Physiologically-based pharmacokinetic modeling of genistein in rats, part I: Model development

Risk Analysis

Volumn 26, Issue 2, 2006, Pages 483-500

  Schlosser, Paul M ^a,d   Borghoff, Susan J ^a   Coldham, Nicholas G ^b   David, John A ^a,c   Ghosh, Sujit K ^c  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Endocrine active; Genistein; PBPK; Phytoestrogen; Rat

Indexed keywords

GENETIC ENGINEERING; HORMONES; MATHEMATICAL MODELS; PHYSIOLOGICAL MODELS;

ENDOCRINE-ACTIVE; GENISTEIN; PBPK; PHYTOESTROGEN; RAT;

PHARMACOKINETICS;

GENISTEIN; PHYTOESTROGEN; PLASMA PROTEIN;

BIOCHEMISTRY; MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT; CALIBRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; ENTEROHEPATIC CIRCULATION; EXPERIMENTAL MODEL; FEMALE; GASTROINTESTINAL TRACT; MALE; NONHUMAN; RAT; TARGET ORGAN;

ANIMALS; BLOOD PROTEINS; FEMALE; GENISTEIN; HUMANS; MALE; MODELS, BIOLOGICAL; PHYTOESTROGENS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RISK; TISSUE DISTRIBUTION;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33645288581     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2006.00743.x     Document Type: Article

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