Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44 highCD62L- effector memory T cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 5, 2006, Pages

  Kanai, T ^a   Tanimoto, K ^a   Nemoto, Y ^a   Fujii, R ^a   Makita, S ^a   Totsuka, T ^a   Watanabe, M ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Interleukin 2; Murine colitis model

Indexed keywords

CD4 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; PADGEM PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; IMMUNE RESPONSE; LAMINA PROPRIA; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COCULTURE TECHNIQUES; COLITIS; FEMALE; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MODELS, ANIMAL; MUCOUS MEMBRANE; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 33645824349     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00429.2005     Document Type: Article

References (20)

1. Asseman C, Mauze S, Leach MW, Coffman RL, and Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190: 995-1004, 1999.
2. + regulatory T cell function. Eur J Immunol 34: 2480-2488, 2004.
3. + regulatory T cell function. J Exp Med 196: 851-857, 2002.
4. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, and Watanabe M. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 171: 4156-4163, 2003.
5. Klein L, Khazaie K, and von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci USA 100: 8886-8891, 2003.
6. + regulatory T cells cure murine colitis: the role of IL-10, TGF-β, and CTLA4. J Immunol 171: 5012-5017, 2003.
7. bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 173: 3119-3130, 2004.
8. + regulatory T cells. J Immunol 170: 3939-3943, 2003.
9. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5: 1461-1471, 1993.
10. + regulatory cells that control intestinal inflammation. J Exp Med 192: 295-302, 2000.
11. Reinhardt RL, Khoruts A, Merica R, Zell T, and Jenkins MK. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410: 101-105, 2001.
12. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22: 531-562, 2004.
13. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164, 1995.
14. - thymocytes. J Exp Med 189: 279-288, 1999.
15. Singh B, Read S, Asseman C, Malmström V, Mottet C, Stephens LA, Stepankova R, Tlaskalova H, and Powrie F. Control of intestinal inflammation by regulatory T cells. Immunol Rev 182: 190-200, 2001.
16. + T helper cells. Eur J Immunol 34: 1303-1311, 2004.
17. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 192: 303-310, 2000.
18. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287-296, 1998.
19. + immunoregulatory T cells is antigen nonspecific. J Immunol 164: 183-190, 2000.
20. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, and Watanabe M. Ameliorating effect of anti-ICOS monoclonal antibody in a murine model of chronic colitis. Gastroenterology 124: 410-421, 2003.