Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81

Journal of General Virology

Volumn 81, Issue 10, 2000, Pages 2451-2459

  Allander, T ^a   Drakenberg, K ^a   Beyene, A ^a   Rosa, D ^a   Abrignani, S ^a   Houghton, M ^a   Widell, A ^a   Grillner, L ^a   Persson, M A A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD81 ANTIGEN; EPITOPE; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1; RECOMBINANT ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

ADULT; ANIMAL CELL; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BINDING COMPETITION; BINDING SITE; BONE MARROW; CHO CELL; CONTROLLED STUDY; DONOR; ESCHERICHIA COLI; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION;

ANIMALIA; ESCHERICHIA COLI; HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0033804602     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-81-10-2451     Document Type: Article

References (41)

1. Patients infected with the same hepatitis C virus strain display different kinetics of the isolate-specific antibody response
2. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
3. Synthetic human antibodies: Selecting and evolving functional proteins
4. Assembly of combinatorial antibody libraries on phase surfaces: The gene III site
5. Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin
6. Dissection of human humoral immune response against hepatitis C virus E2 glycoprotein by repertoire cloning and generation of recombinant Fab fragments
7. A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals
8. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
9. Human monoclonal antibody Fab fragments cloned from combinatorial libraries: Potential usefulness in prevention and/or treatment of major human viral diseases
10. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
11. Formation of native hepatitis C virus glycoprotein complexes
12. Lack of protective immunity against reinfection with hepatitis C virus
13. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization
14. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
15. Incidence of hepatitis C in patients receiving different preparations of hepatitis B immunoglobulins after liver transplantation
16. Functional characterization of intracellular and secreted forms of a truncated hepatitis C virus E2 glycoprotein
17. Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1
18. Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties
19. High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C
20. Combinatorial immunoglobulin libraries in phage lambda
21. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus
22. Effect of immune globulin on the prevention of experimental hepatitis C virus infection
23. A test for clonal relatedness in a set of lymphocytes
24. HIV-1 antibody - Debris or virion?
25. Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning
26. Binding of hepatitis C virus to CD81
27. An inhibition enzyme immunoassay for estimating relative antibody affinity and affinity heterogeneity
28. Differential cytotoxic Tlymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
29. Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C
30. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells
31. Chimeric macaque/human Fab molecules neutralize simian immunodeficiency virus
32. Human antibodies from phage libraries: Neutralizing activity against human immunodeficiency virus type 1 equally improved after expression as Fab and IgG in mammalian cells
33. Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp70) hypervariable region 1 in viremic hepatitis C virus-infected patients
34. Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies
35. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses
36. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures
37. Characterization of the hepatitis C virus E2/NS1 gene product expressed mammalian cells
38. Genotyping of hepatitis C virus isolates by a modified polymerase chain reaction assay using type specific primers: Epidemiological applications
39. Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment
40. Early antibody response against hypervariable region 1 is associated with acute self-limiting infections of hepatitis C virus