Tumour necrosis factor-α production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn's disease

Clinical and Experimental Immunology

Volumn 143, Issue 3, 2006, Pages 550-559

  Whittall, T ^a   Wang, Y ^a   Kelly, C G ^a   Thompson, R ^b   Sanderson, J ^b   Lomer, M ^b   Soon, S Y ^b   Bergmeier, L A ^e   Singh, M ^c   Lehner, T ^a,d  

^a GUY S HOSPITAL   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e NONE

Author keywords

Crohn's disease; Dendritic cells; HSP70; TNF

Indexed keywords

ARGINYLGLUTAMYLLYSYLGLUTAMINYLTYROSYLLEUCYLISOLEUCYLASPARAGINYLSERYL GLUTAMINE; CD40 ANTIGEN; CD40 LIGAND; HEAT SHOCK PROTEIN 70; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; LYSYLGLUTAMYLGLUTAMYLTHREONYLLYSYLLYSYLGLUTAMYLASPARAGINYLSERYL PHENYLALANYLGLUTAMYLMETHIONYLGLUTAMINYLLYSYLGLYCYLASPARTYLGLUTAMINYLASPARAGINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PEPTIDE DERIVATIVE; SERYLLEUCYLSERYLGLUTAMINYLPROLYLGLYCYLGLUTAMINYLLYSYLLEUCYLVALYLSERYL ASPARTYLSERYLTHREONYLGLUTAMYLPHENYLALANYLTHREONYLGLUTAMYLTHREONYLGLUTAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CIRCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DENDRITIC CELL; ELUTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE MUCOSA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ANTIGENS, CD40; CD40 LIGAND; COLITIS, ULCERATIVE; CROHN DISEASE; DENDRITIC CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, MUCOSAL; INTERLEUKIN-12; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MONOCYTES; PEPTIDE FRAGMENTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645059961     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03010.x     Document Type: Article

References (46)

1. Duchmann R Zeitz M Crohn's disease In Ogra PL Mestecky J Lamm ME Strober W Bienenstock J McGhee JR eds Mucosal immunology San Diego Academic Press 2000 1055 80
2. Bouma G Strober W The immunological and genetic basis of inflammatory bowel disease Nat Rev Immunol 2003 3 321 533
3. Mathew CG Lewis CM Genetics of inflammatory bowel disease: progress and prospects Hum Mol Genet 2004 13 161 8
4. Hampe J Frenzel H Mirza MM et al. Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p Proc Natl Acad Sci USA 2002 99 321 6
5. Sanderson JD Moss MT Tizard ML Hermon-Taylor J Mycobacterium paratuberculosis DNA in Crohn's disease tissue Gut 1992 33 890 6
6. Naser SA Ghobrial G Romero C Valentine JF Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease Lancet 2004 18 1039 44
7. Liu Y van Kruiningen HS West AB Cartun RW Cortot A Colombel JF Immunocytochemical evidence of listeria, E. coli, and streptococcus antigens in Crohn's disease Gastroenterology 1995 108 1369 404
8. Robertson D Sandler R Measles virus and Crohn's disease: a critical appraisal of the current literature Inflamm Bowel Dis 2001 7 51 7
9. Duchmann R Kaiser I Hermann E Mayet W Ewe K Zum M Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD) Clin Exp Immunol 1995 102 448 55
10. Ludwig D Stahl M Ibrahim ET et al. Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel disease Dig Dis Sci 1999 44 1440 7
11. Elsaghier A Prantera C Bothamley E Wilkins E Jindal S Ivanyi J Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins Clin Exp Immunol 1992 89 305 9
12. Pirzer U Schonhaar A Fleischer B Hermann E Meyer E Meyersum Buschenfelde K-H Reactivity infiltrating T lymphocytes with microbial antigens in Crohn's disease Lancet 1991 338 1238 9
13. Musch MW Ciancio MJ Sarge K Chang EB Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury Am J Physiol 1996 270 C429 36
14. Wischmeyer PE Musch MW Madonna MB Thisted R Chang EB Glutamine protects intestinal epithelial cells: role of inducible HSP70 Am J Physiol 1997 272 G879 84
15. Lehner T Bergmeier LA Wang Y et al. Heat shock proteins generate β-chemokines which function as innate adjuvants enhancing adaptive immunity Eur J Immunol 2000 30 594 603
16. Trinchieri G Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes Blood 1994 84 4006 27
17. Parronchi P Romagnani P Annunziato F et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease Am J Pathol 1997 150 823 32
18. Monteleone G Biancone L Marasco R et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells Gastroenterology 1997 112 1169 78
19. Kakazu T Hara J Matsumo T et al. Type 1 helper cell predominance in granulomas of Crohn's disease Am J Gastroenterol 1999 8 2149 55
20. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5 J Immunol 1996 157 1261 70
21. Breese EJ Michie CA Nicholls SW et al. Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease Gastroenterology 1994 106 1455 66
22. Reinecker H-C Steffen M Witthoeft T et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1β by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease Clin Exp Immunol 1993 94 174 81
23. Woywodt A Neustock P Kruse A et al. Cytokine expression in intestinal mucosal biopsies. In situ hybridisation of the mRNA for interleukin-1β, interleukin-6 and tumour necrosis factor-α in inflammatory bowel disease Eur Cytokine Netw 1994 5 387 95
24. Kollias G Douni E Kassiotis G Kontoyiannis D On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease Immunol Rev 1999 169 175 94
25. Targan SR Hanauer SB van Deventer SJ et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease Crohn's Disease cA2 Study Group. N Engl J Med 1997 337 1029 35
26. Rutgeerts P Van Assche G Vermeier S Optimizing anti-TNF treatment in inflammatory bowel disease Gastroenterology 2004 126 1593 610
27. Feldman M Maini RN Anti-TNF-α therapy of rheumatoid arthritis: what have we learned? Ann Rev Immunol 2001 19 163 96
28. Wang Y Kelly CG Karttunen JT et al. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines Immunity 2001 15 971 83
29. Wang Y Kelly CG Singh M et al. Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells and adjuvant function by the peptide binding fragment of heat shock protein 70 J Immunol 2002 169 2422 9
30. Wang Y Whittall T McGowan E et al. Identification of stimulating and inhibitory epitopes within the HSP70 molecule which modulate cytokine production and maturation of dendritic cells J Immunol 2005 174 3306 16
31. Mehlert A Young DB Biochemical and antigenic characterization of the Mycobacterial tuberculosis 71 kD antigen, a member of the 70 kD heat-shock protein family Mol Microbiol 1989 3 125 30
32. Sallusto F Lanzavecchia A Mobilizing dendritic cells for tolerance, priming and chronic inflammation J Exp Med 1999 189 611
33. Steinman RM Hawiger D Nussenzweig MC Tolerogenic dendritic cells In Paul WE Fathman CG Glimcher LH eds Annual review of immunology vol. 21. Palo Alto Non-profit publishers 2003 685- 711
34. Moser M Dendritic cells in immunity and tolerance - do they display opposite function [Review]. Immunity 2003 19 5 8
35. Wright SD Ramos RA Tobias TS Ulevitch RJ Mathison JC CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 1990 249 1431 3
36. Danese S Sans M Fiocchi C The CD40/CD40L costimulatory pathway in inflammatory bowel disease Gut 2004 53 1035 43
37. Battaglia E Biancone L Resegotti A Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's disease Am J Gastroenterol 1999 94 3279 84
38. Gelbmann CM Leeb SN Vogel D Inducible CD40 expression mediates NFB activation and cytokine secretion in human colonic fibroblasts Gut 2003 52 1448 56
39. Vogel JD West GA Sturm A CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines causing T-cell transmigration Gastroenterology 2004 126 63 80
40. Liu Z Colpaert S D'Haens GR et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production J Immunol 1999 163 4049 57
41. Sawada-Hase N Kiyohara T Miyagawa J et al. An increased number of CD40-high monocytes in patients with Crohn's disease Am J Gastroenterol 2000 95 1516 23
42. Clegg CH Rulffes JT Harald S et al. Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice Int Immunol 1997 9 1111 22
43. Becker T Hartl F-U Weiland F CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes J Cell Biol 2002 158 1277 85
44. Lazarevic V Myers AJ Scanga CA Flynn JL CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection Immunity 2003 19 823 35
45. Millar DG Garza KM Odermatt B et al. HSP70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo Nat Med 2003 9 1469 523
46. Hunt C Morimoto RI Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70 Proc Natl Acad Sci USA 1985 82 6455 9