Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 126 B, Issue 1, 2004, Pages 79-81

  Jamra, Rami Abou ^a   Schumacher, Johannes ^a   Golla, Astrid ^a   Richter, Carola ^a   Otte, Andreas C J ^a   Schulze, Thomas G ^a,b   Ohlraun, Stephanie ^a,b   Maier, Wolfgang ^a   Rietschel, Marcella ^a,b   Cichon, Sven ^c   Propping, Peter ^a   Nöthen, Markus M ^c  

^a UNIVERSITY OF BONN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Adrenergic receptor genes; Manic depression; Transmission disequilibrium test

Indexed keywords

ALPHA 1C ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ARGININE; CYSTEINE;

ADRA 1C GENE; ADRA 2A GENE; ADRA 2C GENE; ARTICLE; BIPOLAR DISORDER; CHROMOSOMAL LOCALIZATION; CHROMOSOME 10Q; CHROMOSOME 4P; CHROMOSOME 8P; FAMILY STUDY; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NORADRENERGIC NERVE; PATHOGENESIS; PRIORITY JOURNAL; PROGENY; TRANSMISSION DISEQUILIBRIUM TEST;

EID: 12144291220     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20145     Document Type: Article

References (22)

1. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders. 4th Edn. Washington, DC: American Psychiatric Association.
2. Baldessarini RJ. 1996. Drugs and the treatment of psychiatric disorders: Depression and mania. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, editors. The pharmacological basis of therapeutics. New York, NY: McGraw-Hill. pp 431-459.
3. Barchas JD, Altemus M. 1998. Biochemical hypotheses of mood and anxiety disorders. In: Siegel GJ, Agranoff BW, Albers RW, Fisher S, Uhler MD, editors. Basic neurochemistry: Molecular, cellular and medical aspects. Philadelphia, PA: Lippincott-Raven. pp 1073-1094.
4. Barr CL, Wigg K, Zai G, Roberts W, Malone M, Schachar R, Tannock R, Kennedy JL. 2001. Attention-deficit hyperactivity disorder and the adrenergic receptors α1C and α2C. Mol Psychiatry 6:334-337.
5. Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St. Clair DM, Porteous DJ, Muir WJ. 1996. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12:427-430.
6. Chen WM, Deng HW. 2001. A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes. Genet Epidemiol 21:53-67.
7. Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, Schulze TG, Schmidt-Wolf G, Albus M, Borrmann-Hassenbach M, Franzek E, Lanczik M, Fritze J, Kreiner R, Reuner U, Weigelt B, Minges J, Lichtermann D, Lerer B, Kanyas K, Baur MP, Wienker TF, Maier W, Rietschel M, Propping P, Nothen MM. 2001. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 25:2933-2944.
8. Comings DE, Gade-Andavolu R, Gonzalez N, Blake H, Wu S, MacMurray JP. 1999. Additive effect of three noradrenergic genes (ADRA2a, ADRA2c, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 55:160-172.
9. Ewald H, Flint T, Kruse TA, Mors O. 2002. A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7:734-744.
10. First MB, Spitzer RL, Gibbon M, Williams JBW. 1997. Structured clinical interview for DSM-IV axis I disorders. Patient edition. Biometrics Research Department. New York State Psychiatric Institute
11. Goodwin FK, Jamison KR. 1990. Manic-depressive illness. Oxford: Oxford University Press.
12. Hein L, Altman JD, Kobilka BK. 1999. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402:181-184.
13. Hoehe MR, Otterud B, Hsieh WT, Martinez MM, Stauffer D, Holik J, Berrettini WH, Byerley WF, Gershon ES, Lalouel JM. 1995. Genetic mapping of adrenergic receptor genes in humans. J Mol Med 73:299-306.
14. Jobe CJ, Dailey JW, Wernicke JF. 1999. A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Crit Rev Neurobiol 13:317-356.
15. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H. 2001. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98:585-590.
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347-1363.
17. Lange C, DeMeo DL, Laird NM. 2002. Power and design considerations for a general class of family-based association tests: Quantitative traits. Am J Hum Genet 71:1330-1341.
18. Lario S, Calls J, Cases A, Oriola J, Torras A, Rivera F. 1997. MspI identifies a biallelic polymorphism in the promoter region of the alpha 2A-adrenergic receptor gene. Clin Genet 51:129-130.
19. Riess O, Weber B, Hayden MR. 1992. (CA)n-dinucleotide repeat polymorphism at the locus for the alpha2C adrenergic receptor (ADRA2C) on 4p16. Hum Mol Genet 1:452.
20. Shibata K, Hirasawa A, Moriyama N, Kawabe K, Ogawa S, Tsujimoto G. 1996. Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. Br J Pharmacol 118:1403-1408.
21. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
22. Xu C, Schachar R, Tannock R, Roberts W, Malone M, Kennedy JL, Barr CL. 2001. Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families. Am J Med Genet 105:159-162.