Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated photoreceptor synaptic and retinal degeneration by apoptosis

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 4, 2006, Pages 1281-1292

  Mori, Naoki ^a,b   Ishiba, Yasutsugu ^a   Kubota, Shinya ^c   Kobayashi, Akira ^d   Higashide, Tomomi ^d   McLaren, Margaret J ^e   Inana, George ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^e Gray Matter Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 2; BINDER OF ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 2; CASPASE 3; CYTOCHROME C; MUTANT PROTEIN; PROTEIN HRG4; UNCLASSIFIED DRUG; CASP3 PROTEIN, MOUSE; CASPASE; MICROTUBULE PROTEIN; SIGNAL PEPTIDE; UNC119 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; IMMUNOFLUORESCENCE; MITOCHONDRION; MORPHOMETRICS; MOUSE; NICK END LABELING; NONHUMAN; OXYGEN SATURATION; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN BINDING; RETINA DEGENERATION; SYNAPSE; WESTERN BLOTTING; ANIMAL; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; STOP CODON; TRANSGENIC MOUSE;

ADENINE NUCLEOTIDE TRANSLOCATOR 1; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CODON, NONSENSE; CYTOCHROMES C; ENZYME ACTIVATION; IN SITU NICK-END LABELING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MICROTUBULE PROTEINS; MITOCHONDRIA; PHOTORECEPTORS, VERTEBRATE; RETINAL DEGENERATION; SYNAPSES;

EID: 33645971984     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0493     Document Type: Article

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