A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 2900-2904

  Guare, James P ^a   Wai, John S ^a   Gomez, Robert P ^a   Anthony, Neville J ^a   Jolly, Samson M ^a   Cortes, Amanda R ^a   Vacca, Joseph P ^a   Felock, Peter J ^a   Stillmock, Kara A ^a   Schleif, William A ^a   Moyer, Gregory ^a   Gabryelski, Lori J ^a   Jin, Lixia ^a   Chen, I Wu ^a   Hazuda, Daria J ^a   Young, Steven D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HIV 1; Inhibitor; Integrase; Macaque; Monkey; Naphthyridine; Rhesus

Indexed keywords

ANTIVIRUS AGENT; INTEGRASE INHIBITOR; N (4 FLUOROBENZYL) 8 HYDROXY[1,6]NAPHTHYRIDINE 7 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONKEY; NONHUMAN; RAT; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

AMINATION; HIV INTEGRASE INHIBITORS; MOLECULAR STRUCTURE; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33646037293     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.003     Document Type: Article

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17. 4: C, 59.29; H, 4.74; N, 16.46. Found: C, 59.40; H, 4.65; N, 16.34. Mp: 195-196 °C.