Risk factors for benign thyroid disease

Danish Medical Bulletin

Volumn 52, Issue 4, 2005, Pages 160-185

  Knudsen, Nils ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; ORAL CONTRACEPTIVE AGENT; THYROGLOBULIN;

AGE DISTRIBUTION; ALCOHOL CONSUMPTION; CIGARETTE SMOKING; COHORT ANALYSIS; ECHOGRAPHY; EDUCATION; EPIDEMIOLOGICAL DATA; GOITER; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; IODINE DEFICIENCY; MULTIVARIATE ANALYSIS; ORAL CONTRACEPTION; PARITY; QUESTIONNAIRE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; THYROGLOBULIN BLOOD LEVEL; THYROID ADENOMA; THYROID DISEASE; THYROID FUNCTION; THYROID NODULE; THYROID WEIGHT; UNSPECIFIED SIDE EFFECT; URINARY EXCRETION;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); DENMARK; FEMALE; GOITER; HUMANS; IODINE; MALE; MIDDLE AGED; MODELS, STATISTICAL; PREVALENCE; RISK FACTORS; THYROID DISEASES;

EID: 33646144665     PISSN: 16039629     EISSN: 16039629     Source Type: Journal    
DOI: None     Document Type: Review

References (273)

1. Knudsen N, Jørgensen T, Rasmussen S, Christiansen E, Perrild H 1999 The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf) 51 (3):361-367.
2. Knudsen N, Bols B, Bulow I, Jorgensen T, Perrild H, Ovesen L, Laurberg P 1999 Validation of ultrasonography of the thyroid gland for epidemiological purposes. Thyroid 9 (11):1069-1074.
3. Knudsen N, Perrild H, Christiansen E, Rasmussen S, Dige-Petersen H, Jorgensen T 2000 Thyroid structure and size and two-year follow-up of solitary cold thyroid nodules in an unselected population with borderline iodine deficiency. Eur J Endocrinol 142 (3):224-230.
4. Knudsen N, Christiansen E, Brandt-Christensen M, Nygaard B, Perrild H 2000 Age- and sex-adjusted iodine/creatinine ratio. A new standard in epidemiological surveys? Evaluation of three different estimates of iodine excretion based on casual urine samples and comparison to 24 h values. Eur J Clin Nutr 54 (4):361-363.
5. Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H 2000 Goitre prevalence and thyroid abnormalities at ultrasonography. A comparative epidemiological study in two regions with slightly different iodine status. Clin Endocrinol (Oxf) 53 (4):479-485.
6. Knudsen N, Bulow I, Jørgensen T, Laurberg P, Ovesen L, Perrild H 2000 Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status. Eur J Endocrinol 143 (4):485-491.
7. Knudsen N, Bulow I, Jorgensen T, Perrild H, Ovesen L, Laurberg P 2001 Serum tg-a sensitive marker of thyroid abnormalities and iodine deficiency in epidemiological studies. J Clin Endocrinol Metab 86 (8):3599-3603.
8. Knudsen N, Bulow I, Laurberg P, Perrild H, Ovesen L, Jorgensen T 2001 Alcohol consumption is associated with reduced prevalence of goitre and solitary thyroid nodules. Clin Endocrinol (Oxf) 55 (1):41-46.
9. Knudsen N, Bulow I, Laurberg P, Ovesen L, Perrild H, Jørgensen T 2002 Association of Tobacco Smoking with Goiter in a Low-lodine-Intake Area. Arch Intern Med 162 (439-443.
10. Knudsen N, Bulow I, Laurberg P, Perrild H, Ovesen L, Jorgensen 2002 Low goitre prevalence among users of oral contraceptives in a population sample of 3712 women. Clin Endocrinol (Oxf) 57 (1):71-76.
11. Knudsen N, Bulow I, Laurberg P, Ovesen L, Perrild H, Jorgensen T 2002 Parity is associated with increased thyroid volumes solely among smokers in an area with moderate to mild iodine deficiency. Eur J Endocrinol 146 (1):39-43.
12. Knudsen N, Bulow I, Laurberg P, Perrild H, Ovesen L, Jorgensen T 2002 High occurrence of thyroid multinodularity and low occurrence of subclinical hypothyroidism among tobacco smokers in a large population study. J Endocrinol 175 (3):571-576.
13. Knudsen N, Bulow I, Laurberg P, Ovesen L, Perrild H, Jorgensen T 2003 Low socio-economic status and familial occurrence of goitre are associated with a high prevalence of goitre. Eur J Epidemiol 18 (2):175-181.
14. Burgi H, Supersaxo Z, Selz B 1990 Iodine deficiency diseases in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goitre prevalence data. Acta Endocrinol (Copenh) 123 (6):577-590.
15. Delange F 1994 The disorders induced by iodine deficiency. Thyroid 4 (1):107-128.
16. Laurberg P 1994 Iodine Intake - What Are We Aiming At? J Clin Endocrinol Metab 79 (1):17-19.
17. Laurberg P, Nohr SB, Pedersen KM, Hreidarsson AB, Andersen S, Bulow P, I, Knudsen N, Perrild H, Jorgensen T, Ovesen L 2000 Thyroid disorders in mild iodine deficiency. Thyroid 10 (11):951-963.
18. Gaitan E 1990 Goitrogens in food and water. Annu Rev Nutr 10:21-39.
19. Bertelsen JB and Hegedus L 1994 Cigarette smoking and the thyroid. Thyroid 4 (3):327-331.
20. Bartalena L, Bogazzi F, Tanda ML, Manetti L, Dell'Unto E, Martino E 1995 Cigarette smoking and the thyroid. Eur J Endocrinol 133 (5):507-512.
21. Brix TH, Kyvik KO, Hegedus L 1999 Major role of genes in the etiology of simple goiter in females: a population-based twin study. J Clin Endocrinol Metab 84 (9):3071-3075.
22. Brix TH, Kyvik KO, Hegedus L 2000 A population-based study of chronic autoimmune hypothyroidism in Danish twins. J Clin Endocrinol Metab 85 (2):536-539.
23. Brix TH, Kyvik KO, Hegedus L 1998 What is the evidence of genetic factors in the etiology of Graves' disease? A brief review. Thyroid 8 (8):727-734.
24. Delange F 1995 Correction of iodine deficiency: benefits and possible side effects. Eur J Endocrinol 132 (5):542-543.
25. Delange F, de Benoist B, Pretell E, Dunn JT 2001 Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 11 (5):437-447.
26. Pfannenstiel P. Schilddrüsenreport. 1997. Darmstadt, Germany, Merck KGaA.
27. Pedersen KM, Nohr SB, Laurberg P 1997 Iodine intake in Denmark. Ugeskr Laeger 159 (15):2201-2206.
28. Munkner T, Hummer L, Sorensen SS 1977 Nuclear medical studies in congenital thyroid defects. Ugeskr Laeger 139 (41):2435-2439.
29. Knudsen N 2001 Regional variations in goitre prevalence in Denmark - and the impact of tobacco smoking. PhD thesis, available from the author at nils.knudsenδadlnet.dk
30. Bulow Pedersen I, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Laurberg P 2002 Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake. A prospective comparative register based population survey. J Clin Endocrinol Metab 87 (10):4462-4469.
31. Lendvay J, Kuulasma J, Evans A, Molarius A, Ruokokoski F 1993 Quality assesment of smoking data in the second survey of the WHO MONICA project. MONICA Memo 247A
32. Molarius A, Kuulasma K, Evans A, McCrum E, Tolonen H 1999 Quality assessment of data on smoking behaviour in the WHO MONICA project. http://www.ktl.fi/publications/monica/smoking/qa30.htm
33. Bland JM and Altman DG 1999 Measuring agreement in method comparison studies. Stat Methods Med Res 8 (2):135-160.
34. Gutekunst R, Becket W, Hehrmann R, Olbricht T, Pfarmenstiel P 1988 Ultraschalldiagnostik der Schilddruse. Dtsch Med Wochenschr 113 (27):1109-1112.
35. Hegedus L, Karstrup S, Rasmussen N 1986 Evidence of cyclic alterations of thyroid size during the menstrual cycle in healthy women. Am J Obstet Gynecol 155 (1):142-145.
36. Hill AB 1965 The environment and disease: association or causation? Proc R Soc Med 58:295-300.
37. Olsen J 2003 What characterises a useful concept of causation in epidemiology? J Epidemiol Community Health 57 (2):86-88.
38. Weed DL 1997 On the use of causal criteria. Int J Epidemiol 26 (6): 1137-1141.
39. Rasmussen LB, Ovesen L, Bulow I, Jorgensen T, Knudsen N, Laurberg P, Perrild H 2002 The relation between various measures of iodine intake and thyroid volume, thyroid nodularity and serum thyroglobulin. Am J Clin Nutr 76 (5):1069-1076.
40. Hegedus L, Rasmussen N, Ravn V, Kastrup J, Krogsgaard K, Aldershvile J 1988 Independent effects of liver disease and chronic alcoholism on thyroid function and size: the possibility of a toxic effect of alcohol on the thyroid gland. Metabolism 37 (3):229-233.
41. Greenland S. Applications of Stratified Analysis Methods. Rothman, J and Greenland, S. Modern Epidemiology. 2.[16], 281-300.1998. Philadelphia, Lippincott-Raven Publishers.
42. Miettinen OS 1974 Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol 99 (5):325-332.
43. Vought RL, London WT, Lutwak L, Dublin TD 1963 Reliability of Estimates of Serum Inorganic Iodine and Daily Fecal and Urinary Iodine Excretion from Single Casual Specimens. Clin Endocrinol Metab 23:1218-1228.
44. Rasmussen LB, Ovesen L, Bulow I, Jorgensen T, Knudsen N, Laurberg P, Perrild H 2001 Evaluation of a semi-quantitative food frequency questionnaire to estimate iodine intake. Eur J Clin Nutt 55 (4):287-292.
45. Rasmussen LB, Ovesen L, Christiansen E 1999 Day-to-day and within-day variation in urinary iodine excretion. Eur J Clin Nutt 53 (5):401-407.
46. Bourdoux P. Biochemical Evaluation of Iodine Status. Delange, F. Iodine Deficiency in Europe. 119-124. 1993. New York, Plenum Press.
47. Thomson CD, Smith TE, Butler KA, Packer MA 1996 An Evaluation of Urinary Measures of Iodine and Selenium Status. J Trace Elements med Biol 10:214-222.
48. Als C, Keller A, Minder C, Haldimann M, Gerber H 2000 Age- and gender-dependent urinary iodine concentrations in an area-covering population sample from the bernese region in Switzerland [In Process Citation]. Eur J Endocrinol 143 (5):629-637.
49. Simpson FO, Nye ER, Bolli P, Waal MH, Goulding AW, Phelan EL, de-Hamel FA, Stewart RD, Spears GF, Leek GM, Stewart AC 1978 The Milton survey: Part 1, General methods, height, weight and 24-hour excretion of sodium, potassium, calcium, magnesium and creatinine. N Z Med J 87 (613):379-382.
50. Bleiler RE and Schedl HP 1962 Creatinine excretion: Variability and relationships to diet and body size. J Lab & Chn Med 59 (6):945-955.
51. Scott PJ and Hurley PJ 1968 Demonstration of individual variation in constancy of 24-hour urinary creatinine excretion. Clin Chim Acta 21 (3):411-414.
52. Greenblatt DJ, Ransil BJ, Harmatz JS, Smith TW, Duhme DW, Koch-Weser J 1976 Variability of 24-hour Urinary Creatinine by Normal Subjects. J Clin Pharmacol 16:321-328.
53. Kesteloot H and Joossens JV 1996 On the determinants of the creatinine clearance: a population study. J Hum Hypertens 10 (4):245-249.
54. Frey H 1986 The prevalence of hypothyroidism in the elderly [editorial]. Acta Med Scand 219 (2):145-146.
55. Konno N, Yuri K, Taguchi H, Miura K, Taguchi S, Hagiwara K, Murakami S 1993 Screening for thyroid diseases in an iodine sufficient area with sensitive thyrotrophin assays, and serum thyroid autoantibody and urinary iodide determinations. Clin Endocrinol Oxf 38 (3):273-281.
56. Bourdoux P 1998 Evaluation of the iodine intake: problems of the iodine/ creatinine ratio-comparison with iodine excretion and daily fluctuations of iodine concentration. Exp Clin Endocrinol Diabetes 106 Suppl 3 (S17-S20.
57. Jolin T and Escobar del Ray F 1965 Evaluation of iodine/creatinine ratios of casual samples as indices of daily urinary iodine output during field studies. J Clin Endocrinol Metab 25:540-542.
58. Sackett-Lundeen L, Nicolau GY, Lakatua DJ, Ehresman DJ, Dumitriu L, Plinga L, Petrescu E, Haus E 1990 Circadian and seasonal variation in iodine excretion in children in an endemic goitre area. Chronobiology: Its Role in Clinical Medicine, General Biology, and Agriculture A:689-698.
59. Als C, Helbling A, Peter K, Haldimann M, Zimmerli B, Gerber H 2000 Urinary iodine concentration follows a cirradian rhythm: a study with 3023 spot urine samples in adults and children. J Clin Endocrinol Metab 85 (4):1367-1369.
60. Brunn J, Block U, Ruf G, Bos I, Kunze WP, Scriba PC 1981 Volumetrie der Schilddrusenlappen mittels Real-time-Sonographie. Dtsch Med Wochenschr 106 (41):1338-1340.
61. Peterson S, Sanga A, Eklof H, Bunga B, Taube A, Gebre-Medhin M, Rosling H 2000 Classification of thyroid size by palpation and ultrasonography in field surveys. Lancet 355 (9198):106-110.
62. Siminoski K 1995 Does this patient have a goiter? JAMA 273 (10):813-817.
63. Zimmermann M, Saad A, Hess S, Torresani T, Chaouki N 2000 Thyroid ultrasound compared with World Health Organization 1960 and 1994 palpation criteria for determination of goiter prevalence in regions of mild and severe iodine deficiency. Ent J Endocrinol 143 (6):727-731.
64. Jarlov AE, Hegedus L, Gjorup T, Hansen JE 1991 Accuracy of the clinical assessment of thyroid size. Dan Med Bull 38 (1):87-89.
65. Tannahill AJ, Hooper MJ, England M, Ferriss JB, Wilson GM 1978 Measurement of thyroid size by ultrasound, palpation and scintiscan. Clin Endocrinol Oxf 8 (6):483-486.
66. Berghout A, Wiersinga WM, Smits NJ, Touber JL 1988 The value of thyroid volume measured by ultrasonography in the diagnosis of goitre. Clin Endocrinol Oxf 28 (4):409-414.
67. Gutekunst R, Smolarek H, Hasenpusch U, Stubbe P, Friedrich HJ, Wood WG, Scriba PC 1986 Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinol Copenh 112 (4):494-501.
68. Smyth PP, Darke C, Parkes AB, Smith DF, John R, Hetherton AM, Lazarus JH 1999 Assessment of goiter in an area of endemic iodine deficiency. Thyroid 9 (9):895-901.
69. Brander A, Viikinkoski P, Tuuhea J, Voutilainen L, Vivisaari L 1992 Clinical versus ultrasound examination of the thyroid gland in common clinical practice. J Clin Ultrasound 20 (1):37-42.
70. Brown MC and Spencer R 1978 Thyroid gland volume estimated by use of ultrasound in addition to scintigraphy. Acta Radiol Oncol Radiat Phys Biol 17 (4):337-341.
71. Rasmussen SN and Hjorth L 1974 Determination of thyroid volume by ultrasonic scanning. J Clin Ultrasound 2 (2):143-147.
72. Hegedus L, Perrild H, Poulsen LR, Andersen JR, Holm B, Schnohr P, Jensen G, Hansen JM 1983 The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. J Clin Endocrinol Metab 56 (2):260-263.
73. Yokoyama N, Nagayama Y, Kakezono F, Kiriyama T, Morita S, Ohtakara S, Okamoto S, Morimoto I, Izumi M, Ishikawa N et a 1986 Determination of the Volume of the Thyroid Gland by a High Resolutional Ultrasonic Scanner. J Nucl Med 27 (9):1475-1479.
74. Nygaard B, Nygaard T, Court-Payen M, Jensen LI, Soe-Jensen P, Gerhard NK, Fugl M, Hegedus L 2002 Thyroid volume measured by ultrasonography and CT. Acta Radiol 43 (3):269-274.
75. Schlogl S, Werner E, Lassmann M, Terekhova J, Muffert S, Seybold S, Reiners C 2001 The use of three-dimensional ultrasound for thyroid volumetry. Thyroid 11 (6):569-574.
76. Szebeni A and Beleznay E 1992 New simple method for thyroid volume determination by ultrasonography. J Clin Ultrasound 20 (5):329-337.
77. Hampel R, Kulberg T, Klein K, Jerichow JU, Pichmann EG, Clausen V Schmidt I 1995 Strumapravalenz in Deutschland grosser als bisher angenommen. Med Klin 90 (6):324-329.
78. Zimmermann MB, Molinari L, Spehl M, Weidinger-Toth J, Podoba J, Hess S, Delange F 2001 Toward a consensus on reference values for thyroid volume in iodine-replete schoolchildren: results of a workshop on inter-observer and inter-equipment variation in sonographic measurement of thyroid volume. Eur J Endocrinol 144 (3):213-220.
79. Scheler S, Becker W, Reiners C, Börner W 1986 Physiological Variations and Technical Variability in the Sonographic Measurement of Thyroid Volume. Akt Endokr Stoffw 7:40-42.
80. Vitti P, Martino E, Aghini LF, Rago T, Antonangeli L, Maccherini D, Nanni P, Loviselli A, Balestrieri A, Araneo G, et a 1994 Thyroid volume measurement by ultrasound in children as a tool for the assessment of mild iodine deficiency. J Clin Endocrinol Metab 79 (2):600-603.
81. Pedersen KM, Borlum KG, Knudsen PR, Hansen ES, Johannesen PL, Laurberg P 1988 Urinary iodine excretion is low and serum thyroglobulin high in pregnant women in parts of Denmark. Acta Obstet Gynecol Scand 67 (5):413-416.
82. Berghout A, Wiersinga WM, Smits NJ, Touber JL 1987 Determinants of thyroid volume as measured by ultrasonography in healthy adults in a non-iodine deficient area. Clin Endocrinol Oxf 26 (3):273-280.
83. Jarlov AE, Nygard B, Hegedus L, Karstrup S, Hansen JM 1993 Observer variation in ultrasound assessment of the thyroid gland. Br J Radiol 66 (787):625-627.
84. Pedersen OM, Aardal NP, Larssen TB, Varhaug JE, Myking O, Vik-Mo H 2000 The value of ultrasonography in predicting autoimmune thyroid disease. Thyroid 10 (3):251-259.
85. Hayashi N, Tamaki N, Konishi J, Yonekura Y, Senda M, Kasagi K, Yamamoto K, Iida Y, Misaki T, Endo K 1986 Sonography of Hashimoto's thyroiditis. J Clin Ultrasound 14 (2):123-126.
86. Vitti P, Lampis M, Piga M, Loviselli A, Brogioni S, Rago T, Pinchera A, Martino E 1994 Diagnostic usefulness of thyroid ultrasonography in atrophic thyroiditis. J Clin Ultrasound 22 (6):375-379.
87. Bennedbaek FN and Hegedus L 1997 The value of ultrasonography in the diagnosis and follow-up of subacute thyroiditis. Thyroid 7 (1):45-50.
88. Spencer CA, LoPresti JS, Fatemi S, Nicoloff JT 1999 Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid 9 (5):435-441.
89. Hidaka Y, Nishi I, Tamaki H, Takeoka K, Tada H, Mitsuda N, Amino N 1994 Differentiation of postpartum thyrotoxicosis by serum thyroglobulin: usefulness of a new multisite immunoradiometric assay. Thyroid 4 (3):275-278.
90. Mariotti S, Martino E, Cupini C, Lari R, Giani C, Baschieri L, Pinchera A 1982 Low serum thyroglobulin as a clue to the diagnosis of thyrotoxicosis factitia. N Engl J Med 307 (7):410-412.
91. Matsubara S, Inoh M, Tarumi Y, Sato M, Takahara J 1995 An outbreak (159 cases) of transient thyrotoxicosis without hyperthyroidism in Japan. Intern Med 34 (6):514-519.
92. Date J, Feldt-Rasmussen U, Blichert-Toft M, Hegedus L, Graversen HP 1996 Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. World J Surg 20 (3):351-356.
93. Burgi U, Scazziga BR, Rosselet PO, Burgi H, Studer H 1988 Can serum thyroglobulin predict the effect of thyroid hormone therapy on goitre growth? Acta Endocrinol (Copenh) 119 (1):118-124.
94. Feldt-Rasmussen U, Hegedus L, Hansen JM, Perrild H 1984 Relationship between thyroid volume and serum thyroglobulin during longterm suppression with triiodothyronine in patients with diffuse non-toxic goitre. Acta Endocrinol (Copenh) 105 (2):184-189.
95. Pacini F, Pinchera A, Giani C, Grasso L, Doveri F, Baschieri L 1980 Serum thyroglobulin in thyroid carcinoma and other thyroid disorders. J Endocrinol Invest 3 (3):283-292.
96. Feldt-Rasmussen U, Bech K, Date J 1979 Serum thyroglobulin in patients with toxic and non-toxic goitres compared to sex- and age- matched control subjects. Acta Endocrinol (Copenh) 91 (2):264-270.
97. Berghout A, Wiersinga WM, Smits NJ, Touber JL 1990 Interrelationships Between Age, Thyroid Volume, Thyroid Nodularity, and Thyroid Function in Patients with Sporadic Nontoxic Goiter. Am J Med 89 (5):602-608.
98. Pezzino V, Vigneri R, Squatrito S, Filetti S, Camus M, Polosa P 1978 Increased serum thyroglobulin levels in patients with nontoxic goiter. J Clin Endocrinol Metab 46 (4):653-657.
99. Szabolcs I, Bernard W, Horster FA 1994 Serum thyroglobulin in hospitalized chronic geriatric patients: its relationship to age, non-thyroidal illness, goitre and thyroid dysfunction in a follow-up study. Eur J Endocrinol 131 (5):462-466.
100. Shlossberg AH, Jacobson JC, Ibbertson HK 1979 Serum thyroglobulin in the diagnosis and management of thyroid carcinoma. Clin Endocrinol (Oxf) 10 (1):17-27.
101. Gartner R, Hainzinger A, Horn K, Pickardt RC 1983 Evidence for autonomous thyroglobulin release from euthyroid and hyperthyroid nodular goitre - thyroglobulin, a possible helpful parameter in diagnosis of non-malignant thyroid disorders. Klin Wochenschr 61 (15):737-741.
102. Gerfo PL, Colacchio T, Colacchio D, Feind C 1979 Thyroglobulin in benign and malignant thyroid disease. JAMA 241 (9):923-924.
103. Torrigiani G, Doniach D, Roitt IM 1969 Serum thyroglobulin levels in healthy subjects and in patients with thyroid disease. J Clin Endocrinol Metab 29 (3):305-314.
104. Tomimori E, Pedrinola F, Cavaliere H, Knobel M, Medeiros-Neto G. 1995 Prevalence of incidental thyroid disease in a relatively low iodine intake area. Thyroid 5 (4):273-276.
105. Feldt-Rasmussen U, Hegedus L, Perrild H, Rasmussen N, Hansen JM 1989 Relationship between serum thyroglobulin, thyroid volume and serum TSH in healthy non-goitrous subjects and the relationship to seasonal variations in iodine intake. Thyroidology 1 (3):115-118.
106. Hintze G, Windeler J, Baumert J, Stein H, Kobberling J 1991 Thyroid volume and goitre prevalence in the elderly as determined by ultrasound and their relationships to laboratory indices. Acta Endocrinol Copenh 124 (1):12-18.
107. Feldt-Rasmussen U 1983 Serum thyroglobulin and thyroglobulin autoantibodies in thyroid diseases. Pathogenic and diagnostic aspects. Allergy 38 (6):369-387.
108. Van Herle AJ, Vassart G, Dumont JE 1979 Control of thyroglobulin synthesis and secretion (second of two parts). N Engl J Med 301 (6):307-314.
109. Madeddu G, Casu AR, Marrosu A, Marras G, Langer M 1984 Serum thyroglobulin in patients with autonomous thyroid nodules. Clin Endocrinol (Oxf) 21 (4):377-382.
110. Fenzi GF, Ceccarelli C, Macchia E, Monzani F, Bartalena L, Giani C, Ceccarelli P, Lippi F, Baschieri L, Pinchera A 1985 Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area. Clin Endocrinol (Oxf) 23 (2):115-122.
111. Nakamura S, Sakata S, Minamori Y, Komaki T, Kojima N, Kamikubo K, Yasuda K, Miura K 1984 Serum thyroglobulin (Tg) concentration in healthy subjects: absence of age- and sex-related differences. Endocrinol Jpn 31 (1):93-98.
112. Van Herle AJ, Vassart G, Dumont JE 1979 Control of thyroglobulin synthesis and secretion. (First of two parts). N Engl J Med 301 (5):239-249.
113. Torres MS, Ramirez L, Simkin PH, Braverman LE, Emerson CH 2001 Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects. J Clin Endocrinol Metab 86 (4):1660-1664.
114. Van Herle AJ, Hershman JM, Hornabrook RW, Chopra IJ 1976 Serum thyroglobulin in inhabitants of an endemic goiter region of New Guinea. J Clin Endocrinol Metab 43 (3):512-516.
115. Lima N, Knobel M, Medeiros-Neto G 1986 Long-term effect of iodized oil on serum thyroglobulin levels in endemic goitre patients. Clin Endocrinol (Oxf) 24 (6):635-641.
116. Missler U, Gutekunst R, Wood WG 1994 Thyroglobulin is a more sensitive indicator of iodine deficiency than thyrotropin: development and evaluation of dry blood spot assays for thyrotropin and thyroglobulin in iodine-deficient geographical areas. Eur J Clin Chem Clin Biochem 32 (3):137-143.
117. Premawardhana LD, Lo SS, Phillips DI, Prentice LM, Rees SB 1994 Variability of serum thyroglobulin levels is determined by a major gene. Clin Endocrinol (Oxf) 41 (6):725-729.
118. Fukayama H, Nasu M, Murakami S, Sugawara M 1992 Examination of antithyroid effects of smoking products in cultured thyroid follicles: only thiocyanate is a potent antithyroid agent. Acta Endocrinol (Copenh) 127 (6):520-525.
119. Dunn JT 1996 Seven deadly sins in confronting endemic iodine deficiency, and how to avoid them. J Clin Endocrinol Metab 81 (4):1332-1335.
120. Buchinger W, Lorenz-Wawschinek O, Semlitsch G, Langsteger W, Binter G, Bonelli RM, Eber O 1997 Thyrotropin and thyroglobulin as an index of optimal iodine intake: correlation with iodine excretion of 39, 913 euthyroid patients. Thyroid 7 (4):593-597.
121. Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR 1998 Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 83 (3):765-769.
122. Szabolcs I, Podoba J, Feldkamp J, Dohan O, Farkas I, Sajgo M, Takats KI, Goth M, Kovacs L, Kressinszky K, Hnilica. P, Szilagyi G 1997 Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake. Clin Endocrinol Oxf 47 (1):87-92.
123. Laurberg P, Bulow P, I, Knudsen N, Ovesen L, Andersen S 2001 Environmental iodine intake affects the type of nonmalignant thyroid disease. Thyroid 11 (5):457-469.
124. Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y 1965 "Endemic coast goitre" in Hokkaido, Japan. Acta Endocrinol (Copenh) 50(2):161-176.
125. Zhao J, Wang P, Shang L, Sullivan KM, van der HF, Maberly G 2000 Endemic goiter associated with high iodine intake. Am J Public Health 90 (10):1633-1635.
126. Li M, Liu DR, Qu CY, Zhang PY, Qian QD, Zhang CD, Jia QZ, Wang HX, Eastman CJ, Boyages SC 1987 Endemic goitre in central China caused by excessive iodine intake. Lancet 2 (8553):257-259.
127. Olbricht T and Hoff HG 1988 Factors affecting thyroid gland volume. A contribution to the epidemiology of goiter. Med Klin 83 (8-9):279-284.
128. Barrere X, Valeix P, Preziosi P, Bensimon M, Pelletier B, Galan P, Hercberg S 2000 Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clin Endocrinol (Oxf) 52 (3):273-278.
129. Gomez JM, Maravall FJ, Gomez N, Guma A, Soler J 2000 Determinants of thyroid volume as measured by ultrasonography in healthy adults randomly selected. Clin Endocrinol (Oxf) 53 (5):629-634.
130. Olbricht T, Schmitka T, Mellinghoff U, Benker G, Reinwein D 1983 Sonographische Bestimmung von Schilddrusenvolumina bei Schilddrusengesunden. Dtsch Med Wochenschr 108 (36):1355-1358.
131. Nygaard B, Gideon P, Dige-Petersen H., Jespersen N, Solling K, Veje A 1993 Thyroid volume and morphology and urinary iodine excretion in a Danish municipality. Acta Endocrinol Copenh 129 (6):505-510.
132. Schaaf L, Pohl T, Schmidt R, Vardali I, Teuber J, Schlote SB, Nowotny B, Schiebeler H, Zober A, Usadel KH 1993 Screening for thyroid disorders in a working population. Clin Investig 71 (2):126-131.
133. Wesche MF, Wiersinga WM, Smits NJ 1998 Lean body mass as a determinant of thyroid size. Clin Endocrinol (Oxf) 48 (6):701-706.
134. Aghini-Lombardi F, Antonangeli L, Martino E, Vitti P, Maccherini D, Leoli F, Rago T, Grasso L, Valeriano R, Balestrieri A, Pinchera A 1999 The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin Endocrinol Metab 84 (2):561-566.
135. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA 1977 The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol Oxf 7 (6):481-493.
136. Matovinovich J, Hayner NS, Epstein FH, Kjelsberg MO 1965 Goiter and Other Thyroid Diseases in Tecumseh, Michigan. JAMA 192 (3):134-140.
137. Ericsson UB and Lindgarde F 1990 The epidemiology of thyroid disorders in a seaport community in southern Sweden. J Clin Epidemiol 43 (7):645-650.
138. Struve C and Hinrichs J 1989 Schilddrusenvolumina und Haufigkeit herdformiger Veranderungen bei schilddrusengesunden Mannern und Frauen verschiedener Altersklassen. Dtsch Med Wochenschr 114 (8):283-287.
139. Andersen-Ranberg K, Jeune B, Hoier-Madsen M, Hegedus L 1999 Thyroid function, morphology and prevalence of thyroid disease in a population-based study of Danish centenarians. J Am Geriatr Soc 47 (10):1238-1243.
140. Trowbridge FL, Hand KE, Nichaman MZ 1975 Findings relating to goiter and iodine in the Ten-State Nutrition Survey. Am J Clin Nutr 28 (7):712-716.
141. Woestyn J, Afschrift M, Schelstraete K, Vermeulen A 1985 Demonstration of nodules in the normal thyroid by echography. Br J Radiol 58:1179-1182.
142. Miki H, Oshimo K, Inoue H, Kawano M, Tanaka K, Komaki K, Uyama T, Morimoto T, Monden Y 1993 Incidence of ultrasonographically-detected thyroid nodules in healthy adults. Tokushima J Exp Med 40 (1-2): 43-46.
143. Brander A, Viikinkoski P, Nickels J, Kivisaari L 1989 Thyroid Gland: US Screening in Middle-aged Women with No Previous Thyroid Disease. Radiology 173 (2):507-510.
144. Ezzat S, Sarti DA, Cain DR, Braunstein GD 1994 Thyroid incidentalomas. Prevalence by palpation and ultrasonography. Arch Intern Med 154 (16):1838-1840.
145. Carroll BA 1982 Asymptomatic Thyroid Nodules: Incidental Sonographic Detection. AJR Am J Roentgenol 138 (3):499-501.
146. Mazzaferri EL, de-los-Santos ET, Rofagha KS 1988 Solitary thyroid nodule: diagnosis and management. Med Clin North Am 72 (5):1177-1211.
147. Stark DD, Clark OH, Gooding GA, Moss AA 1983 High-resolution ultrasonography and computed tomography of thyroid lesons in patients with hyperparathyroidism. Surgery 94 (6):863-868.
148. Brander AE, Viikinkoski VP, Nickels JI, Kivisaari LM 2000 Importance of thyroid abnormalities detected at US screening: a 5-year follow-up. Radiology 215 (3):801-806.
149. Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F, Panunzi C, Rinaldi R, Toscano V, Pacella CM 2002 Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab 87 (5):1941-1946.
150. Tan GH and Gharib H 1997 Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med 126 (3):226-231.
151. Leenhardt L, Hejblum G, Franc B, Fediaevsky LD, Delbot T, Le Guillouzic D, Menegaux F, Guillausseau C, Hoang C, Turpin G, Aurengo A 1999 Indications and limits of ultrasound-guided cytology in the management of nonpalpable thyroid nodules. J Clin Endocrinol Metab 84 (1):24-28.
152. Belfiore A, La Rosa GL, Padova G, Sava L, Ippolito O, Vigneri R 1987 The frequency of cold thyroid nodules and thyroid malignancies in patients from an iodine-deficient area. Cancer 60 (12):3096-3102.
153. Sprogel P and Storm HH 1989 Thyroid cancer: incidence, mortality and histological pattern in Denmark. Int J Epidemiol 18 (4):990-992.
154. Chopra IJ, Hershman JM, Hornabrook RW 1975 Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea. J Clin Endocrinol Metab 40 (2):326-333.
155. Hansen PS, Brix TH, Sorensen TI, Kyvik KO, Hegedus L 2004 Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. J Clin Endocrinol Metab 89 (3):1181-1187.
156. Brix TH, Kyvik KO, Christensen K, Hegedus L 2001 Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 86 (2):930-934.
157. Seck T, Scheidt NC, Ziegler R, Pfeilschifiter J 1997 Prevalence of thyroid gland dysfunctions in 50- to 80-year-old patients. An epidemiologic cross-sectional study in a southwestern community. Med Klin 92 (11):642-646.
158. Eggertsen R, Petersen K, Lundberg PA, Nystrom E, Lindstedt G 1988 Screening for thyroid disease in a primary care unit with a thyroid stimulating hormone assay with a low detection limit. BMJ 297 (6663):1586-1592.
159. Sawin CT, Castelli WP, Hershman JM, McNamara P, Bacharach P 1985 The aging thyroid. Thyroid deficiency in the Framingham Study. Arch Intern Med 145 (8):1386-1388.
160. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE 2002 Serum TSH, T (4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87 (2):489-499.
161. Okamura K, Nakashima T, Ueda K, Inoue K, Omae T, Fujishima M 1987 Thyroid Disorders in the General Population of Hisayama Japan, with Special Reference to Prevalence and Sex Differences. Int J Epidemiol 16 (4):545-549.
162. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, Grimley EJ, Hasan DM, Rodgers H, Tunbridge F, et al 1995 The incidence of thyroid disorders in the community: a twenty-year followup of the Whickham Survey. Clin Endocrinol Oxf 43 (1):55-68.
163. Demers LM and Spencer CA (Editors) 2003 Laboratory Medicine Practice Guidelines for the Diagnosis and Monitoring of Thyroid Disease. Thyroid 13 (1):36.
164. Roberts CG and Ladenson PW 2004 Hypothyroidism. Lancet 363 (9411):793-803.
165. Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L, Brochmann H 2000 Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The health study of nord-trondelag (HUNT). Eur J Endocrinol 143 (5):639-647.
166. Laurberg P, Bulow P, I, Pedersen KM, Vestergaard H 1999 Low incidence rate of overt hypothyroidism, compared with hyperthyroidism in an area with moderately low iodine intake. Thyroid 9 (1):33-38.
167. Laurberg P, Pedersen KM, Vestergaard H, Sigurdsson G 1991 High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. J Intern Med 229 (5):415-420.
168. Petersen K, Lindstedt G, Lundberg PA, Bengtsson C, Lapidus L, Nystrom E 1991 Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking. J Intern Med 229 (5):407-413.
169. Roti E, Gardini E, D'Amato L, Salvi M, Robuschi G, Manfredi A, Dallara G, Pino S, Guazzi AM, Gnudi A 1986 Goiter size and thyroid function in an endemic goiter area in northern Italy. J Clin Endocrinol Metab 63 (3):558-563.
170. Laurberg P, Pedersen KM, Vestergaard P, Vestergaard H 1991 Hyper-functioning thyroid nodules. Thyroidology 3 (1):1-6.
171. Tonacchera M and Pinchera A 2000 Thyrotropin receptor polymorphisms and thyroid diseases. J Clin Endocrinol Metab 85 (8):2637-2639.
172. Derwahl M and Studer H 2001 Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. Exp Clin Endocrinol Diabetes 109 (5):250-260.
173. Tonacchera M, Agretti P, Chiovato L, Rosellini V, Ceccarini G, Perri A, Viacava P, Naccarato AG, Miccoli P, Pinchera A, Vitti P 2000 Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter. J Clin Endocrinol Metab 85 (6):2270-2274.
174. Tonacchera M, Vitti P, Agretti P, Giulianetti B, Mazzi B, Cavaliere R, Ceccarini G, Fiore E, Viacava P, Naccarato A, Pinchera A, Chiovato L 1998 Activating thyrotropin receptor mutations in histologically heterogeneous hyperfunctioning nodules of multinodular goiter. Thyroid 8 (7):559-564.
175. Tonacchera M, Chiovato, L, Pinchera A, Agretti P, Fiore E, Cetani F, Rocchi R, Viacava P, Miccoli P, Vitti P 1998 Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. J Clin Endocrinol Metab 83 (2):492-498.
176. Derwahl M, Hamacher C, Russo D, Broecker M, Manole D, Schatz H, Kopp P, Filetti S 1996 Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas. J Clin Endocrinol Metab 81 (5):1898-1904.
177. Corvilain B, Van Sande J, Dumont JE, Bourdoux P, Ermans AM 1998 Autonomy in endemic goiter. Thyroid 8 (1):107-113.
178. Derwahl M and Studer H 2001 Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. Exp Clin Endocrinol Diabetes 109 (5):250-260.
179. Robuschi G, Safran M, Braverman LE, Gnudi A, Roti E 1987 Hypothyroidism in the elderly. Endocr Rev 8 (2):142-153.
180. Bulow Pedersen I, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Laurberg P 2002 Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol (Oxf) 58 (1):36-42.
181. Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K 1994 Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 78 (2):393-397.
182. Tajiri J, Higashi K, Morita M, Umeda T, Sato T 1986 Studies of hypothyroidism in patients with high iodine intake. J Clin Endocrinol Metab 63 (2):412-417.
183. Prummel MF and Wiersinga WM 1993 Smoking and risk of Graves' disease. JAMA 269 (4):479-482.
184. Bartalena L, Martino E, Marcocci C, Bogazzi F, Panicucci M, Velluzzi F, Loviselli A, Pinchera A 1989 More on smoking habits and Graves' ophthalmopathy. J Endocrinol Invest 12 (10):733-737.
185. Hegedus L, Karstrup S, Veiergang D, Jacobsen B, Skovsted L, Feldt-Rasmussen U 1985 High frequency of goitre in cigarette smokers. Clin Endocrinol (Oxf) 22 (3):287-292.
186. Ericsson UB and Lindgarde F 1991 Effects of cigarette smoking on thyroid function and the prevalence of goitre, thyrotoxicosis and autoimmune thyroiditis. J Intern Med 229 (1):67-71.
187. Christensen SB, Ericsson UB, Janzon L, Tibblin S, Melander A 1984 Influence of Cigarette Smoking on Goiter Formation, Thyroglobulin, and Thyroid Hormone Levels in Women. J Clin Endocrinol Metab 58 (4):615-618.
188. Brix TH, Hansen PS, Kyvik KO, Hegedus L 2000 Cigarette smoking and risk of clinically overt thyroid disease: a population-based twin case-control study. Arch Intern Med 160 (5):661-666.
189. Georgiadis E, Papapostolou C, Korakis T, Evagelopoulou K, Mantzoros C, Batrinos M 1997 The influence of smoking habits on thyroid gland volume: an ultrasonic approach. J R Soc Health 117 (6):355-358.
190. Chen YL, Chang TC, Chen CJ 1994 Influence of smoking on Graves' disease with or without ophthalmopathy and nontoxic nodular goiter in Taiwan. J Formos Med Assoc 93 (1):40-44.
191. Lio S, Napolitano G, Marinuzzi G, Monaco F 1989 Role of smoking in goiter morphology and thyrotropin response to TRH in untreated goitrous women. J Endocrinol Invest 12 (2):93-97.
192. Rossing MA, Cushing KL, Voigt LF, Wicklund KG, Daling JR 2000 Risk of papillary thyroid cancer in women in relation to smoking and alcohol consumption. Epidemiology 11 (1):49-54.
193. Galanti MR, Hansson L, Lund E, Bergstrom R, Grimelius L, Stalsberg H, Carlsen E, Baron JA, Persson I, Ekbom A 1996 Reproductive history and cigarette smoking as risk factors for thyroid cancer in women: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 5 (6):425-431.
194. Eden S, Jagenburg R, Lindstedt G, Lundberg PA, Mellstrom D 1984 Thyroregulatory changes associated with smoking in 70-year-old men. Clin Endocrinol (Oxf) 21 (6):605-610.
195. Melander A, Nordenskjold E, Lundh B, Thorell J 1981 Influence of smoking on thyroid activity. Acta Med Scand 209 (1-2):41-43.
196. Fisher CL, Mannino DM, Herman WH, Frumkin H 1997 Cigarette smoking and thyroid hormone levels in males. Int J Epidemiol 26 (5):972-977.
197. Karakaya A, Tuncel N, Alptuna G, Kocer Z, Erbay G 1987 Influence of cigarette smoking on thyroid hormone levels. Hum Toxicol 6 (6):507-509.
198. Sepkovic DW, Haley NJ, Wynder EL 1984 Thyroid activity in cigarette smokers. Arch Intern Med 144 (3):501-503.
199. Vestergaard P, Rejnmark L, Weeke J, Hoeck HC, Nielsen HK, Rungby J, Laurberg P, Mosekilde L 2002 Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism. Thyroid 12 (1):69-75.
200. Vestergaard P 2002 Smoking and thyroid disorders - a meta-analysis. Eur J Endocrinol 146 (2):153-161.
201. Williams ED, Doniach I, Bjarnason O, Michie W 1977 Thyroid cancer in an iodide rich area: a histopathological study. Cancer 39 (1):215-222.
202. Colzani R, Fang SL, Alex S, Braverman LE 1998 The effect of nicotine on thyroid function in rats. Metabolism 47 (2):154-157.
203. Melander A, Westgren U, Ericson LE, Sundler F 1977 Influence of the sympathetic nervous system on the secretion and metabolism of thyroid hormone. Endocrinology 101 (4):1228-1237.
204. Hart P, Farrell GC, Cooksley WG, Powell LW 1976 Enhanced drug metabolism in cigarette smokers. Br Med J 2 (6028):147-149.
205. Metcalfe RA and Weetman AP 1994 Stimulation of extraocular muscle fibroblasts by cytokines and hypoxia: possible role in thyroid-associated ophthalmopathy. Clin Endocrinol (Oxf) 40 (1):67-72.
206. Hegedus L 1984 Decreased thyroid gland volume in alcoholic cirrhosis of the liver. J Clin Endocrinol Metab 58 (5):930-933.
207. Burke V, Puddey IB, Beilin LJ 1995 Mortality associated with wines, beers, and spirits. Australian data suggest that choice of beverage relates to lifestyle and personality. BMJ 311 (7013):1166-
208. Tjonneland A, Gronbaek M, Stripp C, Overvad K 1999 Wine intake and diet in a random sample of 48763 Danish men and women. Am J Clin Nutr 69 (1):49-54.
209. Klatsky AL, Armstrong MA, Kipp H 1990 Correlates of alcoholic beverage preference: traits of persons who choose wine, liquor or beer. Br J Addict 85 (10):1279-1289.
210. Rasmussen LB, Larsen EH, Ovesen L 2000 Iodine content in drinking water and other beverages in Denmark. Eur J Clin Nutr 54 (1):57-60.
211. Clark OH and Gerend PL 1986 Effect of ethyl alcohol on the TSH-receptor-cyclase system in thyroid and nonthyroid tissues. World J Surg 10 (5):787-796.
212. Hegedus L, Kastrup J, Feldt-Rasmussen U, Petersen PH 1983 Serum thyroglobulin in acute and chronic liver disease. Clin Endocrinol (Oxf) 19 (2):231-237.
213. Noach EL 1955 Influence of oestrogens on thyroid function (1). Acta Endocrinol (Copenh) 19:127-138.
214. Furlanetto TW, Nguyen LQ, Jameson JL 1999 Estradiol increases proliferation and down-regulates the sodium/iodide symporter gene in FRTL-5 cells. Endocrinology 140 (12):5705-5711.
215. del Senno L, degli UE, Hanau S, Piva R, Rossi R, Trasforini G 1989 In vitro effects of estrogen on tgb and c-myc gene expression in normal and neoplastic human thyroids. Mol Cell Endocrinol 63 (1-2):67-74.
216. Rumsey TS, Elsasser TH, Kahl S 1997 Roasted soybeans and an estrogenic growth promoter affect the thyroid status of beef steers. J Nutr 127 (2):352-358.
217. Kuhl H, Gahn G, Romberg G, Althoff PH, Taubert HD 1985 A randomized cross-over comparison of two low-dose oral contraceptives upon hormonal and metabolic serum parameters: II. Effects upon thyroid function, gastrin, STH, and glucose tolerance. Contraception 32 (1):97-107.
218. Zaninovich AA, Boado R, Ulloa E, Bromage NR, Matty AJ 1982 Inhibition of thyroidal iodine release by oestrogens in euthyroid subjects. Acta Endocrinol (Copenh) 99 (3):386-392.
219. Weeke J and Hansen AP 1975 Serum TSH and serum T3 levels during normal menstrual cycles and during cycles on oral contraceptives. Acta Endocrinol (Copenh) 79 (3):431-438.
220. Muller AF, Verhoeff A, Mantel MJ, De Jong FH, Berghout A 2000 Decrease of free thyroxine levels after controlled ovarian hyperstimulation. J Clin Endocrinol Metab 85 (2):545-548.
221. Frank P and Kay CR 1978 Incidence of thyroid disease associated with oral contraceptives. Br Med J 2 (6151):1531.
222. Wong FL, Ron E, Gierlowski T, Schneider AB 1996 Benign thyroid tumors: general risk factors and their effects on radiation risk estimation. Am J Epidemiol 144 (8):728-733.
223. Strieder TG, Prummel MF, Tijssen JG, Endert E, Wiersinga WM 2003 Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives ofpatients with autoimmune thyroid disease. Clin Endocrinol (Oxf) 59 (3):396-401.
224. Sorger D, Schenk S, Schneider G 1992 Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3. Z Gesamte Inn Med 47 (2):58-64.
225. Wang R, Nelson JC, Weiss RM, Wilcox RB 2000 Accuracy of free thyroxine measurements across natural ranges of thyroxine binding to serum roteins. Thyroid 10 (1):31-39.
226. Lisboa PC, Curty FH, Moreira RM, Pazos-Moura CC 1997 Effects of estradiol benzoate on 5'-iodothyronine deiodinase activities in female rat anterior pituitary gland, liver and thyroid gland. Braz J Med Biol Res 30 (12):1479-1484.
227. Rossi R, Zatelli MC, Franceschetti P, Maestri I, Magri E, Aguiari G, Cavazzini P, degli Uberti EC, del Senno L 1996 Inhibitory effect of dihydrotestosterone on human thyroid cell growth. J Endocrinol 151 (2):185-194.
228. Casson PR, Elkind-Hirsch KE, Buster JE, Hornsby PJ, Carson SA, Snabes MC 1997 Effect of postmenopausal estrogen replacement on circulating androgens. Obstet Gynecol 90 (6):995-998.
229. Furlanetto TW, Nunes RB, Sopelsa AM, Maciel RM 2001 Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells. Braz J Med Biol Res 34 (2):259-263.
230. Ramey JN, Burrow GN, Polackwich RJ, Donabedian RK 1975 The effect of oral contraceptive steroids on the response of thyroid-stimulating hormone to thyrotropin-releasing hormone. J Clin Endocrinol Metab 40 (4):712-714.
231. Rey-Stocker I, Zufferey MM, Lemarchand MT, Rais M 1981 The sensibility of the hypophysis, the gonads and the thyroid of adolescents before and after the administration of oral contraceptives. A resume. Pediatr Ann 10 (12):15-20.
232. Arafah BM 2001 Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med 344 (23):1743-1749.
233. Banu KS, Govindarajulu P, Aruldhas MM 2001 Testosterone and estradiol modulate TSH-binding in the thyrocytes of Wistar rats: influence of age and sex. J Steroid Biochem Mol Biol 78 (4):329-342.
234. Wang SH, Myc A, Koenig RJ, Bretz JD, Arscott PL, Baker JR 2000 2-Methoxyestradiol, an endogenous estrogen metabolite, induces thyroid cell apoptosis. Mol Cell Endocrinol 165 (1-2):163-172.
235. Carayon P, Lefort G, Nisula B 1980 Interaction of human chorionic gonadotropin and human luteinizing hormone with human thyroid membranes. Endocrinology 106 (6):1907-1916.
236. Williams JF, Davies TF, Catt KJ, Pierce JG 1980 Receptor-binding activity of highly purified bovine luteinizing hormone and thyrotropin, and their subunits. Endocrinology 106 (5):1353-1359.
237. Taliadouros GS, Canfield RE, Nisula BC 1978 Thyroid-stimulating activity of chorionic gonadotropin and luteinizing hormone. J Clin Endocrinol Metab 47 (4):855-860.
238. Glinoer D 1999 What happens to the normal thyroid during pregnancy? Thyroid 9 (7):631-635.
239. Balen AH, Tan SL, Jacobs HS 1993 Hypersecretion of luteinising hormone: a significant cause of infertility and miscarriage. Br J Obstet Gynaecol 100 (12):1082-1089.
240. Fleury Y, Van Melle GG, Woringer V, Gaillard RC, Portmann L 2001 Sex-Dependent Variations and Timing of Thyroid Growth during Puberty. J Clin Endocrinol Metab 86 (2):750-754.
241. Glinoer D, De Nayer P, Bourdoux P, Lemone M, Robyn C, van Steirteghem A, Kinthaert J, Lejeune B 1990 Regulation of maternal thyroid during pregnancy. J Clin Endocrinol Metab 71 (2):276-287.
242. Smyth PP, Hetherton AM, Smith DF, Radcliff M, O'Herlihy C 1997 Maternal iodine status and thyroid volume during pregnancy: correlation with neonatal iodine intake. J Clin Endocrinol Metab 82 (9):2840-2843.
243. Rasmussen NG, Hornnes PJ, Hegedus L 1989 Ultrasonographically determined thyroid size in pregnancy and post partum: the goitrogenic effect of pregnancy. Am J Obstet Gynecol 160 (5 Pt 1):1216-1220.
244. Romano R, Jannini EA, Pepe M, Grimaldi A, Olivieri M, Spennati P, Cappa F, D'Armiento M 1991 The effects of iodoprophylaxis on thyroid size during pregnancy. Am J Obstet Gynecol 164 (2):482-485.
245. Glinoer D, De Nayer P, Delange F, Lemone M, Toppet V, Spehl M, Grun JP, Kinthaert J, Lejeune B 1995 A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects. J Clin Endocrinol Metab 80 (1):258-269.
246. Pedersen KM, Laurberg P, Iversen E, Knudsen PR, Gregersen HE, Rasmussen OS, Larsen KR, Eriksen GM, Johannesen PL 1993 Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. J Clin Endocrinol Metab 77 (4):1078-1083.
247. Kung AW, Lao TT, Chau MT, Tam SC, Low LC 2000 Goitrogenesis during pregnancy and neonatal hypothyroxinaemia in a borderline iodine sufficient area. Clin Endocrinol (Oxf) 53 (6):725-731.
248. Nelson M, Wickus GG, Caplan RH, Beguin EA 1987 Thyroid gland size in pregnancy. An ultrasound and clinical study. J Reprod Med 32 (12):888-890.
249. Berghout A, Endert E, Ross A, Hogerzeil HV, Smits NJ, Wiersinga WM 1994 Thyroid function and thyroid size in normal pregnant women living in an iodine replete area. Clin Endocrinol (Oxf) 41 (3):375-379.
250. Long TJ, Felice ME, Hollingsworth DR 1985 Goiter in pregnant teenagers. Am J obstet Gynecol 152 (6 Pt 1):670-674.
251. Levy RP, Newman DM, Rejali LS, Barford DA 1980 The myth of goiter in pregnancy. Am J Obstet Gynecol 137 (6):701-703.
252. Crooks J, Tulloch MI, Turnbull AC, Davidsson D, Skulason T, Snaedal G 1967 Comparative incidence of goitre in pregnancy in Iceland and Scotland. Lancet 2 (7517):625-627.
253. Rotondi M, Amato G, Biondi B, Mazziotti G, Del Buono A, Rotonda NM, Balzano S, Bellastella A, Glinoer D, Carella C 2000 Parity as a Thyroid Size-Determining Factor in Areas with Moderate Iodine Deficiency. J Clin Endocrinol Metab 85 (12):4534-4537.
254. Struve CW, Haupt S, Ohlen S 1993 Influence of frequency of previous pregnancies on the prevalence of thyroid nodules in women without clinical evidence of thyroid disease. Thyroid 3 (1):7-9.
255. Kung AW, Chao MT, Lao TT, Tam SC, Low LC 2002 The effect of pregnancy on thyroid nodule formation. J Clin Endocrinol Metab 87 (3):1010-1014.
256. Chaouki ML and Benmiloud M 1994 Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Eur J Endocrinol 130 (6):547-551.
257. Liesenkotter KP, Gopel W, Bogner U, Stach B, Gruters A 1996 Earliest prevention of endemic goiter by iodine supplementation during pregnancy. Eur J Endocrinol 134 (4):443-448.
258. Aboul-Khair SA, Crooks J, Turnbull AC, Hytten FE 1964 The physiological changes in thyroid function during pregnancy. Clin Sci 27:195-207.
259. Muzzo S, Burgueno M, Carvajal F, Moreno R, Leiva L 1994 Endemic goiter in three census areas of Chile. Arch Latinoam Nutr 44 (2):82-86.
260. Freire-Maia DV and Freire-Maia A 1981 Endemic goitre in whites and negroes: racial or social effect? Trop Geogr Med 33 (4):387-392.
261. Mertz DP and Tomaras K 1976 The importance of sociomedical factors for the regression of endemic goiter in South Baden. MMW Munch Med Wochenschr 118 (44):1419-1422.
262. Stone T 1984 Endemic goitre, nutrition, and landholding in Bangladesh. Int J Epidemiol 13 (1):58-64.
263. Joshi DC, Mishra VN, Bhatnagar M, Singh RB, Garg SK, Chopra H 1993 Socioeconomic factors and prevalence of endemic goitre. Indian J Public Health 37 (2):48-53.
264. Freire-Maia DV, Freire-Maia A, Scholl WJ, Morton NE, Quelce-Salgado A, Lobo LC 1983 Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. Isr J Med Sci 19 (1):11-16.
265. Gibson HB, Howeler JF, Clements FW 1960 Seasonal epidemics of endemic goitre in Tasmania. Med J Aust June 4:875-880.
266. Koutras DA, Katsouyanni EK, Livadas DP, Piperingos GD, Tzonou A, Trichopoulos D 1982 An epiderniologic survey of thyroid enlargement among schoolchildren in a non-endemic area. Endokrinologie 79 (3):349-354.
267. Hess SY, Zimmermann MB, Adou P, Torresani T, Hurrell RF 2002 Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Cote d'Ivoire. Am J Clin Nutr 75 (4):743-748.
268. Hess SY, Zimmermann MB, Arnold M, Langhans W, Hurrell RF 2002 Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutt 132 (7):1951-1955.
269. Delange F 1998 Risks and benefits of iodine supplementation. Lancet 351 (9107):923-924.
270. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC 2000 Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 132 (4):270-278.
271. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM 2000 Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol (Oxf) 53 (6):733-737.
272. Toft AD 2001 Clinical practice. Subclinical hyperthyroidism. N Engl J Med 345 (7):512-516.
273. Nohr SB, Jorgensen A, Pedersen KM, Laurberg P 2000 Postpartum thyroid dysfunction in pregnant thyroid peroxidase antibody-positive women living in an area with mild to moderate iodine deficiency: is iodine supplementation safe? J Clin Endocrinol Metab 85 (9):3191-3198.