Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model

Annals of Plastic Surgery

Volumn 56, Issue 3, 2006, Pages 320-326

  Tyner, Tim R ^a,b   Tong, Winnie ^a   Donovan, Kelli ^b   McDonald, Travis ^b   Sian, Kenty ^a   Yamaguchi, Kent T ^a  

^a University Medical Center Fresno   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Dichloroacetate; Skin flap necrosis; TRAM flap

Indexed keywords

DICHLOROACETIC ACID; LACTIC ACID;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT SURVIVAL; HISTOLOGY; HYPOXEMIA; INFERIOR EPIGASTRIC ARTERY; INFLAMMATION; ISCHEMIA; ISCHEMIC PRECONDITIONING; LACTATE BLOOD LEVEL; MALE; MUSCLE BIOPSY; MUSCLE NECROSIS; MYOCUTANEOUS FLAP; NONHUMAN; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RAT; RECTUS ABDOMINIS MUSCLE; TISSUE NECROSIS;

ANALYSIS OF VARIANCE; ANIMALS; DICHLOROACETATE; DISEASE MODELS, ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; MALE; NECROSIS; PROBABILITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECTUS ABDOMINIS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SURGICAL FLAPS;

EID: 33646081799     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sap.0000194549.39544.cd     Document Type: Article

References (44)

1. Kroll SS, Netscher DT. Complications of TRAM flap breast reconstruction in obese patients. Plast Reconstr Surg. 1989;84:886.
2. Kerrigan CL. Skin flap failure: pathophysiology. Plast Reconstr Surg. 1983;72:766.
3. Myers MB, Cherry G. Causes of necrosis in pedicle flaps. Plast Reconstr Surg. 1968;42:43.
4. Carlson GW. Breast reconstruction. Surgical options and patient selection. Cancer. 1994;74(suppl):436.
5. Paige KT, Bostwick J, Bried JT, et al. A comparison of morbidity from bilateral, unipedicled and unilateral, unipedicled TRAM flap breast reconstructions. Plast Reconstr Surg. 1998;101:1819.
6. Shrotria S, Webster DJ, Mansel RE, et al. Complications of rectus abdominis myocutaneous flaps in breast surgery. Eur J Surg Oncol. 1993;19:80.
7. Myers MB, Cherry G. Differences in the delay phenomenon in the rabbit, rat and pig. Plast Reconstr Surg. 1971;47:73.
8. Restifo RJ, Ahmed SS, Isenberg JS, et al. Timing, magnitude, and utility of surgical delay in the RAMJ flap: I. Animal studies. Plast Reconstruct Surg. 1997;99:1211.
9. Karacaoglu E, Yuksel F, Turan SO, et al. Chemical delay: an alterative to surgical delay experimental study. Ann Plast Surg. 2002;49:73.
10. Zahir KS, Syed SA, Zink JR, et al. Ischemic preconditioning improves the survival of skin and myocutaneous flaps in a rat model. Reconstr Surg. 1998;102:140.
11. Seify H, Bilkay U, Jones G. Improvement of TRAM flap viability using human VEGF-induced angiogenesis: a comparative study of delay techniques. Plast Reconstr Surg. 2003;112:1032.
12. Zhang F, Fischer K, Komorowska-Timek E, et al. Improvement of skin paddle survival by application of vascular endothelial growth factor in a rat TRAM flap model. Ann Plast Surg. 2001;46:314.
13. Lineaweaver WC, Lei MP, Mustain W, et al. Vascular endothelium growth factor, surgical delay, and skin flap survival. Ann Surg. 2004;239:866.
14. Hijjawi J, Mogofrd J, Chandler L, et al. Platelet-derived growth factor B, but not fibroblast growth factor 2, plasmid DNA improves survival of ischemic myocutaneous flaps. Arch Surg. 2004;139:142.
15. Stacpoole PW, Henderson GN, Yan Z, et al. Clinical pharmacology and toxicology of dichloroacetate. Environ Health Perspect. 1998;106(suppl 4):989.
16. Hong JP, Kwon H, Chung YK, et al. The effect of hyperbaric oxygen on ischemia-reperfusion injury: an experimental study in a rat musculocutaneous flap. Ann Plast Surg. 2003;51:478.
17. Dunn RM, Huff W, Mancoll J. The rat recrus abdominis myocutaneous flap: a true myocutaneous flap model. Ann Plast Surg. 1993;31:352.
18. Hallock GG, Rice DC. Physiologic superiority of the anatomic dominant pedicle of the TRAM flap in a rat model. Plast Reconstr Surg. 1995;96:111.
19. Zhang F, Lineaweaver WC, Kao S, et al. Microvascular transfer of the rectus abdominis muscle and myocutaneous flap in rats. Microsurgery. 1993;14:420.
20. Wilson JS, Rushing G, Johnson BL, et al. The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion. J Am Coll Surg. 2003;197:591.
21. Wilson JS, Rushing G, Johnson BL, et al. Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia. Vasc Endvasc Surg. 2003;37:T1.
22. Matsuoka S, Toshima K, Naito E, et al. Effects of dichloroacetate on the mechanical function of the isolated ischemic heart. Jpn Heart J. 1987;28:531.
23. McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol. 1990;259:H1079.
24. Shangraw RE, Jahoor F. Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis. Metabolism. 2004;53:1087.
25. Contaldo C, Plock J, Djonov V, et al. The influence of trauma and ischemia on carbohydrate metabolites monitored in hamster flap tissue. Anesth Analg. 2005;100:817.
26. Larson JL, Bull RJ. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol Appl Pharmacol. 1992;115:268.
27. Lin EL, Mattox JK, Daniel FB. Tissue distribution, excretion, and urinary metabolites of dichloroacetic acid in the male Fischer 344 rat. J Toxicol Environ Health. 1993;38:19.
28. Gonzalez-Leon A, Schultz IR, Xu G, et al. Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking water. Toxicol Appl Pharmacol. 1997;146:189.
29. Tong Z, Board PG, Anders MW. Glutathione transferase Zeta catalyzes the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem J. 1998;331:371.
30. Anderson WB, Board PG, Gargano B, et al. Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking α-haloalkanoic acids. Chem Res Toxicol. 1999;12:1144.
31. Cornett R, James MO, Henderson GN, et al. Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity. Biochem Biophys Res Commun. 1999;262:752.
32. Saghir AS, Schultz IR. Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naïve and GST-ξ depleted rats. Envir Health Persp. 2002;110:757.
33. Curry SH, Chu PI, Baumgartner TG, et al. Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate. Clin Pharmacol Ther. 1985;37:89.
34. Henderson GN, Curry SH, Derendorf H, et al. Pharmacokinetics of dichloroacetate in adult patients with lactic acidosis. J Clin Pharmacol. 1997;37:416.
35. McMurtry MS, Bonnet S, Wu XC, et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res. 2004;95:830.
36. Michelakis ED, McMurtry MS, Wu XC, et al. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation. 2002;105:244.
37. Scheufler O, Exner K, Andresen R. Investigation of TRAM flap oxygenation and perfusion by near-infrared reflection spectroscopy and color-coded duplex sonography. Plast Reconstr Surg. 2004;113:141.
38. Hjortdal VE, Sinclair T, Kerrigan CL, et al. Arterial ischemia in skin flaps: microcirculatory intravascular thrombosis. Plast Reconstr Surg. 1994;93:375.
39. Khouri RK, Cooley BC, Kunselman AR, et al. A prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg. 1998;102:711.
40. Torkvist L, Lofberg R, Raud J, et al. Heparin protects against skin flap necrosis: relationship to neutrophil recruitment and anti-coagulant activity. Inflamm Res. 2004;53:1.
41. Bonde CT, Heslet L, Jansen E, et al. Salvage of free flaps after venous thrombosis: case report. Microsurgery. 2004;24:298.
42. Krapohl BD, Siemionow M, Zins JE. Tissue-plasminogen activator restores muscle flap perfusion in the rat. J Hand Surg [Am]. 1999;24:1036.
43. Diamond MP, El-Hammady E, Wang R, et al. Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. Am J Obstet Gynecol. 2004;190:926.
44. Stacpoole PW, Barnes CL, Hurbanis MD, et al. Treatment of congenital lactic acidosis with dichloroacetate. Arch Dis Child. 1997;77:535.