Embryonic stem-cell gametes: The new frontier in human reproduction

Human Reproduction

Volumn 21, Issue 4, 2006, Pages 857-863

  Master, Zubin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Assisted human reproduction; Embryonic stem cells; Nuclear transfer; Reproductive liberty; Scientific and social value

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; GAMETE; GENE MUTATION; HAPLOIDY; HUMAN; HUMAN CELL; INDEPENDENCE; INFERTILITY THERAPY; MEDICAL EDUCATION; MEDICAL ETHICS; MEDICAL RESEARCH; PHYSICAL DISEASE; POPULATION GENETICS; PSYCHOLOGICAL ASPECT; RISK BENEFIT ANALYSIS; SOCIAL ASPECT;

EID: 33645280872     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei430     Document Type: Article

References (90)

1. Anteby I, Cohen E, Anteby E and BenEzra D (2001) Ocular manifestations in children born after in vitro fertilization. Arch Ophthalmol 119,1525-1529.
2. Baschat AA, Schwinger E and Diedrich K (1996) Debate. Assisted reproductive techniques - are we avoiding the genetic issues? Hum Reprod 11,926-928.
3. Bauwens C, Yin T, Dang S, Peerani R and Zandstra PW (2005) Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: Oxygen-mediated enhancement of cardiomyocyte output. Biotechnol Bioeng 90,452-461.
4. Betts D, Bordignon V, Hill J, Winger Q, Westhusin M, Smith L and King W (2001) Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci U S A 98,1077-1082.
5. Boiani M, Eckardt S, Scholer HR and McLaughlin KJ (2002) Oct4 distribution and level in mouse clones: Consequences for pluripotency. Genes Dev 16,1209-1219.
6. Bonduelle M, Aytoz A, Van Assche E, Devroey P, Liebaers I and Van Steirteghem A (1998) Incidence of chromosomal aberrations in children born after assisted reproduction through intracytoplasmic sperm injection. Hum Reprod 13,781-782.
7. Bonduelle M, Van Assche E, Joris H, Keymolen K, Devroey P, Van Steirteghem A and Liebaers I (2002) Prenatal testing in ICSI pregnancies: Incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Hum Reprod 17,2600-2614.
8. Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC and Jaenisch R (2003) Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 130,1673-1680.
9. Brewaeys A, Ponjaert I, Van Hall EV and Golombok S (1997) Donor insemination: Child development and family functioning in lesbian mother families. Hum Reprod 12,1349-1359.
10. Buchanan A, Brock DW, Daniels N and Wilker D (2000) From Chance to Choice Genetics and Justice. Cambridge University Press, New York, NY, pp. 204-213.
11. Cibelli JB, Campbell KH, Seidel GE, West MD and Lanza RP (2002) The health profile of cloned animals. Nat Biotechnol 20,13-14.
12. Clark AT, Bodnar MS, Fox M, Rodriguez RT, Abeyta MJ, Firpo MT and Pera RA (2004) Spontaneous differentiation of germ cells from human embryonic stem cells in vitro. Hum Mol Genet 13,727-739.
13. Cohen CB (2000) 'Give me children or I shall die!': New reproductive technologies and harm to children. In Boetzkes, E and Waluchow, WJ (eds), Readings in Health Care Ethics, Broadview Press, Ltd., New York, NY, pp. 199-210.
14. Colpin H and Soenen S (2002) Parenting and psychosocial development of IVF children: A follow-up study. Hum Reprod 17,1116-1123.
15. Cox GF, Burger J, Lip V, Mau UA, Sperling K, Wu BL and Horsthemke B (2002) Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet 71,162-164.
16. Cruysberg JR, Moll AC and Imhof SM (2002) Bilateral sporadic retinoblastoma in a child born after in vitro fertilization. Arch Ophthalmol 120,1773-1774.
17. Dang SM, Gerecht-Nir S, Chen J, Itskovitz-Eldor J and Zandstra PW (2004) Controlled, scalable embryonic stem cell differentiation culture. Stem Cells 22,275-282.
18. Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E and Reik W (2001) Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos. Proc Natl Acad Sci U S A 98,13734-13738.
19. DeBaun MR, Niemitz EL and Feinberg AP (2003) Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet 72,156-160.
20. Dennis C (2003) Developmental biology: Synthetic sex cells. Nature 424,364-366.
21. Edwards JL, Schrick FN, McCracken MD, van Amstel SR, Hopkins FM, Welborn MG and Davies CJ (2003) Cloning adult farm animals: A review of the possibilities and problems associated with somatic cell nuclear transfer. Am J Reprod Immunol 50,113-123.
22. Eggan K, Akutsu H, Hochedlinger K, Rideout W III, Yanagimachi R and Jaenisch R (2000) X-Chromosome inactivation in cloned mouse embryos. Science 290,1578-1581.
23. Engel W, Murphy D and Schmid M (1996) Are there genetic risks associated with microassisted reproduction? Hum Reprod 11,2359-2370.
24. Ferraris S, Silengo M, Ponzone A and Perugini L (1999) Goldenhar anomaly in one of triplets derived from in vitro fertilization. Am J Med Genet 84,167-168.
25. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K and Daley GQ (2004) Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 427,148-154.
26. Gerecht-Nir S, Cohen S and Itskovitz-Eldor J (2004) Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation. Biotechnol Bioeng 86,493-502.
27. Gicquel C, Gaston V, Mandelbaum J, Siffroi JP, Flahault A and Le Bouc Y (2003) In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet 72,1338-1341.
28. Golombok S (2005) Unusual families. Reprod Biomed Online 10 (Suppl. 1),9-12.
29. Golombok S, Cook R, Bish A and Murray C (1995) Families created by the new reproductive technologies: Quality of parenting and social and emotional development of the children. Child Dev 66,285-298.
30. Golombok S, MacCallum F and Goodman E (2001) The "test-tube" generation: Parent-child relationships and the psychological well-being of in vitro fertilization children at adolescence. Child Dev 72,599-608.
31. Golombok S, Spencer A and Rutter M (1983) Children in lesbian and single-parent households: Psychosexual and psychiatric appraisal. J Child Psychol Psychiatry 24,551-572.
32. Hansen M, Kurinczuk JJ, Bower C and Webb S (2002) The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 346,725-730.
33. Harris J (2005) Reproductive liberty, disease and disability. Reprod Biomed Online 10 (Suppl. 1),13-16.
34. Hewitson L (2004) Primate models for assisted reproductive technologies. Reproduction 128,293-299.
35. Hochedlinger K and Jaenisch R (2003) Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med 349,275-286.
36. Hubner K, Fuhrmann G, Christenson LK, Kehler J, Reinhold R, De La FR, Wood J, Strauss JF III, Boiani M and Scholer HR (2003) Derivation of oocytes from mouse embryonic stem cells. Science 300,1251-1256.
37. Human Fertilisation and Embryology Authority (HFEA): Donor Anonymity 2005 (http://www.hmso.gov.uk/acts/acts1990/Ukpga_19900037_en_1.htm).
38. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR and Jaenisch R (2002) Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A 99,12889-12894.
39. Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM III, Biniszkiewicz D, Yanagimachi R and Jaenisch R (2001) Epigenetic instability in ES cells and cloned mice. Science 293,95-97.
40. Hwang WS, Roh SI, Lee BC, Kang SK, Kwon DK, Kim S, Kim SJ, Park SW, Kwon HS, Lee CK et al. (2005) Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science 308,1777-1783.
41. Hwang WS, Ryu YJ, Park JH, Park ES, Lee EG, Koo JM, Jeon HY, Lee BC, Kang SK, Kim SJ et al. (2004) Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 303,1669-1674.
42. Johnson MD (1998) Genetic risks of intracytoplasmic sperm injection in the treatment of male infertility: Recommendations for genetic counseling and screening. Fertil Steril 70,397-411.
43. Kang YK, Koo DB, Park JS, Choi YH, Chung AS, Lee KK and Han YM (2001) Aberrant methylation of donor genome in cloned bovine embryos. Nat Genet 28,173-177.
44. Kang YK, Park JS, Koo DB, Choi YH, Kim SU, Lee KK and Han YM (2002) Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos. EMBO J 21,1092-1100.
45. Kim ED, Bischoff FZ, Lipshultz LI and Lamb DJ (1998) Genetic concerns for the subfertile male in the era of ICSI. Prenat Diagn 18,1349-1365.
46. Kurinczuk JJ (2003) Safety issues in assisted reproduction technology. From theory to reality - just what are the data telling us about ICSI offspring health and future fertility and should we be concerned? Hum Reprod 18,925-931.
47. Lacham-Kaplan O, Chy H and Trounson A (2005) Testicular cell conditioned medium supports differentiation of embryonic stem (ES) cells into ovarian structures containing oocytes. Stem Cells. in press.
48. Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N et al. (2000) Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288,665-669.
49. Lippman A, Newman SA, Testa G and Harris J (2005) The Ethics of Deriving Gametes from ES Cells. Science 307,515c-517c.
50. MacCallum F and Golombok S (2004) Children raised in fatherless families from infancy: A follow-up of children of lesbian and single heterosexual mothers at early adolescence. J Child Psychol Psychiatry 45,1407-1419.
51. Maher ER (2005) Imprinting and assisted reproductive technology. Hum Mol Genet, 14 Spec 1,R133-R138.
52. Maher ER, Brueton LA, Bowdin SC, Luharia A, Cooper W, Cole TR, Macdonald F, Sampson JR, Barratt CL, Reik W et al. (2003) Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet 40,62-64.
53. Master Z (2005) Can we really bypass the moral debate for embryo research? Am J Bioeth 5,27-28.
54. Mathews TJ and Hamilton BE (2002) Mean Age of Mother, 1970-2000. Natl Vital Stat Rep 51,1-16.
55. Meschede D, Lemcke B, Exeler JR, De Geyter C, Behre HM, Nieschlag E and Horst J (1998) Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection - prevalence, types, sex distribution and reproductive relevance. Hum Reprod 13,576-582.
56. Miyashita N, Shiga K, Yonai M, Kaneyama K, Kobayashi S, Kojima T, Goto Y, Kishi M, Aso H, Suzuki T et al. (2002) Remarkable differences in telomere lengths among cloned cattle derived from different cell types. Biol Reprod 66,1649-1655.
57. Moll AC, Imhof SM, Cruysberg JR, Schouten-van Meeteren AY, Boers M and van Leeuwen FE (2003) Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 361,309-310.
58. Moore KL, Persaud TVN and Shiota K (2000) Colour Atlas of Clinical Embryology. W.B. Saunders Company, Philadelphia, pp. 2, 4, 55.
59. National Center for Health Statistics (2004) Health, United States, 2004. Center for Disease Control and Prevention. US Department of Health and Human Services, pp. 9, 11, 207.
60. Newson AJ and Smajdor AC (2005) Artificial gametes: New paths to parenthood? J Med Ethics 31,184-186.
61. Ogonuki N, Inoue K, Yamamoto Y, Noguchi Y, Tanemura K, Suzuki O, Nakayama H, Doi K, Ohtomo Y, Satoh M et al. (2002) Early death of mice cloned from somatic cells. Nat Genet 30,253-254.
62. Olivennes F, Fanchin R, Ledee N, Righini C, Kadoch IJ and Frydman R (2002) Perinatal outcome and developmental studies on children born after IVF. Hum Reprod Update 8,117-128.
63. Pattinson SD and Caulfield T (2004) Variations and voids: The regulation of human cloning around the world. BMC Med Ethics 5,E9.
64. Pence GE (2004) Classic Cases in Medical Ethics Accounts of Cases that Have Shaped Medical Ethics, with Philosophical, Legal, and Historical Backgrounds. McGraw Hill, New York, NY, pp. 163-164.
65. Pickering SJ, Minger SL, Patel M, Taylor H, Black C, Burns CJ, Ekonomou A and Braude PR (2005) Generation of a human embryonic stem cell line encoding the cystic fibrosis mutation deltaF508, using preimplantation genetic diagnosis. Reprod Biomed Online 10,390-397.
66. Rideout WM III, Eggan K and nd Jaenisch R (2001) Nuclear cloning and epigenetic reprogramming of the genome. Science 293,1093-1098.
67. Robertson JA (1994) Children of Choice: Freedom and the New Reproductive Technologies. Princeton University Press, Princeton, NJ, pp. 15-42, 173-180.
68. Robertson JA (2004) Procreative liberty and harm to offspring in assisted reproduction. Am J Law Med 30,7-40.
69. Roesch C, Steinbicker V, Korb C, von Rohden L and Schmitt J (2001) Goldenhar anomaly in one triplet derived from intracytoplasmic sperm injection (ICSI). Am J Med Genet 101,82-83.
70. Simerly C, Dominko T, Navara C, Payne C, Capuano S, Gosman G, Chong KY, Takahashi D, Chace C, Compton D et al. (2003) Molecular correlates of primate nuclear transfer failures. Science 300,297.
71. Simerly C, Navara C, Hyun SH, Lee BC, Kang SK, Capuano S, Gosman G, Dominko T, Chong KY, Compton D et al. (2004) Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: Overcoming defects caused by meiotic spindle extraction. Dev Biol 276,237-252.
72. Steinbock B and McClamrock R (1994) When is birth unfair to the child? Hastings Cent Rep 24,15-21.
73. Stromberg B, Dahlquist G, Ericson A, Finnstrom O, Koster M and Stjernqvist K (2002) Neurological sequelae in children born after in-vitro fertilisation: A population-based study. Lancet 359,461-165.
74. Surani MA (2004) Stem cells: How to make eggs and sperm. Nature 427,106-107.
75. Sutcliffe AG, D'Souza SW, Cadman J, Richards B, McKinlay IA and Lieberman B (1995) Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Hum Reprod 10,3332-3337.
76. Testa G and Harris J (2004) Genetics. Ethical aspects of ES cell-derived gametes. Science 305,1719.
77. Testa G and Harris J (2005) Ethics and synthetic gametes. Bioethics 19,146-166.
78. Tian XC, Xu J and Yang X (2000) Normal telomere lengths found in cloned cattle. Nat Genet 26,272-273.
79. Toyooka Y, Tsunekawa N, Akasu R and Noce T (2003) Embryonic stem cells can form germ cells in vitro. Proc Natl Acad Sci U S A 100,11457-11462.
80. Vogel G (2003a) Biotechnology. Sheep fail to produce golden fleece. Science 300,2015-2016.
81. Vogel G (2003b) Embryonic stem cells. Scientists make sperm in a dish. Science 302,1875.
82. Vogel G (2003c) Stem cells. Oocytes spontaneously generated. Science 300,721.
83. Vogt PH and Fernandes S (2003) Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis? APMIS 111,115-126.
84. Wakayama T, Shinkai Y, Tamashiro KL, Niida H, Blanchard DC, Blanchard RJ, Ogura A, Tanemura K, Tachibana M, Perry AC et al. (2000) Cloning of mice to six generations. Nature 407,318-319.
85. Weiss R (2003) Development in mice raises issues for human reproduction. Washington Post, The Washington Post Company A12.
86. West JA and Daley GQ (2004) In vitro gametogenesis from embryonic stem cells. Curr Opin Cell Biol 16,688-692.
87. Westphal SP (2003) The next IVF revolution? New Sci 178,4-5.
88. Wilmut I (2002) Are there any normal cloned mammals? Nat Med 8,215-216.
89. Wrenzycki C, Lucas-Hahn A, Herrmann D, Lemme E, Korsawe K and Niemann H (2002) In vitro production and nuclear transfer affect dosage compensation of the X-linked gene transcripts G6PD, PGK, and Xist in preimplantation bovine embryos. Biol Reprod 66,127-134.
90. Yu VY (1998) Assisted reproduction technology, multiple births, and adverse perinatal outcome. Croat Med J 39,208-211.