Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patients with acute traumatic brain injury or cerebral hemorrhage

Critical Care Medicine

Volumn 26, Issue 4, 1998, Pages 748-754

  Heard, Stephen O ^a   Fink, Mitchell P ^a   Gamelli, Richard L ^a   Solomkin, Joseph S ^a   Joshi, Manjari ^a   Trask, Arthur L ^a   Fabian, Timothy C ^a   Hudson, Leonard D ^a   Gerold, Kevin B ^a   Logan, Eileen D ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Bacteremia; Brain injury; Cerebral hemorrhage; Granulocyte colony stimulating factor; Infection; Nosocomial pneumonia

Indexed keywords

PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; BACTEREMIA; BRAIN HEMORRHAGE; BRAIN INJURY; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUTROPHIL; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; URINARY TRACT INFECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APACHE; BACTEREMIA; BRAIN INJURIES; CEREBRAL HEMORRHAGE; CROSS INFECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FILGRASTIM; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPHILS; PNEUMONIA; URINARY TRACT INFECTIONS;

EID: 7144257846     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199804000-00027     Document Type: Article

References (41)

1. Banerjee SN, Emori TG, Culver DH, et al: Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989: National Nosocomial Infections Surveillance System. Am J Med 1991; 91(Suppl 3B): 86S-89S
2. Pittet D, Wenzel RP: Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to hospital deaths. Arch Intern Med 1995; 155:1177-1184
3. Craven DE, Kunches LM, Kilinsky V, et al: Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986; 133:792-796
4. Fink MP, Helsmoortel CM, Stein KL, et al: The efficacy of an oscillating bed in the prevention of lower respiratory tract infection in critically ill victims of blunt trauma. A prospective study. Chest 1990; 97:132-137
5. Sacks GS, Brown RO, Teague D, et al: Early nutrition support modifies immune function in patients sustaining severe head injury. JPEN 1995; 19:387-392
6. Meert KL, Long M, Kaplan J, et al: Alterations in immune function following head injury in children. Crit Care Med 1995; 23:822-828
7. Wolach B, Sazbon L, Gavrieli R, et al: Some aspects of the humoral and neutrophil functions in post-comatose unawareness patients. Brain Inj 1993; 7:401-410
8. Souza LM, Boone TC, Gabrilove J, et al: Recombinant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells. Science 1986; 232:61-65
9. Begley CG, Lopez AF, Nicola NA, et al: Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony-stimulating factors. Blood 1986; 68: 162-166
10. Wang JM, Chen ZG, Colella S, et al: Chemotactic activity of recombinant human granulocyte colony-stimulating factor. Blood 1988; 72:1456-1460
11. Görgen I, Hartung T, Leist M, et al: Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-α. J Immunol 1992; 149: 918-924
12. Hebert JC, O'Reilly M, Gamelli RL: Protective effect of recombinant human granulocyte colony-stimulating factor against pneumococcal infections in splenectomized mice. Arch Surg 1990; 125:1075-1078
13. Mooney DP, Gamelli RL, O'Reilly M, et al: Recombinant human colony-stimulating factor and Pseudomonas burn wound sepsis. Arch Surg 1988; 123: 1353-1357
14. Lundblad R, Wang MY, Kvalheim G, et al: Granulocyte colony-stimulating factor improves myelopoiesis and host defense in fulminant intra-abdominal sepsis in rats. Shock 1995; 4:68-73
15. O'Reilly M, Silver GM, Greenhalgh DG, et al: Treatment of intra-abdominal infection with granulocyte colony-stimulating factor. J Trauma 1992; 33:679-682
16. Silver GM, Gamelli RL, O'Reilly M: The beneficial effect of granulocyte colony-stimulating factor (G-CSF) in combination with gentamicin on survival after Pseudomonas burn wound infection. Surgery 1989; 106:452-455
17. Glaspy JA, Baldwin GC, Robertson PA, et al: Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Ann Intern Med 1988; 109:789-795
18. Pingleton SK, Fagon JY, Leeper KV: Patient selection for clinical investigation of ventilator-associated pneumonia: Criteria for evaluating diagnostic technique. Chest 1992; 102(Suppl): 553S-556S
19. Stark RP, Maki DG: Bacteriuria in the catheterized patient. What quantitative level of bacteriuria is relevant? N Engl J Med 1984; 311:560-564
20. MacGregor RR, Beaty HN: Evaluation of positive blood cultures. Guidelines for early differentiation of contaminated from valid positive cultures. Arch Intern Med 1972; 130:84-87
21. Dixon WJ: BMDP Statistical Software Manual. Vols 1 and 2. Berkeley, CA, University of California Press, 1990, p 1385
22. 2 tests. Biometrics 1954; 10:417-451
23. Weiland JE, Davis WB, Holter JF, et al: Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Am Rev Respir Dis 1986; 133:218-225
24. Koizumi T, Kubo K, Shinozaki S, et al: Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury in sheep. Am Rev Respir Dis 1993; 148:132-137
25. Kanazawa M, Ishizaka A, Hasegawa N, et al: Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am Rev Respir Dis 1992; 145:1030-1035
26. Fink MP, O'Sullivan BP, Menconi MJ, et al: Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J Trauma 1993; 34:571-577
27. Amgen Inc: Filgrastim Investigator's Brochure. Thousand Oaks, CA, Amgen, 1995
28. Schilero GJ, Oropello J, Benjamin E: Impairment in gas exchange after granulocyte colony-stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. Chest 1995;107:276-278
29. White K, Cebon J: Transient hypoxemia during neutrophil recovery in febrile patients. Lancet 1995; 345: 1022-1024
30. Demuynck H, Zachee P, Verhoef GEG, et al: Risks of rhG-CSF treatment in drug-induced agranulocytosis. Ann Hematol 1995; 70:143-147
31. Freeman BD, Correa R, Karzai W, et al: Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 1996; 80:2066-2076
32. King J, Deboisblanc BP, Mason CM, et al: Effect of granulocyte colony-stimulating factor on acute lung injury in the rat. Am J Respir Crit Care Med 1995; 151:302-309
33. Donowitz LG, Wenzel RP, Hoyt JW: High risk of hospital acquired infection in the ICU patient. Crit Care Med 1982; 10:355-357
34. Pittet D, Tarara D, Wenzel RP: Nosocomial bloodstream infection in critically ill patients: Excess length of stay, extra costs, and attributable mortality. JAMA 1994; 271:1598-1601
35. Leibovici L, Samra Z, Konigsberger H, et al: Long-term survival following bacteremia or fungemia. JAMA 1995; 274:807-812
36. Colton T: Statistics in Medicine. Boston, MA, Little, Brown and Co, 1974
37. Hsieh AH, Bishop MJ, Kubilis PS, et al: Pneumonia following closed head injury. Am Rev Respir Dis 1992; 146:290-294
38. Bonten MJM, Gaillard CA, Wouters EFM, et al: Problems in diagnosing nosocomial pneumonia in mechanically ventilated patients: A review. Crit Care Med 1994; 22:1683-1691
39. Marquette CH, Copin MC, Wallet F, et al: Diagnostic tests for pneumonia in ventilated patients: Prospective evaluation of diagnostic accuracy using histology as a diagnostic gold standard. Am J Respir Crit Care Med 1995; 151:1878-1888
40. Chastre J, Fagon JY, Bornet-Lesco M, et al: Evaluation of bronchoscopic techniques for the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 1995; 152:231-240
41. Scarffe JH, Kamthan A: Clinical studies of granulocyte colony stimulating factor (G-CSF). Cancer Surv 1990; 9: 115-130