Identification of steviol glucuronide in human urine

Journal of Agricultural and Food Chemistry

Volumn 54, Issue 7, 2006, Pages 2794-2798

  Geuns, Jan M C ^a   Buyse, Johan ^b   Vankeirsbilck, Annelies ^c   Temme, Elisabeth H M ^c   Compernolle, Frans ^a   Toppet, Suzanne ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Laboratory of Physiology and Immunology of Domestic Animals   (Belgium)

^c Faculty of Medicine   (Belgium)

Author keywords

Stevia rebaudiana (Bertoni) Bertoni (Asteraceae); Steviol; Steviol glucuronide; Stevioside degradation

Indexed keywords

ASTERACEAE; STEVIA REBAUDIANA;

GLUCOSIDE; GLUCURONIDE; KAURANE DERIVATIVE; STEVIOL; STEVIOSIDE;

ARTICLE; HUMAN; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET SPECTROPHOTOMETRY; URINE;

DITERPENES, KAURANE; GLUCOSIDES; GLUCURONIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33646004270     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf052693e     Document Type: Article

References (16)

1. Geuns, J. M. C. Review: The safety of stevioside used as a sweetener. In Proceedings of the First Symposium on the Safety of Stevioside, KULeuven; Geuns, J. M. C., Buyse, J., Eds.; Euprint Editions: Heverlee-Leuven, Belgium, 2004; p 127.
2. JECFA: http://216.239.59.104/custom?q=cache:FfNn3Y0zbg4J: www.who.int/ipcs/publications/jecfa/en/Summary63final.pdf+ Jecfa+2004&hl=en&ie=UTF-8&client=pub-7469705895903706.
3. Hutapea, A. M.; Toskulkao, C.; Buddhasukh, D.; Wilairat, P.; Glinsukon, T. Digestion of stevioside, a natural sweetener, by various digestive enzymes. J. Clin. Biochem. Nutr. 1997, 23, 177-186.
4. Koyama, E.; Kitazawa, K.; Ohori, Y.; Izawa, O.; Kakegawa, K.; Fujino, A.; Ui, M. In vitro metabolism of the glycosidic sweeteners, Stevia mixture and enzymatically modified Stevia in human intestinal microflora. Food Chem. Toxicol. 2003, 41, 359-374.
5. Gardana, C.; Simonetti, P.; Canzi, E.; Zanchi, R.; Pietta, P. G. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J. Agric. Food Chem. 2003, 51, 6618-6622.
6. Geuns, J. M. C.; Augustijns, P.; Mols, R.; Buyse, J. G.; Driessen, B. Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol. Food Chem. Toxicol. 2003, 41, 1599-1607.
7. Simonetti, P.; Gardana, C.; Bramati, L.; Pietta, P. G. Bioavail-ability of stevioside from Stevia rebaudiana in human volunteers: Preliminary report. In Proceedings of the First Symposium on the Safety of Stevioside, KULeuven; Geuns, J. M. C., Buyse, J., Eds.; Euprint Editions: Heverlee-Leuven, Belgium, 2004; pp 51-62.
8. Geuns, J. M. C.; Buyse, J.; Vankeirsbilck, A.; Temme, E. H. M. About the safety of stevioside used as a sweetener. In Proceedings of the First Symposium on the Safety of Stevioside, KULeuven; Geuns, J. M. C., Buyse, J., Eds.; Euprint Editions: Heverlee-Leuven, Belgium, 2004; pp 75-83.
9. Ogawa, T.; Nozaki, M.; Matsui, M. Total synthesis of stevioside. Tetrahedron 1980, 36, 2641-2648.
10. Jaffé, M. Ueber den niederschlag welche pikrinsaure in normalem harn erzeugt und ueber eine neue reaction des kreatinins (in German). Hoppe Seyler Z. Physiol. Chem. 1886, 10, 391-400.
11. Gindler, E. M.; King, J. D. Rapid colorimetric determination of calcium in biogenic fluids with methylthymol blue. Am. J. Clin. Pathol. 1972, 58, 362-382.
12. Talke, H.; Schubert, G. E. Enzymatische harnstoffbestimmung im blut und serum im optischen test nach Warburg. Klin. Wschr. 1965, 43, 174-175.
13. Minne, V.; Compernolle, F.; Toppet, S.; Geuns, J. M. C. Steviol quantification at the picomol level by HPLC. J. Agric. Food Chem. 2004, 52, 2445-2449.
14. Hutchison, M.; Lewer, P.; MacMillan, J. Carbon-13 nuclear magnetic resonance spectra of eighteen derivatives of eni-kaur-16-en-19-oic acid. J. Chem. Soc., Perkin Trans. 1984, 1, 2363-2366.
15. Koyama, E.; Sakai, N.; Ohori, Y.; Kitazawa, K.; Izawa, O.; Kakegawa, K.; Fujino, A.; Ui, M. Absorption and metabolism of the glycosidic sweeteners, Stevia related compounds in human and rat. Food Chem. Toxicol. 2003, 41, 875-883.
16. Setchell, K. D. R. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am. J. Clin. Nutr. 2002, 447-453.