Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus - Associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factorn - Producing cells that occur mainly in type II cryoglobulinemia

Blood

Volumn 96, Issue 10, 2000, Pages 3578-3584

  De Re, V ^a   De Vita, S ^a   Marzotto, A ^a   Rupolo, M ^a   Gloghini, A ^a   Pivetta, B ^a   Gasparotto, D ^a   Carbone, A ^a   Boiocchi, M ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN RECEPTOR; RHEUMATOID FACTOR;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CRYOGLOBULINEMIA; FEMALE; FRAMESHIFT MUTATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE PROLIFERATION; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0034670010     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.10.3578     Document Type: Article

References (46)

1. A new case of IgE myeloma
2. Lymphoproliferation in type II mixed cryoglobulinemia
3. Characterization of overt B-cell lymphomas in patients with hepatitis C virus infection
4. Hepatitis C virus infection: A new bridge between hematologists and gastroenterologists?
5. Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders
6. Hepatitis C virus, non-Hodgkin's, lymphomas and hepatocellular carcinoma
7. Hepatitis C virus infection in non-Hodgkin's B-cell lymphoma complicating mixed cryoglobulinaemia
8. Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia
9. Gastric mucosa as an additional extrahepatic localization of hepatitis C virus: Viral detection n gastric low-grade ymphoma associated with autoimmune disease and in chronic gastritis
10. Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglolbulinemia and neoplastic or non-neoplastic lymphoproliferation
11. Hepatitis C virus infection in subsets of neoplastic lymphoproliferations not associated with cryoglobulinemia
12. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia
13. Hepatitis C virus infection in mixed cryoglobulinemia and B-ceil non-Hodgkin's lymphoma: Evidence for a pathogenetic role
14. Clonal evolution of a follicular lymphoma: Evidence for antigen selection
15. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas
16. Premalignant and malignant lymphoprolifeations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process
17. Clonal evolution of B cells in transformation from low- to high-grade lymphoma
18. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection
19. Oligoclonal non-neoplastic B cell expansions is the key feature of type II mixed cryoglobulinemia
20. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
21. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypepetide hormones with radioimmunoassay antibodies
22. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)
23. The relevance of VDJ PCR protocols in detecting B-cell clonal expansion in lymphomas and other lymphoproliferative disorders
24. Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction
25. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
26. Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain
27. A role for hepatitis C virus infection in type II cryoglobulinemia
28. Hepatitis C virus infection, mixed cryoglobulinemia, and non-Hodgkin's lymphoma: An emerging picture
29. Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia
30. Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients
31. Human rheumatoid factor cross-idiotypes, IV: Studies on WA Xld-positive IgM without rheumatoid factor activity provide evidence that the WA Xld is not unique to rheumatoid factors and is distinct from the 17.109 and G6 Xlds
32. Clonal deletion of autospecific B lymphocytes
33. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
34. Peripheral deletion of self-reactive B cells
35. Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regions
36. The association of hepatitis C virus infection with monoclonal rheumatoid factors bearing the WA cross-idle-type: Implications for the etiopathogenesis and therapy of mixed cryoglobulinemia
37. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis
38. Mixed cryoglobulinemia cross-reactive idiotypes: Implications for the relationship of MC to rheumatic and lymphoproliferative diseases
39. Cellular origin of human B-cell lymphomas
40. Structural restriction in the heavy chain CDR3 of human rheumatoid factors
41. Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia. Evidence for somatic mutations and intraclonal diversity of the expressed VH region gene
42. Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjogren's syndrome
43. Malignant lymphoma in primary Sjogren's syndrome: A multicenter, retrospective, clinical study by the European Concerted Action on Sjogren's Syndrome
44. Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sjogren's syndrome) begin as non malignant antigen-selected expansions
45. Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage
46. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells