Investigation of effective anesthesia induction doses using a wide range of infusion rates with undiluted and diluted propofol

Anesthesiology

Volumn 92, Issue 4, 2000, Pages 1017-1028

  Kazama, Tomiei ^a   Ikeda, Kazuyuki ^b   Morita, Koji ^b   Kikura, Mutsuhito ^b   Ikeda, Takehiko ^b   Kurita, Tadayoshi ^b   Sato, Shigehito ^b  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Overdose; Residual dose; Time lag; Transit

Indexed keywords

PROPOFOL;

ADULT; ANESTHESIA INDUCTION; ARTICLE; CARDIOPULMONARY INSUFFICIENCY; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DILUTION; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HUMAN; HYPOTENSION; INJECTION PAIN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TIME; UNCONSCIOUSNESS;

EID: 0034071055     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200004000-00019     Document Type: Article

References (23)

1. Claeys MA, Gepts E, Camu F: Haemodynamic changes during anaesthesia induced and maintained with propofol. Br J Anaesth 1988; 60:3-9
2. Dundee JW, Robinson FP, McCollun JSC, Patterson CC: Sensitivity to propofol in the elderly. Anaesthesia 1986; 41:482-5
3. Stokes DN, Hutton P: Rate-dependent induction phenomena with propofol: Implications for the relative potency of intravenous anesthetics. Anesth Analg 1991; 72:578-83
4. Peacock JE, Lewis RP, Reilly CS, Nimmo WS: Effect of different rates of infusion of propofol for induction of anaesthesia in elderly patients. Br J Anaesth 1990; 65:346-352
5. Rolly G, Versichelen L, Huyghe L, Mungroop H: Effect of speed of injection on induction of anaesthesia using propofol. Br J Anaesth 1985; 57:743-6
6. Cockshott ID, Douglas EJ, Prys-Roberts C, Turtle M, Coates DP: The pharmacokinetics of propofol during and after intravenous infusion in man. Eur J Anaesth 1990; 7:265-75
7. Peacock JE, Blackburn A, Sherry KM, Reilly CS: Arterial and jugular venous bulb blood propofol concentrations during induction of anesthesia. Anesth Analg 1995; 80:1002-6
8. James WPT: Research in Obesity. London, Her Majesty's Printing Office, 1976
9. Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ: The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. ANESTHESIOLOGY 1998; 88:1170-82
10. Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ: The influence of age on propofol pharmacodynamics. ANESTHESIOLOGY 1999; 90:1502-16
11. Gillies GW, Lees NW: The effects of speed of injection on induction with propofol. Anaesthesia 1989; 44:386-8
12. Steepstra GL, Booij LH, Rutten CLG, Coenen LGJ: Propofol forinduction and maintenance of anaesthesia: Comparison between younger and older patients. Br J Anaesth 1989; 62:54-60
13. Peacock JE, Spiers SPW, McLauchlan GA, Edmondson WC, Berthoud M, Reilly CS: Infusion of propofol to identify smallest effective doses for induction of anaesthesia in young and elderly patients. Br J Anaesth 1992; 69:363-7
14. Shafer SL, Gregg KM: Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J Pharmacokinet Biopharm 1992; 20:147-69
15. Shafer SL: Advances in propofol pharmacokinetics and pharmacodynamics. J Clin Anesth 1993; 5:14-21s
16. Henthorn TK, Avram MJ, Krejcie TC, Shanks CA, Asada A, Kaczynski DA: Minimal compartmental model of circulatory mixing of indocyanine green. Am J Physiol 1992; 31:H903-10
17. Van Rosum JM, Van Lingen BG, Teeuwen HWA: Perspectives in pharmacokinetics: Pharmacokinetics from a dynamical systems point of view. J Pharmacokinet Biopharm 1989; 17:365-97
18. Roerig DL, Kotrly KJ, Vucins EJ, Ahlf SB, Dawson CA, Kampaine JP: First pass uptake of fentanyl, meperidine, and morphine in the human lung. ANESTHESIOLOGY 1987; 67:466-72
19. Iwasaki H, Igarashi M, Kawana S, Namiki A: Accelerated onset of vecuronium neuromuscular block with pulmonary arterial administration. Can J Anaesth 1994; 41:1178-80
20. Upton RN, Huang YF: Influence of cardiac output, injection time and injection volume on the initial mixing of drugs with venous blood after i.v. bolus administration to sheep. Br J Anaesth 1993; 70:333-8
21. Upton RN, Ludbrook GL, Grant C, Martinez AM: Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration. Anesth Analg 1999; 89:545-52
22. eo of propofol for blood pressure and EEG bispectral index in elderly and younger patients. ANESTHESIOLOGY 1999; 90:1517-27
23. Upton RN, Ludbrook GL: A physiological model of induction of anaesthesia with propofol in sheep: I. Structure and estimation of variables. Br J Anaesth 1997; 79:497-504