High throughput metabolic stability screen for lead optimization in drug discovery

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 833, Issue 2, 2006, Pages 165-173

  Tong, Xinchun S ^a   Xu, Suoyu ^a   Zheng, Song ^a   Pivnichny, James V ^a   Martin, Jesus ^a   Dufresne, Claude ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automation; High throughput; Metabolic stability

Indexed keywords

DATA PROCESSING; FLUID DYNAMICS; LEAD; METABOLISM; OPTIMIZATION; PURIFICATION; THERMAL CONDUCTIVITY;

BIOMEK FX LIQUID HANDLING SYSTEM; HIGH THROUGHPUT; METABOLIC STABILITY;

DRUG PRODUCTS;

ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; INCUBATION TIME; INCUBATOR; INFORMATION PROCESSING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MICROSOME; NONHUMAN; PIPETTE; PRIORITY JOURNAL; PURIFICATION; THERMAL CONDUCTIVITY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG DESIGN; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; REPRODUCIBILITY OF RESULTS;

EID: 33645213640     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.01.037     Document Type: Article

References (28)

1. M. MacCoss, and T.A. Baillie Science 303 2004 1810
2. J. Wang, and L. Urban Drug Discov. World 2004 73
3. A.F. Nassar, and R.E. Talaat Drug Discov. Today 9 2004 317
4. A.F. Nassar, A.M. Kamel, and C. Clarimont Drug Discov. Today 9 2004 1020
5. C.M. Masimirembwa, U. Bredberg, and T.B. Andersson Clin. Pharmacokinet. 42 2003 515
6. Y.Y. Lau, G. Krishna, N.P. Yumibe, D.E. Grotz, E. Sapidou, L. Norton, I. Chu, C. Chen, a.D. Soares, and C. Lin Pharm. Res. 19 2002 1606
7. J.H. Lin Drug Metab. Dispos. 26 1998 1202
8. Th. Lave, S. Dupin, C. Schmitt, R.C. Chou, D. Jaeck, and Ph. Coassolo J. Pharm. Sci. 86 1997 584
9. R. Scott Obach Drug Metab. Dispos. 27 1999 1350
10. Y. Naritomi, S. Terashita, S. Kimura, A. Suzuki, A. Kagayama, and Y. Sugiyama Drug Metab. Dispos. 29 2001 1316
11. T. Iwatsubo, N. Hirota, T. Ooie, H. Suzuki, N. Shimada, K. Chiba, T. Ishizaki, C.E. Green, C.A. Tyson, and Y. Sugiyama Pharmacol. Ther. 73 1997 147
12. K. Ito, and J.B. Houston Pharm. Res. 21 2004 785
13. M. Reza Anari, and T.A. Baillie Drug Discov. Today 10 2005 711
14. C.L. Fernandez-Metzler, and R.C. King Curr. Top. Med. Chem. 1 2002 67 76
15. A.P. Watt, R.J. Mortishire-Smith, U. Gerhard, and S.T. Thomas Curr. Opin. Drug Discov. Dev. 1 2003 57 65
16. Y.Q. Xia, J.D. Miller, R. Bakhtiar, R.B. Franklin, and D.Q. Liu Rapid Commun. Mass Spectrom. 17 2003 1137
17. H.K. Lim, K.W. Chan, S. Sisenwine, and J.A. Scatina Anal. Chem. 73 2001 2140
18. L.E. Chovan, C. Black-Schaefer, P.J. Dandliker, and Y.Y. Lau Rapid Commun. Mass. Spectrom. 18 2004 3105
19. G. Hopfgartner, C. Husser, and M. Zell J. Mass Spectrom. 38 2003 138
20. W.Z. Shou, L. Magis, A.C. Li, W. Naidong, and M.S. Bryant J. Mass Spectrom. 40 2005 1347
21. A. Reddy, T. Heimbach, S. Freiwald, D. Smith, R. Winters, S. Michael, N. Surendran, and H. Cai J. Pharm. Biomed. Anal. 37 2005 319
22. D.B. Kassel Curr. Opin. Chem. Biol. 8 2004 339
23. K.M. Jenkins, R. Angeles, M.T. Quintos, R. Xu, D.B. Kassel, and R.A. Rourick J. Pharm. Biomed. Anal. 34 2004 989
24. L. Di, E.H. Kerns, N. Gao, S.Q. Li, Y. Huang, J.L. Bourassa, and D.M. Huryn J. Pharm. Sci. 93 2004 1537
25. R. Xu, C. Nemes, K.M. Jenkins, R.A. Rourick, D.B. Kassel, and C.Z.C. Liu J. Am. Soc. Mass Spectrom. 13 2002 155
26. K.L. Hanson, and C.P. Cartwright J. Clin. Microbiol. 39 2001 1975
27. W.A. Korfmacher, C.A. Palmer, C. Nardo, K. Dunn-Meynell, D. Grotz, K. Cox, C. Lin, C. Elicone, C. Liu, and E. Duchoslav Rapid Commun. Mass. Spectrom. 13 1999 901
28. J. Linget, and P. du Vignaud J. Pharm. Biomed. Anal. 19 1999 893