Granulocyte-Colony Stimulating Factor (G-CSF) as an adjunct to antibiotics in the treatment of pneumonia in adults

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2009, Pages

  Cheng, Allen C ^a   Stephens, Dianne P ^b   Currie, Bart J ^c  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL DARWIN HOSPITAL   (Australia)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

Author keywords

Adult; Anti bacterial agents *therapeutic use ; Chemotherapy, adjuvant; Community acquired infections drug therapy; mortality ; Granulocyte colony stimulating factor, recombinant *therapeutic use ; Humans; Pneumonia *drug therapy; mortality ; Randomized controlled trials as topic

Indexed keywords

ANTIBIOTIC AGENT; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; ANTIBIOTIC THERAPY; COCHRANE LIBRARY; COMMUNITY ACQUIRED PNEUMONIA; DRUG EFFICACY; DRUG SAFETY; FEBRILE NEUTROPENIA; HOSPITAL INFECTION; HUMAN; MORTALITY; PNEUMONIA; REVIEW; SYSTEMATIC REVIEW; VENTILATOR ASSOCIATED PNEUMONIA;

EID: 77950219804     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Cheng 2006 {unpublished data only} Cheng A. A randomized placebo controlled trial of G-CSF for severe melioidosis. Unpublished data 2006.
2. Hartmann 2005 {published and unpublished data} Hartmann P, Lammertink J, Mansmann G, Hubel K, Salzburger B, Engert A, et al.A randomized, placebo-controlled study of the use of filgrastim in non-neutropenic patients with nosocomial pneumonia. European Journal of Medical Research 2005;10(1):29-35. [MEDLINE: 15737951]
3. Mansmann G, Lammertink J, Hartmann P, Hübel K, Oberhäuser F, Stützer H, et al.A randomized, placebo-controlled trial of Granulocyte Colony-Stimulating Factor (G-CSF, Filgrastim) in nonneutropenic patients with nosocomial pneumonia. Unpublished manuscript 2005.
4. Mansmann G, Lammertink J, Hartmann P, Salzberger B, Engert A, Fatkenheuer G. Results of a randomised, placebo-controlled study on the use of Granulocyte colony stimulating factor (G-CSF) in nosocomial pneumonia (NP) [Ergebnisse einer randomisierten, plazebokontrollierten Studie zum Einsatz von Granulozyten-Kolonien-stimulierender Faktor (G-CSF) bei nosokomialer Pneumonie (NP)]. Pneumologie 2001;55(Suppl):60.
5. Nelson 1998 {published data only} Nelson S, Belknap SM, Carlson RW, Dale D, DeBoisblanc B, Farkas S, et al.A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. CAP Study Group. Journal of Infectious Diseases 1998;178(4):1075-80.
6. Nelson 2000 {published data only} Nelson S, Heyder AM, Stone J, Bergeron MG, Daugherty S, Peterson G. A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. Journal of Infectious Diseases 2000;182(3):970-3.
7. Root 2003 {published data only} Root RK, Lodato RF, Patrick W, Cade JF, Fotheringham N, Milwee S, et al.Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Critical Care Medicine 2003;31(2): 367-73.
8. Wunderink 2001 {published data only} Wunderink R, Leeper K Jr, Schein R, Nelson S, DeBoisblanc B, Fotheringham N, et al.Filgrastim in patients with pneumonia and severe sepsis or septic shock. Chest 2001;119(2):523-9.
9. deBoisblanc 1997 {published data only} deBoisBlanc BP, Mason CM, Andresen J, Logan E, Bear MB, Johnson S, et al.Phase 1 safety trial of Filgrastim (r-metHuG-CSF) in non-neutropenic patients with severe pneumonia. Respiratory Medicine 1997;91:387-94.
10. Droemann 2006 {published data only} Droemann D, Hansen F, Aries SP, Braun J, Zabel P, Dalhoff K, et al.Neutrophil apoptosis, activation and anti-inflammatory cytokine response in granulocyte colony-stimulating factor-treated patients with community-acquired pneumonia. Respiration 2006;73(3):340-6.
11. Hustinx 1998 {published data only} Hustinx WN, Van Kessel CP, Heezius E, Burgers S, Lammers JW, Hoepelman IM. Effects of granulocyte colony-stimulating factor (G-CSF) treatment on granulocyte function and receptor expression in patients with ventilator-dependent pneumonia. Clinical and Experimental Immunology 1998;112(2):334-40.
12. Meyanci 2001 {published data only} Meyanci G, Oz H. Combination of granulocyte colony-stimulating factor and antibacterial drugs for the treatment of ventilatory associated nosocomial pneumonia. Middle Eastern Journal of Anaesthesiology 2001;16(1):91-101.
13. Alderson 2004 Alderson P, Green S, Higgins JPT. Assessment of study quality. Cochrane Reviewers' Handbook 4.2.1. Section 6 [updated December, 2003]. Vol.Issue 1, Chichester, UK: John Wiley & Sons, 2004.
14. Annane 2002 Annane D, Sibille C, Charpentier C, Bollaert PE, Francois B, Korach JM, et al.Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288(7):862-71.
15. ATS 2005 American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated and healthcare- associated pneumonia. American Journal of Respiratory and Critical Care Medicine 2005;171:388-416.
16. Azoulay 2001 Azoulay E, Attalah H, Harf A, Schlemmer B, Delclaux C. Granulocyte colony-stimulating factor or neutrophil-induced pulmonary toxicity: myth or reality? Systematic review of clinical case reports and experimental data. Chest 2001;120(5):1695-1701.
17. Bartlett 1995 Bartlett JG, Mundy LM. Community-acquired pneumonia. New England Journal of Medicine 1995;333(24):1618-24.
18. Berghmans 2002 Berghmans T, Paesmans M, Lafitte JJ, Mascaux C, Meert AP, Jacquy C, et al.Therapeutic use of granulocyte and granulocyte-macrophage colony- stimulating factors in febrile neutropenic cancer patients. A systematic review of the literature with meta-analysis. Supportive Care in Cancer 2002;10(3):181-8.
19. Bernard 2001 Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al.Efficacy and safety of recombinant human activated protein C for severe sepsis. New England Journal of Medicine 2001;344(10):699-709.
20. Bone 1993 Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. Chest 1993;101(6):1644-55.
21. BTS 2001 British Thoracic Society. BTS guidelines for the management of community acquired pneumonia in adults. Thorax 2001;56(Suppl 4):iv1-iv64.
22. Ewig 1998 Ewig S, Ruiz M, Mensa J, Marcos MA, Martinez JA, Arancibia F. Severe community-acquired pneumonia. Assessment of severity criteria. American Journal of Respiratory and Critical Care Medicine 1998;158(4):1102-8. [MEDLINE: 5]
23. Fagon 1993a Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. American Journal of Medicine 1993;94(3):281-8. [MEDLINE: 6]
24. Fagon 1993b Fagon JY, Chastre J, Hance AJ, Domart Y, Trouillet JL, Gibert C. Evaluation of clinical judgment in the identification and treatment of nosocomial pneumonia in ventilated patients. Chest 1993;103(2):547-53. [MEDLINE: 9]
25. Fine 1997 Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, et al.A prediction rule to identify low-risk patients with community-acquired pneumonia. New England Journal of Medicine 1997;336(4):243-50. [MEDLINE: 11]
26. Foote 2003 Foote M. Personal communication 2003.
27. Garner 1988 Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections. American Journal of Infection Control 1988;16(3):128-40. [MEDLINE: 8]
28. Hartung 1999 Hartung T. Granulocyte colony-stimulating factor: its potential role in infectious disease. AIDS 1999;13(Suppl 2):3-9. [MEDLINE: 20061789]
29. Hebert 1990 Hebert JC, O'Reilly M, Gamelli RL. Protective effect of recombinant human granulocyte colony-stimulating factor against pneumococcal infections in splenectomized mice. Archives of Surgery 1990;125(8):1075-8. [MEDLINE: 2]
30. Higgins 2005 Higgins JPT, Green S, editors. Developing and documenting a search strategy for studies and organizing search results. Cochrane Handbook for Systematic Reviews of Interventions 4.2 [updated May 2005]; Section 5. In: The Cochrane Library, Issue 3. Chichester, UK: John Wiley & Sons, Ltd, 2005.
31. Kober 2004 Kober T, Engert A. Personal communication 2004.
32. McKenna 1996 McKenna P, Nelson S, Andresen J. Filgrastim (rHuG-CSF) enhances ciprofloxacin uptake and bactericidal activity of human neutrophils in vitro [abstract 535, American Thoracic Society meeting, May, 1996]. American Journal of Respiratory and Critical Care Medicine 1996;153:A535.
33. Niederman 1993 Niederman MS, Bass JB, Jr, Campbell GD, Fein AM, Grossman RF, Mandell LA, et al.Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. American Thoracic Society. Medical Section of the American Lung Association. American Review of Respiratory Disease 1993;148(5):1418-26. [MEDLINE: 4]
34. Sanchez-Nieto 1998 Sanchez-Nieto JM, Torres A, Garcia-Cordoba F, El Ebiary M, Carrillo A, Ruiz J, et al.Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot study. American Journal of Respiratory and Critical Care Medicine 1998;157(2):371-6. [MEDLINE: 7]
35. Smith 1995 Smith WS, Sumnicht GE, Sharpe RW, Samuelson D, Millard FE. Granulocyte colony-stimulating factor versus placebo in addition to penicillin G in a randomized blinded study of gram-negative pneumonia sepsis: analysis of survival and multisystem organ failure. Blood 15-8-1995;86(4):1301-9. [MEDLINE: 3]
36. Stephens 2002 Stephens DP, Fisher DA, Currie BJ. An audit of the use of granulocyte colony-stimulating factor in septic shock. Internal Medicine Journal 2002;32(4):143-8. [MEDLINE: 1]
37. Weiss 1999 Weiss M, Moldawer LL, Schneider EM. Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis. Blood 1999;93(2):425-39.
38. Welte 1996 Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF): the first 10 years. Blood 1996;88(6):1907-29.
39. Cheng 2003 Granulocyte colony stimulating factor as an adjunct to antibiotics for treating pneumonia in adults. Cheng AC, Stephens DP, Currie BJ. Cochrane Database of Systematic Reviews 2003, Issue 4.
40. Cheng 2004 Cheng AC, Stephens DP, Currie BJ. Granulocyte colony stimulating factor as an adjunct to antibiotics for treating pneumonia in adults. Cochrane Database of Systematic Reviews 2004, Issue 3.