Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6n-3) and docosapentaenoic acid (22:5n-6) on cardiovascular risk factors in healthy men and women

British Journal of Nutrition

Volumn 95, Issue 3, 2006, Pages 525-531

  Sanders, Thomas A B ^a   Gleason, Kelly ^a   Griffin, Bruce ^b   Miller, George J ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

C reactive protein; Docosahexaenoic acid; Docosapentaenoic acid; Haemostasis; Lipids

Indexed keywords

ADRENIC ACID; ARACHIDONIC ACID; BLOOD CLOTTING FACTOR 7; C REACTIVE PROTEIN; CAROTENOID; CREATINE KINASE; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE PHOSPHOLIPID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; TOCOPHEROL; TRIACYLGLYCEROL; TROPONIN I; VON WILLEBRAND FACTOR;

ADULT; ALGA; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHROCYTE MEMBRANE; FAT INTAKE; FEMALE; FOOD CHAIN; GLUCOSE BLOOD LEVEL; HUMAN; LIVER FUNCTION TEST; MALE; MARINE ENVIRONMENT; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; STATISTICAL ANALYSIS;

ADULT; ALGAE; BLOOD PRESSURE; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; ERYTHROCYTES; FACTOR VII; FATTY ACIDS; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; MALE; PHOSPHOLIPIDS; RISK FACTORS; TRIGLYCERIDES;

ALGAE; SCHIZOCHYTRIUM;

EID: 33645534838     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1079/BJN20051658     Document Type: Article

References (31)

1. Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN & Manson JE (1998) Fish consumption and risk of sudden cardiac death. JAMA 279, 23-28.
2. British Nutrition Foundation (1992) Unsaturated Fatty Acids: Nutritional and Physiological Significance: The Report of the British Nutrition Foundation's Task Force. London: Chapman and Hall.
3. Bucher HC, Hengstler P, Schindler C & Meier G (2002) n-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 112, 298-304.
4. Cooper JA, Miller GJ, Bauer KA, Morrissey JH, Meade TW, Howarth DJ, Barzegar S, Mitchell JP & Rosenberg RD (2000) Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease. Circulation 102, 2816-2822.
5. Davidson MH, Maki KC, Kalkowski J, Schaefer EJ, Torri SA & Drennan KB (1997) Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. J Am Coll Nutr 16, 236-243.
6. Davies IG, Graham JM & Griffin BA (2003) Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation. Clin Chem 49, 1865-1872.
7. Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R, Calder PC & Williams CM (2003) Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 77, 783-795.
8. Friedewald WT, Levi RI & Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the ultracentrifuge. Clin Chem 18, 499-502.
9. Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR & Kok FJ (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20, 1493-1499.
10. Harris WS (1997) n-3 Fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 65, Suppl., S1645-S1654.
11. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, Hunter D & Manson JE (2002) Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 287, 1815-1821.
12. Makrides M, Neumann MA, Jeffrey B, Lien EL & Gibson RA (2000) A randomized trial of different ratios of linoleic to alpha-linolenic acid in the diet of term infants: effects on visual function and growth. Am J Clin Nutr 71, 120-129.
13. Marchioli R, Barzi F, Bomba E, et al. (2002) Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105, 1897-1903.
14. Meade TW, Ruddock V, Stirling Y, Chakrabarti R & Miller GJ (1993) Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 342, 1076-1079.
15. Metz JG, Roessler P, Facciotti D, Levering C, Dittrich F, Lassner M, Valentine R, Lardizabal K, Domergue F, Yamada A, Yazawa K, Knauf V & Browse J (2001) Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes. Science 293, 290-293.
16. Minihane AM, Khan S, Leigh-Firbank EC, Talmud P, Wright JW, Murphy MC, Griffin BA & Williams CM (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20, 1990-1997.
17. Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD & Beilin LJ (2000) Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 71, 1085-1094.
18. Mozaffarian D, Longstreth WT Jr, Lemaitre RN, Manolio TA, Kuller LH, Burke GL & Siscovick DS (2005) Fish consumption and stroke risk in elderly individuals: The Cardiovascular Health Study. Arch Intern Med 165, 200-206.
19. Ridker PM, Hennekens CH, Buring JE & Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Eng J Med 342, 836-843.
20. Rosell MS, Lloyd-Wright Z, Appleby PN, Sanders TA, Allen NE & Key TJ (2005) Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. Am J Clin Nutr 82, 327-334.
21. Sanders TA & Hinds A (1992) The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers. Br J Nutr 68, 163-173.
22. Sanders TA, Oakley FR, Cooper JA & Miller GJ (2001) Influence of a stearic acid-rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects. Am J Clin Nutr 73, 715-721.
23. Sanders TA, Oakley FR, Miller GJ, Mitropoulos KA, Crook D & Oliver MF (1997) Influence of n-6 versus n-3 polyunsaturated fatty acids in diets low in saturated fatty acids on plasma lipoproteins and hemostatic factors. Arterioscler Thromb Vasc Biol 17, 3449-3460.
24. Sanders TA, Vickers M & Haines AP (1981) Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clin Sci (Lond) 61, 317-324.
25. Schlenk H, Sand DM & Gellerman JL (1969) Retroconversion of docosahexaenoic acid in the rat. Biochim Biophys Acta 187, 201-207.
26. Sullivan DR, Sanders TA, Trayner IM & Thompson GR (1986) Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil. Atherosclerosis 61, 129-134.
27. Theobald HE, Chowienczyk PJ, Whittall R, Humphries SE & Sanders TA (2004) LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. Am J Clin Nutr 79, 558-563.
28. Thompson SG, Kienast J, Pyke SD, Haverkate F & van de Loo JC (1995) Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. N Engl J Med 332, 635-641.
29. Thurnham DI, Smith E & Flora PS (1988) Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard. Clin Chem 34, 377-381.
30. Tontonoz P & Mangelsdorf DJ (2003) Liver X receptor signalling pathways in cardiovascular disease. Mol Endocrinol 17, 985-993.
31. Yoshikawa T, Shimano H, Yahagi N, et al. (2002) Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 277, 1705-1711.