Zinc stimulates DNA synthesis during its antiapoptotic action independently with increments of an antiapoptotic protein, Bcl-2, in porcine kidney LLC-PK1 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 923-928

  Ishido, Masami ^a   Suzuki, Tsuguyoshi ^a   Adachi, Tatsumi ^a   Kunimoto, Manabu ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CADMIUM; DNA FRAGMENT; PROTEIN BCL 2; ZINC;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STIMULATION; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; GENE OVEREXPRESSION; KIDNEY CELL; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SWINE;

ANIMALS; ANTIMETABOLITES; APOPTOSIS; BLOTTING, WESTERN; BROMODEOXYURIDINE; DNA; DNA FRAGMENTATION; HUMANS; IN SITU NICK-END LABELING; KIDNEY; LLC-PK1 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; STIMULATION, CHEMICAL; SWINE; TRANSFECTION; ZINC;

EID: 0032788737     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Azzouzi BE, Tsangaris GT, Pellegrini O, Manuel, Y, Benveniste J and Thomas Y (1994) Cadmium induces apoptosis in a human T cell line. Toxicology 88:127-139.
2. Cohen JJ and Duke RC (1984) Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132:38-42.
3. Coleman JE (1992) Zinc proteins: Enzymes, storage proteins, transcription factors, and replication proteins. Annu Rev Biochem 61:897-946.
4. Dignam JD, Lebovite RM and Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extraction from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
5. D'Mello SR, Borodezt K and Soltoff P (1997) Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathway: Possible involvement of PI3-kinase in IGF-1 signalling. J Neurosci 17:1548-1560.
6. D'Mello SR, Galli C, Ciotti T and Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
7. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR and Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Wash DC) 275:661-665.
8. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Perm LZ and Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128.
9. Gaido ML and Cidlowski JA (1991) Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. J Biol Chem 266:18580-18585.
10. 2+. Biochem Biophys Res Commun 181:915-920.
11. Graham and Van der Eb (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
12. Harrington EA, Bennett MR, Fanidi A and Evan GI (1994) c-MYC-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13:3286-3295.
13. 1 cells. Life Sci 56:PL351-PL356.
14. Ishido M, Homma S, Tohyama C and Suzuki T (1998) Apoptosis in rat renal proximal tubular cells induced by cadmium. J Toxicol Environ Health 55:101-112.
15. Jung Y-K, Miura M and Yuan J (1996) Suppression of interleukin-1β-converting enzyme-mediated cell death by insulin-like growth factor. J Biol Chem 271:5112-5117.
16. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
17. Lohmann RD and Beyersmann D (1994) Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei. Environ Health Perspect 102(Suppl):269-271
18. Marte BM and Downward J (1997) PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 22:355-358.
19. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG and Hannun YA (1997) Zinc is a potent inhibitor of the apoptotic protease, caspase 3: A novel target for zinc in the inhibition of apoptosis. J Biol Chem 272:18530-18533.
20. Porras A, Alvarez AM, Valladares A and Benito M (1997) TNF-α induces apoptosis in rat fetal brown adipocytes in primary culture. FEBS Lett 416:324-328.
21. Reyes JG (1996) Zinc transport in mammalian cells. Am J Physiol 270:C401-C410.
22. Takahashi A, Alnemri ES, Lazebnik YA, Alnemri TF, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH and Earnshaw WC (1996) Cleavage of lamin A by Mch2α but not CPP32: Multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci USA 93:8395-8400.
23. Tsujimoto Y (1989) Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell. Oncogene 4:1331-1336.
24. Vallee BL and Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:75-118.
25. Vaux DL, Cory S and Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (Lond) 336:440-442.
26. Wylle AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond) 284:555-556.
27. Xu C, Johnson JE, Singh PK, Jones MM, Yan H and Carter CE (1996) In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107:1-8.
28. Yan H, Carter CE, Xu C, Singh PK, Jones MM, Johnson JE and Dietrich MS (1997) Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation. J Toxicol Environ Health 52:149-168.
29. Yao R and Cooper GMR (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science (Wash DC) 267:2003-2006.