Gangliosides of the nuclear membrane: A crucial locus of cytoprotective modulation

Journal of Cellular Biochemistry

Volumn 97, Issue 5, 2006, Pages 893-903

  Ledeen, Robert W ^a   Wu, Gusheng ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Cytoprotection by nuclear exchanger GM1; Gangliosides; GM1 sodium calcium exchanger complex; Nuclear calcium; Nuclear membrane; Sodium calcium exchanger

Indexed keywords

CALCIUM ION; GANGLIOSIDE; GANGLIOSIDE GD 1A; GANGLIOSIDE GM1; KAINIC ACID; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; CELL PROTECTION; CELL TYPE; CONTROLLED STUDY; EMBRYO; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SODIUM CALCIUM EXCHANGE;

ANIMALS; CALCIUM; CELL NUCLEUS; CYTOPROTECTION; G(M1) GANGLIOSIDE; G(M2) GANGLIOSIDE; GANGLIOSIDES; GANGLIOSIDOSIS, GM1; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NUCLEAR ENVELOPE; RATS; SODIUM-CALCIUM EXCHANGER;

ANIMALIA;

EID: 33645237744     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20731     Document Type: Article

References (64)

1. Albi E, Viola Magni MP. 2004. The role of the intranuclear lipids. Biol Cell 96:657-667.
2. Al-Mohanna FA, Caddy KWT, Bolsover SR. 1994. The nucleus is insulated from large cytosolic calcium ion changes. Nature 367:745-750.
3. Badminton MN, Kendall JM, Rembold CM, Campbell AK. 1998. Current evidence suggests independent regulation of nuclear calcium. Cell Calcium 23:79-86.
4. Blaustein MP, Lederer WJ. 1999. Sodium/calcium exchange: Its physiological implications. Physiol Rev 79: 763-854.
5. Copani A, Melchiorri D, Caricasole A, Martini F, Sale P, Carnevale R, Gradini R, Sortino MA, Lenti L, De Maria R, Nicoletti F. 2002. β-Amyloid-induced synthesis of the ganglioside Gd3 is a requisite for cell cycle reactivation and apoptosis in neurons. J Neurosci 22:3963-3968.
6. 2+ channel. J Neurosci Res 69: 669-680.
7. + gradients in hepatocyte nuclei. J Membr Biol 187:97-115.
8. Gerasimenko O, Gerasimenko J. 2004. New aspects of nuclear calcium signaling. J Cell Sci 117:3087-3094.
9. 2+ from the nuclear envelope. Cell 80:439-444.
10. 2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol 163:271-282.
11. Gilchrist JSC, Pierce GN. 1993. Identification and purification of a calcium-binding protein in hepatic nuclear membranes. J Biol Chem 268:4291-4299.
12. Gillard BK, Thurmon LT, Marcus DM. 1993. Variable subcellular localization of glycoshpingolipids. Glycobiol 3:57-67.
13. Hakomori S-I. 2001. Traveling for the glycosphingolipid path. Glycoconj J 17:627-647.
14. 2+ exchanger in rat astrocytes and neurons by PKA. J Neurosci 18:4833-4841.
15. Humbert J-P, Matter N, Artault JC, Köppler P, Malviya AN. 1996. Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. J Biol Chem 271:478-485.
16. Irvine RF. 2003. Nuclear lipid signalling. Nature Rev Mol Cell Biol 4:349-361.
17. Katoh N, Kira T, Yuasa A. 1993. Protein kinase C substrates and ganglioside inhibitors in bovine mammary nuclei. J Dairy Sci 76:3400-3409.
18. Keenan TW, Morré DJ, Huang CM. 1972. Distribution of gangliosides among subcellular fractions from rat liver and bovine mammary gland. FEBS Lett 24:204-208.
19. 2+ exchanger. J Biol Chem 269: 5145-5149.
20. 3H]tetrakisphosphate binding sites on rat liver nuclei. J Biol Chem 268: 26248-26252.
21. Kozireski-Chuback D, Wu G, Ledeen RW. 1999. Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. Devel Brain Res 115:201-208.
22. Ledeen RW. 1989. Biosynthesis, metabolism, and biological effects of gangliosides. In: Margolis RU, Margolis RK, editors. Neurobiology of glycoconjugates. New York: Plenum. pp. 43-83.
23. Ledeen RW, Wu G. 1992. Ganglioside function in the neuron. Trends Glycosci Glycotechnol 4:174-187.
24. Ledeen RW, Wu G. 2002. Ganglioside function in calcium homeostasis and signaling. Neurochem Res 27:637-647.
25. Ledeen RW, Wu G. 2004. Nuclear lipids: Key signaling effectors in the nervous system and other tissues. J Lipid Res 45:1-8.
26. Ledeen RW, Parsons SM, Diebler MF, Sbaschnig-Agler M, Lazareg S. 1988. Gangliosides composition of synaptic vesicles from Torpedo electric organ. J Neurochem 51: 1465-1469.
27. Ledeen RW, Wu G, Lu Z-H, Kozireski-Chubak DF, Fang Y. 1998. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new findings. Ann NY Acad Sc 845:161-175.
28. Lewis RS. 2001. Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 19:487-521.
29. Manev H, Favaron M, Vicini S, Guidotti A, Costa E. 1990. Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: Protection by synthetic derivatives of endogenous sphingolipids. J Pharmacol Exp Ther 252:419-427.
30. Maraldi NM, Zini N, Santi S, Ognibene A, Rizzoli R, Mazzotti G, Manzoli FA. 1998. Cytochemistry of the functional domains of the nucleus in normal and in pathological conditions. Eur J Histochem 42:41-53.
31. Mattson MP, Chan SL. 2003. Calcium orchestrates apoptosis. Nat Cell Biol 5:1041-1043.
32. Matyas GR, Morre DJ. 1987. Subcellular distribution and biosynthesis of rat liver gangliosides. Biochim Biophys Acta 921:599-614.
33. Misasi R, Sorice M, Garofalo T, Griggi T, Campana WM, Giammatteo M, Pavan A, Hiraiwa M, Pontieri GM, O'Brien JS. 1998. Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neural cells. J Neurochem 71:2313-2321.
34. Mutoh T, Tokuda A, Miyadai T, Hamaguchi M, Fujiki N. 1995. Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc Natl Acad Sci USA 92:5087-5091.
35. Parijs LV, Abbas AK. 1998. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science 280:243-248.
36. Parkinson ME, Smith CG, Garland PB, van Heyningen S. 1989. Identification of cholera toxin-binding sites in the nucleus of intestinal epithelial cells. FEBS Lett 242:309-313.
37. Petersen OH, Gerasimenko OV, Gerasimenko JV, Mogami H, Tepikin AV. 1998. The calcium store in the nuclear envelope. Cell Calcium 23:87-90.
38. Philipson KD, Nicoll DA. 2000. Sodium-calcium exchange: A molecular perspective. Annu Rev Physiol 62:111-133.
39. 2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat. Am J Physiol 272:C1250-C1261.
40. Saito M, Sugiyama K. 2002. Characterization of nuclear gangliosides in rat brain: Concentration, composition, and developmental changes. Arch Biochem Biophys 398: 153-159.
41. Saito M, Fronda LL, Yu RK. 1996. Sialidase activity in nuclear membranes of rat brain. J Neurochem 66:2205-2208.
42. Saito M, Kitamura H, Sugiyama K. 2001. Occurrence of gangliosides in the common squid and pacific octopus among protostomia. Biochim Biophys Acta 1511:271-280.
43. 2+ exchanger. J Biol Chem 275:182-188.
44. Smirnova GP, Kochetkov NK. 1980. A novel sialoglycolipid from hepatopancreas of the starfish Patiria pectinifera. Biochim Biophys Acta 618:486-495.
45. Sonnino S, Ghidoni R, Masserini M, Aport F, Tettamanti G. 1981. Changes in rabbit brain cytosolic and membrane-bound gangliosides during prenatal life. J Neurochem 36:227-232.
46. 3 receptor channels. Neuron 14:163-167.
47. 2+ stores in intact mammalian cells. J Gen Physiol 113:239-248.
48. Sugita M. 1979. Studies of the glycosphingolipids of the starfish Asterina pectinifera. J Biochem 86:765-772.
49. Tamiya-Koizumi K. 2002. Nuclear lipid metabolism & signaling. J Biochem 132:13-22.
50. Thurneysen T, Nicoll DA, Philipson KD, Porzig H. 2002. Sodium/calcium exchanger subtypes NCX1, NCX2, and NCX3 show cell-specific expression in rat hippocampus cultures. Mol Brain Res 107:145-156.
51. 2-terminal protein. Cell Calcium 30:191-198.
52. Weiss A, Imboden J, Shoback D, Stobo J. 1984. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci USA 81:4169-4173.
53. Wu G, Ledeen RW. 1994. Gangliosides as modulators of neuronal calcium. Prog Brain Res 101:101-112.
54. Wu G, Lu Z-H, Ledeen RW. 1995a. Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane. J Neurosci 15:3739-3746.
55. Wu G, Lu Z-H, Ledeen RW. 1995b. GM1 ganglioside in the nuclear membrane modulates nuclear calcium homeostasis during neurite outgrowth. J Neurochem 64:1419-1422.
56. Wu G, Xie X, Lu Z-H, Ledeen RW. 2001. Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium. Proc Natl Acad Sci USA 98:307-312.
57. Wu G, Lu Z, Ledeen RW. 2004a. Role of GM1 ganglioside in operation of TRPC5 calcium channels. J Neurochem (Abstr.) 90:90.
58. Wu G, Lu Z-H, Xie X, Ledeen RW. 2004b. Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: Rescue by GM1 and LIGA20. Glycoconj J 21:305-313.
59. Wu G, Lu Z-H, Wang J, Wang Y, Xie X, Meyenhofer MF, Ledeen RW. 2005. Enhanced susceptibility to kainite-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides. Protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci 25:11014-11022.
60. Xie X, Wu G, Lu Z-H, Ledeen RW. 2002. Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside. J Neurochem 81:1185-1195.
61. Xie X, Wu G, Lu Z-H, Rohowsky-Kochan C, Ledeen RW. 2004a. Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: Nature of exchanger-GM1 interaction. Neurochem Res 29: 2135-2146.
62. Xie X, Wu G, Ledeen RW. 2004b. C6 cells express a sodium-calcium exchanger/GM1 complex in the nuclear envelope but have no exchanger in the plasma membrane: Comparison to astrocytes. J Neurosci Res 76:363-375.
63. Yu RK, Saito M. 1989. Structure and localization of gangliosides. In: Margolis RU, Margolis RK, editors. Neurobiology of glycoconjugates. New York: Plenum. pp. 1-42.
64. Zvezdina ND, Sadykova KA, Martynova LE, Prokazova NV, Mikhailov AT, Buznikov GA, Bergelson LD. 1989. Gangliosides of sea urchin embryos. Eur J Biochem 186:189-194.