The effects of granulocyte colony-stimulating factor in preclinical models of infection and acute inflammation

Shock

Volumn 24, Issue SUPPL. 1, 2005, Pages 120-129

  Marshall, John C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b 9 EN 234 ^*  (Canada)

Author keywords

G CSF (Granulocyte Colony Stimulating Factor); Neutropenia; Neutrophils; Pre clinical models; Sepsis; Shock

Indexed keywords

CYTOKINE; ENDOTOXIN; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ABDOMINAL INFECTION; ADJUVANT THERAPY; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; CHEMOPROPHYLAXIS; CLINICAL TRIAL; COMMUNITY ACQUIRED PNEUMONIA; DRUG EFFICACY; ESCHERICHIA COLI; EXPERIMENTAL INFECTION; EXPERIMENTAL MODEL; FEBRILE NEUTROPENIA; GRAM NEGATIVE INFECTION; HOSPITAL INFECTION; HUMAN; IN VIVO STUDY; INFLAMMATION; KLEBSIELLA; META ANALYSIS; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PERITONITIS; PNEUMONIA; PROVOCATION TEST; REVIEW; SEPSIS; SHOCK; SYSTEMATIC REVIEW;

ANIMALS; CHEMOTHERAPY, ADJUVANT; COMMUNICABLE DISEASES; CROSS INFECTION; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI INFECTIONS; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HUMANS; INFLAMMATION; PNEUMONIA, BACTERIAL;

EID: 33646003501     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000191344.21228.b6     Document Type: Review

References (115)

1. Barreda DR, Hanington PC, Belosevic M: Regulation of myeloid development and function by colony-stimulating factors. Dev Comp Immunol 28:509-554, 2004.
2. Marshall JC: The effects of granulocyte colony-stimulating factor (G-CSF) in pre-clinical models of infection and acute inflammation. Sepsis 2:213-220, 1998.
3. Bradley TR, Metcalf D: The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 44:287-294, 1966.
4. Ichikawa Y, Pluznik DH, Sachs RJ: In vitro control of the development of macrophage and granulocyte colonies. Proc Natl Acad Sci USA 56:488-495, 1966.
5. Nicola NA, Metcalf D, Matsumoto M, Johnson GR: Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. J Biol Chem 258:9017-9023, 1983.
6. Metcalf D, Nicola NA: Proliferative effects of purified granulocyte colony-stimulating factor (G-CSF) on normal mouse hemopoietic cells. J Cell Physiol 116:198-206, 1983.
7. Hubel K, Dale DC, Liles WC: Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and interferon-γ. J Infect Dis 185:1490-1501, 2002.
8. Nelson S, Bagby GJ: Granulocyte colony-stimulating factor and modulation of inflammatory cells in sepsis. Clin Chest Med 17:319-332, 1996.
9. Avalos BR: Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 88:761-777, 1996.
10. Kawakami M, Tsutsumi H, Kumakawa T, Abe H, Hirai M, Kurosawa S, Mori M, Fukushima M: Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 78:3254-3258, 1990.
11. Cebon J, Layton J, Maher D, Morstyn G: Endogenous hematopoietic growth factors in neutropenia and infection. Br J Haematol 86:265-274, 1994.
12. Boneberg EM, Hareng L, Gantner F, Wendel A, Hartung T: Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ. Blood 95:270-276, 2000.
13. Boneberg TM, Hartung T: Molecular aspects of anti-inflammatory action of G-CSF. Inflamm Res 51:119-128, 2002.
14. Liu F, Poursine-Laurent J, Link DC: The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophoshamide or interleukin-8 but not flt-3 ligand. Blood 90:2522-2528, 1997.
15. Seymour JF, Lieschke GJ, Grail D, Quilici C, Hodgson G, Dunn AR: Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival. Blood 90:3037-3049, 1997.
16. Lawlor KE, Campbell IK, Metcalf D, O'Donnell K, van Nieuwenhuijze A, Roberts AW, Wicks IP: Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Proc Natl Acad Sci USA 101:11398-11403, 2004.
17. Anderlini P, Przepiorka D, Champlin R, Körbling M: Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals. Blood 88:2819-2825, 1996.
18. Molineux G: The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des 10:1235-1244, 2004.
19. Tian S-S, Lamb P, King AG, Miller SG, Kessler L, Luengo JI, Averill L, Johnson RK, Gleason JG, Pelus LM, Dillon SB, Rosen J: A small, nonpeptidyl mimic of granulocyte colony-stimulating factor. Science 281:257-259, 1998.
20. Clark OA, Lyman G, Castro AA, Clark LG, Djulbegovic B: Colony stimulating factors for chemotherapy induced febrile neutropenia. Cochrane Database Syst Rev 2003:CD003039, 2003.
21. Cheng AC, Stephens DP, Currie BJ: Granulocyte-colony stimulating factor (G-CSF) as an adjunct to antibiotics in the treatment of pneumonia in adults. Cochrane Database Syst Rev 2004:CD004400, 2004.
22. Ishikawa K, Tanaka H, Matsuoka T, Shimazu T, Yoshioka T, Sugimoto H: Recombinant human granulocyte colony-stimulating factor attenuates inflammatory responses in septic patients with neutropenia. J Trauma 44:1047-1054, 1998.
23. Wunderink RG, Leeper KV Jr, Schein R, Nelson S, Deboisblanc BP, Fotheringham N, Welch W, Milwee S, Root R: Filgrastim in patients with pneumonia and severe sepsis or septic shock. Chest 119:523-529, 2001.
24. Nelson S, Belknap SM, Carlson RW, Dale D, DeBoisblanc B, Farkas S, Fotheringham N, Ho H, Marrie T, Movahhed H, Root R, Wilson J: A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. J Infect Dis 178:1075-1080, 1998.
25. Nelson S, Heyder AM, Stone J, Bergeron MG, Dougherty S, Peterson G, Fotheringham N, Welch W, Milwee S, Root R: A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J Infect Dis 182:970-973, 2000.
26. Heard SO, Fink MP, Gamelli RL, Solomkin JS, Joshi M, Trask AL: Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patients with acute traumatic brain injury or cerebral hemorrhage. Crit Care Med 26:748-754, 1998.
27. Schneider C, Von Aulock S, Zedler S, Schinkel C, Hartung T, Faist E: Perioperative recombinant human granulocyte colony-stimulating factor (filgrastim) treatment prevents immunoinflammatory dysfunction associated with major surgery. Ann Surg 239:75-81, 2004.
28. Schafer H, Hubel K, Bohlen H, Mansmann G, Hegener K, Richarz B, Oberhauser F, Wassmer G, Hoelscher AH, Pichlmaier H, Diehl V, Engert A: Perioperative treatment with filgrastim stimulates granulocyte function and reduces infectious complications after esophagectomy. Ann Hematol 79:143-151, 2000.
29. Schaefer H, Engert A, Grass G, Mansmann G, Wassmer G, Hubel K, Loehlein D, Ulrich BC, Lippert H, Knoefel WT, Hoelscher AH: Perioperative granulocyte colony-stimulating factor does not prevent severe infections in patients undergoing esophagectomy for esophageal cancer: a randomized placebo-controlled clinical trial. Ann Surg 240:68-75, 2004.
30. Winston DJ, Foster PF, Somberg KA, Busuttil RW, Levy MF, Sheiner PA, Reddy KR, Fotheringham N, Armstrong M, Logan E: Randomized, placebo-controlled, double-blind, multicenter trial of efficacy and safety of granulocyte colony-stimulating factor in liver transplant recipients. Transplantation 68:(2)1298-1304, 1999.
31. Gough A, Clapperton M, Rolando N, Foster AV, Philpott-Howard J, Edmonds ME: Randomized placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet 350:855-859, 1997.
32. De Lalla F, Pellizzer G, Strazzabosco M, Martini Z, Du Jardin G, Lora I, Fabris P, Benedetti P, Erle G: Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection. Antimicrob Agents Chemother 45:(4)1094-1098, 2001.
33. Yonem A, Cakir B, Guler S, Azal OO, Corakci A: Effects of granulocyte-colony stimulating factor in the treatment of diabetic foot infection. Diabetes Obes Metab 3:332-337, 2001.
34. Kastenbauer T, Hornlein B, Sokol, Irsigler K: Evaluation of granulocyte-colony stimulating factor (filgrastim) in infected diabetic foot ulcers. Diabetologia 46:27-30, 2003.
35. Takahashi Y, Kobayashi Y, Chikayama S, Ikeda M, Kondo M: Effect of granulocyte/colony-stimulating factor on the onset of the adult respiratory distress syndrome. Acta Haematol (Basel) 101:124-129, 1999.
36. Piper RD, Cook DJ, Bone RC, Sibbald WJ: Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 24:2059-2070, 1996.
37. Barsig J, Bundschuh DS, Hartung T, Bauhofer A, Sauer A, Wendel A: Control of fecal peritoneal infection in mice by colony-stimulating factors. J Infect Dis 174:790-799, 1996.
38. Basu S, Hodgson G, Zhang HH, Katz M, Quilici C, Dunn AR: "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection. Blood 95:3725-3733, 2000.
39. Zhan Y, Lieschke GJ, Grail D, Dunn AR, Cheers C: Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice. Blood 91:863-869, 1998.
40. Metcalf D, Robb L, Dunn AR, Mifsud S, Di Rago L: Role of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in the development of an acute neutrophil inflammatory response in mice. Blood 88:3755-3764, 1996.
41. Silverstein R: D-Galactosamine lethality model: scope and limitations. J Endotoxin Res 10:147-162, 2004.
42. Gorgen I, Hartung T, Leist M, Niehorster M, Tiegs G, Uhlig S, Weizel F, Wendel A: Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-α. J Immunol 149:918-924, 1992.
43. Aoki Y, Hiromatsu K, Kobayashi N, Hotta T, Saito H, Igarashi H, Niho Y, Yoshikai Y: Protective effect of granulocyte colony-stimulating factor against T-cell-mediated lethal shock triggered by superantigens. Blood 86:1420-1427, 1995.
44. Koizumi T, Kubo K, Shinozaki S, Koyama S, Kobayashi T, Sekiguchi M: Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury in sheep. Am Rev Respir Dis 148:132-137, 1993.
45. Hanaoka M, Kubo K, Miyahara T, Hayano T, Koizumi T, Kobayashi T, Sekiguchi M: Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. Exp Lung Res 24:15-25, 1998.
46. Fink MP, O'Sullivan BP, Menconi MJ, Wollert SP, Wang H, Youssef ME, Bellelsle JM: Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J Trauma 34:571-578, 1993.
47. Terashima T, Kanazawa M, Sayama K, Ishizaka A, Urano T, Sakamaki F, Nakamura H, Waki Y, Tasaka S: Granulocyte colony-stimulating factor exacerbates acute lung injury induced by intratracheal endotoxin in guinea pigs. Am J Respir Crit Care Med 149:1295-1303, 1994.
48. Vollmar B, Messner S, Wanner GA, Hartung T, Menger MD: Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: an intravital microscopic analysis of Kupffer cell and leukocyte response. J Leukocyte Biol 62:710-718, 1997.
49. Freeman BD, Quezado Z, Zeni F, Natanson C, Danner RL, Banks S, Quezado M, Fitz Y, Bacher J, Eichacker PQ: rG-CSF reduces endotoxemia and improves survival during E. coli pneumonia. J Appl Physiol 83:1467-1475, 1997.
50. Zhang P, Bagby GJ, Stoltz DA, Spitzer JA, Summer WR, Nelson S. Modulation of the lung host response by granulocyte colony-stimulating factor in rats challenged with intrapulmonary endotoxin. Shock 7(3):193-199, 1997.
51. Kanazawa M, Ishizaka A, Hasegawa N, Suzuki Y, Yokoyama T: Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am Rev Respir Dis 145:1030-1035, 1992.
52. Haberstroh J, Breuer H, Lucke I, Massarrat K, Fruh R, Mand U, Hagedorn P, Brunnberg L, von Specht BU: Effect of recombinant human granulocyte colony-stimulating factor on hemodynamic and cytokine response in a porcine model of Pseudomonas sepsis. Shock 4:216-224, 1995.
53. Haberstroh J, Wiese K, Geist A, Dursunoglu GB, Gippner-Steppert C, Jochum M, von Specht BU: Effect of delayed treatment with recombinant human granulocyte colony-stimulating factor on survival and plasma cytokine levels in a non-neutropenic porcine model of Pseudomonas aeruginosa sepsis. Shock 9:128-134, 1998.
54. Kullberg B-J, Netea MG, Curfs JH, Keuter M, Meis JF, van der Meer JW: Recombinant murine granulocyte colony-stimulating factor protects against acute disseminated Candida albicans infection in non-neutropenic mice. J Infect Dis 177:175-181, 1998.
55. Graybill JR, Bocanegra R, Luther M: Antifungal combination therapy with granulocyte colony-stimulating factor and fluconazole in experimental disseminated Candidiasis. Eur J Clin Microbiol Infect Dis 14:700-703, 1995.
56. Hamood M, Bluche PF, De Vroey C, Corazza F, Bujan W, Fondu P: Effects of recombinant human granulocyte colony-stimulating factor on neutropenic mice infected with Candida albicans: acceleration of recovery from neutropenia and potentiation of anti-C. albicans resistance. Mycoses 37:93-99, 1994.
57. Steinshamn S, Bergh K, Waage A: Effects of stem cell factor and granulocyte colony-stimulating factor on granulocyte recovery and Candida albicans infection in granulocytopenic mice. J Infect Dis 168:1444-1448, 1993.
58. Polak-Wyss A: Protective effect of human granulocyte colony-stimulating factor (h G-CSF) on Candida infections in normal and immunosuppressed mice. Mycoses 34:109-118, 1991.
59. DeMarsh PL, Sucolski SK, Frey CL, Bhatnagar PK, Koltin Y, Actor P, Petteway SR: Efficacy of the hematoregulatory peptide SK&F 107647 in experimental Candida albicans infections in normal and immunosuppressed mice. Immunopharmacology 27:199-206, 1994.
60. Uchida K, Yamamoto Y, Klein TW, Friedman H, Yamaguchi H: Granulocyte colony-stimulating factor facilitates the restoration of resistance to opportunistic fungi in leukopenic mice. J Med Vet Mycol 30:293-300, 1992.
61. Cairo MS, Plunkett JM, Mauss D, Van de Ven C: Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and Group B streptococcus sepsis. Blood 76:1788-1794, 1990.
62. Novales JS, Salva AM, Modanlou HD, Kaplan DL, del Castillo J, Andersen J, Medlock ES: Maternal administration of granulocyte colony-stimulating factor improves neonatal rat survival after lethal group B streptococcal infection. Blood 81:923-927, 1993.
63. Iguchi K, Inoue S, Kmar A: Effect of recombinant human granulocyte colony-stimulating factor administration in normal and experimentally infected newborn rats. Exp Hematol 19:352-358, 1991.
64. Buisman AM, Langermans JA, Van Furth R: Effect of granulocyte colony-stimulating factor on the course of infection with gram-positive bacteria in mice during granulocytopenia induced by sublethal irradiation or cyclophosphamide. J Infect Dis 174:417-421, 1996.
65. Serushago BA, Yoshikai Y, Handa T, Mitsuyama M, Muramori K, Nomoto K: Effect of recombinant human granulocyte colony-stimulating factor (rh G-CSF) on murine resistance against Listeria monocytogenes. Immunology 75:475-480, 1992.
66. Shinomiya N, Tsuru S, Katsura Y, Kayashima S, Nomoto K: Enhanced resistance against Listeria monocytogenes achieved by pretreatment with granulocyte colony-stimulating factor. Infect Immun 59:4740-4743, 1991.
67. Kayashima S, Tsuruu S, Hata N, Rokutanda M: Therapeutic effect of granulocyte colony-stimulating factor (G-CSF) on the protection against Listeria infection in SCID mice. Immunology 80:471-476, 1993.
68. Hebert JC, O'Reilly M, Barry B, Shatney L, Sartorelli K: Effects of exogenous cytokines on intravascular clearance of bacteria in normal and splenectomized mice. J Trauma 43:875-879, 1997.
69. Matsumoto M, Matsubara S, Yokota T: Effect of combination therapy with recombinant human granulocyte colony-stimulating factor (r G-CSF) and antibiotics in neutropenic mice unresponsive to antibiotics alone. J Antimicrob Chemother 28:447-453, 1991.
70. Wakiyama H, Tsuru S, Hata N, Shinomiya M, Shinomiya N, Noritake M, Umezawa Y, Rokutanda M: Therapeutic effect of granulocyte colony-stimulating factor and cephem antibiotics against experimental infections in neutropenic mice induced by cyclophosphamide. Clin Exp Immunol 92:218-224, 1993.
71. Preheim LC, Snitily MU, Gentry MJ: Effects of granulocyte colony-stimulating factor in cirrhotic rats with pneumococcal pneumonia. J Infect Dis 174:225-228, 1996.
72. Dallaire F, Ouellet N, Simard M, Bergeron Y, Bergeron MG: Efficacy of recombinant human granulocyte colony-stimulating factor in a murine model of pneumococcal pneumonia: effects of lung inflammation and timing of treatment. J Infect Dis 183:70-77, 2001.
73. Karzai W, von Specht BU, Parent C, Haberstroh J, Wollersen K, Natanson C, Banks SM, Eichacker PQ: G-CSF during Escherichia coli versus Staphylococcus aureus pneumonia in rats has fundamentally different and opposite effects. Am J Respir Crit Care Med 159:(5Pt1)1377-1382, 1999.
74. Oz N, Agalar C, Daphan CE, Agalar F, Turkyilmaz R: Effect of teicoplanin and G-CSF on survival in experimental MRSA pneumonia in neutropenic mice. Int J Surg Investig 2:347-352, 2001.
75. Freeman BD, Correa R, Karzai W, Natanson C, Patterson M, Banks S, Fitz Y, Danner RL, Wilson L, Eichacker PQ: Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 80:2066-2076, 1996.
76. Held TK, Mielke ME, Chedid M, Unger M, Trautmann M, Huhn D, Cross AS: Granulocyte colony-stimulating factor worsen the outcome of experimental Klebsiella pneumoniae pneumonia through direct interaction with the bacteria. Blood 91:2525-2535, 1998.
77. Shirai R, Kadoto T, Tomono K, Ogawa K, Iida K, Kawakami K, Kohno S: Protective effect of granulocyte colony-stimulating factor (G-CSF) in a granulocytopenic mouse model of Pseudomonas aeruginosa lung infection through enhanced phagocytosis and killing by alveolar macrophages through priming tumor necrosis factor α (TNF-α) production. Clin Exp Immunol 109:73-79, 1997.
78. Babalola CP, Nightingale CH, Nicolau DP: Adjunctive efficacy of granulocyte colony-stimulating factor on treatment of Pseudomonas aeruginosa pneumonia in neutropenic and non-neutropenic hosts. J Antimicrob Chemother 53:1098-1100, 2004.
79. Lister PD, Gentry MJ, Preheim LC: Granulocyte colony-stimulating factor protects control rats but not ethanol-fed rats from fatal pneumococcal pneumonia. J Infect Dis 168:922-926, 1993.
80. Smith WS, Sumnicht GE, Sharpe RW, Samuelson D, Millard FE: Granulocyte colony-stimulating factor versus placebo in addition to penicillin G in a randomized blinded study of gram-negative pneumonia sepsis: analysis of survival and multisystem organ failure. Blood 86:1301-1309, 1995.
81. Hustinx W, Benaissa-Trouw B, Van Kessel K, Kuenen J, Tavares L, Kraaijeveld K, Verhoef J, Hoepelman A: Granulocyte colony-stimulating factor enhances protection by anti-K1 capsular IgM antibody in murine Escherichia coli sepsis. Eur J Clin Invest 27:1044-1048, 1997.
82. Dunne JR, Dunkin BJ, Nelson S, White JC: Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Escherichia coli peritonitis. J Surg Res 61:348-354, 1996.
83. Eichacker PQ, Waisman Y, Natanson C, Farese A, Hoffman WD, Banks SM, Macvittie TJ: Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. J Appl Physiol 77:2366-2373, 1994.
84. Quezado Z, Parent C, Karzai W, Depietro M, Natanson C, Hammond W, Danner RL, Cui X, Fitz Y, Banks SM: Acute G-CSF therapy is not protective during lethal E. coli sepsis. Am J Physiol Integr Comp Physiol 281:R1177-R1185, 2004.
85. O'Reilly M, Silver GM, Greenhalgh DG, Gamelli RL, Davis JH, Hebert JC: Treatment of intra-abdominal infection with granulocyte colony-stimulating factor. J Trauma 33:679-682, 1992.
86. Patton JH Jr, Lyden SP, Rgasdale DN, Croce MA, Fabian TC, Proctor KG: Granulocyte colony-stimulating factor improves host defense to resuscitated shock and polymicrobial sepsis without provoking generalized neutrophil-mediated damage. J Trauma 44:750-758, 1998.
87. Goya T, Torisu M, Doi F, Yoshida T: Effects of granulocyte colony-stimulating factor and monobactam antibiotics (Aztreonam) on neutrophil functions in sepsis. Clin Immunol Immunopathol 69:278-284, 1993.
88. Toda H, Murata A, Matsuura N, Uda K, Oka Y, Tanaka N, Mori T: Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model. Stem Cells 11:228-234, 1993.
89. Zhang P, Bagbg GJ, Stoltz DA, Summer WR, Nelson S: Enhancement of peritoneal leukocyte function by granulocyte colony-stimulating factor in rats with abdominal sepsis. Crit Care Med 26:315-321, 1998.
90. Canturk Z, Canturk NZ, Onen F: Effects of rhG-CSF on neutrophil functions and survival in sepsis induced diabetic rats. Endocr Res 24:141-157, 1998.
91. Villa P, Shaklee CL, Meazza C, Agnello D, Ghezzi P, Senaldi G: Granulocyte colony-stimulating factor and antibiotics in the prophylaxis of a murine model of polymicrobial peritonitis and sepsis. J Infect Dis 178:471-477, 1998.
92. Lundblad R, Wang MY, Kvalheim G, Lingaas E, Giercksky KE: Granulocyte colony-stimulating factor improves myelopoiesis and host defense in fulminant intra-abdominal sepsis in rats. Shock 4:68-73, 1995.
93. Davis KA, Fabian TC, Ragsdale DN, Trenthem LL, Croce MA, Proctor KG: Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis. Surgery 126:305-313, 1999.
94. Lorenz W, Reimund K-P, Weitzel F, Celik I, Kurnatowski M, Schneider C, Mannheim W, Heiske A, Neumann K, Sitter H: Granulocyte colony-stimulating factor prophylaxis before operation protects against lethal consequences of postoperative peritonitis. Surgery 116:925-934, 1994.
95. Bauhofer A, Stinner B, Kohlert F, Reckzeh B, Lorenz W, Celik I: Granulocyte colony-stimulating factor but not peritoneal lavage increases survival rate after experimental abdominal contamination and infection. Br J Surg 89:457-464, 2002.
96. Bauhofer A, Tischer B, Middeke M, Plaul U, Lorenz W, Torossian A: The genetic background of hypertensive, septic rats determines outcome improvement with antibiotic and G-CSF prophylaxis. Shock 20:326-331, 2003.
97. Torossian A, Ruehlmann S, Middeke M, Sessler DI, Lorenz W, Wulf HF, Bauhofer A: Deleterious effects of mild hypothermia in septic rats are ameliorated by granulocyte colony-stimulating factor. Anesthesiology 99:1087-1092, 2003.
98. Lundblad R, Nesland JM, Giercksky KE: Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Crit Care Med 24:820-826, 1996.
99. Koike K, Moore FA, Moore EE, Poggetti RS, Tuder RM, Banerjee A: Endotoxin after gut ischemia/reperfusion causes irreversible lung injury. J Surg Res 52:656-662, 1992.
100. Abraham E, Stevens P: Effects of granulocyte colony stimulating factor in modifying mortality from Pseudomonas aeruginosa pneumonia after hemorrhage. Crit Care Med 20:1127-1133, 1992.
101. Attalah HL, Azoulay E, Yang K, Lasclos C, Jouault H, Soussy CJ, Guillot T, Brochard L, Brun-Buisson C, Harf A, Delclaux C: Granulocyte colony-stimulating factor enhances host defenses against bacterial pneumonia following peritonitis in non-neutropenic rats. Crit Care Med 30:2107-2114, 2002.
102. Eaves-Pyles T, Alexander JW: Granulocyte colony-stimulating factor enhances killing of translocated bacteria but does not affect barrier function in a burn mouse model. J Trauma 41:1013-1017, 1996.
103. Yalcin O, Soybir G, Koksoy F, Kose H, Ozturk R, Cokneseli B: Effects of granulocyte colony-stimulating factor on bacterial translocation due to burn wound sepsis. Surg Today 27:154-158, 2004.
104. Peter FW, Schuschke DA, Barker JH, Fleischer-Peter B, Pierangeli S, Vogt PM, Steinan HU: The effect of severe burn injury on proinflammatory cytokines and leukocyte behavior: its modulation with granulocyte colony-stimulating factor. Burns 25:477-486, 1999.
105. Agalar F, Iskit AB, Agalar C, Hamaloglu E, Guc MO: The effects of G-CSF treatment and starvation on bacterial translocation in hemorrhagic shock. J Surg Res 78:143-147, 1998.
106. Meng ZH, Dyer K, Billiar TR, Tweardy DJ: Distinct effects of systemic infusion of G-CSF versus IL-6 on lung and liver inflammation and injury in hemorrhagic shock. Shock 14:41-48, 2000.
107. Rao R, Prinz RA, Kazantsev GB, Hecht D, Gattuso P, Jacobs HK, Djuricin G, Castelli M: Effects of granulocyte colony-stimulating factor in severe pancreatitis. Surgery 119:657-663, 1996.
108. Whalen MJ, Carlos TM, Wisniewski SR, Clark RS, Mellick JA, Marion DW, Kochanek PM: Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Crit Care Med 28:3710-3717, 2000.
109. Nose M, Uzawa A, Ogyu T, Suzuki G: OK-432 reduces mortality and bacterial translocation in irradiated and granulocyte-colony stimulating factor (G-CSF)-treated mice. J Radiat Res 42:191-200, 2001.
110. King J, Deboisblanc BP, Mason CM, Onofrio JM, Lipscomb G, Mercante DE, Summer WR, Nelson S: Effect of granulocyte colony-stimulating factor on acute lung injury in the rat. Am J Respir Crit Care Med 151:(2Pt1)302-309, 1995.
111. Wolkoff LI, Levine CR, Koo HC, LaGamma EF, Pollack S, Chester D, Bashore J, Davis JM: Effects of granulocyte colony-stimulating factor on hyperoxia-induced lung injury in newborn piglets. Lung 180:229-239, 2002.
112. Azoulay E, Attalah H, Yang K, Herigault S, Joaault H, Brun-Buisson C, Brochard L, Harf A: Exacerbation with granulocyte colony-stimulating factor of prior acute lung injury during neutropenia recovery in rats. Crit Care Med 31:157-165, 2003.
113. Polmächer T, Korth C, Mullington J, Schreiber W, Sauer J, Veddar H, Galanos C, Holsboer F: Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men. Blood 87:900-905, 1996.
114. Pajkrt D, Manten A, van Der Poll T, Tiel van Buul MMC, Jansen J, Wouter ten Cate J, Van Deventer SJH: Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans. Blood 90:1415-1424, 1997.
115. Nathens AB, Rotstein OD, Marshall JC: Tertiary peritonitis: clinical features of a complex nosocomial infection. World J Surg 22:158-163, 1998.