Cardiomyocyte apoptosis in the ischemic and failing heart

Drug Discovery Today: Disease Mechanisms

Volumn 2, Issue 1, 2005, Pages 47-53

  Patten, Richard D ^a   Karas, Richard H ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BENZOTHIAZOL 2 YL[2 [[2 (3 PYRIDINYL)ETHYL]AMINO] 4 PYRIMIDINYL]ACETONITRILE; 4 [4 (4 FLUOROPHENYL) 1 (3 PHENYLPROPYL) 5 (4 PYRIDINYL) 1H IMIDAZOL 2 YL] 3 BUTYN 1 OL; AS 601245; CASPASE INHIBITOR; FAS LIGAND; IDN 1965; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N [(1,3 DIMETHYLINDOLE 2 CARBONYL)VALINYL] 3 AMINO 4 OXO 5 FLUOROPENTANOIC ACID; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; DISEASE COURSE; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HUMAN; MORBIDITY; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TARGETING; PUBLIC HEALTH; REVIEW; SIGNAL TRANSDUCTION;

EID: 33645099156     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2005.05.018     Document Type: Review

References (50)

1. American Heart Association Heart Disease and Stroke Statistics: 2005 Statistical Supplement 2005 American Heart Association pp. 1-60
2. P.M. Kang S. Izumo Apoptosis and heart failure: A critical review of the literature Circ. Res. 86 2000 1107-1113
3. N. Orike et. al. Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons J. Cell Biol. 154 2001 995-1006
4. J.M. Hare Oxidative stress and apoptosis in heart failure progression Circ. Res. 89 2001 198-200
5. D.R. Green J.C. Reed Mitochondria and apoptosis Science 281 1998 1309-1312
6. A. Ashkenazi V.M. Dixit Death receptors: Signaling and modulation Science 281 1998 1305-1308
7. N.A. Thornberry Y. Lazebnik Caspases: Enemies within Science 281 1998 1312-1316
8. J.C. Reed G. Paternostro Postmitochondrial regulation of apoptosis during heart failure Proc. Natl. Acad. Sci. USA 96 1999 7614-7616
9. S. Bialik et. al. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53 J. Clin. Invest. 100 1997 1363-1372
10. Z.Q. Zhao et. al. Reperfusion induces myocardial apoptotic cell death Cardiovasc. Res. 45 2000 651-660
11. E. Palojoki et. al. Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats Am. J. Physiol. Heart Circ. Physiol. 280 2001 H2726-H2731
12. T.A. Holly et. al. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo J. Mol. Cell. Cardiol. 31 1999 1709-1715
13. H. Yaoita et. al. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor Circulation 97 1998 276-281
14. K. Mani R.N. Kitsis Myocyte apoptosis: Programming ventricular remodeling J. Am. Coll. Cardiol. 41 2003 761-764
15. G. Olivetti et. al. Apoptosis in the failing human heart N. Engl. J. Med. 336 1997 1131-1141
16. A. Saraste et. al. Apoptosis in human acute myocardial infarction Circulation 95 1997 320-323
17. A. Baldi et. al. Apoptosis and post-infarction left ventricular remodeling J. Mol. Cell. Cardiol. 34 2002 165-174
18. L. Hofstra et. al. Visualisation of cell death in vivo in patients with acute myocardial infarction Lancet 356 2000 209-212
19. A. Abbate et. al. Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure J. Am. Coll. Cardiol. 41 2003 753-760
20. G. Condorelli et. al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat Circulation 99 1999 3071-3078
21. F. Sam et. al. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart Am. J. Physiol. Heart Circ. Physiol. 279 2000 H422-H428
22. J.M. Adams S. Cory The Bcl-2 protein family: Arbiters of cell survival Science 281 1998 1322-1326
23. T. Kadokami et. al. Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression J. Clin. Invest. 106 2000 589-597
24. D. Engel et. al. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression Am. J. Physiol. Heart Circ. Physiol. 287 2004 H1303-H1311
25. D. Wencker et. al. A mechanistic role for cardiac myocyte apoptosis in heart failure J. Clin. Invest. 111 2003 1497-1504
26. R.N. Kitsis D.L. Mann Apoptosis and the heart: A decade of progress J. Mol. Cell. Cardiol. 38 2005 1-2
27. R.S-Y. Foo et. al. Death begets failure in the heart J. Clin. Invest. 115 2005 565-571
28. A. Saraste et. al. Cardiomyocyte apoptosis and progression of heart failure to transplantation Eur. J. Clin. Invest. 29 1999 380-386
29. J. Narula et. al. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy Proc. Natl. Acad. Sci. USA 96 1999 8144-8149
30. R.D. Patten et. al. Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart J. Am. Coll. Cardiol. 45 2005 1419-1424
31. R.D. Patten et. al. 17{beta}-Estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling Circ. Res. 95 2004 692-699
32. M.T. Crow et. al. The mitochondrial death pathway and cardiac myocyte apoptosis Circ. Res. 95 2004 957-970
33. Y. Hayakawa et. al. Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of G{alpha}q transgenic mice Circulation 108 2003 3036-3041
34. Y. Chandrashekhar et. al. Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction J. Am. Coll. Cardiol. 43 2004 295-301
35. Ferrandi, C. et al. (2004) Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br. J. Pharmacol. 142, 953-960
36. F. See et. al. p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat J. Am. Coll. Cardiol. 44 2004 1679-1689
37. M. van Eickels et. al. 17-Beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction J. Am. Coll. Cardiol. 41 2003 2084-2092
38. P. Lee et. al. Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo Am. J. Physiol. Heart Circ. Physiol. 284 2003 H456-H463
39. Y. Li et. al. Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure Circ. Res. 95 2004 627-636
40. C-F. Peng et. al. Multiple independent mutations in apoptotic signaling pathways markedly decrease infarct size due to myocardial ischemia-reperfusion Circulation 104 2001 II-187
41. L.A. Kirshenbaum D. de Moissac The bcl-2 gene product prevents programmed cell death of ventricular myocytes Circulation 96 1997 1580-1585
42. S. Chatterjee et. al. Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure Circulation 106 2002 I-212-I-217
43. N. Weisleder et. al. Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy PNAS 101 2004 769-774
44. A.B. Gustafsson et. al. TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective Circulation 106 2002 735-739
45. C.P. Baines J.D. Molkentin STRESS signaling pathways that modulate cardiac myocyte apoptosis J. Mol. Cell. Cardiol. 38 2005 47-62
46. A. Brunet et. al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 1999 857-868
47. S. Pugazhenthi et. al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein J. Biol. Chem. 275 2000 10761-10766
48. W. Miao et. al. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo J. Mol. Cell. Cardiol. 32 2000 2397-2402
49. T. Matsui et. al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo Circulation 104 2001 330-335
50. O.F. Bueno et. al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice EMBO J. 19 2000 6341-6350