-
1
-
-
0025070774
-
Ecteinascidins 729, 743, 745, 759A, 759B, and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata [Erratum to document cited in CA113(9):75189d]
-
Rinehart, K.L., et al., Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata [Erratum to document cited in CA113(9):75189d], J. Org. Chem., 55, 4512–4515, 1990.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 4512-4515
-
-
Rinehart, K.L.1
-
2
-
-
0024818627
-
Renieramycins E and F from the sponge Reniera sp.: Reassignment of the stereochemistry of the renieramycins
-
He, H., Faulkner, D.J., Renieramycins E and F from the sponge Reniera sp.: reassignment of the stereochemistry of the renieramycins, J. Org. Chem., 54, 5822–5824, 1989.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 5822-5824
-
-
He, H.1
Faulkner, D.J.2
-
3
-
-
0142141605
-
Mode of action of Ecteinascidin 743, a natural marine compound with antitumor activity
-
Erba, E., et al., Mode of action of Ecteinascidin 743, a natural marine compound with antitumor activity, Ann. Oncol., 9, 535, 1998.
-
(1998)
Ann. Oncol.
, vol.9
, pp. 535
-
-
Erba, E.1
-
4
-
-
0035146702
-
Ecteinascidin 743, a natural marine compound with a unique mechanism of action
-
Erba, E., et al., Ecteinascidin 743, a natural marine compound with a unique mechanism of action, Eur. J. Cancer, 37, 97–105, 2001.
-
(2001)
Eur. J. Cancer
, vol.37
, pp. 97-105
-
-
Erba, E.1
-
5
-
-
0032542724
-
Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2
-
Moore, B.M., et al., Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2, J. Am. Chem. Soc., 120, 2490–2491, 1998.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 2490-2491
-
-
Moore, B.M.1
-
6
-
-
0032561788
-
Molecular basis for the DNA sequence selectivity of Ecteinascidin 736 and 743: Evidence for the dominant role of direct readout via hydrogen bonding
-
Seaman, F.C., Hurley, L.H., Molecular basis for the DNA sequence selectivity of Ecteinascidin 736 and 743: evidence for the dominant role of direct readout via hydrogen bonding, J. Am. Chem. Soc., 120, 13028–13041, 1998.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 13028-13041
-
-
Seaman, F.C.1
Hurley, L.H.2
-
7
-
-
0036519363
-
DNA and its associated processes as targets for cancer therapy, Nat
-
Hurley, L.H., DNA and its associated processes as targets for cancer therapy, Nat. Rev. Cancer, 2, 188–200, 2002.
-
(2002)
Rev. Cancer
, vol.2
, pp. 188-200
-
-
Hurley, L.H.1
-
8
-
-
0034814388
-
Differential rates of reversibility of Ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favoured bonding sites
-
Zewail-Foote, M., Hurley, L.H., Differential rates of reversibility of Ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favoured bonding sites, J. Am. Chem. Soc., 123, 6485–6495, 2001.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 6485-6495
-
-
Zewail-Foote, M.1
Hurley, L.H.2
-
9
-
-
0034612352
-
Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
-
Sheng, K., et al., Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation, Proc. N.Y. Acad. Sci., 97, 6775–6779, 2000.
-
(2000)
Proc. N.Y. Acad. Sci.
, vol.97
, pp. 6775-6779
-
-
Sheng, K.1
-
10
-
-
0034612344
-
Interference of transcriptional activation by the antineoplastic drug Ecteinascidin 743
-
Minuzzo, M., et al., Interference of transcriptional activation by the antineoplastic drug Ecteinascidin 743, Proc. N.Y. Acad. Sci., 97, 6780–6784, 2000.
-
(2000)
Proc. N.Y. Acad. Sci.
, vol.97
, pp. 6780-6784
-
-
Minuzzo, M.1
-
11
-
-
85055229175
-
The antitumor agent Ecteinascidin 743 inhibits transcriptional activation of the MDR1 gene by multiple inducers
-
Jin, S., Hu, Z., Scotto, K., The antitumor agent Ecteinascidin 743 inhibits transcriptional activation of the MDR1 gene by multiple inducers, Clin. Cancer Res., 5, 302, 1999.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 302
-
-
Jin, S.1
Hu, Z.2
Scotto, K.3
-
12
-
-
0013576750
-
Effect on ET-743 on the interaction between transcription factors and DNA
-
Mantovani, R., et al., Effect on ET-743 on the interaction between transcription factors and DNA, Ann. Oncol., 9, 534, 1998.
-
(1998)
Ann. Oncol.
, vol.9
, pp. 534
-
-
Mantovani, R.1
-
13
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold, T.W., Dussault, I., Forman, B.M., The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux, Nat. Med., 7, 584–590, 2001
-
(2001)
Nat. Med.
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
14
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcriptioncoupled nucleotide-excision repair
-
Takebayashi, Y., et al., Antiproliferative activity of ecteinascidin 743 is dependent upon transcriptioncoupled nucleotide-excision repair, Nat. Med., 7, 961–966, 2001.
-
(2001)
Nat. Med.
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
-
15
-
-
0035199322
-
The inefficiency of incisions of Ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicity of this antitumor agent
-
Zewail-Foote, M., et al., The inefficiency of incisions of Ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicity of this antitumor agent. Chem. Biol., 8, 1033–1049, 2001.
-
(2001)
Chem. Biol.
, vol.8
, pp. 1033-1049
-
-
Zewail-Foote, M.1
-
16
-
-
0032844806
-
Effect of Ecteinascidin 743 on the interaction between DNA binding proteins and DNA
-
Bonfanti, M., et al., Effect of Ecteinascidin 743 on the interaction between DNA binding proteins and DNA, Anticancer Drug Des., 14, 179–186, 1999.
-
(1999)
Anticancer Drug Des.
, vol.14
, pp. 179-186
-
-
Bonfanti, M.1
-
17
-
-
0037096739
-
Ecteinascidin 743 inhibits activated by not constitutive transcription
-
Friedman, D., et al., Ecteinascidin 743 inhibits activated by not constitutive transcription. Cancer Res., 62, 3377–3381, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 3377-3381
-
-
Friedman, D.1
-
18
-
-
0009561729
-
Incomplete cross-resistance between ET-743 and standard chemotherapeutic agents against primary tumors in human tumor cloning assay
-
Izbicka, E., et al., Incomplete cross-resistance between ET-743 and standard chemotherapeutic agents against primary tumors in human tumor cloning assay, Ann. Oncol., 9, 130, 1998.
-
(1998)
Ann. Oncol.
, vol.9
, pp. 130
-
-
Izbicka, E.1
-
19
-
-
0031848159
-
Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts
-
Valoti, G., et al., Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts, Clin. Cancer Res., 4, 1977–1983, 1998.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 1977-1983
-
-
Valoti, G.1
-
20
-
-
0032693607
-
High antitumor activity of ET-743 against human tumor xenografts from melanoma, non-small cell lung and ovarian cancer
-
Hendriks, H.R., et al., High antitumor activity of ET-743 against human tumor xenografts from melanoma, non-small cell lung and ovarian cancer, Ann. Oncol., 10, 1233–1240, 1999.
-
(1999)
Ann. Oncol.
, vol.10
, pp. 1233-1240
-
-
Hendriks, H.R.1
-
21
-
-
0041953121
-
Effective combinations of ET-743 and doxorubicin for tumor growth inhibitions against murine and human sarcomas in athymic mice
-
Riccardi, R., et al., Effective combinations of ET-743 and doxorubicin for tumor growth inhibitions against murine and human sarcomas in athymic mice, Proc. Am. Assoc. Cancer Res., 42, 1132, 2001.
-
(2001)
Proc. Am. Assoc. Cancer Res.
, vol.42
, pp. 1132
-
-
Riccardi, R.1
-
22
-
-
0142089888
-
The combination of Yondelis and cisplatin is synergistic against human tumor xenografts
-
D’Incalci, M., et al., The combination of Yondelis and cisplatin is synergistic against human tumor xenografts, Eur. J. Cancer, 39, 1920–1926, 2003.
-
(2003)
Eur. J. Cancer
, vol.39
, pp. 1920-1926
-
-
D’Incalci, M.1
-
23
-
-
0034813203
-
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: Identification of ecteinascidin 743 as a potent cytotoxic agent
-
Li, W.W., et al., Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin 743 as a potent cytotoxic agent, Clin. Cancer Res., 7, 2908–2911, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2908-2911
-
-
Li, W.W.1
-
24
-
-
0034786774
-
Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 with doxorubicin or paclitaxel in soft tissue sarcoma cells
-
Takahashi, N., et al., Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 with doxorubicin or paclitaxel in soft tissue sarcoma cells, Clin. Cancer Res., 7, 3251–3257, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3251-3257
-
-
Takahashi, N.1
-
26
-
-
85055226341
-
Invasiveness of chondrosarcoma cells in vitro is altered by ET743
-
Hornicek, F., Weissbach, L., Invasiveness of chondrosarcoma cells in vitro is altered by ET743, Proc. Am. Assoc. Cancer Res., 43, 539, 2002.
-
(2002)
Proc. Am. Assoc. Cancer Res.
, vol.43
, pp. 539
-
-
Hornicek, F.1
Weissbach, L.2
-
27
-
-
85055232362
-
In vivo combinations of chemotherapeutic agents with ET743 against solid tumors
-
Faircloth, G.T., Grant, W., Hornicek, F., In vivo combinations of chemotherapeutic agents with ET743 against solid tumors, Clin. Cancer Res., 7, 387, 2001.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 387
-
-
Faircloth, G.T.1
Grant, W.2
Hornicek, F.3
-
28
-
-
0041953117
-
Dexamethasone potentiates the activity of Ecteinascidin 743 in preclinical melanoma and osteosarcoma models
-
#379
-
Faircloth, G.T., et al., Dexamethasone potentiates the activity of Ecteinascidin 743 in preclinical melanoma and osteosarcoma models, Proc. Am. Assoc. Cancer Res., 43, 73, #379, 2002.
-
(2002)
Proc. Am. Assoc. Cancer Res
, vol.43
, pp. 73
-
-
Faircloth, G.T.1
-
29
-
-
0037341360
-
Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis
-
Morioka, H., et al., Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis, Clin. Cancer Res., 9, 1211–1217, 2003.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1211-1217
-
-
Morioka, H.1
-
30
-
-
0037341360
-
Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis
-
Morioka, H., et al., Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis, Clin. Cancer Res., 8, 1211–1217, 2003.
-
(2003)
Clin. Cancer Res.
, vol.8
, pp. 1211-1217
-
-
Morioka, H.1
-
31
-
-
85055223515
-
Enhancing the preclinical in vivo antitumor activity of Ecteinascidin 743, a marine natural product currently in phase II clinical trials
-
Faircloth, G.T., Grant, W., Jimeno, J., Enhancing the preclinical in vivo antitumor activity of Ecteinascidin 743, a marine natural product currently in phase II clinical trials, Clin. Cancer Res., 5, 306, 1999.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 306
-
-
Faircloth, G.T.1
Grant, W.2
Jimeno, J.3
-
32
-
-
0031733644
-
In vitro schedule dependancy of myelotoxicity and cytotoxicity of Ecteinascidin 743
-
Ghielmini, M., et al., In vitro schedule dependancy of myelotoxicity and cytotoxicity of Ecteinascidin 743, Ann. Oncol., 9, 989–993, 1998.
-
(1998)
Ann. Oncol
, vol.9
, pp. 989-993
-
-
Ghielmini, M.1
-
33
-
-
0036288919
-
In vitro toxicity of ET743 and Apldine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors: Comparison with the clinical results
-
Albella, B., et al., In vitro toxicity of ET743 and Apldine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors: comparison with the clinical results, Eur. J. Cancer, 38, 1395–1404, 2002.
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 1395-1404
-
-
Albella, B.1
-
34
-
-
0029805757
-
Enantioselective total synthesis of Ecteinascidin 743
-
Corey, E.J., Gin, D.Y., Kania, R.S., Enantioselective total synthesis of Ecteinascidin 743, J. Am. Chem. Soc., 118, 9202, 1996.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 9202
-
-
Corey, E.J.1
Gin, D.Y.2
Kania, R.S.3
-
35
-
-
0037067104
-
Total synthesis of Ecteinascidin 743
-
Endo, A., et al., Total synthesis of Ecteinascidin 743, J. Am. Chem. Soc., 124, 6552, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 6552
-
-
Endo, A.1
-
36
-
-
0034632436
-
Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B
-
Cuevas, C., et al., Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B, Org. Lett., 2, 2545, 2000.
-
(2000)
Org. Lett.
, vol.2
, pp. 2545
-
-
Cuevas, C.1
-
37
-
-
0242660871
-
Synthesis of natural Ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from Cyanosafracin B
-
Menchaca, R., et al., Synthesis of natural Ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from Cyanosafracin B. J. Org. Chem., 68, 8859, 2003.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 8859
-
-
Menchaca, R.1
-
38
-
-
0242399173
-
An exploratory analysis of tumor growth rate (TGR) variations induced by trabectedin (ecteinascidin-743, ET-743) in patients (pts) with pretreated advanced soft tissue sarcoma (PASTS)
-
abst. 3293
-
Lopez-Martin, A.J., et al., An exploratory analysis of tumor growth rate (TGR) variations induced by trabectedin (ecteinascidin-743, ET-743) in patients (pts) with pretreated advanced soft tissue sarcoma (PASTS), Proc. Am. Soc. Clin. Oncol., 22, 819, abst. 3293, 2003.
-
(2003)
Proc. Am. Soc. Clin. Oncol
, vol.22
, pp. 819
-
-
Lopez-Martin, A.J.1
-
39
-
-
0036189675
-
On behalf of the EORTC Soft Tissue and Bone Sarcoma Group. Progressionfree rate as the principal end-point for phase II trials in soft-tissue sarcomas
-
Van Glabbeke, M., et al., On behalf of the EORTC Soft Tissue and Bone Sarcoma Group. Progressionfree rate as the principal end-point for phase II trials in soft-tissue sarcomas, Eur. J. Cancer, 38, 543–549, 2002.
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 543-549
-
-
Van Glabbeke, M.1
-
40
-
-
4244123424
-
Phase II and pharmacokinetics study of 3-hr infusion ET-743 in ovarian cancer patients failing platinum-taxanes
-
abst. 880
-
Colombo, N., et al., Phase II and pharmacokinetics study of 3-hr infusion ET-743 in ovarian cancer patients failing platinum-taxanes, Proc. Am. Soc. Clin. Oncol., 21, 221a, abst. 880, 2002.
-
(2002)
Proc. Am. Soc. Clin. Oncol
, vol.21
-
-
Colombo, N.1
-
41
-
-
0242650889
-
Phase I and pharmacokinetic (PK) study of ecteinascidin-743 (ET, Trabectedin) and cisplatin (P) combination in pre-treated patients (pts) with selected advanced solid tumors
-
abst. 542
-
Grasselli, G., et al., Phase I and pharmacokinetic (PK) study of ecteinascidin-743 (ET, Trabectedin) and cisplatin (P) combination in pre-treated patients (pts) with selected advanced solid tumors, Proc. Am. Soc. Clin. Oncol., 22, 135, abst. 542, 2003.
-
(2003)
Proc. Am. Soc. Clin. Oncol
, vol.22
, pp. 135
-
-
Grasselli, G.1
-
42
-
-
85055219152
-
An Interspecies Comparison of the Metabolism of the Anticancer Agent YondelisTM (Trabectedin, ET-743). Cytochrome P450, Biochemistry, Biophysics and Drug Metabolism
-
June 29–July 3
-
Vermier, M., et al., An Interspecies Comparison of the Metabolism of the Anticancer Agent YondelisTM (Trabectedin, ET-743). Cytochrome P450, Biochemistry, Biophysics and Drug Metabolism. 13th International Conference on Cytochromes P450, Prague, Czech Republic, June 29–July 3, 2003.
-
(2003)
13Th International Conference on Cytochromes P450, Prague, Czech Republic
-
-
Vermier, M.1
-
43
-
-
85055226777
-
Novel Antiviral and Cytotoxic Agent
-
Appl. WO 91.04985, Apr. 18, 1991; GB Appl. 89/22,026, Sept. 29, 1989; Chem. Abstr, 248086q
-
Rinehart, K.L., Lithgow-Berelloni, A.M., Novel Antiviral and Cytotoxic Agent, PCT Int. Pat. Appl. WO 91.04985, Apr. 18, 1991; GB Appl. 89/22,026, Sept. 29, 1989; Chem. Abstr., 1991, 115, 248086q.
-
(1991)
PCT Int. Pat
, pp. 115
-
-
Rinehart, K.L.1
Lithgow-Berelloni, A.M.2
-
44
-
-
0019470678
-
Structures of the didemnins, antiviral and cytotoxic depsipeptides from a caribbean tunicate
-
Rinehart, K.L., et al., Structures of the didemnins, antiviral and cytotoxic depsipeptides from a caribbean tunicate, J. Am. Chem. Soc., 103, 1857–1859, 1981.
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 1857-1859
-
-
Rinehart, K.L.1
-
45
-
-
0023874315
-
Didemnins and tunichlorin: Novel natural products from the marine tunicate Trididemnum solidum
-
Rinehart, K.L., et al., Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum, J. Nat. Prod., 51, 1–21, 1988.
-
(1988)
J. Nat. Prod.
, vol.51
, pp. 1-21
-
-
Rinehart, K.L.1
-
46
-
-
0029670281
-
Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
-
Urdiales, J.L., et al., Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates, Cancer Lett., 102, 31–37, 1996.
-
(1996)
Cancer Lett.
, vol.102
, pp. 31-37
-
-
Urdiales, J.L.1
-
47
-
-
0001944650
-
Dehydrodidemnin B, a new marine derived antitumor agent with activity against experimental tumor models
-
Faircloth, G.T., et al., Dehydrodidemnin B, a new marine derived antitumor agent with activity against experimental tumor models, Ann. Oncol., 7, 34, 1996.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 34
-
-
Faircloth, G.T.1
-
48
-
-
8944252332
-
Structure activity relationships of didemnins
-
Sakai, R., et al., Structure activity relationships of didemnins, J. Med. Chem., 39, 2819–2834, 1996.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2819-2834
-
-
Sakai, R.1
-
49
-
-
0013046247
-
Mechanism of antileukemic activity of Aplidin
-
Erba, E., et al., Mechanism of antileukemic activity of Aplidin, Proc. Amer. Assoc. Cancer Res., 40, 3, 1999.
-
(1999)
Proc. Amer. Assoc. Cancer Res.
, vol.40
, pp. 3
-
-
Erba, E.1
-
50
-
-
0028300782
-
GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1-alpha
-
Crews, C.M., et al., GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1-alpha, J. Biol. Chem., 269, 15411–15414, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15411-15414
-
-
Crews, C.M.1
-
51
-
-
0029913829
-
Didemnin binds to the palmitoyl protein thioesterase responsible for infantile neuronal ceroid lipofuscinosis
-
Crews, C.M., Lane, W.S., Schreiber, S.L., Didemnin binds to the palmitoyl protein thioesterase responsible for infantile neuronal ceroid lipofuscinosis, Proc. N.Y. Acad. Sci., 93, 4316–4319, 1996.
-
(1996)
Proc. N.Y. Acad. Sci.
, vol.93
, pp. 4316-4319
-
-
Crews, C.M.1
Lane, W.S.2
Schreiber, S.L.3
-
52
-
-
4243968879
-
Is Aplidin acting as an ornithine decarboxylase (ODC) inhibitor?
-
Erba, E., et al., Is Aplidin acting as an ornithine decarboxylase (ODC) inhibitor? AACR-EORTC-NCI Conference, 312, 1999.
-
(1999)
AACR-EORTC-NCI Conference
, pp. 312
-
-
Erba, E.1
-
53
-
-
85055218408
-
Evaluation of molecular targets for Aplidin, a novel anticancer agent
-
Izbicka, E., et al., Evaluation of molecular targets for Aplidin, a novel anticancer agent, 11th NCIEORTC-AACR Symposium on New Drugs in Cancer Therapy, 213, 2000.
-
(2000)
11Th NCIEORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 213
-
-
Izbicka, E.1
-
54
-
-
0032531143
-
Concomitant changes in polyamine pools and DNA methylation during growth inhibition of human colonic cancer cells
-
Duranton, B., et al., Concomitant changes in polyamine pools and DNA methylation during growth inhibition of human colonic cancer cells, Exp. Cell Res., 243, 319–325, 1998.
-
(1998)
Exp. Cell Res.
, vol.243
, pp. 319-325
-
-
Duranton, B.1
-
55
-
-
0013046247
-
Mechanism of antileukemic activity of Aplidin
-
Erba, E., et al., Mechanism of antileukemic activity of Aplidin, Proc. Amer. Assoc. Cancer Res., 40, 3, 1999.
-
(1999)
Proc. Amer. Assoc. Cancer Res.
, vol.40
, pp. 3
-
-
Erba, E.1
-
56
-
-
4243635843
-
Changes in gene expression in tumor cells exposed to the two marine compounds ET-743 and Aplidin by using cDNA microarrays
-
Broggini, M., et al., Changes in gene expression in tumor cells exposed to the two marine compounds ET-743 and Aplidin by using cDNA microarrays, 10th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, 310, 1998.
-
(1998)
10Th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 310
-
-
Broggini, M.1
-
57
-
-
85055230249
-
Aplidin-induced apoptosis in Molt-4 cells is mediated by its ability to block VEGF secretion
-
Broggini, M., et al., Aplidin-induced apoptosis in Molt-4 cells is mediated by its ability to block VEGF secretion, 12th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, 384, 2002.
-
(2002)
12Th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 384
-
-
Broggini, M.1
-
58
-
-
0041733458
-
Effect of Aplidin in acute lymphoblastic leukaemia cells
-
Erba, E., et al., Effect of Aplidin in acute lymphoblastic leukaemia cells, Br. J. Cancer, 89, 763–773, 2003.
-
(2003)
Br. J. Cancer
, vol.89
, pp. 763-773
-
-
Erba, E.1
-
59
-
-
0037766254
-
In vitro cytotoxicity of Aplidin and crossresistance with other cytotoxic drugs in childhood leukemias and normal bone marrow and blood samples: A rational basis for clinical development
-
Bresters, D., et al., In vitro cytotoxicity of Aplidin and crossresistance with other cytotoxic drugs in childhood leukemias and normal bone marrow and blood samples: a rational basis for clinical development, Leukemia, 17, 1338–1343, 2003.
-
(2003)
Leukemia
, vol.17
, pp. 1338-1343
-
-
Bresters, D.1
-
60
-
-
85055215707
-
Preclinical studies of the clinical development of Aplidin® for the treatment of multiple myeloma, American Society of Hematology
-
Mitsiades, C.S., et al., Preclinical studies of the clinical development of Aplidin® for the treatment of multiple myeloma, American Society of Hematology, 45th Ann. Meeting and Exposition, abst. 250, 2003.
-
(2003)
45Th Ann. Meeting and Exposition, Abst
, pp. 250
-
-
Mitsiades, C.S.1
-
61
-
-
0037388458
-
Rapid and selective apoptosis in human leukemia cells induced by Aplidin through a Fas/CD95-and mitochondrial-mediated mechanism
-
Gajate, C., An, F., Mollinedo, F., Rapid and selective apoptosis in human leukemia cells induced by Aplidin through a Fas/CD95-and mitochondrial-mediated mechanism, Clin. Cancer Res., 9, 1535–1545, 2003.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1535-1545
-
-
Gajate, C.1
An, F.2
Mollinedo, F.3
-
62
-
-
0346036093
-
Aplidin™ induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK
-
Cuadrado, A., et al., Aplidin™ induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK, J. Biol. Chem., 278, 241–250, 2003.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 241-250
-
-
Cuadrado, A.1
-
63
-
-
3042781436
-
Aplidin™ induce the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 and protein kinase C
-
Garcia-Fernandez, L.F., et al., Aplidin™ induce the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 and protein kinase C, Oncogene, 21, 7533–7544, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 7533-7544
-
-
Garcia-Fernandez, L.F.1
-
64
-
-
1842411316
-
Effect of Dehydrodidemnin B on human colon carcinoma cell lines
-
Lobo, C., et al., Effect of Dehydrodidemnin B on human colon carcinoma cell lines, Anticancer Research, 17, 333–336, 1997.
-
(1997)
Anticancer Research
, vol.17
, pp. 333-336
-
-
Lobo, C.1
-
65
-
-
85055219984
-
Schedule-dependency of Aplidin, a marine depsipeptide with antitumor activity
-
Faircloth, G.T., et al., Schedule-dependency of Aplidin, a marine depsipeptide with antitumor activity, 10th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, 394, 1998.
-
(1998)
10Th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 394
-
-
Faircloth, G.T.1
-
66
-
-
85055237432
-
Cytotoxicity and neurocytotoxicity of Aplidin, a new marine anticancer agent evaluated using in vitro assays
-
Mastbergen, S.C., et al., Cytotoxicity and neurocytotoxicity of Aplidin, a new marine anticancer agent evaluated using in vitro assays, 10th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, 131, 1998.
-
(1998)
10Th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 131
-
-
Mastbergen, S.C.1
-
67
-
-
0003574453
-
Preclinical characterization of Aplidin, a new marine anticancer depsipeptide
-
Faircloth, G.T., et al., Preclinical characterization of Aplidin, a new marine anticancer depsipeptide, Proc. Am. Assoc. Cancer Res., 38, 692, 1997.
-
(1997)
Proc. Am. Assoc. Cancer Res.
, vol.38
, pp. 692
-
-
Faircloth, G.T.1
-
68
-
-
0031713769
-
In vitro characterization of Aplidin, a new marine derived anticancer compound, on freshly explanted clonogenic human tumor cells and haematopoietic precursor cells
-
Depenbrock, H., et al., In vitro characterization of Aplidin, a new marine derived anticancer compound, on freshly explanted clonogenic human tumor cells and haematopoietic precursor cells, Br. J. Cancer, 78, 739–744, 1998.
-
(1998)
Br. J. Cancer
, vol.78
, pp. 739-744
-
-
Depenbrock, H.1
-
69
-
-
26244439742
-
New drugs of marine origin
-
D’Incalci, M., et al., New drugs of marine origin, Ann. Oncol., 7, 19, 1996.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 19
-
-
D’Incalci, M.1
-
70
-
-
0009587313
-
Preclinical development of Aplidin, a novel marine-derived agent with potent antitumor activity
-
Faircloth, G.T., et al., Preclinical development of Aplidin, a novel marine-derived agent with potent antitumor activity, 10th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, 129, 1998.
-
(1998)
10Th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
, pp. 129
-
-
Faircloth, G.T.1
-
71
-
-
0003503162
-
Aplidin is a novel, marine derived depsipeptide with in vivo antitumor activity
-
Faircloth, G.T., et al., Aplidin is a novel, marine derived depsipeptide with in vivo antitumor activity, Proc. Am. Assoc. Cancer Res., 39, 227, 1986.
-
(1986)
Proc. Am. Assoc. Cancer Res.
, vol.39
, pp. 227
-
-
Faircloth, G.T.1
-
72
-
-
0034830752
-
In vitro hematotoxicity of Aplidin on human bone marrow and cord blood progenitor cells
-
Gomez, S.G., et al., In vitro hematotoxicity of Aplidin on human bone marrow and cord blood progenitor cells, Toxicology In Vitro, 15, 347–350, 2001.
-
(2001)
Toxicology
, vol.15
, pp. 347-350
-
-
Gomez, S.G.1
-
73
-
-
0036178591
-
Natural products as probes of cell biology: 20 years of didemnin research
-
Vera, M.D., Joullié, M.M., Natural products as probes of cell biology: 20 years of didemnin research, Med. Res. Rev., 22, 102–145, 2002.
-
(2002)
Med. Res. Rev.
, vol.22
, pp. 102-145
-
-
Vera, M.D.1
Joullié, M.M.2
-
74
-
-
0023939819
-
Total synthesis of the didemnins — I. Synthesis of the peptolide ring
-
Schmidt, U., Kroner, M., Griesser, H., Total synthesis of the didemnins — I. Synthesis of the peptolide ring, Tet. Lett., 29, 3057, 1988.
-
(1988)
Tet. Lett.
, vol.29
, pp. 3057
-
-
Schmidt, U.1
Kroner, M.2
Griesser, H.3
-
75
-
-
0023724253
-
Total synthesis of the didemnins — II. Synthesis of didemnins A, B, C and prolyldidemnin A
-
Schmidt, U., Kroner, M., Griesser, H., Total synthesis of the didemnins — II. Synthesis of didemnins A, B, C and prolyldidemnin A, Tet. Lett., 29, 4407, 1988.
-
(1988)
Tet. Lett.
, vol.29
, pp. 4407
-
-
Schmidt, U.1
Kroner, M.2
Griesser, H.3
-
76
-
-
0003352870
-
Total synthesis of the didemnins — III. Synthesis of proptected (2R, 3S)-allo-isoleucine and (3S, 4R, 5S)-isostatine derivatives-amino acids from hydroxyl acids
-
Schmidt, U., Kroner, M., Griesser, H., Total synthesis of the didemnins — III. Synthesis of proptected (2R, 3S)-allo-isoleucine and (3S, 4R, 5S)-isostatine derivatives-amino acids from hydroxyl acids, Synthesis, 832–835, 1989.
-
(1989)
Synthesis
, pp. 832-835
-
-
Schmidt, U.1
Kroner, M.2
Griesser, H.3
-
77
-
-
0031045880
-
Total synthesis of dehydrodidemnin B. Use of uranium and phosphonium salt coupling reagents in peptide synthesis in solution
-
Jou, G., et al., Total synthesis of dehydrodidemnin B. Use of uranium and phosphonium salt coupling reagents in peptide synthesis in solution, J. Org. Chem., 62, 354, 1997.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 354
-
-
Jou, G.1
-
78
-
-
0001133886
-
And Pharmacokinetic (PK) Study of Aplidin (APL) using A 24-hour, weekly schedule
-
abst. 734
-
Anthoney, A., Paz-Ares, L., Twelves, C., Phase I And Pharmacokinetic (PK) Study of Aplidin (APL) using A 24-hour, weekly schedule, Proc. Am. Soc. Clin. Oncol., abst. 734, 2000.
-
(2000)
Proc. Am. Soc. Clin. Oncol
-
-
Anthoney, A.1
Paz-Ares, L.2
Twelves, C.3
Phase, I.4
-
79
-
-
24844477479
-
Phase I clinical and pharmacokinetic study of the marine compound Aplidin (APL) administered as a 3 hour infusion every 2 weeks
-
abst. 422
-
Ciruelos, E.M., et al., Phase I clinical and pharmacokinetic study of the marine compound Aplidin (APL) administered as a 3 hour infusion every 2 weeks, Proc. Am. Soc. Clin. Oncol., abst. 422, 2002.
-
(2002)
Proc. Am. Soc. Clin. Oncol
-
-
Ciruelos, E.M.1
-
80
-
-
0012650745
-
Phase I clinical and pharmacokinetic (PK) study of the marine compound Aplidin (APL), administered as A 1 hour weekly infusion
-
abst. 476
-
Bowman, A., et al., Phase I clinical and pharmacokinetic (PK) study of the marine compound Aplidin (APL), administered as A 1 hour weekly infusion, Proc. Am. Soc. Clin. Oncol., abst. 476, 2001.
-
(2001)
Proc. Am. Soc. Clin. Oncol.
-
-
Bowman, A.1
-
81
-
-
0000165435
-
Phase I and pharmacokinetic study of Aplidin (APL) given as a 24-hour continuous infusion every other week (Q2w) in patients (Pts) with solid tumor (ST) and lymphoma (NHL)
-
abst. 477
-
Armand, J.P., et al., Phase I and pharmacokinetic study of Aplidin (APL) given as a 24-hour continuous infusion every other week (Q2w) in patients (Pts) with solid tumor (ST) and lymphoma (NHL), Proc. Am. Soc. Clin. Oncol., abst. 477, 2001.
-
(2001)
Proc. Am. Soc. Clin. Oncol
-
-
Armand, J.P.1
-
82
-
-
0041465706
-
Phase I study of Aplidin in a 5 day bolus Q 3 weeks in patients with solid tumors and lymphomas
-
abst. 2082
-
Maroun, J.A., et al., Phase I study of Aplidin in a 5 day bolus Q 3 weeks in patients with solid tumors and lymphomas, Proc. Am. Soc. Clin. Oncol., abst. 2082, 2001.
-
(2001)
Proc. Am. Soc. Clin. Oncol
-
-
Maroun, J.A.1
-
83
-
-
2542500409
-
Phase I (PI) trials with aplidin (APL), a new marine derived anticancer compound
-
Raymond, E., et al., Phase I (PI) trials with aplidin (APL), a new marine derived anticancer compound, Eur. J. Cancer, 37, S32, 2001.
-
(2001)
Eur. J. Cancer
, vol.37
, pp. 32
-
-
Raymond, E.1
-
84
-
-
0012765539
-
Activity of APL, a new marine compound, against medullary thyroid carcinoma (MTC): Phase I trials as screening tools for rare tumors
-
Raymond, E., et al., Activity of APL, a new marine compound, against medullary thyroid carcinoma (MTC): phase I trials as screening tools for rare tumors, Ann. Oncol., 13, 22, 2002.
-
(2002)
Ann. Oncol.
, vol.13
, pp. 22
-
-
Raymond, E.1
-
85
-
-
1942452836
-
Progress in the clinical development of new marine-derived anticancer compounds
-
Jimeno, J., et al., Progress in the clinical development of new marine-derived anticancer compounds, Anticancer Drugs, 15, 321–329. 2004.
-
(2004)
Anticancer Drugs
, vol.15
, pp. 321-329
-
-
Jimeno, J.1
-
86
-
-
0027296890
-
A bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp
-
Hamann, M.T., Scheuer, P.J., Kahalalide F., A bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp., J. Am. Chem. Soc., 115, 5825–5826, 1993.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 5825-5826
-
-
Hamann, M.T.1
Scheuer, P.J.2
Kahalalide, F.3
-
87
-
-
0035930006
-
Synthesis and structural determination of Kahalalide F
-
López-Macia, A., et al., Synthesis and structural determination of Kahalalide F, J. Am. Chem. Soc., 123, 11398–11401, 2001.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 11398-11401
-
-
López-Macia, A.1
-
88
-
-
0029842550
-
Kahalalides, bioactive depsipeptides from the sacoblassan mollusk Elysia rufescens and the green alga Bryopsis sp
-
Hamann, M.T., et al., Kahalalides, bioactive depsipeptides from the sacoblassan mollusk Elysia rufescens and the green alga Bryopsis sp., J. Org. Chem., 61, 6594–6600, 1996.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 6594-6600
-
-
Hamann, M.T.1
-
89
-
-
0033835762
-
Mollusc-algal chloroplast endosymbiosis. Photosynthesis, thylakoid protein maintenance, and chloroplast gene expression continue for many months in the absence of the algal nucleus
-
Green, B.J., et al., Mollusc-algal chloroplast endosymbiosis. Photosynthesis, thylakoid protein maintenance, and chloroplast gene expression continue for many months in the absence of the algal nucleus, Plant Physiol., 124, 331–342, 2000.
-
(2000)
Plant Physiol.
, vol.124
, pp. 331-342
-
-
Green, B.J.1
-
90
-
-
0035161213
-
Chemical defences of the sacoglossan mollusk Elysia rufescens and its host alga Briopsis sp
-
Bercero, M.A., et al., Chemical defences of the sacoglossan mollusk Elysia rufescens and its host alga Briopsis sp., J. Chem. Ecology, 27, 2287–2299, 2001.
-
(2001)
J. Chem. Ecology
, vol.27
, pp. 2287-2299
-
-
Bercero, M.A.1
-
91
-
-
79955922890
-
In vitro chemosensitivity, cell cycle redistribution and apoptosis induction by Kahalalide F, a new marine compound in a panel of human tumoral cells
-
Córdoba, S., et al., In vitro chemosensitivity, cell cycle redistribution and apoptosis induction by Kahalalide F, a new marine compound in a panel of human tumoral cells, Eur. J. of Cancer Suppl., 1, S173, 2003.
-
(2003)
Eur. J. of Cancer Suppl
, vol.1
-
-
Córdoba, S.1
-
92
-
-
0030053875
-
The antitumoral compound Kahalalide F acts on cell lysosomes
-
García-Rocha, M., Bonay, P., Avila, J., The antitumoral compound Kahalalide F acts on cell lysosomes. Cancer Lett., 99, 43–50, 1996.
-
(1996)
Cancer Lett.
, vol.99
, pp. 43-50
-
-
García-Rocha, M.1
Bonay, P.2
Avila, J.3
-
93
-
-
0020635123
-
Perturbations of vesicular traffic with the carboxylic ionophore monensin
-
Tartakoff A.M., Perturbations of vesicular traffic with the carboxylic ionophore monensin, Cell, 32, 1026–1028, 1983.
-
(1983)
Cell
, vol.32
, pp. 1026-1028
-
-
Tartakoff, A.M.1
-
94
-
-
0030828009
-
Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns
-
Wosikowski, K., Schuurhuis, D., Johnson, K., Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns, J. Nat. Cancer Inst., 89, 1505–1515, 1997.
-
(1997)
J. Nat. Cancer Inst.
, vol.89
, pp. 1505-1515
-
-
Wosikowski, K.1
Schuurhuis, D.2
Johnson, K.3
-
95
-
-
0642318239
-
A new marine-derived compound induces oncosis in human prostate and breast cancer cells
-
Suarez, J., et al., A new marine-derived compound induces oncosis in human prostate and breast cancer cells, Mol. Cancer Ther., 2, 863–872, 2003.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 863-872
-
-
Suarez, J.1
-
96
-
-
85055223374
-
Kahalalide F appears to promote necrotic cell death in hepatoma cell lines
-
abst. 1509
-
Sewell, J.M., et al., Kahalalide F appears to promote necrotic cell death in hepatoma cell lines, Proc. Am. Assoc. Cancer Res., abst. 1509, 2004.
-
(2004)
Proc. Am. Assoc. Cancer Res
-
-
Sewell, J.M.1
-
97
-
-
85055228190
-
Kahalalide F induces caspase-independent cytotoxicity that correlates with HER2 and/or HER3 expression levels and is accompanied by down-regulation of AKT signaling
-
abst. 5328
-
Janmaat, M.L., et al., Kahalalide F induces caspase-independent cytotoxicity that correlates with HER2 and/or HER3 expression levels and is accompanied by down-regulation of AKT signaling, Proc. Am. Assoc. Cancer Res., abst. 5328, 2004.
-
(2004)
Proc. Am. Assoc. Cancer Res
-
-
Janmaat, M.L.1
-
98
-
-
0034759073
-
Development of a lyophilized, parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent Kahalalide F
-
Nuijen, B., et al., Development of a lyophilized, parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent Kahalalide F, Drug Dev. Ind. Pharm., 27, 767–780, 2001.
-
(2001)
Drug Dev. Ind. Pharm.
, vol.27
, pp. 767-780
-
-
Nuijen, B.1
-
99
-
-
0142227045
-
In vitro toxicity of three new antitumoral drugs (Trabectedin, aplidin and Kahalalide F) on hematopoietic progenitors and stem cells
-
Gómez, S.G., et al., In vitro toxicity of three new antitumoral drugs (trabectedin, aplidin and Kahalalide F) on hematopoietic progenitors and stem cells, Exp. Hemat., 31, 1104–1111, 2003.
-
(2003)
Exp. Hemat
, vol.31
, pp. 1104-1111
-
-
Gómez, S.G.1
-
100
-
-
0036392375
-
Preclinical toxicity of Kahalalide F, a new anticancer agent: Single and multiple dosing regimens in the rat, Cancer Chemother
-
Brown, A.P., et al., Preclinical toxicity of Kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat, Cancer Chemother. Pharmacol., 50, 333–340, 2002.
-
(2002)
Pharmacol.
, vol.50
, pp. 333-340
-
-
Brown, A.P.1
-
101
-
-
0012722053
-
Phase I and pharmacokinetic study of Kahalalide F in patients with advanced androgen refractory prostate cancer
-
Schellens, J.H., et al., Phase I and pharmacokinetic study of Kahalalide F in patients with advanced androgen refractory prostate cancer, Proc. Am. Soc. Clin. Oncol., 451, 2002.
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, pp. 451
-
-
Schellens, J.H.1
-
102
-
-
0042458241
-
A phase I clinical and pharmacokinetic study with Kahalalide F in patients with advanced solid tumors with a continuous weekly 1-hour iv infusion schedule
-
Circuelos, C., et al., A phase I clinical and pharmacokinetic study with Kahalalide F in patients with advanced solid tumors with a continuous weekly 1-hour iv infusion schedule, Eur. J. Cancer, 38, 33, 2002.
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 33
-
-
Circuelos, C.1
-
103
-
-
0041953119
-
Preliminary results of Phase II study of ecteinascidin 743 (ET-743) with the 24-hour continuous infusion q3 week schedule in pretreated advanced/metastatic breast cancer patients [Abstract]
-
Zelek, L., et al., Preliminary results of Phase II study of ecteinascidin 743 (ET-743) with the 24-hour continuous infusion q3 week schedule in pretreated advanced/metastatic breast cancer patients [Abstract], Proc. 11th NCI-EORTC-AACR Symposium, 6, 45085, 2000.
-
(2000)
Proc. 11Th NCI-EORTC-AACR Symposium
, vol.6
, pp. 45085
-
-
Zelek, L.1
|