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Volumn 395, Issue 2, 2006, Pages 393-403

Adaptation of enterocytic Caco-2 cells to glucose modulates triacylglycerol-rich lipoprotein secretion through triacylglycerol targeting into the endoplasmic reticulum lumen

Author keywords

Apolipoprotein B; Caco 2 cell; Cytosolic lipid droplet; Enterocyte; Lipoprotein secretion; Microsomal triacylglycerol transfer protein (MTP)

Indexed keywords

BIOLOGICAL ORGANS; BIOSYNTHESIS; GLUCOSE; LIPIDS; PROTEINS;

EID: 33645761650     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051359     Document Type: Article
Times cited : (16)

References (60)
  • 1
    • 11144283176 scopus 로고    scopus 로고
    • Dietary fat, lipogenesis and energy balance
    • Schutz, Y. (2004) Dietary fat, lipogenesis and energy balance. Physiol. Behav. 83, 557-564
    • (2004) Physiol. Behav. , vol.83 , pp. 557-564
    • Schutz, Y.1
  • 2
    • 0001297576 scopus 로고
    • Intestinal lipid absorption
    • (Johnson, L. R., ed.), Raven Press, New York
    • Tso, P. (1994) Intestinal lipid absorption. In Physiology of the Gastrointestinal Tract (Johnson, L. R., ed.), pp. 1867-1907, Raven Press, New York
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1867-1907
    • Tso, P.1
  • 3
    • 0030753971 scopus 로고    scopus 로고
    • Regulation of the expression of lipogenic enzyme genes by carbohydrate
    • Towle, H. C., Kaytor, E. N. and Shih, H. M. (1997) Regulation of the expression of lipogenic enzyme genes by carbohydrate. Annu. Rev. Nutr. 17, 405-433
    • (1997) Annu. Rev. Nutr. , vol.17 , pp. 405-433
    • Towle, H.C.1    Kaytor, E.N.2    Shih, H.M.3
  • 4
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • Foufelle, F. and Ferre, P. (2002) New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 366, 377-391
    • (2002) Biochem. J. , vol.366 , pp. 377-391
    • Foufelle, F.1    Ferre, P.2
  • 5
    • 0030175841 scopus 로고    scopus 로고
    • Biosynthesis of triacylglycerols
    • Lehner, R. and Kuksis, A. (1996) Biosynthesis of triacylglycerols. Prog. Lipid Res. 35, 169-201
    • (1996) Prog. Lipid Res. , vol.35 , pp. 169-201
    • Lehner, R.1    Kuksis, A.2
  • 6
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • Coleman, R. A. and Lee, D. P. (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43, 134-176
    • (2004) Prog. Lipid Res. , vol.43 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 7
    • 0014151758 scopus 로고
    • The monoglyceride pathway of fat absorption in man
    • Kayden, H. J., Senior, J. R. and Mattson, F. H. (1967) The monoglyceride pathway of fat absorption in man. J. Clin. Invest. 46, 1695-1703
    • (1967) J. Clin. Invest. , vol.46 , pp. 1695-1703
    • Kayden, H.J.1    Senior, J.R.2    Mattson, F.H.3
  • 8
    • 0016831474 scopus 로고
    • Triacylglycerol biosynthesis in everted sacs of rat intestinal mucosa
    • Breckenridge, W. C. and Kuksis, A. (1975) Triacylglycerol biosynthesis in everted sacs of rat intestinal mucosa. Can. J. Biochem. 53, 1184-1195
    • (1975) Can. J. Biochem. , vol.53 , pp. 1184-1195
    • Breckenridge, W.C.1    Kuksis, A.2
  • 9
    • 35848943500 scopus 로고    scopus 로고
    • Assembly and secretion of lipoproteins
    • (Vance, D. E. and Vance, J. E., eds.), 4th edn, Elsevier, Amsterdam
    • Vance, J. E. (2002) Assembly and secretion of lipoproteins. In Biochemistry of Lipids, Lipoproteins and Membranes (Vance, D. E. and Vance, J. E., eds.), 4th edn, pp. 505-526, Elsevier, Amsterdam
    • (2002) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 505-526
    • Vance, J.E.1
  • 10
    • 0034443707 scopus 로고    scopus 로고
    • Intracellular assembly of VLDL: Two major steps in separate cell compartments
    • Olofsson, S. O., Stillemark-Billton, P. and Asp, L. (2000) Intracellular assembly of VLDL: two major steps in separate cell compartments. Trends Cardiovasc. Med. 10, 338-345
    • (2000) Trends Cardiovasc. Med. , vol.10 , pp. 338-345
    • Olofsson, S.O.1    Stillemark-Billton, P.2    Asp, L.3
  • 11
    • 0035085155 scopus 로고    scopus 로고
    • Very-low-density lipoprotein assembly and secretion
    • Shelness, G. S. and Sellers, J. A. (2001) Very-low-density lipoprotein assembly and secretion. Curr. Opin. Lipidol. 12, 151-157
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 151-157
    • Shelness, G.S.1    Sellers, J.A.2
  • 12
    • 0037124084 scopus 로고    scopus 로고
    • Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins
    • Fisher, E. A. and Ginsberg, H. N. (2002) Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J. Biol. Chem. 277, 17377-17380
    • (2002) J. Biol. Chem. , vol.277 , pp. 17377-17380
    • Fisher, E.A.1    Ginsberg, H.N.2
  • 13
    • 0346099348 scopus 로고    scopus 로고
    • Lipid-dependent bidirectional traffic of apolipoprotein B in polarized enterocytes
    • Morel, E., Demignot, S., Chateau, D., Chambaz, J., Rousset, M. and Delers, F. (2004) Lipid-dependent bidirectional traffic of apolipoprotein B in polarized enterocytes. Mol. Biol. Cell 15, 132-141
    • (2004) Mol. Biol. Cell , vol.15 , pp. 132-141
    • Morel, E.1    Demignot, S.2    Chateau, D.3    Chambaz, J.4    Rousset, M.5    Delers, F.6
  • 14
    • 12944259029 scopus 로고    scopus 로고
    • Lipid micelles stimulate the secretion of triglyceride-enriched apolipoprotein B48-containing lipoproteins by Caco-2 cells
    • Chateau, D., Pauquai, T., Delers, F, Roussel, M., Chambaz, J. and Demignot, S. (2005) Lipid micelles stimulate the secretion of triglyceride-enriched apolipoprotein B48-containing lipoproteins by Caco-2 cells. J. Cell. Physiol. 202, 767-776
    • (2005) J. Cell. Physiol. , vol.202 , pp. 767-776
    • Chateau, D.1    Pauquai, T.2    Delers, F.3    Roussel, M.4    Chambaz, J.5    Demignot, S.6
  • 15
    • 0017737407 scopus 로고
    • Electron microscopic studies of the assembly, intracellular transport, and secretion of chylomicrons by rat intestine
    • Sabesin, S. M. and Frase, S. (1977) Electron microscopic studies of the assembly, intracellular transport, and secretion of chylomicrons by rat intestine. J. Lipid Res. 18, 496-511
    • (1977) J. Lipid Res. , vol.18 , pp. 496-511
    • Sabesin, S.M.1    Frase, S.2
  • 16
    • 0019590585 scopus 로고
    • Morphometric analysis of the membranes and organelles of small intestinal enterocytes. II. Lipid-fed hamster
    • Buschmann, R. J. and Manke, D. J. (1981) Morphometric analysis of the membranes and organelles of small intestinal enterocytes. II. Lipid-fed hamster. J. Ultrastruct. Res. 76, 15-26
    • (1981) J. Ultrastruct. Res. , vol.76 , pp. 15-26
    • Buschmann, R.J.1    Manke, D.J.2
  • 17
    • 0031846319 scopus 로고    scopus 로고
    • Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
    • Hamilton, R. L., Wong, J. S., Cham, C. M., Nielsen, L. B. and Young, S. G. (1998) Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency J. Lipid Res. 39, 1543-1557
    • (1998) J. Lipid Res. , vol.39 , pp. 1543-1557
    • Hamilton, R.L.1    Wong, J.S.2    Cham, C.M.3    Nielsen, L.B.4    Young, S.G.5
  • 18
    • 0033746041 scopus 로고    scopus 로고
    • Intracellular events in the assembly of chylomicrons in rabbit enterocytes
    • Cartwright, I. J., Plonne, D. and Higgins, J. A. (2000) Intracellular events in the assembly of chylomicrons in rabbit enterocytes. J. Lipid Res. 41, 1728-1739
    • (2000) J. Lipid Res. , vol.41 , pp. 1728-1739
    • Cartwright, I.J.1    Plonne, D.2    Higgins, J.A.3
  • 19
    • 0032911957 scopus 로고    scopus 로고
    • Mechanisms of lipid-body formation
    • Murphy, D. J. and Vance, J. (1999) Mechanisms of lipid-body formation. Trends Biochem. Sci. 24, 109-115
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 109-115
    • Murphy, D.J.1    Vance, J.2
  • 20
    • 0035809929 scopus 로고    scopus 로고
    • Caveolin, cholesterol, and lipid droplets?
    • van Meer, G. (2001) Caveolin, cholesterol, and lipid droplets? J. Cell Biol. 152, F29-F34
    • (2001) J. Cell Biol. , vol.152
    • Van Meer, G.1
  • 21
    • 0037199988 scopus 로고    scopus 로고
    • Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction
    • Haidari, M., Leung, N., Mahbub, F., Uffelman, K. D., Kohen-Avramoglu, R., Lewis, G. F. and Adeli, K. (2002) Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction. J. Biol. Chem. 277, 31646-31655
    • (2002) J. Biol. Chem. , vol.277 , pp. 31646-31655
    • Haidari, M.1    Leung, N.2    Mahbub, F.3    Uffelman, K.D.4    Kohen-Avramoglu, R.5    Lewis, G.F.6    Adeli, K.7
  • 22
    • 0007326339 scopus 로고
    • Composition of the diacyl glyceryl ethers and triglycerides of the flesh and liver of the dogfish (Squalus acanthias)
    • Malins, D. C., Wekell, J. C. and Houle, C. R. (1965) Composition of the diacyl glyceryl ethers and triglycerides of the flesh and liver of the dogfish (Squalus acanthias) J. Lipid Res. 79, 100-105
    • (1965) J. Lipid Res. , vol.79 , pp. 100-105
    • Malins, D.C.1    Wekell, J.C.2    Houle, C.R.3
  • 23
    • 0002446244 scopus 로고
    • The glycerylethers in the liver oils of elasmobranch fish
    • Hallgren, B. and Larsson, S. (1962) The glycerylethers in the liver oils of elasmobranch fish. J. Lipid Res. 3, 31-38
    • (1962) J. Lipid Res. , vol.3 , pp. 31-38
    • Hallgren, B.1    Larsson, S.2
  • 24
    • 0037199962 scopus 로고    scopus 로고
    • Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation
    • Kulinski, A., Rustaeus, S. and Vance, J. E. (2002) Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J. Biol. Chem. 277, 31516-31525
    • (2002) J. Biol. Chem. , vol.277 , pp. 31516-31525
    • Kulinski, A.1    Rustaeus, S.2    Vance, J.E.3
  • 25
    • 0034141535 scopus 로고    scopus 로고
    • Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells
    • Yu, W., Cassara, J, and Weller, P. F. (2000) Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood 95, 1078-1085
    • (2000) Blood , vol.95 , pp. 1078-1085
    • Yu, W.1    Cassara, J.2    Weller, P.F.3
  • 27
    • 21244457607 scopus 로고    scopus 로고
    • Intestinal glucose-dependent expression of glucose-6-phosphatase: Involvement of the aryl receptor nuclear translocator transcription factor
    • Carriere, V., Le Gall, M., Gouyon-Saumande, F., Schmoll, D., Brot-Laroche, E., Chauffeton, V., Chambaz, J. and Rousset, M. (2005) Intestinal glucose-dependent expression of glucose-6-phosphatase: involvement of the aryl receptor nuclear translocator transcription factor. J. Biol. Chem. 280, 20094-20101
    • (2005) J. Biol. Chem. , vol.280 , pp. 20094-20101
    • Carriere, V.1    Le Gall, M.2    Gouyon-Saumande, F.3    Schmoll, D.4    Brot-Laroche, E.5    Chauffeton, V.6    Chambaz, J.7    Rousset, M.8
  • 29
    • 0001658127 scopus 로고
    • Mise en évidence des polysaccharides sur coupes fines en microscopie électronique
    • Thiery, J. P. (1967) Mise en évidence des polysaccharides sur coupes fines en microscopie électronique J. Microsc. 6, 987-1018
    • (1967) J. Microsc. , vol.6 , pp. 987-1018
    • Thiery, J.P.1
  • 30
    • 0022509516 scopus 로고
    • The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for the study of intestinal differentiation
    • Rousset, M. (1986) The human colon carcinoma cell lines HT-29 and Caco-2: two in vitro models for the study of intestinal differentiation. Biochimie 68, 1035-1040
    • (1986) Biochimie , vol.68 , pp. 1035-1040
    • Rousset, M.1
  • 31
    • 0028293986 scopus 로고
    • Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption
    • Mahraoui, L., Rodolosse, A., Barbat, A., Dussaulx, E., Zweibaum, A., Rousset, M. and Brot-Laroche, E. (1994) Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption. Biochem. J. 298, 629-633
    • (1994) Biochem. J. , vol.298 , pp. 629-633
    • Mahraoui, L.1    Rodolosse, A.2    Barbat, A.3    Dussaulx, E.4    Zweibaum, A.5    Rousset, M.6    Brot-Laroche, E.7
  • 33
    • 35448973012 scopus 로고    scopus 로고
    • Lipoprotein structure
    • (Vance, D. E. and Vance, J. E., eds.), 4th edn, Elsevier, Amsterdam
    • Jonas, A. (2002) Lipoprotein structure. In Biochemistry of Lipids, Lipoproteins and Membranes (Vance, D. E. and Vance, J. E., eds.), 4th edn, pp. 483-504, Elsevier, Amsterdam
    • (2002) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 483-504
    • Jonas, A.1
  • 34
    • 0027191375 scopus 로고
    • Fatty acid esterification during differentiation of the human intestinal cell line Caco-2
    • Trotter, P. J. and Storch, J. (1993) Fatty acid esterification during differentiation of the human intestinal cell line Caco-2. J. Biol. Chem. 268, 10017-10023
    • (1993) J. Biol. Chem. , vol.268 , pp. 10017-10023
    • Trotter, P.J.1    Storch, J.2
  • 35
    • 0242304509 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein: A multifunctional protein
    • Hussain, M. M., Iqbal, J., Anwar, K., Rava, P. and Dai, K. (2003) Microsomal triglyceride transfer protein: a multifunctional protein. Front. Biosci. 8, s500-s506
    • (2003) Front. Biosci. , vol.8
    • Hussain, M.M.1    Iqbal, J.2    Anwar, K.3    Rava, P.4    Dai, K.5
  • 36
    • 0034717836 scopus 로고    scopus 로고
    • Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly
    • Gordon, D. A. and Jamil, H. (2000) Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim. Biophys. Acta 1486, 72-83
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 72-83
    • Gordon, D.A.1    Jamil, H.2
  • 38
    • 0038498128 scopus 로고    scopus 로고
    • Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum
    • Higashi, Y., Itabe, H., Fukase, H., Mori, M., Fujimoto, Y. and Takano, T. (2003) Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum. J. Biol. Chem. 278, 21450-21458
    • (2003) J. Biol. Chem. , vol.278 , pp. 21450-21458
    • Higashi, Y.1    Itabe, H.2    Fukase, H.3    Mori, M.4    Fujimoto, Y.5    Takano, T.6
  • 39
    • 0029154712 scopus 로고
    • Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells: Possible role of p-glycoprotein
    • Field, F. J., Born, E., Chen, H., Murthy, S. and Mathur, S. N. (1995) Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells: possible role of p-glycoprotein. J. Lipid Res. 36, 1533-1543
    • (1995) J. Lipid Res. , vol.36 , pp. 1533-1543
    • Field, F.J.1    Born, E.2    Chen, H.3    Murthy, S.4    Mathur, S.N.5
  • 40
    • 5644266305 scopus 로고    scopus 로고
    • Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: Potential role in the regulation of apolipoprotein B secretion
    • Casaschi, A., Rubio, B. K., Maiyoh, G. K. and Theriault, A. G. (2004) Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis 176, 247-253
    • (2004) Atherosclerosis , vol.176 , pp. 247-253
    • Casaschi, A.1    Rubio, B.K.2    Maiyoh, G.K.3    Theriault, A.G.4
  • 41
    • 16644369497 scopus 로고    scopus 로고
    • Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells
    • Ganji, S. H., Tavintharan, S., Zhu, D., Xing, Y., Kamanna, V. S. and Kashyap, M. L. (2004) Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. J. Lipid Res. 45, 1835-1845
    • (2004) J. Lipid Res. , vol.45 , pp. 1835-1845
    • Ganji, S.H.1    Tavintharan, S.2    Zhu, D.3    Xing, Y.4    Kamanna, V.S.5    Kashyap, M.L.6
  • 42
    • 0033559856 scopus 로고    scopus 로고
    • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
    • Muoio, D. M., Seefeld, K., Witters, L. A. and Coleman, R. A. (1999) AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J. 338, 783-791
    • (1999) Biochem. J. , vol.338 , pp. 783-791
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 43
    • 0018575856 scopus 로고
    • Uptake and metabolism of long chain fatty acids in isolated chicken intestinal epithelial cells
    • Bierbach, H., Haag, G. F. and Holldorf, A. W. (1979) Uptake and metabolism of long chain fatty acids in isolated chicken intestinal epithelial cells. Digestion 19, 392-403
    • (1979) Digestion , vol.19 , pp. 392-403
    • Bierbach, H.1    Haag, G.F.2    Holldorf, A.W.3
  • 45
    • 0030957455 scopus 로고    scopus 로고
    • Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: Possible roles in very-low-density lipoprotein triacylglycerol secretion
    • Owen, M. R., Corstorphine, C. C. and Zammit, V. A. (1997) Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion. Biochem. J. 323, 17-21
    • (1997) Biochem. J. , vol.323 , pp. 17-21
    • Owen, M.R.1    Corstorphine, C.C.2    Zammit, V.A.3
  • 46
    • 0033544873 scopus 로고    scopus 로고
    • Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases
    • Abo-Hashema, K. A., Cake, M. H., Power, G. W. and Clarke, D. (1999) Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases. J. Biol. Chem. 274, 35577-35582
    • (1999) J. Biol. Chem. , vol.274 , pp. 35577-35582
    • Abo-Hashema, K.A.1    Cake, M.H.2    Power, G.W.3    Clarke, D.4
  • 47
    • 0018231639 scopus 로고
    • Rapid transbilayer diffusion of 1,2-diacylglycerol and its relevance to control of membrane curvature
    • Allan, D., Thomas, P. and Michell, R. H. (1978) Rapid transbilayer diffusion of 1,2-diacylglycerol and its relevance to control of membrane curvature. Nature (London) 276, 289-290
    • (1978) Nature (London) , vol.276 , pp. 289-290
    • Allan, D.1    Thomas, P.2    Michell, R.H.3
  • 48
    • 0033739779 scopus 로고    scopus 로고
    • ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane
    • Joyce, C. W., Shelness, G. S., Davis, M. A., Lee, R. G., Skinner, K., Anderson, R. A. and Rudel, L. L. (2000) ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane. Mol. Biol. Cell 11, 3675-3687
    • (2000) Mol. Biol. Cell , vol.11 , pp. 3675-3687
    • Joyce, C.W.1    Shelness, G.S.2    Davis, M.A.3    Lee, R.G.4    Skinner, K.5    Anderson, R.A.6    Rudel, L.L.7
  • 49
  • 50
    • 7244242391 scopus 로고    scopus 로고
    • Overexpression of human diacylglycerol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    • Liang, J. J., Oelkers, P., Quo, C., Chu, P. C., Dixon, J. L., Ginsberg, H. N. and Sturley, S. L. (2004) Overexpression of human diacylglycerol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. J. Biol. Chem. 279, 44938-44944
    • (2004) J. Biol. Chem. , vol.279 , pp. 44938-44944
    • Liang, J.J.1    Oelkers, P.2    Quo, C.3    Chu, P.C.4    Dixon, J.L.5    Ginsberg, H.N.6    Sturley, S.L.7
  • 51
    • 14744304497 scopus 로고    scopus 로고
    • Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice
    • Chen, H. C. and Farese. Jr, R. V. (2005) Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler. Thromb. Vasc. Biol 25, 482-486
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 482-486
    • Chen, H.C.1    Farese Jr., R.V.2
  • 53
    • 0031882256 scopus 로고    scopus 로고
    • Participation of the microsomal triglyceride transfer protein in lipoprotein assembly in Caco-2 cells: Interaction with saturated and unsaturated dietary fatty acids
    • van Greevenbroek, M. M., Robertus-Teunissen, M. G., Erkelens, D. W. and de Bruin, T. W. (1998) Participation of the microsomal triglyceride transfer protein in lipoprotein assembly in Caco-2 cells: interaction with saturated and unsaturated dietary fatty acids. J. Lipid Res. 39, 173-185
    • (1998) J. Lipid Res. , vol.39 , pp. 173-185
    • Van Greevenbroek, M.M.1    Robertus-Teunissen, M.G.2    Erkelens, D.W.3    De Bruin, T.W.4
  • 54
    • 0038267443 scopus 로고    scopus 로고
    • Butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells
    • Marcil, V., Delvin, E., Garofalo, C. and Levy, E. (2003) Butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells. J. Nutr. 133, 2180-2183
    • (2003) J. Nutr. , vol.133 , pp. 2180-2183
    • Marcil, V.1    Delvin, E.2    Garofalo, C.3    Levy, E.4
  • 55
    • 0032717454 scopus 로고    scopus 로고
    • Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B
    • Tietge, U. J., Bakillah, A., Maugeais, C., Tsukamoto, K., Hussain, M. and Rader, D. J. (1999) Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B. J. Lipid Res. 40, 2134-2139
    • (1999) J. Lipid Res. , vol.40 , pp. 2134-2139
    • Tietge, U.J.1    Bakillah, A.2    Maugeais, C.3    Tsukamoto, K.4    Hussain, M.5    Rader, D.J.6
  • 56
    • 0036429189 scopus 로고    scopus 로고
    • Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
    • Meegalla R. L., Billheimer, J. T. and Cheng, D. (2002) Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem. Biophys. Res. Commun. 298, 317-323
    • (2002) Biochem. Biophys. Res. Commun. , vol.298 , pp. 317-323
    • Meegalla, R.L.1    Billheimer, J.T.2    Cheng, D.3
  • 57
    • 0141818124 scopus 로고    scopus 로고
    • Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
    • Gilham, D., Ho, S, Rasouli, M., Martres, P., Vance, D. E. and Lehner, R. (2003) Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. FASEB J. 17, 1685-1687
    • (2003) FASEB J. , vol.17 , pp. 1685-1687
    • Gilham, D.1    Ho, S.2    Rasouli, M.3    Martres, P.4    Vance, D.E.5    Lehner, R.6
  • 58
    • 1642378564 scopus 로고    scopus 로고
    • Tracking down lipid flippases and their biological functions
    • Pomorski, T., Holthuis, J. C., Herrmann, A. and van Meer, G. (2004) Tracking down lipid flippases and their biological functions. J. Cell Sci. 117, 805-813
    • (2004) J. Cell Sci. , vol.117 , pp. 805-813
    • Pomorski, T.1    Holthuis, J.C.2    Herrmann, A.3    Van Meer, G.4
  • 59
    • 0942287191 scopus 로고    scopus 로고
    • Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic
    • Liu, P., Ying, Y., Zhao, Y., Mundy, D. I., Zhu, M. and Anderson, R. G. (2004) Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J. Biol. Chem. 279, 3787-3792
    • (2004) J. Biol. Chem. , vol.279 , pp. 3787-3792
    • Liu, P.1    Ying, Y.2    Zhao, Y.3    Mundy, D.I.4    Zhu, M.5    Anderson, R.G.6
  • 60
    • 0035004468 scopus 로고    scopus 로고
    • High-energy diets, fatty acids and endothelial cell function: Implications for atherosclerosis
    • Hennig, B., Toborek, M. and McClain, C. J. (2001) High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J. Am. Coll. Nutr. 20, 97-105
    • (2001) J. Am. Coll. Nutr. , vol.20 , pp. 97-105
    • Hennig, B.1    Toborek, M.2    McClain, C.J.3


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