Genotype relative-risks and association tests for nuclear families with missing parental data

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 1113-1118

  Schaid, Daniel J ^a   Li, Hongzhe ^a  

^a MAYO CLINIC   (United States)

Author keywords

Expectation maximization algorithm; Marker association

Indexed keywords

ALGORITHM; ALLELE; CONFERENCE PAPER; FAMILY; GENE FREQUENCY; GENETIC MARKER; GENOTYPE; MAXIMUM LIKELIHOOD METHOD; PARENT; RISK; SIBLING; STATISTICAL MODEL; TECHNIQUE;

ALGORITHMS; ALLELES; FEMALE; GENETIC DISEASES, INBORN; GENETIC MARKERS; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; MALE; NUCLEAR FAMILY; PARENTS; PHENOTYPE; PROBABILITY; RISK FACTORS;

EID: 0031455778     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1113::AID-GEPI92>3.0.CO;2-J     Document Type: Conference Paper

References (18)

1. Curtis D, Sham PC (1995): A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 56:811-812.
2. Ewens WJ, Spielman RS (1995): The transmission/disequilibrium test: History, subdivision, and admixture. Am J Hum Genet 57:455-464.
3. Jin K, Speed TP, Klitz W, Thomson G (1994): Testing for segregation distortion in the HLA complex. Biometrics 50:1189-1198.
4. Knapp M, Seuchter SA, Baur MP (1993): The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 52:1085-1093.
5. Knapp M, Wassmer G, Baur MP (1995): The relative efficiency of the Hardy-Weinberg Equilibrium-likelihood and the conditional on parental genotype-likelihood methods for candidate-gene association studies. Am J Hum Genet 57:1476-1485.
6. Lange K, Goradia TM (1987): An algorithm for automatic genotype elimination. Am J Hum Genet 40:250-256.
7. Ott J (1989): Statistical properties of the haplotype relative risk. Genet Epidemiol 6:127-130.
8. Risch N (1984): Segregation analysis incorporating linkage markers. I. Single-locus models with an application to Type I diabetes. Am J Hum Genet 36:363-386.
9. Risch N (1996): The future of genetic studies of complex human diseases. Science 273:1516-1517.
10. Schaid DJ, Sommer SS (1993): Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 53:1114-1126.
11. Schaid DJ, Sommer SS (1994): Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402-409.
12. Schaid DJ (1996): General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449.
13. Self SG, Longton G, Kopecky KJ, and Liang KY (1991): On estimating HLA/disease association with application to a study of aplastic anemia. Biometrics 47:53-61.
14. Spielman RS, Ewens WJ (1996): The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
15. Spielman RS, McGinnis RE, Ewens WJ (1993): Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
16. Terwilliger JD, Ott J (1992): A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum Hered 42:337-346.
17. Thomson G (1995a): Analysis of complex human genetic traits: An ordered-notation method and new tests for model of inheritance. Am J Hum Genet 57:474-486.
18. Thomson G (1995b): Mapping disease genes: family-based association studies. Am J Hum Genet 57:487-498.