Regulatory mechanisms and functions of intermediate filaments: A study using site- and phosphorylation state-specific antibodies

Cancer Science

Volumn 97, Issue 3, 2006, Pages 167-174

  Izawa, Ichiro ^a   Inagaki, Masaki ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; CYCLIN DEPENDENT KINASE 1; DESMIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERMEDIATE FILAMENT PROTEIN; KERATIN; KERATIN 18; KERATIN 8; PHOSPHOSPECIFIC ANTIBODY; POLO LIKE KINASE 1; RHO KINASE; SERINE; TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG; VIMENTIN;

APOPTOSIS; CANCER INVASION; CARCINOGENESIS; CYTOKINESIS; CYTOSKELETON; DAUGHTER CELL; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; INTERMEDIATE FILAMENT; METAPHASE; METASTASIS; MITOSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RELIABILITY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INTERMEDIATE FILAMENTS; KERATINS; MITOSIS; PHOSPHORYLATION;

EID: 33646004279     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00161.x     Document Type: Review

References (69)

1. Herrmann H, Hesse M, Reichenzeller M, Aebi U, Magin TM. Functional complexity of intermediate filament cytoskeletons: From structure to assembly to gene ablation. Int Rev Cytol 2003; 223: 83-175.
2. Coulombe PA, Wong P. Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds. Nat Cell Biol 2004; 6: 699-706.
3. Fuchs E, Cleveland DW. A structural scaffolding of intermediate filaments in health and disease. Science 1998; 279: 514-19.
4. Omary MB, Coulombe PA, McLean WHI. Intermediate filament proteins and their associated diseases. N Engl J Med 2004; 351: 2087-100.
5. Gruenbaum Y, Margalit A, Goldman RD, Shumaker DK, Wilson KL. The nuclear lamina comes of age. Nat Rev Mol Cell Biol 2005; 6: 21-31.
6. Moll R. Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell Biochem 1998; 31: 205-62.
7. Hendrix MJC, Seftor EA, Chu YH, Trevor KT, Seftor REB. Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev 1996; 15: 507-25.
8. Inagaki M, Nishi Y, Nishizawa K, Matsuyama M, Sato C. Site-specific phosphorylation induces disassembly of vimentin filaments in vitro. Nature 1987; 328: 649-52.
9. Inagaki M, Matsuoka Y, Tsujimura K et al. Dynamic property of intermediate filaments: Regulation by phosphorylation. Bioessays 1996; 18: 481-7.
10. Chang L, Goldman RD. Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol 2004; 5: 601-13.
11. Peter M, Nakagawa J, Dorée M, Labbé JC, Nigg EA. In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell 1990; 61: 591-602.
12. cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro. J Cell Biol 1991; 112: 523-33.
13. Inagaki N, Ito M, Nakano T, Inagaki M. Spatiotemporal distribution of protein kinase and phosphatase activities. Trends Biochem Sci 1994; 19: 448-52.
14. Inagaki M, Inagaki N, Takahashi T, Takai Y. Phosphorylation-dependent control of structures of intermediate filaments: A novel approach using site- and phosphorylation state-specific antibodies. J Biochem 1997; 121: 407-14.
15. Nagata K, Izawa I, Inagaki M. A decade of site- and phosphorylation state-specific antibodies: Recent advances in studies of spatiotemporal protein phosphorylation. Genes Cells 2001; 6: 653-64.
16. Nishizawa K, Yano T, Shibata M et al. Specific localization of phospho-intermediate filament protein in the constricted area of dividing cells. J Biol Chem 1991; 266: 3074 - 9.
17. Yano T, Taura C, Shibata M et al. A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to a non-radioactive method for measuring protein kinase activities. Biochem Biophys Res Commun 1991; 175: 1144-51.
18. Matsuoka Y, Nishizawa K, Yano T et al. Two different protein kinases act on a different time schedule as glial filament kinase during mitosis. EMBO J 1992; 11: 2895-902.
19. Sekimata M, Tsujimura K, Tanaka J, Takeuchi Y, Inagaki N, Inagaki M. Detection of protein kinase activity specifically activated at metaphase-anaphase transition. J Cell Biol 1996; 132: 635-41.
20. Kosako H, Amano M, Yanagida M et al. Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase. J Biol Chem 1997; 272: 10 333-6.
21. Goto H, Kosako H, Tanabe K et al. Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem 1998; 273: 11 728-36.
22. Yasui Y, Amano M, Nagata K et al. Roles of Rho-associated kinase in cytokinesis: Mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol 1998; 143: 1249-58.
23. Inada H, Togashi H, Nakamura Y, Kaibuchi K, Nagata K, Inagaki M. Balance between activities of Rho-kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments. J Biol Chem 1999; 274: 34 932-9.
24. Goto H, Yasui Y, Kawajiri A et al. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 2003; 278: 8526-30.
25. Kawajiri A, Yasui Y, Goto H et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinately with Rho-kinase. Mol Biol Cell 2003; 14: 1489-500.
26. Yokoyama T, Goto H, Izawa I, Mizutani H, Inagaki M. Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: Possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM). Genes Cells 2005; 10: 127-37.
27. Yamaguchi T, Goto H, Yokoyama T et al. Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. J Cell Biol 2005; 171: 431-6.
28. Evans RM, Fink LM. An alteration in the phosphorylation of vimentin-type intermediate filaments is associated with mitosis in cultured mammalian cells. Cell 1982; 29: 43-52.
29. Celis JE, Lasen PM, Fey SJ, Celis A. Phosphorylation of keratin and vimentin polypeptides in normal and transformed mitotic human epithelial amnion cells: Behavior of keratin and vimentin filaments during mitosis. J Cell Biol 1983; 97: 1429-34.
30. Evans RM. Cyclic AMP-dependent protein kinase-induced vimentin filament disassembly involves modification of N-terminal of intermediate filaments subunits. FEBS Lett 1988; 234: 73-8.
31. Ando S, Tanabe K, Gonda Y, Sato C, Inagaki M. Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure. Biochemistry 1989; 28: 2974-9.
32. Chou YH, Bischoff JR, Beach D, Goldman RD. Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell 1990; 62: 1063-71.
33. SUC1 suppresses the catalytic function of p34 cdc2 kinase for intermediate filament proteins, in vitro. J Biol Chem 1992; 267: 20 937-42.
34. Inagaki M, Gonda Y, Nishizawa K et al. Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-α-helical head domain. J Biol Chem 1990; 265: 4722-9.
35. Inagaki M, Gonda Y, Matsuyama M, Nishizawa K, Nishi Y, Sato C. Intermediate filament reconstitution in vitro. The role of phosphorylation on the assembly-disassembly of desmin. J Biol Chem 1988; 263: 5970-8.
36. Yano T, Tokui T, Nishi Y et al. Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin-dependent protein kinase and by cAMP-dependent protein kinase. Eur J Biochem 1991; 197: 281-90.
37. 2+ -dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain. J Biol Chem 1989; 264: 18 119-27.
38. Nishizawa K, Yano T, Shibata M, Takahashi T, Inagaki M. Distribution of phospho-glial fibrillary acidic protein in astro glial cells. Cell Struct Funct 1990; 15: 497.
39. Yano T, Taura C, Hirono Y et al. Specific antibodies to phospho-glial fibrillary acidic protein: Production and characterization. Cell Struct Funct 1990; 15: 497.
40. Norbury C, Nurse P. Animal cell cycles and their control. Annu Rev Biochem 1992; 61: 441-70.
41. 2+-calmodulin-dependent protein kinase II. J Biochem 1994; 116: 426-34.
42. Chou YH, Ngai KL, Goldman R. The regulation of intermediate filament reorganization in mitosis: P34cdc2 phosphorylates vimentin at a unique N-terminal site. J Biol Chem 1991; 266: 7325 - 8.
43. Tsujimura K, Ogawara M, Takeuchi Y, Imajoh-Ohmi S, Ha MH, Inagaki M. Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis. J Biol Chem 1994; 269: 31 097-106.
44. Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by Rho family GTPases in mammalian cells. Annu Rev Biochem 1999; 68: 459-86.
45. Kosako H, Goto H, Yanagida M et al. Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments. Oncogene 1999; 18: 2783-8.
46. Yasui Y, Goto H, Matsui S et al. Protein kinases required for segregation of vimentin filaments in mitotic process. Oncogene 2001; 20: 2868-76.
47. Carmena M, Earnshaw WC. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 2003; 4: 842-54.
48. Yasui Y, Urano T, Kawajiri A et al. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 2004; 279: 12 997-3003.
49. Kops GJPL, Weaver BAA, Cleveland DW. On the road to cancer: Aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5: 773-85.
50. Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 2004; 5: 45-54.
51. Coulombe PA, Omary MB. 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol 2002; 14: 110-22.
52. Wiche G. Role of plectin in cytoskeleton organization and dynamics. J Cell Sci 1998; 111: 2477-86.
53. Green KJ, Gaudry CA. Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol 2000; 1: 208-16.
54. Oshima RG, Baribault H, Caulín C. Oncogenic regulation and function of keratins 8 and 18. Cancer Metastasis Rev 1996; 15: 445-71.
55. Baribault H, Price J, Miyai K, Oshima RG. Mid-gestational lethality in mice lacking keratin 8. Genes Dev 1993; 7: 1191-202.
56. Baribault H, Penner J, Iozzo RV, Wilson-Heiner M. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 1994; 8: 2964-73.
57. Zatloukal K, Stumptner C, Lehner M et al. Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies. Am J Pathol 2000; 156: 1263-74.
58. Magin TM, Schröder R, Leitgeb S et al. Lessons from keratin 18 knockout mice: Formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol 1998; 140: 1441-51.
59. Owens DW, Lane EB. The quest for the function of simple epithelial keratins. Bioessays 2003; 25: 748-58.
60. Caulin C, Ware CF, Magin TM, Oshima RG. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol 2000; 149: 17-22.
61. Oshima RG. Apoptosis and keratin intermediate filaments. Cell Death Differ 2002; 9: 486-92.
62. Inada H, Izawa I, Nishizawa M et al. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. J Cell Biol 2001; 155: 415-25.
63. Yoneda K, Furukawa T, Zheng YJ et al. An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor α-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex. J Biol Chem 2004; 279: 7296-303.
64. Gilbert S, Loranger A, Daigle N, Marceau N. Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol 2001; 154: 763-73.
65. Lee JC, Schickling O, Stegh AH et al. DEDD regulates degradation of intermediate filaments during apoptosis. J Cell Biol 2002; 158: 1051-66.
66. Dinsdale D, Lee JC, Dewson G, Cohen GM, Peter ME. Intermediate filaments control the intracellular distribution of caspases during apoptosis. Am J Pathol 2004; 164: 395-407.
67. Gilbert S, Loranger A, Marceau N. Keratins modulate c-FLIP/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells. Mol Cell Biol 2004; 24: 7072-81.
68. Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. J Biol Chem 2000; 275: 34 521-7.
69. Nishizawa M, Izawa I, Inoko A et al. Identification of trichoplein, a novel keratin filament-binding protein. J Cell Sci 2005; 118: 1081 - 90. 1081-90.