Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 141 B, Issue 3, 2006, Pages 227-233

  Burcescu, I ^a   Wigg, K ^a   Gomez, L ^a   King, N ^b   Vetro A ^c   Kiss, E ^c   Kapornai, K ^c   Gadoros J ^d   Kennedy, J L ^b   Kovacs, M ^e   Barr, C L ^a,f  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF SZEGED   (Hungary)

^d Vadaskert Hospital   (Hungary)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Adrenergic receptors; Child; Depression; Gene; Genetics; Mood disorders

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR;

ADRENERGIC SYSTEM; ARTICLE; BIPOLAR DISORDER; CHILD; CHILDHOOD ONSET MOOD DISORDER; CHROMOSOME 10Q; CHROMOSOME 4P; CHROMOSOME 5Q; CHROMOSOME 8P; DEPRESSION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; HUNGARY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MOOD DISORDER; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL;

ADOLESCENT; AGE OF ONSET; ALLELES; CHILD; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; HUNGARY; LINKAGE DISEQUILIBRIUM; MALE; MOOD DISORDERS; PROTEIN ISOFORMS; RECEPTORS, ADRENERGIC;

EID: 33645998742     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30292     Document Type: Article

References (26)

1. Abou Jamra R, Schumacher J, Golla A, Richter C, Otte AC, Schulze TG, Ohlraun S, Maier W, Rietschel M, Cichon S, Propping P, Nothen MM. 2004. Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder. Am J Med Genet (Neuropsychiatr Genet) Part B 126B:79-81.
2. Adams JH, Wigg KG, King N, Burcescu I, Vetro A, Kiss E, Baji I, George CJ, Kennedy JL, Kovacs M, Barr CL. 2005. Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. Am J Med Genet (Neuropsychiatr Genet) Part B 132B:90-95.
3. Barrett JC, Fry B, Mailer J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265. Epub 2004 August 5.
4. Berman RM, Narasimhan M, Miller HL, Anand A, Cappiello A, Oren DA, Heninger GR, Charney DS. 1999. Transient depressive relapse induced by catecholamine depletion: Potential phenotypic vulnerability marker? Arch Gen Psychiatry 56(5):395-403.
5. Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St. Clair DM, Porteous DJ, Muir WJ. 1996. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12(4):427-430.
6. Brunello N, Blier P, Judd LL, Mendlewicz J, Nelson CJ, Souery D, Zohar J, Racagni G. 2003. Noradrenaline in mood and anxiety disorders: Basic and clinical studies. Int Clin Psychopharmacol 18(4):191-202.
7. Byerley W, Hoff M, Holik J, Coon H. 1994. A linkage study with D5 dopamine and alpha 2C-adrenergic receptor genes in six multiplex bipolar pedigrees. Psychiatr Genet 4(3):121-124.
8. Charney DS. 1998. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 59(suppl 14):11-14.
9. Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, Schulze TG, Schmidt-Wolf G, Albus M, Borrmann-Hassenbach M, Franzek E, Lanczik M, Fritze J, Kreiner R, Reuner U, Weigelt B, Minges J, Lichtermann D, Lerer B, Kanyas K, Baur MP, Wienker TF, Maier W, Rietschel M, Propping P, Nothen MM. 2001. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 10(25):2933-2944.
10. Clayton D, 1999. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65(4):1170-1177.
11. Delgado PL, Moreno FA. 2000. Role of norepinephrine in depression. J Clin Psychiatry 61(suppl 1):5-12.
12. Ewald H, Flint T, Kruse TA, Mors O. 2002. A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7(7):734-744.
13. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H. 2001. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98(2):585-590. Epub 2001 January 9.
14. Leonard BE. 1997. Noradrenaline in basic models of depression. Eur Neuropsychopharmacol 7(suppl 1):S11-S16; discussion S71-77.
15. Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215.
16. Ohara K, Nagai M, Tani K, Tsukamoto T, Suzuki Y. 1998. Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. Neuroreport 9(7):1291-1294.
17. Ressler KJ, Nemeroff CB. 2000. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12(suppl 1):2-19.
18. Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273(5281):1516-1517.
19. Schatzberg AF. 1998. Noradrenergic versus serotonergic antidepressants: Predictors of treatment response. J Clin Psychiatry 59(suppl 14):15-18.
20. Sham PC, Curtis D. 1995. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59(Pt 3):323-336.
21. Sherrill JT, Kovacs M. 2000. Interview schedule for children and adolescents (ISCA). J Am Acad Child Adolesc Psychiatry 39(1):67-75.
22. Shibata K, Hirasawa A, Moriyama N, Kawabe K, Ogawa S, Tsujimoto G. 1996. Alpha 1a-adrenoceptor polymorphism: Pharmacological characterization and association with benign prostatic hypertrophy. Br J Pharmacol 118(6):1403-1408.
23. Wang Z, Crowe RR, Tanna VL, Winokur G. 1992. Alpha 2 adrenergic receptor subtypes in depression: A candidate gene study. J Affect Disord 25(3):191-196.
24. Wong EH, Sonders MS, Amara SG, Tinholt PM, Piercey MF, Hoffmann WP, Hyslop DK, Franklin S, Porsolt RD, Bonsignori A, Carfagna N, McArthur RA. 2000. Reboxetine: A pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry 47(9):818-829,
25. Zill P, Baghai TC, Engel R, Zwanzger P, Schule C, Minov C, Behrens S, Bottlender R, Jager M, Rupprecht R, Moller HJ, Ackenheil M, Bondy B. 2003. Beta-1-adrenergic receptor gene in major depression: Influence on antidepressant treatment response. Am J Med Genet (Neuropsychiatr Genet) Part B 120B:85-89.
26. Zubenko GS, Maher B, Hughes HB, IIId, Zubenko WN, Stiffler JS, Kaplan BB, Marazita ML. 2003. Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am J Med Genet (Neuropsychiatr Genet) Part B 123B:1-18.