Detailed analysis of the E2-IgM complex in hepatitis C-related type II mixed cryoglobulinaemia

Journal of Viral Hepatitis

Volumn 13, Issue 3, 2006, Pages 166-176

  Ferri, S ^a   Dal Pero, F ^a   Bortoletto, G ^a,c   Bianchi, F B ^b   Lenzi, M ^b   Alberti, A ^a,c   Gerotto, M ^a  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cryoglobulinaemia; EZ HVR1; HCV

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; VIRUS PROTEIN; VIRUS RNA;

ADULT; AGED; ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; BONE MARROW BIOPSY; CLINICAL ARTICLE; CRYOGLOBULINEMIA; CRYOPRECIPITATE; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; LIVER FIBROSIS; MALE; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOMATIC MUTATION; VIRUS CELL INTERACTION;

AGED; AMINO ACID SEQUENCE; ANTIGEN-ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGIONS; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HUMANS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; MUTATION; RNA, VIRAL; SEQUENCE ALIGNMENT; VIRAL ENVELOPE PROTEINS;

EID: 33645103443     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2005.00675.x     Document Type: Article

References (44)

1. Hoofnagle JH Hepatitis C: the clinical spectrum of disease Hepatology 1997 26 15S 20S
2. Agnello V Chung RT Kaplan LM A role for hepatitis C infection in type II cryoglobulinemia N Engl J Med 1992 327 1490 1495
3. Dammacco F Sansonno D Antibodies to hepatitis C virus in essential mixed cryoglobulinemia Clin Exp Immunol 1992 87 352 356
4. Brouet JC Clavuel JP Danon F et al. Biologic and clinical significance of cryoglobulins. A report of 86 cases Am J Med 1974 57 775 788
5. Lunel F Musset L Mixed cryoglobulinemia and hepatitis C virus infection Minerva Med 2001 92 35 42
6. Kayali Z Buckwold VE Zimmerman B Schmidt WN Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis Hepatology 2002 36 978 985
7. Silvestri F Pipan C Barillari G et al. Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders Blood 1996 87 4296 4301
8. Zuckerman E Zuckerman T Levine AM et al. Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma Ann Intern Med 1997 127 423 428
9. Quinn ER Chan CH Hadlock KG Foung SKH Flint M Levy S The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis Blood 2001 98 3745 3749
10. Hermine O Lefrere F Bronowicki JP et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection N Engl J Med 2002 347 89 94
11. Lenzi M Frisoni M Mantovani V et al. Haplotype HLA-B8-DR3 confers susceptibility to hepatitis C virus-related cryoglobulinemia Blood 1998 91 2062 2066
12. Gerotto M Sullivan DG Polyak SJ et al. Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C J Virol 1999 73 7241 7247
13. Puntoriero G Meola A Lahm A et al. Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants EMBO J 1998 17 13 3521 3533
14. Fais F Ghiotto F Hashimoto S et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors J Clin Invest 1998 102 8 1515 1522
15. H 51p1/VL kv 325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas Blood 1998 91 2433 2442
16. H genes are inherently susceptible to amino acid replacement Immunol Today 1994 15 367 373
17. Martin T Crouzier R Weber JC et al. Structure-function studies on a polireactive (natural) autoantibody. Polireactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain J Immunol 1994 152 5988 5996
18. Allander T Drakenberg K Beyene A et al. Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81 J Gen Virol 2000 81 2451 2459
19. De Re V De Vita S Marzotto A et al. Sequence analysis of the immonuglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphoma suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia Blood 2000 96 3578 3584
20. Ferri C Caracciolo F Zignego AL et al. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma Br J Hematol 1994 88 392 394
21. De Rosa G Gobbo ML De Renzo A et al. High prevalence of Hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy Am J Hematol 1997 55 77 82
22. Cresta P Musset L Cacoub P et al. Response to interferon alpha treatment and disappearance of cryoglobulinaemia in patients infected by hepatitis C virus Gut 1999 45 122 128
23. Giannelli F Moscarella S Giannini C et al. Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation Blood 2003 102 4 1196 1201
24. De Re V De Vita S Marzotto A Pre-malignant and malignant lymphoproliferations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process Int J Cancer 2000 87 211 216
25. Weng WK Levy S Hepatitis C virus (HCV) and lymphomagenesis Leuk Lymph 2003 44 7 1113 1120
26. Andrews DW Capra D Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype Proc Natl Acad Sci USA 1981 78 3799 3803
27. Newkirk MM Mageed RA Jefferis R et al. Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, Bor and Kas of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segment J Exp Med 1987 166 550 564
28. Newkirk MM Gram H Gunther FH et al. Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family J Clin Invest 1988 81 1511 1518
29. Silverman GJ Goldfien RD Chen P et al. Idiotypic and subgroup analysis of human monoclonal rheumatoid factors J Clin Invest 1988 82 469 475
30. Sasso H The rheumatoid factor response in the ethiology of mixed cryoglobulins associated with hepatitis C virus infection Ann Med Intern 2000 151 30 40
31. Victor K Randen I Thompspn K et al. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes J Clin Invest 1991 87 1603 1613
32. De Vita S De Re V Gasparotto D et al. Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma Arthritis Rheum 2000 43 1 94 102
33. Marasca R Vaccari P Luppi M et al. Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma Am J Pathol 2001 159 1 253 261
34. Goni F Chen PP Pons-Estel B Carson DA Frangione B Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity J Immunol 1985 135 6 4073 4079
35. Crouzier R Martin T Pasquali JL Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia J Immunol 1995 154 413 421
36. Crouzier R Martin T Pasquali JL Heavy chain variable region, light chain variable region and heavy chain CDR3 influences on the mono- and polireactvity and on the affinity of human monoclonal rheumatoid factors J Immunol 1995 154 4526 4535
37. Ni J Hembrador E Di Bisceglie AM et al. Accumulation of B lymphocytes with a naive resting phenotype in a subset of hepatitis C patients J Immunol 2003 170 3429 3439
38. Martell M Esteban JI Quer J et al. Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation J Virol 1994 68 5 3425 3436
39. Lawal Z Petrik J Wong VS Alexander GJ Allain JP Hepatitis C virus genomic variability in untreated and immunosuppressed patients Virology 1997 28 1 107 111
40. Ni YH Chang MH Chen PJ Lin HH Hsu HY Evolution of hepatitis C virus quasispecies in mothers and infants infected through mother-to-infant transmission J Hepatol 1997 26 5 967 974
41. Odeberg J Yun Z Sonnerborg A Bjoro K Uhlen M Lundeberg J Variation of hepatitis C virus hypervariable region 1 in immunocompromised patients J Infect Dis 1997 175 4 938 943
42. Toyoda H Fukuda Y Koyama Y Takamatsu J Saito H Hayakawa T Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus J Hepatol 1997 26 5 975 982
43. Booth JC Kumar U Webster D Monjardino J Thomas HC Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients Hepatology 1998 27 1 223 227
44. Gomez J Martell M Quer J Cabot B Esteban JI Hepatitis C viral quasispecies J Viral Hepat 1999 6 1 3 16 Review