta aroA delta virG Shigella flexneri 2a strain CVD 1203 as a mucosal Shigella vaccine and as a live-vector vaccine for delivering antigens of enterotoxigenic Escherichia coli. Infect Immun 64 1 (1996) 23-27
42. Ranallo R.T., Fonseka C.P., Cassels F., Srinivasan J., and Venkatesan M.M. Construction and characterization of bivalent Shigella flexneri 2a vaccine strains SC608(pCFAI) and SC608(pCFAI/LTB) that express antigens from enterotoxigenic Escherichia coli. Infect Immun 73 1 (2005) 258-267
43. Favre D., Struck M.M., Cryz Jr. S.J., and Viret J.F. Further molecular characterization and stability of the live oral attenuated cholera vaccine strain CVD103-HgR. Vaccine 14 6 (1996) 526-531
44. Ketley J.M., Michalski J., Galen J., Levine M.M., and Kaper J.B. Construction of genetically marked Vibrio cholerae O1 vaccine strains. FEMS Microbiol Lett 111 1 (1993) 15-21
45. Levine M.M., and Kaper J.B. Live oral vaccines against cholera: an update. Vaccine 11 2 (1993) 207-212
46. Favre D., Cryz Jr. S.J., and Viret J.F. Development of Shigella sonnei live oral vaccines based on defined rfb Inaba deletion mutants of Vibrio cholerae expressing the Shigella serotype D O polysaccharide. Infect Immun 64 2 (1996) 576-584
47. Viret J.F., Cryz Jr. S.J., and Favre D. Expression of Shigella sonnei lipopolysaccharide in Vibrio cholerae. Mol Microbiol 19 5 (1996) 949-963
48. Favre D., Cryz Jr. S.J., and Viret J.F. Construction and characterization of a potential live oral carrier-based vaccine against Vibrio cholerae O139. Infect Immun 64 9 (1996) 3565-3570
49. Acheson D.W., Levine M.M., Kaper J.B., and Keusch G.T. Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR. Infect Immun 64 1 (1996) 355-357
50. Tribble D.R., Hale T.L., and Taylor D.N. ETEC and enteric vaccines. In: Jong E.C., and Zuckerman J. (Eds). Traveler's vaccines (2004), BC Dekker Inc., Hamilton, Canada 275-297
51. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. (1989), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
52. Pitcher D.G., Saunders N.A., and Owen R.J. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate. Lett Appl Microbiol 8 (1989) 151-156
53. Favre D. Improved phenol-based method for the isolation of DNA fragments from low melting temperature agarose gels. Biotechniques 13 1 (1992) 22 25-2, 26
54. Favre D., and Viret J.F. Gene replacement in Gram-negative bacteria: the pMAKSAC vectors. Biotechniques 28 2 (2000) 198-200 202, 204
55. Favre D., and Viret J.F. Versatile cosmid vectors for facilitated analysis and subcloning of the insert. Gene 178 1-2 (1996) 43-49
56. Stoker N.G., Fairweather N.F., and Spratt B.G. Versatile low-copy-number plasmid vectors for cloning in Escherichia coli. Gene 18 3 (1982) 335-341
57. Kohler G., and Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256 5517 (1975) 495-497
58. Alm R.A., Stroeher U.H., and Manning P.A. Extracellular proteins of Vibrio cholerae: nucleotide sequence of the structural gene (hlyA) for the haemolysin of the haemolytic El Tor strain 017 and characterization of the hlyA mutation in the non-haemolytic classical strain 569B. Mol Microbiol 2 4 (1988) 481-488
59. Kaper J.B., Mobley H.L., Michalski J., Herrington D.A., and Levine M.M. Recent advances in developing a safe and effective live oral attenuated Vibrio cholerae vaccine. In: Othomo N., and Sack R.B. (Eds). Advances in research on cholera and related diseases (1988), KTK Scientific Publishers, Tokyo, Japan 161-167
60. Caron J., and Scott J.R. A rns-like regulatory gene for colonization factor antigen I (CFA/I) that controls expression of CFA/I pilin. Infect Immun 58 4 (1990) 874-878
61. Willshaw G.A., McConnell M.M., Smith H.R., and Rowe B. Structural and regulatory genes for coli surface associated antigen 4 (CS4) are encoded by separate plasmids in enterotoxigenic Escherichia coli strains of serotype 0.25.H42. FEMS Microbiol Lett 56 3 (1990) 255-260
62. Evans D.G., Evans Jr. D.J., and Tjoa W. Hemagglutination of human group A erythrocytes by enterotoxigenic Escherichia coli isolated from adults with diarrhea: correlation with colonization factor. Infect Immun 18 2 (1977) 330-337
63. WHO. New frontiers in the development of vaccines against enterotoxigenic (ETEC) and enterohaemorrhagic (EHEC) E. coli infections. Weekly Ep Rec 74 (1999) 97-104
64. Butterton J.R., Ryan E.T., Acheson D.W., and Calderwood S.B. Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains. Infect Immun 65 6 (1997) 2127-2135
65. Killeen K., Spriggs D., and Mekalanos J. Bacterial mucosal vaccines: Vibrio cholerae as a live attenuated vaccine/vector paradigm. Curr Top Microbiol Immunol 236 (1999) 237-254
66. Kochi S.K., Killeen K.P., and Ryan U.S. Advances in the development of bacterial vector technology. Expert Rev Vaccines 2 1 (2003) 31-43
67. Kotton C.N., and Hohmann E.L. Enteric pathogens as vaccine vectors for foreign antigen delivery. Infect Immun 72 10 (2004) 5535-5547
68. Ryan E.T., Butterton J.R., Zhang T., Baker M.A., Stanley Jr. S.L., and Calderwood S.B. Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Infect Immun 65 8 (1997) 3118-3125
69. Silva A.J., Mohan A., and Benitez J.A. Cholera vaccine candidate 638: intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen Coccidioides immitis. Vaccine 21 32 (2003) 4715-4721
70. Grewal H.M., Gaastra W., Svennerholm A.M., Roli J., and Sommerfelt H. Induction of colonization factor antigen I (CFA/I) and coli surface antigen 4 (CS4) of enterotoxigenic Escherichia coli: relevance for vaccine production. Vaccine 11 2 (1993) 221-226
71. Hibberd M.L., McConnell M.M., Willshaw G.A., Smith H.R., and Rowe B. Positive regulation of colonization factor antigen I (CFA/I) production by enterotoxigenic Escherichia coli producing the colonization factors CS5, CS6, CS7, CS17, PCFO9, PCFO159:H4 and PCFO166. J Gen Microbiol 137 8 (1991) 1963-1970
72. Levine M.M., Ristaino P., Marley G., Smyth C., Knutton S., Boedeker E., et al. Coli surface antigens 1 and 3 of colonization factor antigen II-positive enterotoxigenic Escherichia coli: morphology, purification, and immune responses in humans. Infect Immun 44 2 (1984) 409-420
73. Froehlich B., Husmann L., Caron J., and Scott J.R. Regulation of rns, a positive regulatory factor for pili of enterotoxigenic Escherichia coli. J Bacteriol 176 17 (1994) 5385-5392
74. Zheng J.P., Wang L.C., Wang P., Luo G., Li S.Q., Duan H.Q., et al. Co-expression of CFA/I and CS6 of enterotoxigenic Escherichia coli (ETEC) in Shigella flexneri 2a T32 derivative strain FWL01. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35 11 (2003) 1005-1010
75. Simon R., Priefer U., and Pühler A. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria. Biotechnology 1 1 (1983) 784-791
76. Evans D.G., Silver R.P., Evans Jr. D.J., Chase D.G., and Gorbach S.L. Plasmid-controlled colonization factor associated with virulence in Escherichia coli enterotoxigenic for humans. Infect Immun 12 3 (1975) 656-667
77. Blanco J., Gonzalez E.A., Blanco M., Garabal J.I., Alonso M.P., Fernandez S., et al. Enterotoxigenic Escherichia coli associated with infant diarrhoea in Galicia, north-western Spain. J Med Microbiol 35 3 (1991) 162-167
78. Pridmore R.D. New and versatile cloning vectors with kanamycin-resistance marker. Gene 56 2-3 (1987) 309-312
79. Lerner C.G., and Inouye M. Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability. Nucleic Acids Res 18 15 (1990) 4631