Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype

Cancer Research

Volumn 66, Issue 6, 2006, Pages 2907-2912

  Gueven, Nuri ^a   Becherel, Olivier J ^a   Birrell, Geoff ^a   Chen, Philip ^a   DelSal, Giannino ^b   Carney, James P ^c   Grattan Smith, Padraic ^d   Lavin, Martin F ^a,e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Laboratorio Nazionale CIB   (Italy)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d SYDNEY CHILDREN'S HOSPITAL   (Australia)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; COMPLEMENTARY DNA; CYCLOPHILIN; PROTEIN MDM2; PROTEIN P53; PROTEIN PIN1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; GENE INDUCTION; GENE MUTATION; HUMAN; HUMAN CELL; IRRADIATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

APOPTOSIS; ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; LYMPHOCYTES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 33645512221     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3428     Document Type: Article

References (19)

1. Boder E, Sedgwick RP. In: Vinkin PJ, Bruyn W, Klawans HL, editors. Hereditary neuropathies and spinocerebellar atrophies. Liss (AR): New York; 1991. p. 347-423.
2. Lavin MF, Shiloh Y. The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 1997;15:177-202.
3. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
4. Lavin MF, Delia D, Chessa L. Workshop on ataxia telangiectasia; ATM and DNA damage response; Belgirate, Italy June 2005. EMBO Rep 2006;7:154-60.
5. Mirzoeva OK, Petrini JH. DNA replication-dependent nuclear dynamics of the Mrell complex. Mol Cancer Res 2003;1:207-18.
6. Cerosaletti K, Concannon P. Independent roles for nibrin and Mrel1-Rad50 in the activation and function of ATM. J Biol Chem 2004;279:38813-9.
7. Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 2003;22:5612-21.
8. Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF. ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem 2003;278:9309-17.
9. Zacchi P, Gostissa M, Uchida T, et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 2002;419:853-7.
10. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001;276:42462-7.
11. Rubbi CP, Milner J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J 2003;22:6068-77.
12. Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 1996;15:1596-606.
13. Moll UM, Petrenko O. The MDM2-53 interaction. Mol Cancer Res 2003;1:1001-8.
14. Kumar S, Lavin MF. The ICE family of cysteine proteases as effectors of cell death. Cell Death Differ 1996;3:255-67.
15. Duchaud E, Ridet A, Stoppa-Lyonnet D, Janin N, Moustacchi E, Rosselli F. Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity. Cancer Res 1996;56:1400-4.
16. Thompson T, Tovar C, Yang H, et al. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem 2004;279:53015-22.
17. Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15:164-71.
18. Berger M, Stahl N, Del Sal G, Haupt Y. Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage. Mol Cell Biol 2005; 25:5380-8.
19. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994;370:220-3.