Physiologic mechanisms can predict hematologic responses to iron supplements in growing children: A computer simulation model

American Journal of Clinical Nutrition

Volumn 83, Issue 3, 2006, Pages 681-687

  Sharieff, Waseem ^a,d   Zlotkin, Stanley ^a,b   Tondeur, Melody ^a   Feldman, Brian ^a,b   Tomlinson, George ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d ONTARIO MINISTRY OF HEALTH AND LONG TERM CARE   (Canada)

Author keywords

Clinical trial; Iron deficiency; Markov model; Monte Carlo simulation

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON;

ANEMIA; ARTICLE; CHILD GROWTH; CHINA; COMPUTER SIMULATION; DIET SUPPLEMENTATION; DOSE RESPONSE; FERRITIN BLOOD LEVEL; GHANA; HEMOGLOBIN BLOOD LEVEL; IRON ABSORPTION; IRON METABOLISM; IRON THERAPY; PROTEIN BLOOD LEVEL; REGULATORY MECHANISM; VALIDATION STUDY; BIOLOGICAL MODEL; BLOOD; CHILD; CHILD DEVELOPMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; HUMAN; INTESTINE ABSORPTION; IRON DEFICIENCY ANEMIA; IRON INTAKE; METABOLISM; MONTE CARLO METHOD; PHYSIOLOGY; PREDICTION AND FORECASTING; PROBABILITY; RANDOMIZED CONTROLLED TRIAL;

ANEMIA, IRON-DEFICIENCY; CHILD; CHILD DEVELOPMENT; COMPUTER SIMULATION; DIETARY SUPPLEMENTS; FERRITINS; HEMOGLOBINS; HUMANS; INTESTINAL ABSORPTION; IRON, DIETARY; MARKOV CHAINS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS;

EID: 33645640335     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn.83.3.681     Document Type: Article

References (29)

1. Lozoff B, Brittenham GM, Wolf AW, et al. Iron-deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 1987;79:981-95. (Published erratum appears in Pediatrics 1988;81:683.)
2. Pollitt E. Iron deficiency and cognitive function. Annu Rev Nutr 1993;13:521-37.
3. Hallberg L, Hulten L, Gramatkovski E. Iron absorption from the whole diet in men: how effective is the regulation of iron absorption? Am J Clin Nutr 1997;66:347-56.
4. National Academy Press. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2000;290-393. Internet: http://books.nap.edu/books/0309072794/html/R1.html (accessed 12 July 2004).
5. Smith N, Rios E. Iron metabolism and iron deficiency in infancy and childhood. Adv Pediatr 1974;21:239-80.
6. Fomon S, Serfass R, Nelson S, Rogers R, Frantz J. Time course of and effect of dietary iron level on iron incorporation into erythrocytes by infants. J Nutr 2000;130:541-5.
7. Harju E. Clinical pharmacokinetics of iron preparations. Clin Pharmacokinet 1989;17:69-89.
8. Green R, Charlton R, Seftel H, et al. Body iron excretion in man: a collaborative study. Am J Med 1968;45:336-53.
9. Worwood M. Serum ferritin. In: Jacobs A, Worwood M, eds. Iron in biochemistry and medicine. London, United Kingdom: Academic Press, 1980:203-44.
10. Finch C, Huebers H. Perspectives in iron metabolism. N Engl J Med 1982;306:1520-8.
11. Lloyd D, Phillips D. Oxidative DNA damage mediated by copper (II), iron (II) and nickel (II) Fenton reactions: evidence for site specific mechanisms in the formation of double-strand breaks, 8-hydroxyguanosine and putative in-strand cross-links. Mutat Res 1999;424:23-36.
12. Gillespie S, Mason JB, Kevany J, eds. Controlling iron deficiency. United Nations Administrative Committee on Coordination/Subcommittee on Nutrition. Geneva, Switzerland: 1991. (State-of-the-art series nutrition policy discussion paper no. 9.)
13. World Health Organization. Malnutrition. The global picture. Geneva, Switzerland: World Health Organization, 2000.
14. Kapil U. Technical consultation on "Strategies for Prevention and Control of Iron Deficiency Anemia" amongst under three children in India. Indian Pediatr 2002;39:640-7.
15. Sprinkles Global Health Initiative. Micronutrients to fortify life. Internet: http://www.sghi.org (accessed 15 January 2006).
16. Tondeur M, Schauer C, Christofides A, et al. Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method. Am J Clin Nutr 2004;80:1436-44.
17. Zlotkin S, Arthur P, Antwi KY, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr 2001;74:791-5.
18. Sharieff W, Wu M, Yin S, et al. Daily or weekly administration of micronutrient Sprinkles in school has high compliance and does not cause iron overload in Chinese children: a cluster-randomized trial. Public Health Nutr (in press).
19. Linderkamp O, Versmold H, Riegel K, Betke K. Estimation and prediction of blood volume in infants and children. Eur J Pediatr 1977;125:227-34.
20. Centers for Disease Control and Prevention. CDC growth charts. Developed by the National Center for Health Statistics in collaboration with the National Center for Chronic Disease Prevention and Health Promotion. 2000. Internet: http://www.cdc.gov/growthcharts (accessed 25 July 2004).
21. Crosby WH, Conrad ME Jr, Wheby MS. The rate of iron accumulation in iron storage diseases. Blood 1963;22:429-40.
22. Du S, Zhai F, Wang Y, Popkin B. Current methods for estimating dietary iron bioavailability do not work in China. J Nutr 2000;130:193-8.
23. Spiegelhalter DJ, Best NG. Bayesian approaches to multiple sources of evidence and uncertainty in complex cost-effectiveness modelling. Stat Med 2003;22:3687-709.
24. Sokal R, Rohlf J. Biometry. 3rd ed. New York, NY: WH Freeman, 1994.
25. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 1974;290:1213-6.
26. Miret S, Simpson RJ, McKie AT. Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr 2003;23:283-301.
27. Fleming RE, Bacon BR. Orchestration of iron homeostasis. N Engl J Med 2005;352:1741-4.
28. Nestel P, Alnwick D, eds. Iron/multi-micronutrient supplements for young children. Summary and conclusions of a consultation held at UNICEF Copenhagen, Denmark, August 19-20, 1996. Bethesda, MD: International Life Sciences Institute, 1997.
29. Zlotkin S. Current issues for the prevention and treatment of iron deficiency anemia. Indian Pediatr 2002;39:125-9.