The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte

Hepatology Research

Volumn 35, Issue 1, 2006, Pages 53-61

  Gyamfi, Maxwell Afari ^a   Wan, Yu Jui Yvonne ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholic liver disease; Ethanol; Glutathione S transferase; Retinoid X receptor alpha; S Adenosylmethionine; Vitamin E

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALDEHYDE DEHYDROGENASE INHIBITOR; ALPHA TOCOPHEROL; ANTIOXIDANT; CYANAMIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; LIPID; RETINOID X RECEPTOR ALPHA; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; THIOBARBITURIC ACID;

ALCOHOL LIVER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DETOXIFICATION; DISEASE PREDISPOSITION; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER CELL; LIVER CYTOSOL; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROCESS MODEL; WILD TYPE;

EID: 33645935393     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2006.02.003     Document Type: Article

References (62)

1. Room R., Babor T., and Rehm J. Alcohol and public health. Lancet 365 (2005) 519-530
2. Aleynik S.I., Leo M.A., Aleynik M.K., and Lieber C.S. Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. Alcohol Clin Exp Res 22 (1998) 192-196
3. Kalish G.H., and Di Luzio N.R. Peroxidation of liver lipids in the pathogenesis of the ethanol-induced fatty liver. Science 152 (1966) 1390-1392
4. Lee T.D., Sadda M.R., Mendler M.H., et al. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 28 (2004) 173-181
5. Masini A., Ceccarelli D., Gallesi D., Giovannini F., and Trenti T. Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats. The critical role for mitochondrial reduced glutathione. Biochem Pharmacol 47 (1994) 217-224
6. Rouach H., Fataccioli V., Gentil M., French S.W., Morimoto M., and Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 25 (1997) 351-355
7. Hirano T., Kaplowitz N., Tsukamoto H., Kamimura S., and Fernandez-Checa J.C. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16 (1992) 1423-1427
8. Wu D., and Cederbaum A.I. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem 271 (1996) 23914-23919
9. Lieber C.S. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health 27 (2003) 220-231
10. Cederbaum A.I. Introduction-serial review: alcohol, oxidative stress and cell injury. Free Radic Biol Med 31 (2001) 1524-1526
11. Oei H.H., Zoganas H.C., McCord J.M., and Schaffer S.W. Role of acetaldehyde and xanthine oxidase in ethanol-induced oxidative stress. Res Commun Chem Pathol Pharmacol 51 (1986) 195-203
12. Mansouri A., Demeilliers C., Amsellem S., Pessayre D., and Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 298 (2001) 737-743
13. Song Z., Zhou Z., Chen T., Hill D., Kang J., Barve S., et al. S-adenosylmethionine (SAMe) protects against acute alcohol-induced hepatotoxicity in mice. J Nutr Biochem 14 10 (2003) 591-597
14. Wheeler M.D., Nakagami M., Bradford B.U., et al. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem 276 (2001) 36664-36672
15. Hayes J.D., and Pulford D.J. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30 (1995) 445-600
16. Wilce M.C., and Parker M.W. Structure and function of glutathione S-transferases. Biochim Biophys Acta 1205 (1994) 1-18
17. Eaton D.L., and Bammler T.K. Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol Sci 49 (1999) 156-164
18. Morgenstern R., Meijer J., Depierre J.W., and Ernster L. Characterization of rat-liver microsomal glutathione S-transferase activity. Eur J Biochem 104 (1980) 167-174
19. Arteel G.E. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124 (2003) 778-790
20. Chen J., Schenker S., and Henderson G.I. 4-Hydroxynonenal detoxification by mitochondrial glutathione S-transferase is compromised by short-term ethanol consumption in rats. Alcohol Clin Exp Res 26 (2002) 1252-1258
21. Alin P., Danielson U.H., and Mannervik B. 4-Hydroxyalk-2-enals are substrates for glutathione transferase. FEBS Lett 179 (1985) 267-270
22. Harada S., Agarwal D.P., and Goedde H.W. Aldehyde dehydrogenase and glutathione-S-transferase polymorphism: association between phenotype frequencies and alcoholism. Prog Clin Biol Res 241 (1987) 241-250
23. Savolainen V.T., Pjarinen J., Perola M., Penttila A., and Karhunen P.J. Glutathione-S-transferase GST M1 "null" genotype and the risk of alcoholic liver disease. Alcohol Clin Exp Res 20 (1996) 1340-1345
24. Hirvonen A., Husgafvel-Pursiainen K., Anttila S., and Vainio H. The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis 14 (1993) 1479-1481
25. van Poppel G., de Vogel N., van Balderen P.J., and Kok F.J. Increased cytogenetic damage in smokers deficient in glutathione S-transferase isozyme mu. Carcinogenesis 13 (1992) 303-305
26. Bell D.A., Taylor J.A., Paulson D.F., Robertson C.N., Mohler J.L., and Lucier G.W. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85 (1993) 1159-1164
27. Harada S., Misawa S., Nakamura T., Tanaka N., Ueno E., and Nozoe M. Detection of GST1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Hum Genet 90 (1992) 62-64
28. Beckett G.J., Hayes P.C., Hussey A.J., Bouchier I.A., and Hayes J.D. Plasma glutathione S-transferase measurements in patients with alcoholic cirrhosis. Clin Chim Acta 169 (1987) 85-89
29. Zhao P., Kalhorn T.F., and Slattery J.T. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 36 (2002) 326-335
30. Aoyama T., Peters J.M., Iritani N., et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 273 (1998) 5678-5684
31. Crabb D.W., Galli A., Fischer M., and You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol 34 (2004) 35-38
32. Dai T., Wu Y., Leng A.S., et al. RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity. Exp Mol Pathol 75 3 (2003) 194-200
33. Fischer M., You M., Matsumoto M., and Crabb D.W. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 278 (2003) 27997-28004
34. Tanaka N., Hora K., Makishima H., et al. In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha. FEBS Lett 543 (2003) 120-124
35. Nakajima T., Kamijo Y., Tanaka N., et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40 (2004) 972-980
36. Guillouzo A. Liver cell models in in vitro toxicology. Environ Health Perspect 106 (1998) 511-532
37. Colell A., Garcia-Ruiz C., Miranda M., et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115 (1998) 1541-1551
38. Sokol R.J., Devereaux M.W., Traber M.G., and Shikes R.H. Copper toxicity and lipid peroxidation in isolated rat hepatocytes: effect of Vitamin E. Pediatr Res 25 (1989) 55-62
39. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27 3 (1969) 502-522
40. She Q.B., Nagao I., Hayakawa T., and Tsuge H. A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of Vitamin B6 deficiency on these concentrations in rat liver. Biochem Biophys Res Commun 205 (1994) 1748-1754
41. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249 (1974) 7130-7139
42. Reddy C.C., Tu C.P., Burgess J.R., Ho C.Y., Scholz R.W., and Massaro E.J. Evidence for the occurrence of selenium-independent glutathione peroxidase activity in rat liver microsomes. Biochem Biophys Res Commun 101 (1981) 970-978
43. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
44. Vickers A.E. Use of human organ slices to evaluate the biotransformation and drug-induced side-effects of pharmaceuticals. Cell Biol Toxicol 10 (1994) 407-414
45. Fernandez-Checa J.C., and Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol 204 (2005) 263-273
46. Barak A.J., Beckenhauer H.C., Tuma D.J., and Badakhsh S. Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 65 (1987) 230-233
47. Nordmann R. Alcohol and antioxidant systems. Alcohol Alcohol 29 (1994) 513-522
48. Aniya Y., and Anders M.W. Alteration of hepatic glutathione S-transferases and release into serum after treatment with bromobenzene, carbon tetrachloride, or N-nitrosodimethylamine. Biochem Pharmacol 34 (1985) 4239-4244
49. Balasubramaniyan V., Kalaivani Sailaja J., and Nalini N. Role of leptin on alcohol-induced oxidative stress in Swiss mice. Pharmacol Res 47 (2003) 211-216
50. David R.M., and Nerland D.E. Induction of mouse liver glutathione S-transferase by ethanol. Biochem Pharmacol 32 (1983) 2809-2811
51. Devi B.G., Schenker S., Mazloum B., and Henderson G.I. Ethanol-induced oxidative stress and enzymatic defenses in cultured fetal rat hepatocytes. Alcohol 13 (1996) 327-332
52. Gonzalez J., Munoz M.E., Martin M.I., Collado P.S., Fermoso J., and Esteller A. Influence of acute ethanol administration on hepatic glutathione metabolism in the rat. Alcohol 5 (1988) 103-106
53. Van de Wiel J.A., Fijneman P.H., Teeuw K.B., Van Ommen B., Noordhoek J., and Bos R.P. Influence of long-term ethanol treatment on rat liver biotransformation enzymes. Alcohol 10 (1993) 397-402
54. Yang C.M., and Carlson G.P. Influence of ethanol on glutathione-S-transferase activity and glutathione content in the isolated perfused rabbit lung. Toxicology 62 (1990) 249-263
55. Fernandez-Checa J.C., Garcia-Ruiz C., Ookhtens M., and Kaplowitz N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest 87 (1991) 397-405
56. Oh S.I., Kim C.I., Chun H.J., and Park S.C. Chronic ethanol consumption affects glutathione status in rat liver. J Nutr 128 (1998) 758-763
57. Teare J.P., Greenfield S.M., Watson D., et al. Lipid peroxidation in rats chronically fed ethanol. Gut 35 (1994) 1644-1647
58. Remmer H., Kessler W., Einsele H., et al. Ethanol promotes oxygen-radical attack on proteins but not on lipids. Drug Metab Rev 20 (1989) 219-232
59. Jemth P., and Mannervik B. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. Arch Biochem Biophys 348 2 (1997) 247-254
60. Robertson I.G., Guthenberg C., Mannervik B., and Jernstrom B. Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Cancer Res 46 (1986) 2220-2224
61. Warholm M., Guthenberg C., and Mannervik B. Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides. Biochemistry 22 (1983) 3610-3617
62. Wiencke J.K., Kelsey K.T., Lamela R.A., and Toscano Jr. W.A. Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res 50 (1990) 1585-1590