Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 4, 2006, Pages

  O'Mahony, Liam ^a   O'Callaghan, Louise ^a   McCarthy, Jane ^a   Shilling, David ^b   Scully, Paul ^a   Sibartie, Shomik ^a   Kavanagh, Eamon ^b   Kirwan, William O ^b   Redmond, Henry Paul ^b   Collins, John Kevin ^a   Shanahan, Fergus ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Inflammation; Mucosa

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; PROBIOTIC AGENT; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BACTERIAL STRAIN; BIFIDOBACTERIUM LONGUM INFANTIS; BLOOD; CELL ISOLATION; COLITIS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; LACTOBACILLUS SALIVARIUS; LYMPHOID TISSUE; MALE; MESENTERY LYMPH NODE; MONONUCLEAR CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ADULT; BIFIDOBACTERIUM; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; LACTOBACILLUS; LYMPH NODES; MALE; MESENTERY; MIDDLE AGED; SALMONELLA TYPHIMURIUM;

EID: 33645812544     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00112.2005     Document Type: Article

References (31)

1. Akira S, Takeda K, and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immun 2: 675-680, 2001.
2. Berg RD. The indigenous gastrointestinal microflora. Trends Microbiol 4: 430-435, 1996.
3. Boyum A. Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 97: 7, 1968.
4. Christensen HR, Frokiaer H, and Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168: 171-178, 2002.
5. De Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, Wierenga EA, Yazdanbakhsh M, and Kapsenberg ML. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol 168: 1704-1709, 2002.
6. Dunne C, Murphy L, Flynn S, O'Mahony L, O'Halloran S, Feeney M, Morrissey D, Thorton G, Fitzgerald G, Daly C, Kiely B, Quigley EM, O'Sullivan GC, Shanahan F, and Collins JK. Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Antonie Van Leeuwenhoek 76: 279-292, 1999.
7. Geijtenbeek TB, Torensma R, van Vliet SJ, van Duijnhoven GC, Adema GJ, van Kooyk Y, and Figdor CG. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100: 575-585, 2000.
8. Hooper LV and Gordon JI. Commensal host-bacterial relationships in the gut. Science 292: 1115-1118, 2001.
9. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, and Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291: 881-884, 2001.
10. Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, and Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science 294: 870-875, 2001.
11. Iwasaki A and Kelsall BL. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med 190: 229-239, 1999.
12. Iwasaki A and Kelsall BL. Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells. J Immunol 166: 4884-4890, 2001.
13. James SP, Graeff AS, and Zeitz M. Predominance of helper-inducer T cells in mesenteric lymph nodes and intestinal lamina propria of normal nonhuman primates. Cell Immunol 107: 372-383, 1987.
14. James SP, Graeff AS, Zeitz M, Kappus E, and Quinn TC. Cytotoxic and immunoregulatory function of intestinal lymphocytes in Chlamydia trachomatis proctitis of nonhuman primates. Infect Immun 55: 1137-1143, 1987.
15. Kagnoff MF and Eckmann L. Epithelial cells as sensors for microbial infection. J Clin Invest 100: 6-10, 1997.
16. MacDonald TT and Pattersson S. Bacterial regulation of intestinal immune responses. Inflammatory Bowel Dis 6: 116-122, 2000.
17. Macpherson AJ and Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303: 1662-1665, 2004.
18. McCarthy J, O'Mahony L, O'Callaghan L, Sheil B, Vaughan EE, Fitzsimons N, Fitzgibbon J, O'Sullivan GC, Kiely B, Collins JK, and Shanahan F. Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut 52: 975-980, 2003.
19. Medzhitov R and Janeway C. The toll receptor family and microbial recognition. Trends Microbiol 452: 8, 2000.
20. Midtvedt T. Microbial functional activities. In: Intestinal Microflora, edited by Hanson LA and Yolken RH. Philadelphia, PA: Lippincott-Raven, 1999.
21. Miettinem M, Matikainen S, Vuopio-Varkila J, Pirhonen J, Varkila K, Kurimoto M, and Julkunen I. Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells. Infect Immun 66: 6058-6062, 1998.
22. Nagata S, McKenzie C, Pender SL, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, Monteleone G, and MacDonald TT. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J Immunol 165: 5315-5321, 2000.
23. O'Mahony L, Feeney M, O'Halloran S, Murphy L, Kiely B, Fitzgibbon J, Lee G, O'Sullivan G, Shanahan F, and Collins JK. Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 15: 1219-1225, 2001.
24. O'Sullivan GC, Corbett AR, Shanahan F, and Collins JK. Regional immunosuppression in esophageal squamous cancer: evidence from functional studies with matched lymph nodes. J Immunol 157: 4717-4720, 1996.
25. Rook GAW and Stanford JL. Give us this day our daily germs. Immunol Today 19: 113-116, 1998.
26. Schoeffel U, Pelz K, Haring RU, Amberg R, Schandl R, Urbaschek R, von Specht BU, and Farthmann EH. Inflammatory consequences of the translocation of bacteria and endotoxin to mesenteric lymph nodes. Am J Surg 180: 65-72, 2000.
27. Shanahan F. Mechanisms of immunological sensation of intestinal contents. Am J Physiol Gastrointest Liver Physiol 278: G191-G196, 2000.
28. Shanahan F. The host-microbe interface within the gut. Best Practice Res Clin Gastroenterol 16: 915-931, 2002.
29. Sheil B, McCarthy J, O'Mahony L, Bennett MW, Ryan P, Fitzgibbon JJ, Kiely B, Collins JK, and Shanahan F. Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut 53: 694-700, 2004.
30. Sommerfield D, MacSharry J, O'Mahony D, O'Mahony L, Kiely B, Shanahan F, and Quigley E. Effect of probiotic feeding on Salmonella translocation in a mouse model. Gastroenterology 128, Suppl 2: A120-A120, 2005.
31. Stagg AJ, Hart AL, Knight SC, and Kamm MA. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 52: 1522-1529, 2003.