메뉴 건너뛰기




Volumn 11, Issue 2, 2006, Pages 160-165

Genetic engineering of pigs to provide organs for xenotransplantation

Author keywords

Gal 1,3Gal; Nuclear transfer embryo transfer; Transgenic pig; Xenotransplantation; 1,3 galactosyltransferase gene knockout

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CYCLOSPORIN; MONOCLONAL ANTIBODY; REGULATOR PROTEIN;

EID: 33645826074     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (58)
  • 1
    • 0020470466 scopus 로고
    • Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
    • Palmiter RD, Brinster RL, Hammer RE, et al. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 1982; 300:611-615.
    • (1982) Nature , vol.300 , pp. 611-615
    • Palmiter, R.D.1    Brinster, R.L.2    Hammer, R.E.3
  • 2
    • 0019859395 scopus 로고
    • Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs
    • Brinster RL, Chen HY, Trumbauer M, et al. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 1981; 27:223-231.
    • (1981) Cell , vol.27 , pp. 223-231
    • Brinster, R.L.1    Chen, H.Y.2    Trumbauer, M.3
  • 3
    • 0019855228 scopus 로고
    • Introduction of a rabbit beta-globin gene into the mouse germ line
    • Costantini F, Lacy E. Introduction of a rabbit beta-globin gene into the mouse germ line. Nature 1981; 294:92-94.
    • (1981) Nature , vol.294 , pp. 92-94
    • Costantini, F.1    Lacy, E.2
  • 4
    • 2642522640 scopus 로고
    • Genetic transformation of mouse embryos by microinjection of purified DNA
    • U S A
    • Gordon JW, Scangos GA, Plotkin DJ, et al. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci U S A 1980; 77:7380-7384.
    • (1980) Proc Natl Acad Sci , vol.77 , pp. 7380-7384
    • Gordon, J.W.1    Scangos, G.A.2    Plotkin, D.J.3
  • 5
    • 0000051454 scopus 로고
    • Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring
    • U S A
    • Wagner TE, Hoppe PC, Jollick JD, et al. Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci U S A 1981; 78:6376-6380.
    • (1981) Proc Natl Acad Sci , vol.78 , pp. 6376-6380
    • Wagner, T.E.1    Hoppe, P.C.2    Jollick, J.D.3
  • 6
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292:154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 7
    • 0021358883 scopus 로고
    • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
    • Bradley A, Evans M, Kaufman MH, et al. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 1984; 309:255-256.
    • (1984) Nature , vol.309 , pp. 255-256
    • Bradley, A.1    Evans, M.2    Kaufman, M.H.3
  • 8
    • 0023630807 scopus 로고
    • Targeted correction of a mutant HPRT gene in mouse embryonic stem cells
    • Doetschman T, Gregg RG, Maeda N, et al. Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 1987; 330:576-578.
    • (1987) Nature , vol.330 , pp. 576-578
    • Doetschman, T.1    Gregg, R.G.2    Maeda, N.3
  • 9
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987; 51:503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 10
    • 0031044215 scopus 로고    scopus 로고
    • Viable offspring derived from fetal and adult mammalian cells
    • Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature 1997; 385:810-813.
    • (1997) Nature , vol.385 , pp. 810-813
    • Wilmut, I.1    Schnieke, A.E.2    McWhir, J.3
  • 11
    • 0034618722 scopus 로고    scopus 로고
    • Cloned pigs produced by nuclear transfer from adult somatic cells
    • Polejaeva IA, Chen SH, Vaught TD, et al. Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 2000; 407:86-90.
    • (2000) Nature , vol.407 , pp. 86-90
    • Polejaeva, I.A.1    Chen, S.H.2    Vaught, T.D.3
  • 12
    • 0035498411 scopus 로고    scopus 로고
    • Production of nuclear transfer-derived swine that express the enhanced green fluorescent protein
    • Park KW, Cheong HT, Lai L, et al. Production of nuclear transfer-derived swine that express the enhanced green fluorescent protein. Anim Biotechnol 2001; 12:173-181.
    • (2001) Anim Biotechnol , vol.12 , pp. 173-181
    • Park, K.W.1    Cheong, H.T.2    Lai, L.3
  • 13
    • 2642705886 scopus 로고    scopus 로고
    • Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts
    • Schnieke AE, Kind AJ, Ritchie WA, et al. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 1997; 278:2130-2133.
    • (1997) Science , vol.278 , pp. 2130-2133
    • Schnieke, A.E.1    Kind, A.J.2    Ritchie, W.A.3
  • 14
    • 0032509440 scopus 로고    scopus 로고
    • Eight calves cloned from somatic cells of a single adult
    • Kato Y, Tani T, Sotomaru Y, et al. Eight calves cloned from somatic cells of a single adult. Science 1998; 282:2095-2098.
    • (1998) Science , vol.282 , pp. 2095-2098
    • Kato, Y.1    Tani, T.2    Sotomaru, Y.3
  • 15
    • 0032964105 scopus 로고    scopus 로고
    • Production of goats by somatic cell nuclear transfer
    • Baguisi A, Behboodi E, Melican DT, et al. Production of goats by somatic cell nuclear transfer. Nat Biotechnol 1999; 17:456-461.
    • (1999) Nat Biotechnol , vol.17 , pp. 456-461
    • Baguisi, A.1    Behboodi, E.2    Melican, D.T.3
  • 16
    • 0034729804 scopus 로고    scopus 로고
    • Production of gene-targeted sheep by nuclear transfer from cultured somatic cells
    • McCreath KJ, Howcroft J, Campbell KH, et al. Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature 2000; 405:1066-1069.
    • (2000) Nature , vol.405 , pp. 1066-1069
    • McCreath, K.J.1    Howcroft, J.2    Campbell, K.H.3
  • 17
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs
    • Dai Y, Vaught TD, Boone J, et al. Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20:251-255.
    • (2002) Nat Biotechnol , vol.20 , pp. 251-255
    • Dai, Y.1    Vaught, T.D.2    Boone, J.3
  • 18
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295:1089-1092.
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 19
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299:411-414.
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 20
    • 0026041266 scopus 로고
    • Separation of self from non-self in the complement system: A role for membrane cofactor protein and decay accelerating factor
    • Atkinson JP, Oglesby TJ, White D, et al. Separation of self from non-self in the complement system: a role for membrane cofactor protein and decay accelerating factor. Clin Exp Immunol 1991; 86 (Suppl 1):27-30.
    • (1991) Clin Exp Immunol , vol.86 , Issue.1 SUPPL. , pp. 27-30
    • Atkinson, J.P.1    Oglesby, T.J.2    White, D.3
  • 21
    • 0025997903 scopus 로고
    • Reaction of complement with endothelial cells in a model of xenotransplantation
    • Dalmasso AP, Platt JL, Bach FH. Reaction of complement with endothelial cells in a model of xenotransplantation. Clin Exp Immunol 1991; 86 (Suppl 1):31-35.
    • (1991) Clin Exp Immunol , vol.86 , Issue.1 SUPPL. , pp. 31-35
    • Dalmasso, A.P.1    Platt, J.L.2    Bach, F.H.3
  • 22
    • 17144419690 scopus 로고    scopus 로고
    • Porcine complement regulators protect aortic smooth muscle cells poorly against human complement-induced lysis and proliferation: Consequences for xenotransplantation
    • Capey S, van den Berg CW. Porcine complement regulators protect aortic smooth muscle cells poorly against human complement-induced lysis and proliferation: consequences for xenotransplantation. Xenotransplantation 2005; 12:217-226. This paper reports that the distribution of porcine CD55 in pigs is not as it is in humans, and is absent from aortic smooth muscle. Although, it provides no data, it also reports that porcine CD55 is not expressed on porcine endothelium. We can confirm this from our own studies.
    • (2005) Xenotransplantation , vol.12 , pp. 217-226
    • Capey, S.1    Van Den Berg, C.W.2
  • 23
    • 0742288590 scopus 로고    scopus 로고
    • Complement regulatory proteins are expressed at low levels in embryonic human, wild type and transgenic porcine neural tissue
    • Harrower TP, Richards A, Cruz G, et al. Complement regulatory proteins are expressed at low levels in embryonic human, wild type and transgenic porcine neural tissue. Xenotransplantation 2004; 11:60-71. Another publication describing aberrant CD55 expression in pigs.
    • (2004) Xenotransplantation , vol.11 , pp. 60-71
    • Harrower, T.P.1    Richards, A.2    Cruz, G.3
  • 24
    • 0034283678 scopus 로고    scopus 로고
    • Pigs express multiple forms of decay-accelerating factor (CD55), all of which contain only three short consensus repeats
    • Perez de la Lastra JM, Harris CL, Hinchliffe SJ, et al. Pigs express multiple forms of decay-accelerating factor (CD55), all of which contain only three short consensus repeats. J Immunol 2000; 165:2563-2573.
    • (2000) J Immunol , vol.165 , pp. 2563-2573
    • De La Perez Lastra, J.M.1    Harris, C.L.2    Hinchliffe, S.J.3
  • 25
    • 0037181431 scopus 로고    scopus 로고
    • Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation
    • Richards AC, Davies HF, McLaughlin ML, et al. Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation. Transplantation 2002; 73:881-889.
    • (2002) Transplantation , vol.73 , pp. 881-889
    • Richards, A.C.1    Davies, H.F.2    McLaughlin, M.L.3
  • 26
    • 2442458742 scopus 로고    scopus 로고
    • Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity
    • Baumann BC, Forte P, Hawley RJ, et al. Lack of galactose-alpha-1,3- galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity. J Immunol 2004; 172:6460-6467. This paper demonstrates that Gal is not the target for natural killer cytotoxicity.
    • (2004) J Immunol , vol.172 , pp. 6460-6467
    • Baumann, B.C.1    Forte, P.2    Hawley, R.J.3
  • 27
    • 0034026723 scopus 로고    scopus 로고
    • The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection
    • Wang H, DeVries ME, Deng S, et al. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med 2000; 6:549-555.
    • (2000) Nat Med , vol.6 , pp. 549-555
    • Wang, H.1    Devries, M.E.2    Deng, S.3
  • 28
    • 0026760570 scopus 로고
    • Discordant xenograft rejection in an antibody-free model
    • Johnston PS, Wang MW, Lim SM, et al. Discordant xenograft rejection in an antibody-free model. Transplantation 1992; 54:573-576.
    • (1992) Transplantation , vol.54 , pp. 573-576
    • Johnston, P.S.1    Wang, M.W.2    Lim, S.M.3
  • 29
    • 0026362792 scopus 로고
    • Protection of mammalian cells from complement-mediated lysis by transfection of human membrane cofactor and decay accelerating factor
    • Oglesby TJ, White DJG, Tedja I, et al. Protection of mammalian cells from complement-mediated lysis by transfection of human membrane cofactor and decay accelerating factor. Trans Assoc Am Phys 1991; 104:164-172.
    • (1991) Trans Assoc Am Phys , vol.104 , pp. 164-172
    • Oglesby, T.J.1    White, D.J.G.2    Tedja, I.3
  • 30
    • 0027415790 scopus 로고
    • Tissue expression of human decay accelerating factor, a regulator of complement activation expressed in mice: A potential approach to inhibition of hyperacute xenograft rejection
    • Cary N, Moody J, Yannoutsos N, et al. Tissue expression of human decay accelerating factor, a regulator of complement activation expressed in mice: a potential approach to inhibition of hyperacute xenograft rejection. Transplant Proc 1993; 25:400-401.
    • (1993) Transplant Proc , vol.25 , pp. 400-401
    • Cary, N.1    Moody, J.2    Yannoutsos, N.3
  • 31
    • 0030112522 scopus 로고    scopus 로고
    • A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection
    • Yannoutsos N, Ijzermans JN, Harkes C, et al. A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection. Genes Cells 1996; 1:409-419.
    • (1996) Genes Cells , vol.1 , pp. 409-419
    • Yannoutsos, N.1    Ijzermans, J.N.2    Harkes, C.3
  • 32
    • 0025997675 scopus 로고
    • Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: Potential for prevention of xenograft hyperacute rejection
    • Dalmasso AP, Vercellotti GM, Platt JL, et al. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991; 52:530-533.
    • (1991) Transplantation , vol.52 , pp. 530-533
    • Dalmasso, A.P.1    Vercellotti, G.M.2    Platt, J.L.3
  • 33
    • 0025751645 scopus 로고
    • Presence of human chromosome 1 with expression of human decay-accelerating factor (DAF) prevents lysis of mouse/human hybrid cells by human complement
    • Wang MW, Wright LJ, Sims MJ, et al. Presence of human chromosome 1 with expression of human decay-accelerating factor (DAF) prevents lysis of mouse/human hybrid cells by human complement. Scand J Immunol 1991; 34:771-778.
    • (1991) Scand J Immunol , vol.34 , pp. 771-778
    • Wang, M.W.1    Wright, L.J.2    Sims, M.J.3
  • 34
    • 0028809071 scopus 로고
    • Expression of human DAF and MCP on pig endothelial cells protects from human complement
    • Carrington CA, Richards AC, Cozzi E, et al. Expression of human DAF and MCP on pig endothelial cells protects from human complement. Transplant Proc 1995; 27:321-323.
    • (1995) Transplant Proc , vol.27 , pp. 321-323
    • Carrington, C.A.1    Richards, A.C.2    Cozzi, E.3
  • 35
    • 0029068597 scopus 로고
    • The generation of transgenic pigs as potential organ donors for humans
    • Cozzi E, White DJ. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1:964-966.
    • (1995) Nat Med , vol.1 , pp. 964-966
    • Cozzi, E.1    White, D.J.2
  • 36
    • 10744224843 scopus 로고    scopus 로고
    • Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons
    • Loveland BE, Milland J, Kyriakou P, et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004; 11:171-183. This is a meticulous study of the protective effect of a complement regulator on xenograft rejection in nonimmunosuppressed baboons.
    • (2004) Xenotransplantation , vol.11 , pp. 171-183
    • Loveland, B.E.1    Milland, J.2    Kyriakou, P.3
  • 37
    • 0034655731 scopus 로고    scopus 로고
    • The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice
    • Zhao Y, Rodriguez-Barbosa JI, Swenson K, et al. The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice. Transplantation 2000; 69:1447-1451.
    • (2000) Transplantation , vol.69 , pp. 1447-1451
    • Zhao, Y.1    Rodriguez-Barbosa, J.I.2    Swenson, K.3
  • 38
    • 0038012548 scopus 로고    scopus 로고
    • Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model. I: Evidence for pig-specific T-cell unresponsiveness
    • Barth RN, Yamamoto S, LaMattina JC, et al. Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model. I: Evidence for pig-specific T-cell unresponsiveness. Transplantation 2003; 75:1615-1624.
    • (2003) Transplantation , vol.75 , pp. 1615-1624
    • Barth, R.N.1    Yamamoto, S.2    LaMattina, J.C.3
  • 39
    • 20144387609 scopus 로고    scopus 로고
    • Mean xenograft survival of 14.6 days in a small group of hDAF-transgenic pig hearts transplanted orthotopically into baboons
    • Brenner P, Schmoeckel M, Wimmer C, et al. Mean xenograft survival of 14.6 days in a small group of hDAF-transgenic pig hearts transplanted orthotopically into baboons. Transplant Proc 2005; 37:472-476.
    • (2005) Transplant Proc , vol.37 , pp. 472-476
    • Brenner, P.1    Schmoeckel, M.2    Wimmer, C.3
  • 40
    • 4444274059 scopus 로고    scopus 로고
    • Xenotransplantation of human decay accelerating factor transgenic porcine kidney to non-human primates: 4 Years experience at a Canadian center
    • Garcia B, Sun HT, Yang HJ, et al. Xenotransplantation of human decay accelerating factor transgenic porcine kidney to non-human primates: 4 years experience at a Canadian center. Transplant Proc 2004; 36:1714-1716. This paper reviews the different immunosuppressive protocols that are successful in preventing the rejection of transgenic pig kidneys in baboons.
    • (2004) Transplant Proc , vol.36 , pp. 1714-1716
    • Garcia, B.1    Sun, H.T.2    Yang, H.J.3
  • 41
    • 24644482765 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival
    • McGregor CG, Davies WR, Oi K, et al. Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005; 130:844-851. Documents the best series of pig to baboon xenograft survival to date. There does not seem to be anything novel as far as the transgene is concerned, but the paper emphasizes attention to detailed immunosuppressive management.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 844-851
    • McGregor, C.G.1    Davies, W.R.2    Oi, K.3
  • 42
    • 2442720110 scopus 로고    scopus 로고
    • Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination
    • Menoret S, Plat M, Blancho G, et al. Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. Transplantation 2004; 77:1468-1471. Another paper documenting rejection of transgenic pig kidneys in nonimmunosuppressed baboons. Emphasizes the occurrence of coagulopathy at the time of rejection.
    • (2004) Transplantation , vol.77 , pp. 1468-1471
    • Menoret, S.1    Plat, M.2    Blancho, G.3
  • 43
    • 4644297157 scopus 로고    scopus 로고
    • Transgenic expression in pig hearts of both human decay-accelerating factor and human membrane cofactor protein does not provide an additional benefit to that of human decay-accelerating factor alone in pig-to-baboon xenotransplantation
    • Manez R, Lopez-Pelaez E, Centeno A, et al. Transgenic expression in pig hearts of both human decay-accelerating factor and human membrane cofactor protein does not provide an additional benefit to that of human decay-accelerating factor alone in pig-to-baboon xenotransplantation. Transplantation 2004; 78:930-933. The title is fully descriptive; however, the immunosuppressive protocol used was perhaps not appropriate for the overall goal of the study.
    • (2004) Transplantation , vol.78 , pp. 930-933
    • Manez, R.1    Lopez-Pelaez, E.2    Centeno, A.3
  • 44
    • 14644422556 scopus 로고    scopus 로고
    • Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay-accelerating factor
    • Zhou CY, Mclnnes E, Copeman L, et al. Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay-accelerating factor. Xenotransplantation 2005; 12:142-148. An in-vitro study showing the protective advantage of using a triple transgenic pig in preventing complement lysis.
    • (2005) Xenotransplantation , vol.12 , pp. 142-148
    • Zhou, C.Y.1    Mclnnes, E.2    Copeman, L.3
  • 45
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295:1089-1092.
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 46
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299:411-414.
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 47
    • 2442567900 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations
    • U S A
    • Kolber-Simonds D, Lai L, Watt SR, et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A 2004; 101:7335-7340.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 7335-7340
    • Kolber-Simonds, D.1    Lai, L.2    Watt, S.R.3
  • 48
    • 0037623766 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-knockout cloned pigs expressing human alpha 1,2-fucosylosyltransferase
    • Ramsoondar JJ, Machaty Z, Costa C, et al. Production of alpha 1,3-galactosyltransferase-knockout cloned pigs expressing human alpha 1,2-fucosylosyltransferase. Biol Reprod 2003; 69:437-445.
    • (2003) Biol Reprod , vol.69 , pp. 437-445
    • Ramsoondar, J.J.1    Machaty, Z.2    Costa, C.3
  • 49
    • 20044387042 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N- acetylglucosaminyltransferase III
    • Takahagi Y, Fujimura T, Miyagawa S, et al. Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III. Mol Reprod Dev 2005; 71:331-338.
    • (2005) Mol Reprod Dev , vol.71 , pp. 331-338
    • Takahagi, Y.1    Fujimura, T.2    Miyagawa, S.3
  • 50
    • 19944421732 scopus 로고    scopus 로고
    • An efficient method for producing alpha(1,3)-galactosyltransferase gene knockout pigs
    • Harrison S, Boquest A, Grupen C, et al. An efficient method for producing alpha(1,3)-galactosyltransferase gene knockout pigs. Cloning Stem Cells 2004; 6:327-331.
    • (2004) Cloning Stem Cells , vol.6 , pp. 327-331
    • Harrison, S.1    Boquest, A.2    Grupen, C.3
  • 51
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11:29-31. A milestone paper in that it records the first results from transplanting Gal knockout hearts into baboons with survivals ranging from 2 to 6 months (median 78 days). These results have to be encouraging for the future of xenotransplantation.
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 52
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11:32-34. From the same group as above, this paper reports the equally encouraging results with kidney transplants from knockout pigs into baboons. In this study the authors used their 'thymokidney' technique, and report absence of acute vascular rejection in all the grafts.
    • (2005) Nat Med , vol.11 , pp. 32-34
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3
  • 53
    • 33645834605 scopus 로고    scopus 로고
    • Induced anti-non-Gal antibodies lead to acute humoral rejection in baboons using α1, 3-galactosyltransferase gene-knockout pigs as kidney donors
    • in press
    • Chen G, Starzl T, Sun HT, et al. Induced anti-non-Gal antibodies lead to acute humoral rejection in baboons using α1, 3-galactosyltransferase gene-knockout pigs as kidney donors. Nat Med (in press).
    • Nat Med
    • Chen, G.1    Starzl, T.2    Sun, H.T.3
  • 54
    • 20144389921 scopus 로고    scopus 로고
    • Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood
    • Schroeder C, Allan JS, Nguyen BN, et al. Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood. Transplant Proc 2005; 37:512-513.
    • (2005) Transplant Proc , vol.37 , pp. 512-513
    • Schroeder, C.1    Allan, J.S.2    Nguyen, B.N.3
  • 55
    • 33645297480 scopus 로고    scopus 로고
    • Life-supporting pig-to-baboon renal transplantation using GalT knockout donors: Benefit of cotransplanting a vascularized donor thymic graft
    • Yamada K. Life-supporting pig-to-baboon renal transplantation using GalT knockout donors: benefit of cotransplanting a vascularized donor thymic graft. Kidney Int 2005; 68:1971. An in-depth analysis of the thymokidney approach to xenotransplantation.
    • (2005) Kidney Int , vol.68 , pp. 1971
    • Yamada, K.1
  • 56
    • 2142820093 scopus 로고    scopus 로고
    • Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection
    • Ghanekar A, Mendicino M, Liu H, et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol 2004; 172:5693-5701. This study elegantly demonstrates the importance of suppressing fgl2 in prolonging xenograft survival using a knockout mouse-to-rat model. Reports the elimination of thrombin deposition.
    • (2004) J Immunol , vol.172 , pp. 5693-5701
    • Ghanekar, A.1    Mendicino, M.2    Liu, H.3
  • 57
    • 10044240662 scopus 로고    scopus 로고
    • Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
    • Chen D, Weber M, McVey JH, et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004; 4:1958-1963. A most remarkable set of results. Expression of tissue factor pathway inhibitor or hirudin results in the elimination of AVR. Cyclosporine immunosuppression resulted in indefinite graft survival in a mouse-to-rat model. Will it be that easy in a pig-to-baboon transplant?
    • (2004) Am J Transplant , vol.4 , pp. 1958-1963
    • Chen, D.1    Weber, M.2    McVey, J.H.3
  • 58
    • 0034637330 scopus 로고    scopus 로고
    • Successful generation of transgenic pigs for human decay-accelerating factor and human leucocyte antigen DQ
    • Tu CF, Hsieh SL, Lee JM, et al. Successful generation of transgenic pigs for human decay-accelerating factor and human leucocyte antigen DQ. Transplant Proc 2000; 32:913-915.
    • (2000) Transplant Proc , vol.32 , pp. 913-915
    • Tu, C.F.1    Hsieh, S.L.2    Lee, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.