Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119)

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 2, 2002, Pages 308-313

  Kubota, Shinya ^a   Kobayashi, Akira ^a   Mori, Naoki ^a   Higashide, Tomomi ^a   McLaren, Margaret J ^a   Inana, George ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXIN 2; CYTOPLASM PROTEIN; MEMBRANE PROTEIN; MUNC18 PROTEIN; PROTEIN DOC2; PROTEIN HRG4; PROTEIN RSEC8; RABAPTIN 5; RABPHILIN 3A; SNARE PROTEIN; SYNAPSIN II; SYNAPTIC PROTEIN; SYNAPTOGYRIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN; SYNTAXIN 4; SYNTAXIN 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS REACTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RETINA CONE; RETINA DEGENERATION; RETINA DYSTROPHY; RETINA ROD; SYNAPSE VESICLE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOBLOTTING; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; PHOTORECEPTORS, VERTEBRATE; RETINAL DEGENERATION; SYNAPTIC MEMBRANES; SYNAPTIC VESICLES;

EID: 0036157331     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Isolation of human retinal genes: Recoverin cDNA and gene
2. Isolation of candidate genes for retinal degenerations
3. Cloning of the cDNA for a novel photoreceptor protein
4. Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse
5. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
6. Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant δ subunit
7. The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase
8. Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to Unc-119
9. HRG4(UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model
10. The synaptic vesicle cycle: A cascade of protein-protein interactions
11. Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses
12. Distribution of synaptic markers in the retina: Implications for synaptic vesicle traffic in ribbon synapses
13. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
14. Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons
15. Nerve fibre layer loss in diseases of the outer retinal layer
16. Structure of synaptogyrin (p29) defines novel synaptic vesicle protein
17. v- and t-SNARE protein expression in models of insulin resistance: Normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats