Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae

Molecular Microbiology

Volumn 59, Issue 2, 2006, Pages 551-566

  Lu, Ying Jie ^a   Rock, Charles O ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENT; FATTY ACID BIOSYNTHESIS TRANSCRIPTION REGULATOR PROTEIN; ISOENZYME; PROTEIN FABK; SATURATED FATTY ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL MEMBRANE; BACTERIAL STRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE ACTIVITY; GENE CLUSTER; GENE OVEREXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; LIPID COMPOSITION; NONHUMAN; PH MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN FAMILY; PROTEIN PURIFICATION; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACIDS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); RNA, BACTERIAL; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION, GENETIC;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STREPTOCOCCUS PNEUMONIAE;

EID: 33645051218     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04951.x     Document Type: Article

References (66)

1. van Aalten DM. DiRusso CC. Knudsen J. Wierenga RK. 2000 Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold EMBO J 19 5167 5177
2. van Aalten DM. DiRusso CC. Knudsen J. 2001 The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR EMBO J 20 2041 2050
3. Avery OB. MacLeod CM. McCarty M. 1944 Studies on the chemical nature of the substance inducing transformation of pneumococcal types J Exp Med 79 137 158
4. Bartilson M. Marra A. Christine J. Asundi JS. Schneider WP. Hromockyj AE. 2001 Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide Mol Microbiol 39 126 135
5. Bligh EG. Dyer WJ. 1959 A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 911 917
6. Bradford MM. 1976 A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
7. Bricker AL. Camilli A. 1999 Transformation of a type 4 encapsulated strain of Streptococcus pneumoniae FEMS Microbiol Lett 172 131 135
8. Brown T. Mackey K. 1994 Northern hybridization of RNA fractionated by agarose-formaldehyde gel electrophoresis. In Current Protocols in Molecular Biology Ausubel FM. Brent R. Kingston RE. Moore DD. Seidman JG. Smith JA. (eds) New York John Wiley & Sons, pp. 4.9.2 4 9.8
9. Burne RA. Wen ZT. Chen YY. Penders JE. 1999 Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression J Bacteriol 181 2863 2871
10. Campbell JW. Cronan JEJr 2001 Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene J Bacteriol 183 5982 5990
11. Clark DP. de Mendoza D. Polacco ML. Cronan JEJr 1983 β- Hydroxydecanoyl thioester dehydrase does not catalyze a rate-limiting step in Escherichia coli unsaturated fatty acid synthesis Biochemistry 22 5897 5902
12. Cronan JEJr 1967 The unsaturated fatty acids of Escherichia coli Biochim Biophys Acta 144 695 697
13. Cronan JEJr 1997 In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor J Bacteriol 179 1819 1823
14. Cronan JEJr 2003 Bacterial membrane lipids: where do we stand? Annu Rev Microbiol 57 203 224
15. Cronan JE., Jr, Rock CO. 1996 Biosynthesis of membrane lipids. In Escherichia coli and Salmonella typhimurium: Cellular, Molecular Biology Neidhardt FC. Curtis R. Gross CA. Ingraham JL. Lin ECC. Low KB. et al. (eds) Washington, DC American Society for Microbiology, pp. 612 636
16. Cronan JE., Jr, Subrahmanyam S. 1998 FadR, transcriptional co-ordination of metabolic expediency Mol Microbiol 29 937 943
17. Cronan JE. Weisberg LJ. Allen RG. 1975 Regulation of membrane lipid synthesis in Escherichia coli. Accumulation of free fatty acids of abnormal length during inhibition of phospholipid synthesis J Biol Chem 250 5835 5840
18. DiRusso CC. Nunn WD. 1985 Cloning and characterization of a gene (fadR) involved in regulation of fatty acid metabolism in Escherichia coli J Bacteriol 161 583 588
19. DiRusso CC. Heimert TL. Metzger AK. 1992 Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme As J Biol Chem 267 8685 8691
20. DiRusso CC. Tsvetnitsky V. Højrup P. Knudsen J. 1998 Fatty acyl-CoA binding domain of the transcription factor FadR - characterization by deletion, affinity labeling, and isothermal titration calorimetry J Biol Chem 273 33652 33659
21. Fozo EA. Quivey RG. 2004a Shifts in the membrane fatty acid profile of Streptococcus mutans enhance survival in acidic environments Appl Environ Microbiol 70 929 936
22. Fozo EM. Quivey RG. 2004b The fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pH J Bacteriol 186 4152 4158
23. Garwin JL. Cronan JEJr 1980 Thermal modulation of fatty acid synthesis in Escherichia coli does not involve de novo enzyme synthesis J Bacteriol 141 1457 1459
24. Garwin JL. Klages AL. Cronan JEJr 1980 β-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis J Biol Chem 255 3263 3265
25. Haas W. Sublett J. Kaushal D. Tuomanen EI. 2004 Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance J Bacteriol 186 8463 8471
26. Heath RJ. Rock CO. 1995 Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli J Biol Chem 270 26538 26542
27. Heath RJ. Rock CO. 1996 Inhibition of β-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli J Biol Chem 271 10996 11000
28. Heath RJ. Rock CO. 2000 A triclosan-resistant bacterial enzyme Nature (London) 406 145 146
29. Henry MF. Cronan JEJr 1991 Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation J Mol Biol 222 843 849
30. Henry MF. Cronan JEJr 1992 A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding Cell 70 671 679
31. Horton RM. 1995 Pcr-mediated recombination and mutagenesis Mol Biotechnol 3 93 99
32. Hoskins J. Alborn WE. Arnold J. Blaszczak LC. Burgett S. DeHoff BS. et al. 2001 Genome of the bacterium Streptococcus pneumoniae strain R6 J Bacteriol 183 5709 5717
33. Jackowski S. Rock CO. 1981 Regulation of coenzyme A biosynthesis J Bacteriol 148 926 932
34. Kerr MK. Churchill GA. 2001 Bootstrapping cluster analysis: assessing the reliability of conclusions from microarray experiments Proc Natl Acad Sci USA 98 8961 8965
35. Lai CY. Cronan JE. 2003 β-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis J Biol Chem 278 51494 51503
36. LeBlanc DJ. Lee LN. Abualjaibat A. 1992 Molecular, genetic, and functional-analysis of the basic replicon of pva380-1, a plasmid of oral streptococcal origin Plasmid 28 130 145
37. Lu Y-J. Zhang Y-M. Rock CO. 2004 Product diversity and regulation of type II fatty acid synthases Biochem Cell Biol 82 145 155
38. McCue L. Thompson W. Carmack C. Ryan MP. Liu JS. Derbyshire V. Lawrence CE. 2001 Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes Nucleic Acids Res 29 774 782
39. Marrakchi H. Zhang Y-M. Rock CO. 2002a Mechanistic diversity and regulation of type II fatty acid synthesis Biochem Soc Trans 30 1050 1055
40. Marrakchi H. Choi K-H. Rock CO. 2002b A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae J Biol Chem 277 44809 44816
41. Marrakchi H. DeWolf WE., Jr, Quinn C. West J. Polizzi BJ. So CY. et al. 2003 Characterization of Streptococcus pneumoniae enoyl-[acyl carrier protein] reductase (FabK) Biochem J 370 1055 1062
42. Martin RG. Rosner JL. 1995 Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences Proc Natl Acad Sci USA 92 5456 5460
43. de Mendoza D. Cronan JE. 1983 Thermal regulation of membrane lipid fluidity in bacteria Trends Biochem Sci 8 49 52
44. de Mendoza D. Garwin JL. Cronan JEJr 1982 Overproduction of cis-vaccenic acid and altered temperature control of fatty acid synthesis in a mutant of Escherichia coli J Bacteriol 151 1608 1611
45. de Mendoza D. Klages Ulrich A. Cronan JEJr 1983 Thermal regulation of membrane fluidity in Escherichia coli. Effects of overproduction of β-ketoacyl-acyl carrier protein synthase I J Biol Chem 258 2098 2101
46. Moche M. Schneider G. Edwards P. Dehesh K. Lindqvist Y. 1999 Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase J Biol Chem 274 6031 6034
47. Mohedano ML. Overweg K. d la Fuente A. Reuter M. ltabe S. ulholland F. et al. 2005 Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition J Bacteriol 187 2357 2367
48. Ng WL. Kazmierczak KM. Robertson GT. Gilmour R. Winkler ME. 2003 Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors J Bacteriol 185 359 370
49. Oancea E. Meyer T. 1998 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals Cell 95 307 318
50. Omura S. 1976 The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis Microbiol Rev 40 681 697
51. Overath P. Pauli G. Schairer HU. 1969 Fatty acid degradation in Escherichia coli: an inducible acyl-CoA synthetase, the mapping of old-mutantations, and the isolation of regulatory mutants Eur J Biochem 7 559 574
52. Polissi A. Pontiggia A. Feger G. Altieri M. Mottl H. Ferrari L. Simon D. 1998 Large-scale identification of virulence genes from Streptococcus pneumoniae Infect Immun 66 5620 5629
53. Poyart C. Trieu-Cuot P. 1997 A broad-host-range mobilizable shuttle vector for the construction of transcriptional fusions to β-galactosidase in Gram-positive bacteria FEMS Microbiol Lett 156 193 198
54. Raman N. DiRusso CC. 1995 Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding J Biol Chem 270 1092 1097
55. Revill WP. Bibb MJ. Scheu AK. Kieser HJ. Hopwood DA. 2001 β-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2) J Bacteriol 183 3526 3530
56. Rock CO. Cronan JEJr 1996 Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis Biochim Biophys Acta 1302 1 16
57. Russell NJ. 1983 Adaptation to temperature in bacterial membranes Biochem Soc Trans 11 333 335
58. Sampathkumar B. Khachatourians GG. Korber DR. 2004 Treatment of Salmonella enterica serovar enteritidis with a sublethal concentration of trisodium phosphate or alkaline pH induces thermotolerance Appl Environ Microbiol 70 4613 4620
59. Schujman GE. de Mendoza D. 2005 Transcriptional control of membrane lipid synthesis in bacteria Curr Opin Microbiol 8 149 153
60. Schujman GE. Paoletti L. Grossman AD. de Mendoza D. 2003 FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis Dev Cell 4 663 672
61. Sivaraman S. Zwahlen J. Bell AF. Hedstrom L. Tonge PJ. 2003 Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs Biochemistry 42 4406 4413
62. Sulavik MC. Gambino LF. Miller PF. 1995 The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds Mol Med 1 436 446
63. Tettelin H. Nelson KE. Paulsen IT. Eisen JA. Read TD. Peterson S. et al. 2001 Complete genome sequence of a virulent isolate of Streptococcus pneumoniae Science 293 498 506
64. Ulrich AK. de Mendoza D. Garwin JL. Cronan JEJr 1983 Genetic and biochemical analyses of Escherichia coli mutants altered in the temperature-dependent regulation of membrane lipid composition J Bacteriol 154 221 230
65. Xu Y. Heath RJ. Li Z. Rock CO. White SW. 2001 The FadR-DNA complex: transcriptional control of fatty acid metabolism in Escherichia coli J Biol Chem 276 17373 17379
66. Zhang Y-M. Marrakchi H. Rock CO. 2002 The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli J Biol Chem 277 15558 15565