A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies

Human Heredity

Volumn 56, Issue 1-3, 2003, Pages 10-17

  Lange, Christoph ^a,b   Lyon, Helen ^a   DeMeo, Dawn ^a   Raby, Benjamin ^a   Silverman, Edwin K ^a   Weiss, Scott T ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Family based association tests; Quantitative traits; Testing strategies

Indexed keywords

ASTHMA; CHILD; CHILDHOOD DISEASE; CONFERENCE PAPER; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MARKER; HEALTH PROGRAM; HEALTH SURVEY; HUMAN; METHODOLOGY; PHENOTYPE; POPULATION; QUANTITATIVE TRAIT;

ASTHMA; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; GENE FREQUENCY; GENETIC MARKERS; HUMANS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; STATISTICS, NONPARAMETRIC;

EID: 0345257865     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073728     Document Type: Conference Paper

References (29)

1. Clayton D, Jones H: Transmission/disequilibrium tests for extended marker haplotypes. AJHG 1999;65:1161-1169.
2. Daw EW, Payami H, Nemens EJ, Nochlin D, Wijsman EM, Bird TD, Schellenberg GD: The number of trait loci in late-onset Alzheimer's disease. Am J Hum Genet 2000;66:196-204.
3. DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird NM, Weiss ST: Univariate and multivariate family based analysis of the arg130gln polymorphism of the il13 gene in the childhood asthma management program. Genet Epi 2002;24(4):335-348.
4. Falconer DS, Mackay TFC: Introduction to quantitative genetics. London, Longman, 1997.
5. Childhood Asthma Management Program Research Group: The childhood asthma management program (CAMP): Design, rationale, and methods. Control Clin Trials 1999;20:91-120.
6. Horvath S, Laird NM: A discordant-sibship test for disequilibrium and linkage: No need for parental data. Am J Hum Genet 1998;63:1886-1897.
7. Horvath S, Xu X, Laird NM: The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Gen 2001;9:301-306.
8. Laird NM, Horvath S, Xu X: Implementing a unified approach to family-based tests of association. Genet Epidemiol 2000;19(suppl 1):S36-S42.
9. Lake SL, Blacker D, Laird NM: Family-based tests of association in the presence of linkage. Am J Hum Genet 2000;67:1515-1525.
10. Lange C, DeMeo D, Laird NM: Power and design considerations for a general class of family-based association tests: Quantitative traits. Am J Hum Genet 2002;71:1330-1341.
11. Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM: Using the noninformative families in family-based association tests: A powerful new testing strategy. Am J Hum Genet 2003; 73:801-811.
12. Lange C, Laird NM: On a general class of conditional tests for family-based association studies in genetics: The asymptotic distribution, the conditional power and optimality considerations. Genet Epidemiol 2002;23:165-180.
13. Lange C, Laird NM: Analytical sample size and power calculations for a general class of family-based association test: Dichotomous traits. Am J Hum Genet 2002;71:575-584.
14. Lange C, Silverman E, Xu X, Weiss S, Laird NM: A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics 2003;4:195-206.
15. Lange C, Whittaker JC: A generalized estimating equation approach to mapping of quantitative trait loci (qtl). Genetics 2001;159:1325-1337.
16. Lyon H, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST: Univariate and multivariate family based analysis of the il10 gene in the childhood management program. 2003, in preparation.
17. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R: Association between genetic polymorphisms of the beta-2 adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-3188.
18. McCullagh P, Nelder JA: Generalized linear models (2nd ed). London, Chapman and Hall, 1989.
19. Mokliatchouk O, Blacker D, Rabinowitz D: Association tests for traits with variable age at onset. Hum Heredity 2001;51:46-53.
20. Rabinowitz D: A transmission disequilibrium test for quantitative trait loci. Hum Hered 1997;47: 1113-1118.
21. Rabinowitz D, Laird NM: A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 2000;50:211-223.
22. Risch N, Zhang H: Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am J Hum Genet 1996;58: 836-843.
23. Rodnitzky A, Jewell NP: Hypothesis testing of regression parameters in semiparametric generalized linear models for cluster correlated data. Biometrika 1990;77/3:485-497.
24. Schaid DJ: General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 1996;13:423-449.
25. Schaid DJ, Sommer SS: Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 1994;55: 402-409.
26. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52: 506-516.
27. Summerhill E, Leavitt SA, Gidley H, Parry R, Solway J, Ober C: Beta(2)-adrenergic receptor arg16/arg 16 genotype is associated with reduced lung function, but not with asthma, in the hutterites. Am J Respir Crit Care Med 2000;162:599-602.
28. Turki J, Pak J, Green SA, Martin RJ, Liggett SB: Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that gly16 correlates with the nocturnal phenotype. J Clin Invest 1995;95: 1635-1641.
29. Whittaker JC, Lewis CM: Power comparisons of the transmission/ disequilibrium test and sib-transmission/disequilibrium-test statistics. Am J Hum Genet 1998;65:578-580.