The α4β7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine

Clinical and Experimental Allergy

Volumn 36, Issue 4, 2006, Pages 543-553

  Brandt, E B ^a   Zimmermann, N ^a   Muntel, E E ^a   Yamada, Y ^a   Pope, S M ^a   Mishra, A ^a   Hogan, S P ^a   Rothenberg, M E ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

7; Adhesion molecules; Allergy; Eosinophils; Integrins; Intestine; Lung

Indexed keywords

ALPHA4BETA7 INTEGRIN; BETA7 INTEGRIN; INTEGRIN; INTERLEUKIN 4; INTERLEUKIN 5; UNCLASSIFIED DRUG; ALPHA4 INTEGRIN; BETA INTEGRIN; INTEGRIN ALPHA4BETA7;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BLOOD; CELL ISOLATION; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; EOSINOPHIL; GASTROINTESTINAL DISEASE; INTESTINE; LUNG LAVAGE; LUNG PARENCHYMA; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL MOTION; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; LUNG;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL MOVEMENT; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EOSINOPHILS; INTEGRIN ALPHA4; INTEGRIN BETA CHAINS; INTEGRINS; INTERLEUKIN-4; INTERLEUKIN-5; INTESTINES; LUNG; MICE; MICE, INBRED C57BL; PEYER'S PATCHES; SPLEEN;

EID: 33645319459     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2006.02456.x     Document Type: Article

References (50)

1. Rothenberg ME Mishra A Brandt EB Hogan SP. Gastrointestinal eosinophils in health and disease. Adv Immunol 2001 78 291 328.
2. Dombrowicz D Capron M. Eosinophils, allergy and parasites. Curr Opin Immunol 2001 13 716 20.
3. Wardlaw AJ Brightling C Green R Woltmann G Pavord I. Eosinophils in asthma and other allergic diseases. Br Med Bull 2000 56 985 1003.
4. Munitz A Levi-Schaffer F. Eosinophils 'new' roles for 'old' cells. Allergy 2004 59 268 75.
5. Assa'ad AH Spicer RL Nelson DP Zimmermann N Rothenberg ME. Hypereosinophilic syndromes. Chem Immunol 2000 76 208 29.
6. Lee JJ Dimina D Macias MP et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004 305 1773 6.
7. Humbles AA Lloyd CM McMillan SJ et al. A critical role for eosinophils in allergic airways remodeling. Science 2004 305 1776 9.
8. Hogan SP Mishra A Brandt EB et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol 2001 2 353 60.
9. Bochner BS Schleimer RP. Mast cells, basophils, and eosinophils distinct but overlapping pathways for recruitment. Immunol Rev 2001 179 5 15.
10. Broide D Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev 2001 179 163 72.
11. Wardlaw AJ. The role of adhesion in eosinophil function. Chem Immunol 2000 78 93 111.
12. Foster PS Mould AW Yang M et al. Elemental signals regulating eosinophil accumulation in the lung. Immunol Rev 2001 179 173 81.
13. Xu B Wagner N Pham LN et al. Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. J Exp Med 2003 197 1255 67.
14. Gascoigne MH Holland K Page CP et al. The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits. Pulm Pharmacol Ther 2003 16 279 85.
15. Erle DJ Briskin MJ Butcher EC Garcia-Pardo A Lazarovits AI Tidswell M. Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol 1994 153 517 28.
16. Walsh GM Symon FA Lazarovils AL Wardlaw AJ. Integrin alpha 4 beta 7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. Immunology 1996 89 112 9.
17. Lundahl J Sehmi R Moshfegh A et al. Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early Eosinophilic commitment upregulation of beta(7) integrins. Scand J Immunol 2002 56 161 7.
18. Berlin C Berg EL Briskin MJ et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993 74 185 95.
19. Briskin M Winsor-Hines D Shyjan A et al. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 1997 151 97 110.
20. Artis D Humphreys NE Potten CS et al. Beta7 integrin-deficient mice delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection. Eur J Immunol 2000 30 1656 64.
21. Gurish MF Tao H Abonia JP et al. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 2001 194 1243 52.
22. Kitayama J Fuhlbrigge RC Puri KD Springer TA. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol 1997 159 3929 39.
23. Mishra A Hogan SP Brandt EB et al. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem 2002 277 4406 12.
24. Meerschaert J Vrtis RF Shikama Y Sedgwick JB Busse WW Mosher DF. Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro. J Immunol 1999 163 6217 27.
25. Dubree NJ Artis DR Castanedo G et al. Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents. J Med Chem 2002 45 3451 7.
26. Ghosh S. Therapeutic value ofalpha-4 integrin blockade in inflammatory bowel disease the role of natalizumab. Expert Opin Biol Ther 2003 3 995 1000.
27. Feagan BG Greenberg GR Wild G et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005 352 2499 507.
28. Rankin JA Picarella DE Geba GP et al. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci U S A 1996 93 7821 5.
29. Dent LA Strath M Mellor AL Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990 172 1425 31.
30. Zimmermann N King NE Laporte J et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003 111 1863 74.
31. Mishra A Hogan SP Brandt EB Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 2001 107 83 90.
32. Hogan SP Mishra A Brandt EB Foster PS Rothenberg ME. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proc Natl Acad Sci USA 2000 97 6681 6.
33. Zimmermann N Conkright JJ Rothenberg ME. CC chemokine receptor-3 undergoes prolonged ligand-induced internalization. J Biol Chem 1999 274 12611 8.
34. Zimmermann N Hogan SP Mishra A et al. Murine eotaxin-2 a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J Immunol 2000 165 5839 46.
35. Pope SM Zimmermann N Stringer KF Karow ML Rothenberg ME. The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-Induced Pulmonary Eosinophilia. J Immunol 2005 175 5341 50.
36. Pope SM Fulkerson PC Blanchard C et al. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J Biol Chem 2005 280 13952 61.
37. Andrew DP Berlin C Honda S et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 1994 153 3847 61.
38. Mishra A Hogan SP Brandt EB Rothenberg ME. Peyer's patch eosinophils identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin. Blood 2000 96 1538 44.
39. Sriramarao P DiScipio RG Cobb RR et al. VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow. Blood 2000 95 592 601.
40. Justice JP Borchers MT Crosby JR et al. Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol 2003 284 L169 78.
41. Wan HC Lazarovits AI Cruikshank WW Kornfeld H Center DM Weller PF. Expression of alpha 4 beta 7 integrin on eosinophils and modulation of alpha 4-integrin-mediated eosinophil adhesion via CD4. Int Arch Allergy Immunol 1995 107 343 4.
42. Jagels MA Daffern PJ Zuraw BL Hugli TE. Mechanisms and regulation of polymorphonuclear leukocyte and eosinophil adherence to human airway epithelial cells. Am J Respir Cell Mol Biol 1999 21 418 27.
43. Liu LY Sedgwick JB Bates ME et al. Decreased expression of membrane IL-5 receptor alpha on human eosinophils II. IL-5 down-modulates its receptor via a proteinase-mediated process. J Immunol 2002 169 6459 66.
44. Liu LY Jarjour NN Busse WW Kelly EA. Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. J Allergy Clin Immunol 2003 112 556 62.
45. Liu LY Sedgwick JB Bates ME et al. Decreased expression of membrane IL-5 receptor alpha on human eosinophils I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. J Immunol 2002 169 6452 8.
46. Sedgwick JB Calhoun WJ Vrtis RF Bates ME McAllister PK Busse WW. Comparison of airway and blood eosinophil function after in vivo antigen challenge. J Immunol 1992 149 3710 8.
47. Hartnell A Robinson DS Kay AB Wardlaw AJ. CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines. Immunology 1993 80 281 6.
48. Yamamoto H Sedgwick JB Vrtis RF Busse WW. The effect of transendothelial migration on eosinophil function. Am J Respir Cell Mol Biol 2000 23 379 88.
49. Duez C Dakhama A Tomkinson A et al. Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge. J Allergy Clin Immunol 2004 114 820 5.
50. Danese S De la Rue SA Gasbarrini A. Antibody to alpha4beta7 integrin for ulcerative colitis. N Engl J Med 2005 353 1180 1 author reply 1180-1181.