Beta-1-adrenergic receptor gene in major depression: Influence on antidepressant treatment response

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 120 B, Issue 1, 2003, Pages 85-89

  Zill, Peter ^a   Baghai, Thomas C ^a   Engel, Rolf ^a   Zwanzger, Peter ^a   Schüle, Cornelius ^a   Minov, Christo ^a   Behrens, Stefanie ^a   Bottlender, Ronald ^a   Jäger, Markus ^a   Rupprecht, Rainer ^a   Möller, Hans Jürgen ^a   Ackenheil, Manfred ^a   Bondy, Brigitta ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Association study; Beta 1 adrenergic receptor; Major depression; Polymorphism; Treatment response

Indexed keywords

ADENYLATE CYCLASE; ANTIDEPRESSANT AGENT; BETA 1 ADRENERGIC RECEPTOR; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; SEROTONIN AGONIST; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; ALLELISM; AMINO ACID ANALYSIS; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 10744225917     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20017     Document Type: Article

References (14)

1. Banerjee SP, Kung LS, Riggi SJ, Chanda SK. 1977. Development of betaadrenergic receptor subsensitivity by antidepressants. Nature 268: 455-456.
2. Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr. 1967. Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597-598.
3. Longmate JA. 2001. Complexity and power in case-control association studies. Am J Hum Genet 68:1229-1237.
4. Manji HK, Lenox RH. 2000. Signaling: Cellular insights into the pathophysiology of bipolar disorder. Biol Psychiatry 48:518-530.
5. Mason DA, Moore JD, Green SA, Liggett SB. 1999. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem 274:12670-12674.
6. Murphy DL, Andrews AM, Wichems CH, Li Q, Tohda M, GreenbergB. 1998. Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry 59(Suppl 15):4-12.
7. Ordway GA, Gambarana C, Frazer A. 1988. Quantitative autoradiography of central beta adrenoceptor subtypes: Comparison of the effects of chronic treatment with desipramine or centrally administered L-isoproterenol. J Pharmacol Exp Ther 247:379-389.
8. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, et al. 1997. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 74:247-253.
9. Rothman KJ. 1990. No adjustments are needed for multiple comparisons. Epidemiology 1:43-46.
10. Schildkraut JJ. 1965. The catecholamine hypothesis of affective disorders: A review of supporting evidence. J Neuropsychiatry Clin Neurosci 7:524-533.
11. Sulser F. 1984. Antidepressant treatments and regulation of norepinephrine-receptor-coupled adenylate cyclase systems in brain. Adv Biochem Psychopharmacol 39:249-261.
12. Toyota T, Watanabe A, Shibuya H, Nankai M, Hattori E, Yamada K, Kurumaji A, Karkera JD, Detera-Wadleigh SD, Yoshikawa T. 2000. Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the Light Cycler. Mol Psychiatry 5:489-494.
13. Wittchen HU, Zaudig M, Fydrich D. 1997. SKID-I/II: Strukturiertes klinisches Interview für DSM IV.
14. Xie HG, Dishy V, Sofowora G, Kim RB, Landau R, Smiley RM, Zhou HH, Wood AJ, Harris P, Stein CM. 2001. Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics 1:191-197.