Detecting linkage disequilibrium in the presence of locus heterogeneity

Annals of Human Genetics

Volumn 70, Issue 3, 2006, Pages 397-409

  Wang, Deli ^a   Huang, J ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Likelihood; Linkage disequilibrium; Locus heterogeneity; SNP; Tight linkage

Indexed keywords

ALLELE; ARTICLE; DOMINANT GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; MAXIMUM LIKELIHOOD METHOD; NUCLEAR FAMILY; PEDIGREE ANALYSIS; PRIORITY JOURNAL; PROBABILITY; RECESSIVE GENE; SIBLING; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

CHROMOSOME MAPPING; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETICS, POPULATION; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33645743056     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1529-8817.2005.00229.x     Document Type: Article

References (15)

1. Falk, C.T. & Rubinstein, P. (1987) Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations. Annals of Human Genetics 51, 227-233.
2. Greenberg, D.A., Abreu, P. & Hodge, S.E. (1998) The power to detect linkage in complex disease by means of simple lod-score analyses. American Journal of Human Genetics 63, 870-879.
3. Huang, J. & Jiang, Y. (2001) The score statistic of the LD-LOD analysis: Detecting linkage adaptive to linkage disequilibrium. Human Heredity 52, 83-98.
4. Huang, J. & Vieland, V.J. (2001) The null distribution of the heterogeneity LOD score does depend on the assumed genetic model for the trait. Human Heredity 52, 217-222.
5. Martin, E.R., Kaplan, N.L. & Weir, B.S. (1997) Tests for linkage and association in nuclear families. American Journal of Human Genetics 61, 439-448.
6. Rubinstein, P., Walker, M., Carpenter, C., Carrier, C., Krassner, J., Faulk, C. & Ginsberg, F. (1981) Genetics of HLA disease associations: The use of the haplotype relative risk (HRR) and the 'haplo-delta' (Dh) estimates in juvenile diabetes from three racial groups. Human Immunology 3, 384.
7. Schaid, D.J. & Li, H. (1997) Genotype relative-risks and association tsts for nuclear families with missing parental data. Genetic Epidemiology 14, 1113-1118.
8. Schaid, D.J. & Sommer, S.S. (1993) Genotype relative risks: Methods for design and analysis of candidate-gene association studies. American Journal of Humang Genetics 53, 1114-1126.
9. Sham, P.C. & Curtis, D. (1995) An extended transmission/ disequilibrium test (tdt) for multi-allele marker loci. Annals of Human Genetics 59, 323-336.
10. Slager, S.L., Huang, J. & Vieland, V. (2001) Power comparisons between the TDT and two likelihoodbased methods. Genetic Epidemiology 20, 192-209.
11. Smith, C. (1961) Homogeneity test for linkage data. Proceedings of the Second International Congress on Human Genetics 1, 212-213.
12. Spielman, R.S., McGinnis, R.E. & Ewens, W.J. (1993) Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (iddm). American Journal of Human Genetics 52, 506-516.
13. Wassink, T.H., Piven, J., Vieland, V.J., Huang, J., Swiderski, R.E., Pietila, J., Braun, T., Beck, G., Folstein, S.E., Haines, J.L. & Sheffield, V.C. (2001) Evidence supporting wnt2 as an autism susceptibility gene. American Journal of Medical Genetics 105, 406-413.
14. Wicks, J. (2000) Exploiting excess sharing: A more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test. American Journal of Human Genetics 66, 2005-2008.
15. Zhao, H. (2000) Family-based association studies. Statistical Methods in Medical Research 9, 563-587.