Stimulation of N-linked glycosylation and lipid-linked oligosaccharide synthesis by stress responses in metazoan cells

Critical Reviews in Biochemistry and Molecular Biology

Volumn 41, Issue 2, 2006, Pages 51-75

  Lehrman, Mark A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Congenital disorder of glycosylation; Cytoplasmic stress; Endoplasmic reticulum stress; Unfolded protein response

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACTIVATING TRANSCRIPTION FACTOR 6; ADVANCED GLYCATION END PRODUCT RECEPTOR; ASPARAGINE; CALCIUM; CARBOXYPEPTIDASE C; CD8 ANTIGEN; CELL MEMBRANE PROTEIN; DOLICHOL PHOSPHATE; GLUCOSE TRANSPORTER 1; GLUCOSYLTRANSFERASE; GLYCAN; GLYCOPROTEIN; GUANOSINE DIPHOSPHATE MANNOSE; IMMUNOGLOBULIN HEAVY CHAIN; LIPID; MANNOSIDASE; MANNOSYLTRANSFERASE; METFORMIN; N ACETYLGLUCOSAMINE; N ACETYLLACTOSAMINE SYNTHASE; OLIGOSACCHARIDE; PROTEIN; PYROPHOSPHATE; RIBOSOME ASSOCIATED MEMBRANE PROTEIN 4; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE;

AMINO TERMINAL SEQUENCE; BACTERIAL GENE; CALCIUM HOMEOSTASIS; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; CELL STRAIN 3T3; CHO CELL; CONGENITAL DISORDER OF GLYCOSYLATION; CONGENITAL DISORDER OF GLYCOSYLATION TYPE X; CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE 2; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME SUBUNIT; FIBROBLAST CULTURE; GLUCONEOGENESIS; GLYCOGENOLYSIS; GOLGI COMPLEX; HELA CELL; HUMAN; LIPOGENESIS; METAZOON; NONHUMAN; OXIDATIVE STRESS; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ENDOPLASMIC RETICULUM; GLYCOGEN; GLYCOSYLATION; LIPOPOLYSACCHARIDES; MODELS, BIOLOGICAL; POLYSACCHARIDES; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); METAZOA; PARAMYXOVIRIDAE; SACCHAROMYCES CEREVISIAE;

EID: 33645729460     PISSN: 10409238     EISSN: None     Source Type: Journal    
DOI: 10.1080/10409230500542575     Document Type: Review

References (121)

1. Amici, C., Palamara, A.T., Garaci, E., and Santoro, M.G. 1992. Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation. Antiviral Res 19:129-138.
2. Anken, E.V. and Braakman, I. 2005. Versatility of the endoplasmic reticulum protein folding factory. Crit Rev Biochem Mol Biol 40:191-228.
3. Appenzeller, C., Andersson, H., Kappeler, F., and Hauri, H.-P. 1999. The lectin ERGIC-53 is a cargo transport receptor for glycoproteins. Nat Cell Biol 1:330-334.
4. Arnold, S.M., Fessler, L.I., Fessler, J.H., and Kaufman, R.J. 2000. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochem 39:2149-2163.
5. Badet, J. and Jeanloz, R.W. 1988. Isolation and partial purification of lipid-linked oligosaccharides from calf pancreas. Carbohydr Res 178:49-65.
6. Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P., and Ron, D. 2000. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326-332.
7. Birnbaum, M.J. 2005. Activating AMP-activated protein kinase without AMP. Mol Cell 19:289-290.
8. Burda, P., Jakob, C.A., Beinhauer, J., Hegemann, J.H., and Aebi, M. 1999. Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases. Glycobiol 9:617-625.
9. Cabral, C.M., Choudhury, P., Liu, Y., and Sifers, R.N. 2000. Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways. J Biol Chem 275:25015-25022.
10. Caramelo, J.J., Castro, O.A., Alonso, L.G., Prat-Gay, G., and Parodi, A.J. 2003. Inaugural article: UDP-Glc:glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates. Proc Nat Acad Sci 100:86-91.
11. Caramelo, J.J., Castro, O.A., Prat-Gay, G., and Parodi, A.J. 2004. The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermedia tes. J Biol Chem 279:46280-46285.
12. Carling, D. and Hardie, D.G. 1989. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochim Biophys Acta 1012:81-86.
13. Cho, S.K., Gao, N., Pearce, D.A., Lehrman, M.A., and Hofmann, S.L. 2005. Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease. Glycobiol 15:637-648.
14. Cullinan, S.B., Zhang, D., Hannink, M., Arvisais, E., Kaufman, R.J., and Diehl, J.A. 2003. Nrf2 Is a Direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198-7209.
15. Cusi, K. and DeFronzo, R.A. 1998. Metformin: a review of its metabolic effects. Diabetes Revi 6:89-131.
16. Deprez, P., Gautschi, M., and Helenius, A. 2005. More than one glycan is needed for ER glucosidase II to allow entry of glycoproteins into the calnexin/calreticulin cycle. Mol Cell 19:183-195.
17. Doerrler, W.T. and Lehrman, M.A. 1999. Regulation of the dolichol pathway in human fibroblasts by the endoplasmic reticulum unfolded protein response. Proc Natl Acad Sci USA 96:13050-13055.
18. Dupre, T., Barnier, A., de Lonlay, P., Cormier-Daire, V., Durand, G., Codogno, P., and Seta, N. 2000. Defect in N-glycosylation of proteins is tissue-dependent in congenital disorders of glycosylation Ia. Glycobiol 10:1277-1281.
19. Ernst, S.A., Crawford, K.M., Post, M.A., and Cohn, J.A. 1994. Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells. Am J Physiol Cell Physiol 267:C990-1001.
20. Fanchiotti, S., Fernandez, F., D'Alessio, C., and Parodi, A.J. 1998. The UDP-Glc: glycoprotein glucosyltransferase is essential for Schizosaccharomyces pombe viability under conditions of extreme endoplasmic reticulum stress. J Cell Biol 143:625-635.
21. Fernandez, F., Jannatipour, M., Hellman, U., Rokeach, L.A., and Parodi, A.J. 1996. A new stress protein: synthesis of Schizosaccharomyces pombe UDP-Glc: glycoprotein glucosyltransferase mRNA is induced by stress conditions but the enzyme is not essential for cell viability. EMBO J 15:705-713.
22. Fiedler, K., Parton, R.G., Kellner, R., Etzold, T., and Simons, K. 1994. VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells. EMBO J 13:1729-1740.
23. Flores-Diaz, M., Alape-Giron, A., Persson, B., Pollesello, P., Moos, M., Eichel-Streiber, C., Thelestam, M., and Florin, I. 1997. Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene. J Biol Chem 272:23784-23791.
24. Flores-Diaz, M., Higuita, J.C., Florin, I., Okada, T., Pollesello, P., Bergman, T., Thelestam, M., Mori, K., and Alape-Giron, A. 2004. A Cellular UDP-glucose deficiency causes overexpression of glucose/Oxygen-regulated proteins independent of the endoplasmic reticulum stress elements. J Biol Chem 279:21724-21731.
25. Frank, C.G. and Aebi, M. 2005. ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis. Glycobiol 15:1156-1163.
26. Freeze, H.H. and Aebi, M. 2005. Altered glycan structures: the molecular basis of congenital disorders of glycosylation. Curr Opin Struct Biol 15:490-498.
27. Frenkel, Z., Gregory, W., Kornfeld, S., and Lederkremer, G.Z. 2003. Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2. J Biol Chem 278:34119-34124.
28. Gao, N. and Lehrman, M.A. 2002a. Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis. Glycobiol 12:353-360.
29. Gao, N. and Lehrman, M.A. 2002b. Coupling of the dolichol-P-P- oligosacharide pathway to translation by perturbation-sensitive regulation of the initiating enzyme, GlcNAc-1-P transferase. J Biol Chemi 277:39425-39435.
30. Gao, N., Shang, J., and Lehrman, M.A. 2005. Analysis of glycosylation in CDG-Ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis: Implications or extracellular glucose and intracellular mannose-6-phosphate. J Biol Chemi 280:17901-17909.
31. Gershman, H. and Robbins, P.W. 1981. Transitory effects of glucose starvation on the synthesis of dolichol-linked oligosaccharides in mammalian cells. J Biol Chem 256:7774-7780.
32. Gibbs, B.S. and Coward, J.K. 1999. Dolichylpyrophosphate oligosaccharides:large-scale isolation and evaluation as oligosaccharyltransferase substrates. Bioor Med Chem 7:441-447.
33. Gill, A., Gao, N., and Lehrman, M.A. 2002. Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response. J Biol Chem 277:44747-44753.
34. Hammond, C., Braakman, I., and Helenius, A. 1994. Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proc Natl Acad Sci USA 91:913-917.
35. Hara-Kuge, S., Ohkura, T., Seko, A., and Yamashita, K. 1999. Vesicular-integral membrane protein, VIP36, recognizes high-mannose type glycans containing alpha1→2 mannosyl residues in MDCK cells. Glycobiol 9:833-839.
36. Hardie, D.G. 2003. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrin 144:5179-5183.
37. Harding, H.P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. 2000. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5:897-904.
38. Harding, H.P., Zhang, Y., and Ron, D. 1999. Protein translation and folding are coupled by an endoplasmic reticulum resident kinase. Nature 397:271-274.
39. Harding, H.P., Zhang, Y., Zeng, H., Novoa, I., Lu, P.D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., Stojdl, D.F., Bell, J.C., Hettmann, T., Leiden, J.M., and Ron, D. 2003. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11:619-633.
40. Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Mäkelä, T.P., Alessi, D.R., and Hardie, D.G. 2003. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28.1-28.15.
41. Helenius, A. and Aebi, M. 2004. Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem 73:1019-1049.
42. Helenius, J., Ng, D.T.W., Marolda, C.L., Walter, P., Valvano, M.A., and Aebi, M. 2002. Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415:447-450.
43. Hendershot, L.M., Ting, J., and Lee, A.S. 1988. Identity of the immunoglobulin heavy-chain binding protein with the 78,000-Dalton glucose-regulated protein and the role of posttranslational modifications in its binding function. Mol and Cell Biol 8:4250-4256.
44. Henle, K.J., Jethmalani, S.M., and Nagle, W.A. 1995. Heat stress-induced protein glycosylation in mammalian cells. TIGG 7:191-204.
45. Henle, K.J., Jethmalani, S.M., Li, L., and Li, G.C. 1997. Protein Glycosylation in a heat-resistant rat fibroblast cell model expressing human HSP70. Biochem Biophy Res Commun 232:26-32.
46. Henle, K.J., Kaushal, G.P., Nagle, W.A., and Nolen, G.T. 1993. Prompt protein glycosylation during acute heat stress. Exp Cell Research 207:245-251.
47. Herscovics, A., Romero, P.A., and Tremblay, L.O. 2002. The specificity of the yeast and human class I ERα1,2-mannosidases involved in ER quality control is not as strict as previously reported. Glycobiol 12:14G-15G.
48. Hong, M., Luo, S., Baumeister, P., Huang, J.-M., Gogia, R.K., Li, M., and Lee, A.S. 2004. Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J Biol Chem 279:11354-11363.
49. Hosokawa, N., Tremblay, L.O., You, Z., Herscovics, A., Wada, I., and Nagata, K. 2003. Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong alpha1-antitrypsin by human ER mannosidase I. J Biol Chem 278:26287-26294.
50. Hosokawa, N., Wada, I., Hasegawa, K., Yorihuzi, T., Tremblay, L.O., Herscovics, A., and Nagata, K. 2001. A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep 2:415-422.
51. Ikawa, M., Wada, I., Kominami, K., Watanabe, D., Toshimori, K., Nishimune, Y., and Okabe, M. 1997. The putative chaperone calmegin is required for sperm fertility. Nature 387:607-611.
52. Jaeken, J. and Matthijs, G. 2001. Congenital disorders of glycosylation. Annu Rev of Gen Hum Genet 2:129-151.
53. Jakob, C.A., Burda, P., Roth, J., and Aebi, M. 1998. Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J Cell Biol 142:1223-1233.
54. Jethmalani, S.M., Henle, K.J., and Kaushal, G.P. 1994. Heat shock-induced prompt glycosylation. Identification of P-SG67 as calreticulin. J Biol Chem 269:23603-23609.
55. Kelleher, D.J., Kreibich, G., and Gilmore, R. 1992. Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein. Cell 69:55-65.
56. Kelleher, D.J. and Gilmore, R. 1997. DAD , the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase. Proc Nati Acad Sci 94:4994-4999.
57. Kitzman, H.H., Jr., McMahon, R.J., Aslanian, A.M., Fadia, P.M., and Frost, S.C. 1996. Differential regulation of GRP78 and GLUT1 expression in 3T3-L1 adipocytes. Mol Cell Biochem 162:51-58.
58. 2-PP-dolichyl glucosyltransferase. Proc Natl Acad Sci USA 95:13200-13205.
59. Kozlovsky, N., Rudich, A., Potashnik, R., Ebina, Y., Murakami, T., and Bashan, N. 1997. Transcriptional activation of the glut1 gene in response to oxidative stress in L6 myotubes. J Biol Chem 272:33367-33372.
60. Kuznetsov, G., Brostrom, M.A., and Brostrom, C.O. 1993. Role of endoplasmic reticular calcium in oligosaccharide processing of alpha 1-antitrypsin. J Biol Chem 268:2001-2008.
61. Lauc, G., Dabelic, S., Supraha, S., and Flogel, M. 1998. Glycobiology of stress. Ann NY Acad Sci 851:397-403.
62. Lecca, M.R., Wagner, U., Patrignani, A., Berger, E.G., and Hennet, T. 2004. Genome-wide analysis of the unfolded protein response in fibroblasts from congenital disorders of glycosylation type-I patients. FASEB J 19:240-242.
63. Lee, A.H., Iwakoshi, N.N., and Glimcher, L.H. 2003. XBP-1 Regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23::7448-7459.
64. Lee, K., Tirasophon, W., Shen, X., Michalak, M., Prywes, R., Okada, T., Yoshida, H., Mori, K., and Kaufman, R.J. 2002. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 16:452-466.
65. Lehrman, M.A. 1991. Biosynthesis of N-acetylglucosamine-P-P-dolichol, the committed step of asparagine-linked oligosaccharide assembly. Glycobiol 1:553-562.
66. Longnus, S.L., Wambolt, R.B., Parsons, H.L., Brownsey, R.W., and Allard, M.F. 2003. 5-aminoimidazole-4-carboxamide 1-β-ribofuranoside (AICAR) stimualtes myocardial glycogenolysis by allosteric mechanisms. Am J Physiol Regul Integr Comp Physiol 284:R936-R944.
67. Lubas, W.A. and Spiro, R.G. 1988. Evaluation of the role of rat liver Golgi endo-α-D-mannosidase in processing N-linked oligosaccharides. J Biol Chem 263:3990-3998.
68. Mancini, R., Aebi, M., and Helenius, A. 2003. Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells. J Biol Chem 278:46895-46905.
69. Marquardt, T. and Freeze, H. 2001. Congenital disorders of glycosylation: glycosylation defects in man and biological models for their study. Biol Chem 382:161-177.
70. Marquardt, T., Ullrich, K., Niehues, R., Koch, H.-G., and Harms, E. 1996. Carbohydrate-deficient glycoprotein syndrome type I: determination of the oligosaccharide structure of newly synthesized glycoproteins by analysis of calnexin binding. J Inheri Meta Disord 19:246-250.
71. Marquardt, T., Ullrich, K., Zimmer, P., Hasilik, A., Deufel, T., and Harms, E. 1995. Carbohydrate-deficient glycoprotein syndrome (CDGS)- glycosylation, folding, and intracellular transport of newly synthesized glycoproteins. Eur J Cell Biol 66:268-273.
72. Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N., and Moremen, K.W. 2005. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Glycobiol 15:421-436.
73. McMahon, R.J. and Frost, S.C. 1996. Glycogen: a carbohydrate source for GLUT-1 glycosylation during glucose deprivation of 3T3-L1 adipocytes. Am J Physiol 270:E640-E645.
74. Moussalli, M., Pipe, S.W., Hauri, H.-P., Nichols, W.C., Ginsburg, D., and Kaufman, R.J. 1999. Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII. J Biol Chem 274:32539-32542.
75. Munro, S. and Pelham, H.R.B. 1986. An HSP 70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell 46:291-300.
76. Ng, D.T.W., Spear, E.D., and Walter, P. 2000. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150:77-88.
77. Nichols, W.C., Seligsohn, U., Zivelin, A., Terry, V.H., Hertel, C.E., Wheatley, M.A., Moussalli, M.J., Hauri, H.P., Ciavarella, N., Kaufman, R.J., and Ginsburg, D. 1998. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell 93:61-70.
78. Niehues, R., Hasilik, M., Alton, G., Körner, C., Schiebe-Sukumar, M., Koch, H.G., Zimmer, K.P., Wu, R., Harms, E., Reiter, K., von Figura, K., Freeze, H.H., Harms, H.K., and Marquardt, T. 1998. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. J Clin Invest 101:1414-1420.
79. Niewiarowska, A., Caltabiano, M.M., Bailey, D.S., Poste, G., and Greig, R.G. 1987. Alterations in lipid-linked oligosaccharide metabolism in human melanoma cells concomitant with induction of stress proteins. J Biol Chem 262:14815-14820.
80. Olivari, S., Galli, C., Alanen, H., Ruddock, L., and Molinari, M. 2005. A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. J Biol Chem 280:2424-2428.
81. Ou, W.J., Cameron, P.H., Thomas, D.Y., and Bergeron, J.J. 1993. Association of folding intermediates of glycoproteins with calnexin during protein maturation. Nature 364:771-776.
82. Parodi, A.J. 2000. Protein glucosylation and its role in protein folding. Annu Rev Biochem 69:69-93.
83. Peluso, R.W., Lamb, R.A., and Choppin, P.W. 1978. Infection with paramyxoviruses stimulates synthesis of cellular polypeptides that are also stimulated in cells transformed by rous sarcoma virus or deprived of glucose. Proc Nati Acad Sci 75:6120-6124.
84. Pouyssegur, J., Shiu, R.P., and Pastan, I. 1977. Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation. Cell 11:941-947.
85. Rearick, J.I., Chapman, A., and Kornfeld, S. 1981. Glucose starvation alters lipid-linked oligosaccharide biosynthesis in chinese hamster cells. J Biol Chem 256:6255-6261.
86. Rutkowski, D.T. and Kaufman, R.J. 2004. A trip to the ER: coping with stress. Trends Cell Biol 14:20-28.
87. Saito, Y., Ihara, Y., Leach, M.R., Cohen-Doyle, M.F., and Williams, D.B. 1999. Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins. EMBO J 18:6718-6729.
88. Samuelson, J., Banerjee, S., Magnelli, P., Cui, J., Kelleher, D.J., Gilmore, R., and Robbins, P.W. 2005. The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases. Proc Nati Acad Sci 102:1548-1553.
89. Sayeed, A. and Ng, D.T.W. 2005. Search and destroy: ER quality control and ER-associated protein degradation. Crit Rev Biochem Mol Biol 40:75-91.
90. Schenk, B., Fernandez, F., and Waechter, C.J. 2001. The ins(ide) and outs(ide) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum. Glycobiol 11:61R-70R.
91. Schröder, K., Martoglio, B., Hofmann, M., Hölscher, C., Hartmann, E., Prehn, S., Rapoport, T.A., and Dobberstein, B. 1999. Control of glycosylation of MHC class II-associated invariant chain by translocon- associated RAMP4. EMBO J 18:4804-4815.
92. Schroder, M. and Kaufman, R.J. 2005. The Mammalian unfolded protein response. Annu Rev Biochem 74:739-789.
93. Shang, J., Körner, C., Freeze, H., and Lehrman, M.A. 2002. Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts. Glycobiol 12:307-317.
94. Shang, J. and Lehrman, M.A. 2004a. Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR): assessment of glycogen as a precursor of mannosyl residues in glyco-conjugates. J Biol Chem 279:12076-12080.
95. Shang, J. and Lehrman, M.A. 2004b. Metformin-stimulated mannose transport in dermal fibroblasts. J Biol Chem 279:9703-9712.
96. Shen, J., Chen, X., Hendershot, L., and Prywes, R. 2002. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Devel Cell 3:99-111.
97. Shen, J., Snapp, E.L., Lippincott-Schwartz, J., and Prywes, R. 2005a. Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol Cell Biol 25:921-932.
98. Shen, X., Ellis, R.E., Sakaki, K., and Kaufman, R.J. 2005b. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genetics 1:355-368.
99. Shiu, R.P., Pouyssegur, J., and Pastan, I. 1977. Glucose depletion accounts for the induction of two transformation-sensitive membrane proteins in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci USA 74:3840-3844.
100. Spear, E.D. and Ng, D.T.W. 2003. Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways. Mol Biol Cell 14:2756-2767.
101. Spiro, R.G., Zhu, Q., Bhoyroo, V., and Soling, H.-D. 1996. Definition of the lectin-like properties of the molecular chaperone, calreticulin, and demonstration of its copurification with endomannosidase from rat liver Golgi. J Biol Chem 271:11588-11594.
102. Szathmary, R., Bielmann, R., Nita-Lazar, M., Burda, P., and Jakob, C.A. 2005. Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD. Mol Cell 19:765-775.
103. Taguchi, T., Yamashita, E., Mizutani, T., Nakajima, H., Yabuuchi, M., Asano, N., and Miwa, I. 2005. Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration. Am J Physiol Endocrinol Metab 288:E534-E540.
104. Travers, K.J., Patil, C.K., Wodicka, L., Lockhart, D.J., Weissman, J.D., and Walter, P. 2000. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101:249-258.
105. Turco, S.J. 1980. Modification of oligosaccharide-lipid synthesis and protein glycosylation in glucose-deprived cells. Arch Biochem Biophys 205:330-339.
106. Uccelletti, D., O'Callaghan, C., Berninsone, P., Zemtseva, I., Abeijon, C., and Hirschberg, C.B. 2004. ire-1-dependent transcriptional upregulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. J Biol Chem 279:27390-27398.
107. Van Huizen, R., Martindale, J.L., Gorospe, M., and Holbrook, N.J. 2003. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of elF2alpha signaling. J Biol Chem 278:15558-15564.
108. Vashist, S., Frank, C.G., Jakob, C.A., and Ng, D.T.W. 2002. Two distinctly localized P-type ATPases collaborate to maintain organelle homeostasis required for glycoprotein processing and quality control. Mol Biol Cell 13:3955-3966.
109. Wang, D., Weaver, N.D., Kesarwani, M., and Dong, X. 2005. Induction of protein secretory pathway is required for systemic acquired resistance. Science 308:1036-1040.
110. 2 oligosaccharide as an initial step in recognizing unfolded glycoproteins. J Biol Chem 270:4697-4704.
111. Wiernsperger, N.F. 1999. Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes. Diabetes Metab (Paris) 25:110-127.
112. Xu, C., Bailly-Maitre, B., and Reed, J.C. 2005. Endoplasmic reticulum stress: cell life and death decisions. J Clini Invest 115:2656-2664.
113. Yamaguchi, A., Hori, O., Stern, D.M., Hartmann, E., Ogawa, S., and Tohyama, M. 1999. Stress-associated endoplasmic reticulum protein 1 (SERP1)/ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. J Cell Biol 147:1195-1204.
114. Yan, A. and Lennarz, W.J. 2005. Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons. Glycobiol 15:1407-1415.
115. Ye, J., Rawson, R.B., Komuro, R., Chen, X., Dave, U., Prywes, R., Brown, M.S., and Goldstein, J.L. 2000. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 6:1355-1364.
116. Yoshida, H., Matsui, T., Hosokawa, N., Kaufman, R.J., Nagata, K., and Mori, K. 2003a. A time-dependent phase shift in the mammalian unfolded protein response. Devel Cell 4:265-271.
117. Yoshida, Y., Chiba, Y., Tokunaga, F., Kawasaki, H., Iwai, K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K., and Tai, T. 2002. E3 ubiquitin ligase that recognizes sugar chains. Nature 418:438-442.
118. Yoshida, Y., Adachi, E., Fukiya, K., Iwai, K., and Tanaka, K. 2005. Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. EMBO Rep 6:239-244.
119. Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K., and Tai, T. 2003b. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J Biol Chem 278:43877-43884.
120. Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., Musi, N., Hirshman, M., Goodyear, L.J., and Moller, D.E. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174.
121. Zou, M.H., Kirkpatrick, S.S., Davis, B.J., Nelson, J.S., Wiles, W.G., IV, Schlattner, U., Neumann, D., Brownlee, M., Freeman, M.B., and Goldman, M.H. 2004. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: role of mitochondrial reactive nitrogen species. J Biol Chem 279:43940-43951.