Effect of pregnancy on the pharmacokinetics of metformin

Diabetic Medicine

Volumn 23, Issue 3, 2006, Pages 323-326

  Hughes, R C E ^a,b   Gardiner, S J ^a,c   Begg, E J ^a,c   Zhang, M ^c  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b NATIONAL WOMEN S HOSPITAL   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Diabetes mellitus; Metformin; Pharmacokinetics; Pregnancy

Indexed keywords

METFORMIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; FEMALE; GESTATION PERIOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; ONE TAILED TEST; PREGNANCY; PREGNANCY DIABETES MELLITUS; PUERPERIUM; STUDENT T TEST; TREATMENT OUTCOME; TWO TAILED TEST;

ADULT; AREA UNDER CURVE; DIABETES MELLITUS, TYPE 2; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY IN DIABETICS; PREGNANCY TRIMESTER, THIRD;

EID: 33645046633     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01769.x     Document Type: Article

References (20)

1. Kirpichnikov D McFarlane SI Sowers JR Metformin: an update Ann Intern Med 2002 137 25 33
2. Hundal RS Inzucchi SE Metformin: new understandings, new uses Drugs 2003 63 1879 1894
3. Glueck CJ Goldenberg N Pranikoff J Loftspring M Sieve L Wang P Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovarian syndrome who conceived on and continued metformin through pregnancy Hum Reprod 2004 19 1323 1330
4. Glueck CJ Wang P Kobayashi S Phillips H Sieve-Smith L Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome Fertil Steril 2002 77 520 525
5. Glueck CJ Goldenberg N Wang P Loftspring M Sherman A Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: Prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy Hum Reprod 2004 19 510 521
6. Coetzee EJ Jackson WP Metformin in management of pregnant insulin-independent diabetics Diabetologia 1979 16 241 245
7. Gutzin SJ Kozer E Magee LA Feig DS Koren G The safety of oral hypoglycemic agents in the first trimester of pregnancy: a meta-analysis Can J Clin Pharmacol 2003 10 179 183
8. Scheen AJ Clinical pharmacokinetics of metformin Clin Pharmacokinet 1996 30 359 371
9. Sambol NC Brookes LG Chiang J Goodman AM Lin ET Liu CY et al. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin hcl in man Br J Clin Pharmacol 1996 42 510 512
10. Marathe PH Wen Y Norton J Greene DS Barbhaiya RH Wilding IR Effect of altered gastric emptying and gastrointestinal motility on metformin absorption Br J Clin Pharmacol 2000 50 325 332
11. Dressler MJ Xiao G Leabman MK Gray AT Giacomini KM Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hoct2) Pharm Res 2002 19 1244 1247
12. Wang DS Jonker JW Kato Y Kusuhara H Schinkel AH Sugiyama Y Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin J Pharmacol Exp Ther 2002 302 510 515
13. Parry E Shields R Turnbull AC Transit time in the small intestine in pregnancy J Obstet Gynaecol Br Commonw 1970 77 900 901
14. Davison JS Davison MC Hay DM Gastric emptying time in late pregnancy and labour J Obstet Gynaecol Br Commonw 1970 77 37 41
15. Dunlop W Davison JM Renal haemodynamics and tubular function in human pregnancy Baillieres Clin Obstet Gynaecol 1987 1 769 787
16. Davison JM Dunlop W Renal hemodynamics and tubular function in normal human pregnancy Kidney Int 1980 18 152 161
17. Heikkila A Erkkola R Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedules Clin Pharmacokinet 1994 27 49 62
18. Zhang M Moore GA Lever M Gardiner SJ Kirkpatrick CMJ Begg EJ A rapid and simple hplc assay for the determination of metformin in human plasma and breast milk. J Chromatogr B Analyt Technol Biomed Life Sci 2002 766 175 179
19. Leabman MK Giacomini KM Estimating the contribution of genes and environment to variation in renal drug clearance Pharmacogenetics 2003 13 581 584
20. Saffar F Aiache JM Andre P Influence of food on the disposition of the antidiabetic drug metformin in diabetic patients at steady-state Methods Find Exp Clin Pharmacol 1995 17 483 487