Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons

Neuropharmacology

Volumn 38, Issue 12, 1999, Pages 1903-1912

  Gronier, B ^a   Rasmussen, K ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Dopamine autoreceptor; Electrophysiology; Microiontophoresis; Muscarinic receptors; Pertussis toxin; Substantia nigra compacta; Ventral tegmental area

Indexed keywords

4 AMINOBUTYRIC ACID; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 BROMO CYCLIC AMP; APOMORPHINE; CYCLIC AMP DERIVATIVE; DOPAMINE; DOPAMINE RECEPTOR; EDELFOSINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEOMYCIN; OXOTREMORINE M; PERTUSSIS TOXIN; PHOSPHOLIPASE C INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG INHIBITION; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENCEPHALON; MICROIONTOPHORESIS; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE UNIT ACTIVITY; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ACTION POTENTIALS; ANIMALS; DOPAMINE AGONISTS; GTP-BINDING PROTEINS; IONTOPHORESIS; MALE; MESENCEPHALON; MUSCARINIC AGONISTS; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RATS; RECEPTORS, DOPAMINE; RECEPTORS, MUSCARINIC; VIRULENCE FACTORS, BORDETELLA;

EID: 0032711428     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00080-5     Document Type: Article

References (40)

1. Albert P.R., Neve K.A., Bunzow J.R., Civelli O. Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion. J. Biol. Chem. 265:1990;2098-2104.
2. Ashkenazi A., Winslow J.W., Peralta E.G., Peterson G.L., Schimerlik M.I., Capon D.J., Ramachandran J. An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science. 238:1987;672-675.
3. Ashkenazi, A., Peralta, E.G., Winslow, J.W., Ramachandran, J., Capon, D.J., 1989. Functional diversity of muscarinic receptor subtypes in cellular signal transduction and growth. Trends Pharmacol. Sci. Suppl., 16-22.
4. Buckley N.J., Bonner T.I., Buckley C.M., Brann M.R. Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol. 35:1989;469-476.
5. Bunney B.S., Aghajanian G.K., Roth R.H. Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature - New Biol. 245:1973;123-125.
6. Burford N.T., Tobin A.B., Nahorski S.R. Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3′,5′-cyclic monophosphate accumulation in Chinese hamster ovary cells. J. Pharmacol. Exp. Therap. 274:1995;134-142.
7. Chergui K., Charlety P.J., Akaoka H., Saunier C.F., Brunet J.L., Buda M., Svensson T.H., Chouvet G. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur. J. Neurosci. 5:1993;137-144.
8. Diamant S., Lev-Ari I., Uzielli I., Atlas D. Muscarinic agonists evoke neurotransmitter release: possible roles for phosphatidyl inositol bisphosphate breakdown products in neuromodulation. J. Neurochem. 51:1988;795-802.
9. Felder C.C. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J. 9:1995;619-625.
10. Fukuda K., Kubo T., Akiba I., Maeda A., Mishina M., Numa S. Molecular distinction between muscarinic acetylcholine receptor subtypes. Nature. 327:1987;623-625.
11. Gongora-Alfaro J.L., Hernandez-Lopez S., Martinez-Fong D., Brassart J.L., Aceves J. Activation of nigral M1 and M2 muscarinic receptors produces opposing effects on striatal 3,4-dihydroxyphenylacetic acid measured by in vivo voltammetry. Brain Res. 554:1991;329-332.
12. Grace A.A., Bunney B.S. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 1. Identification and characterization. Neuroscience. 10:1983;301-315.
13. Gronier B., Rasmussen K. Activation of midbrain presumed dopaminergic neurones by muscarinic cholinergic receptors: an in vivo electrophysiological study in the rat. Br. J. Pharmacol. 124:1998;455-464.
14. Gronier B., Rasmussen K., Perry K. Neuronal release of dopamine and serotonin in the ventral tegmental area and nucleus accumbens by muscarinic cholinergic receptors. Neurosci. Abstract. 141:1998;18.
15. Herrero I., Miras-Portugal M.T., Sanchez-Prieto J. Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals. Eur. J. Neurosci. 6:1994;115-120.
16. Innis R.B., Aghajanian G.K. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Res. 411:1987;139-143.
17. Johansen P.A., Hu X.T., White F.J. Relationship between D1 dopamine receptors, adenylate cyclase, and the electrophysiological responses of rat nucleus accumbens neurons. J. Neural Trans. - Gen. Section. 86:1991;97-113.
18. Jolkkonen M., van Giersbergen P.L., Hellman U., Wernstedt C., Karlsson E. A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors. FEBS Lett. 352:1994;91-94.
19. Jones, S.V., Heilman, C.J., Brann, M.R., 1991. Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol. 40, 242-247.
20. Jones S.V. Muscarinic receptor subtypes: modulation of ion channels. Life Sci. 52:1993;457-464.
21. Kashihara K., Varga E.V., Waite S.L., Roeske W.R., Yamamura H.I. Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes. Life Sci. 51:1992;955-971.
22. Katada T., Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proceed. Nat. Acad. Sci. USA. 79:1982;3129-3133.
23. Lacey M.G., Calabresi P., North R.A. Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors. J. Pharmacol. Exp. Ther. 253:1990;395-400.
24. Lai J., Waite S.L., Bloom J.W., Yamamura H.I., Roeske W.R. The m2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins. J. Pharmacol. Exp. Therap. 258:1991;938-944.
25. Liscovitch M. Phospholipase D: role in signal transduction and membrane traffic. J. Lipid Med. Cell Signalling. 14:1996;215-221.
26. Martin L.P., Waszczak B.L. D1 agonist-induced excitation of substantia nigra pars reticulata neurons: mediation by D1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway. J. Neurosci. 14:1994;4494-4506.
27. Mei L., Lai J., Yamamura H.I., Roeske W.R. Pharmacologic comparison of selected agonists for the M1 muscarinic receptor in transfected murine fibroblast cells (B82). J. Pharmacol. Exp. Therap. 256:1991;689-694.
28. Overton P., Clark D. Iontophoretically administered drugs acting at the N-methyl-D-aspartate receptor modulate burst firing in A9 dopamine neurons in the rat. Synapse. 10:1992;131-140.
29. Parker G.C., Rugg E.L., Winn P. Cholinergic stimulation of substantia nigra: abolition of carbachol-induced eating by unilateral 6-hydroxydopamine lesion of nigrostriatal dopamine neurones. Exp. Brain Res. 87:1991;597-603.
30. Pedder E.K., Eveleigh P., Poyner D., Hulme E.C., Birdsall N.J. Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes. Br. J. Pharmacol. 103:1991;1561-1567.
31. Powis G., Seewald M.J., Gratas C., Melder D., Riebow J., Modest E.J. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52:1992;2835-2840.
32. Ramkumar V., Stiles G.L. In vivo pertussis toxin administration: effects on the function and levels of Gi alpha proteins and their messenger ribonucleic acids. Endocrinology. 126:1990;1295-1304.
33. Redman R.S., Silinsky E.M. Decrease in calcium currents induced by aminoglycoside antibiotics in frog motor nerve endings. Br. J. Pharmacol. 113:1994;375-378.
34. Steketee J.D., Striplin C.D., Murray T.F., Kalivas P.W. Pertussis toxin in the A10 region increases dopamine synthesis and metabolism. J. Neurochem. 58:1992;811-816.
35. Tepper J.M., Sun B., Martin L.P., Creese I. Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo. J. Neurosci. 17:1997;2519-2530.
36. Wang S.Z., El-Fakahany E.E. Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists. J. Pharmacol. Exp. Ther. 266:1993;237-243.
37. Weiner D.M., Levey A.I., Brann M.R. Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proceed. Nat. Acad. Sci. USA. 87:1990;7050-7054.
38. Wolfe B.B. Subtype of muscarinic cholinergic receptors: ligand binding, functional studies and cloning. Brown J.H. The Muscarinic Receptors. 1989;125-150 Humana Press, Clifton, NJ.
39. Wu Y.L., Pei G., Fan G.H. Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins. Neuroreport. 9:1998;99-103.
40. Yeomans J.S. Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia. Neuropsychopharmacology. 12:1995;3-16.