Relationships between nutrition, alcohol use, and liver disease

Alcohol Research and Health

Volumn 27, Issue 3, 2003, Pages 220-231

  Lieber, Charles S ^a,b,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Section of Liver Disease and Nutrition   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcoholic liver disorder; Chronic AODE (alcohol and other drug effects); Digestion; Ethanol metabolism; Liver function; Malnutrition; MEOS (microsomal ethanol oxidizing system); NAD; Nutrient absorption; Nutritional deficiency; Vitamin therapy; Vitamins

Indexed keywords

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; AMINO ACID; ANTIOXIDANT; BETA CAROTENE; GLUTATHIONE; MEDIUM CHAIN TRIACYLGLYCEROL; PHOSPHATIDYLCHOLINE; POLYENE PHOSPHATIDYLCHOLINE; PROTEIN; REACTIVE SULFUR SPECIES; RETINOL; S ADENOSYLMETHIONINE; SILYMARIN; UNCLASSIFIED DRUG; ALCOHOL;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ALCOHOLIC BEVERAGE; ALCOHOLIC FATTY LIVER; ALCOHOLISM; ANTIOXIDANT ACTIVITY; CANCER RISK; HUMAN; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER DISEASE; LIVER FUNCTION; LIVER TOXICITY; LUNG CANCER; MALNUTRITION; NONHUMAN; NUTRITIONAL STATUS; OXIDATIVE STRESS; REVIEW; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; DRINKING BEHAVIOR; METABOLISM; NUTRITION; PHYSIOLOGY;

ALCOHOL DRINKING; ALCOHOLISM; ETHANOL; HUMANS; LIVER DISEASES, ALCOHOLIC; MALNUTRITION; NUTRITION PHYSIOLOGY;

EID: 16544381988     PISSN: 0090838X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. ADIBI, S.A.; BARAONA, E.; AND LIEBER, C.S. Effects of ethanol on amino acids and protein metabolism. In: Lieber, C.S., ed. Medical and Nutritional Complications of Alcoholism: Mechanism and Management. New York: Plenum Press, 1992. pp. 127-155.
2. AHMED, S.; LEO, M.A.; AND LIEBER, C.S. Interactions between alcohol and beta-carotene in patients with alcoholic liver disease. American Journal of Clinical Nutrition 60:430-436, 1994.
3. ALBANES, D.; HEINONEN, O.P.; TAYLOR, P.R.; ET AL. α-tocopherol and β-carotene supplements and lung cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study: Effects of baseline characteristics and study compliance. Journal of the National Cancer Institute 88:1560-1571, 1996.
4. ALEYNIK, S.I.; LEO, M.A.; ALEYNIK, M.K.; AND LIEBER, C.S. Polyenylphosphatidylcholine prevents carbontetrachloride-induced lipid peroxidation while it attenuates liver injury and fibrosis. Journal of Hepatology 26:554-561, 1997.
5. Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330:1029-1035, 1994.
6. BODE, J.L.; BUCHWALD, B.; AND GOEBELL, H. Inhibition of ethanol breakdown due to protein deficiency in man. German Medical Monthly 1:149-151, 1971.
7. CASINI, A.; CUNNINGHAM, M.; ROJKIND, M.; AND LIEBER, C.S. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 13:758-765, 1991.
8. CHEDID, A.; MENDENHALL, C.L.; GARTSIDE, P.; ET AL. Prognostic factors in alcoholic liver disease. American Journal of Gastroenterology 82:210-216, 1991.
9. DE LA MAZA, M.P.; PETERMANN, M.; BUNOUT, D.; AND HIRSCH, S. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. Journal of the American College of Nutrition 14:192-196, 1995.
10. FEINMAN, L., AND LIEBER, C.S. Nutrition and diet in alcoholism. In: Shils, M.E.; Olson, J.A.; Shike, M.; and Ross, A.C.; eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins, 1998. pp. 1523-1542.
11. FERENCI, P.; DRAGOSICS, B.; DITTRICH, H.; ET AL. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology 9:105-113, 1989.
12. GRUCHOW, H.W.; SOBOCIASKI, K.A.; AND BARBORIAK, J.J. Alcohol nutrient intake and hypertension in U.S. adults. JAMA: Journal of the American Medical Association 253:1567-1570, 1985.
13. KOOP, D.R., AND CASAZZA, J.P. Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. Journal of Biological Chemistry 260:13607-13612, 1985.
14. LEO, M.A., AND LIEBER, C.S. Hepatic vitamin A depletion in alcoholic liver injury. New England Journal of Medicine 307:597-601, 1982.
15. LEO, M.A., AND LIEBER, C.S. Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 3:1-11, 1983.
16. LEO, M.A., AND LIEBER, C.S. Alcohol, vitamin A, and beta-carotene: Adverse interactions, including hepatotoxicity and carcinogenicity. American Journal of Clinical Nutrition 69:1071-1085, 1999.
17. LEO, M.A.; ARAI, M.; SATO, M.; AND LIEBER, C.S. Hepatotoxicity of vitamin A and ethanol in the rat. Gastroenterology 82:194-205, 1982.
18. LEO, M.A.; SATO, M.; AND LIEBER, C.S. Effect of hepatic vitamin A depletion on the liver in humans and rats. Gastroenterology 84:562-572, 1983.
19. LEO, M.A.; KIM, C.; AND LIEBER, C.S. Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanel consumption in the rat. Alcoholism: Clinical and Experimental Research 10:487-492, 1986.
20. LEO, M.A.; LOWE, N.; AND LIEBER, C.S. Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene. Journal of Nutrition 117:70-76, 1987.
21. LEO, M.A.; KIM, C.I.; LOWE, N.; AND LIEBER, C.S. Interaction of ethanol with β-carotene: Delayed blood clearance and enhanced hepatotoxiciry. Hepatology 15:883-891, 1992.
22. LEO, M.A.; ROSMAN, A.; AND LIEBER, C.S. Differential depletion of carotenoids and tocopherol in liver diseases. Hepatology 17:977-986, 1993.
23. LIEBER, C.S. Alcohol and the liver. In: Arai, I.M.; Frenkel, M.S.; and Wilson, J.H.P.; eds. Liver Annual VI. Amsterdam: Excerpta Medica, 1987. pp. 163-240.
24. LIEBER, C.S. Perspectives: Do alcohol calories count? American Journal of Clinical Nutrition 54:976-982, 1991a.
25. LIEBER, C.S. Hepatic, metabolic and toxic effects of ethanol: 1991 update. Alcoholism: Clinical and Experimental Research 15:573-592, 1991b.
26. LIEBER, C.S. Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. New York: Plenum Press, 1992.
27. LIEBER, C.S. Cytochrome P-4502E1: Its physiological and pathological role. Physiological Reviews 77:517-544, 1997.
28. LIEBER, C.S. Hepatic and other medical disorders of alcoholism: From pathogenesis to treatment. Journal of Studies on Alcohol 59:9-25, 1998.
29. LIEBER, C.S. Alcohol: Its metabolism and interaction with nutrients. Annual Review of Nutrition 20:395-430, 2000.
30. LIEBER, C.S. S-adenosylmethionine (SAMe): Its role in the treatment of liver disorders. American Journal of Clinical Nutrition 76:1183S-1187S, 2002.
31. LIEBER, C.S., AND DECARLI, L.M. Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. American Journal of Clinical Nutrition 23:474-478, 1970.
32. LIEBER, C.S., AND SCHMID, R. The effect of ethanol on fatty acid metabolism: Stimulation of hepatic fatty acid synthesis in vitro. Journal of Clinical Investigation 40:394-399, 1961.
33. LIEBER, C.S.; LEFEVRE, A.; SPRITZ, N.; ET AL. Difference in hepatic metabolism of long and medium-chain fatty acids: The role of fatty acid chain length in the production of the alcoholic fatty liver. Journal of Clinical Investigation 46:1451-1460, 1967.
34. LIEBER, C.S.; CASINI, A.; DECARLI, L.M.; ET AL. S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 11:165-172, 1990.
35. LIEBER, C.S.; ROBINS, S.J.; LI, J.; ET AL. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106:152-159, 1994.
36. LIEBER, C.S.; LEO, M.A.; ALEYNIK, S.I.; ET AL. Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcoholism: Clinical and Experimental Research 21:375-379, 1997.
37. LIEBER, C.S.; LEO, M.A.; CAO, Q.; ET AL. Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. Journal of Clinical Gastroenterology 37:336-339, 2003.
38. MA, X.; ZHAO, J.; AND LIEBER, C.S. Polyenylphosphatidylcholine attenuates nonalcoholic hepatic fibrosis and accelerates its regression. Journal of Hepatology 24:604-613, 1996.
39. MARTIN-DUCE, A.M.; ORTIZ, P.; CABRERO, C.; AND MATO, J.M. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 8:65-68, 1988.
40. MATO, J.M.; CAMARA, J.; FERNANDEZ DE PAZ, J.; ET AL. S-adenosylmethionine in alcoholic liver cirrhosis: A randomized placebo-controlled double-blind multicenter clinical trial. Journal of Hepatology 30:1081-1089, 1999.
41. MENDENHALL, C.; ROSELLE, G.A.; GARTSIDE, P.; ET AL. Relationship of protein calorie malnutrition to alcoholic liver disease: A reexamination of data from two Veterans Administration Cooperative studies. Alcoholism: Clinical and Experimental Research 19:635-641, 1995.
42. NANJI, A.A.; YANG, E.K.; FOGT, F.; ET AL. Medium-chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease. Journal of Pharmacology and Experimental Therapeutics 277:1694-1700, 1996.
43. PARES, A.; PLANAS, R.; TORRES, M.; ET AL. Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled double-blind randomized and multicenter trial. Journal of Hepatology 28:615-621, 1998.
44. PIROLA, R.C., AND LIEBER, C.S. The energy cost of the metabolism of drugs including ethanol. Pharmacology 7:185-196, 1972.
45. SATO, M., AND LIEBER, C.S. Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. Journal of Nutrition 111: 2015-2023, 1981.
46. SHAW, S.; RUBIN, K.P.; AND LIEBER, C.S. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: Evidence of lipid peroxidation. Digestive Diseases and Sciences 28:585-589, 1983.
47. TSUTSUMI, M.; LASKER, J.M.; SHIMIZU, M.; ET AL. The intralobular distribution of ethanol inducible P450IIE1 in rat and human liver. Hepatology 10:437-446, 1989.