Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1 -deficient mice

Cell Communication and Adhesion

Volumn 12, Issue 5-6, 2005, Pages 293-305

  King, Timothy J ^a,b,c   Lampe, Paul D ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HAWAII BIOTECH INC   (United States)

Author keywords

Carcinogenesis; Connexin; Connexin32; DEN; Gap junction; Knockout (KO); Liver; Lung; Mouse; p27Kip1; Radiation

Indexed keywords

CARCINOGEN; CONNEXIN 32; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DIETHYLNITROSAMINE; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CHEMICAL CARCINOGENESIS; CLINICAL PROTOCOL; CONTROLLED STUDY; ENZYME ACTIVATION; GAP JUNCTION; GENOTYPE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCIDENCE; KNOCKOUT MOUSE; LIVER CANCER; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN INTERACTION; RADIATION INJURY; TUMOR GROWTH; WILD TYPE;

ANIMALS; BETA CATENIN; CONNEXINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DIETHYLNITROSAMINE; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS, RADIATION-INDUCED;

ANIMALIA;

EID: 33645006029     PISSN: 10615385     EISSN: 15435180     Source Type: Journal    
DOI: 10.1080/15419060500514168     Document Type: Article

References (43)

1. Stout, C and Goodenough, D and Paul, D. (2004) Connexins: Functions without junctions Curr Opin Cell Biol, 16, pp. 507 - 512. [PUBMED] [INFOTRIEVE] [CSA]
2. Willecke, K and Eiberger, J and Degen, J and Eckardt, D and Romualdi, A and Guldenagel, M and Deutsch, U and Sohl, G. (2002) Structural and functional diversity of connexin genes in the mouse and human genome Biol Chem, 383, pp. 725 - 737. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
3. Krutovskikh, V and Yamasaki, H. (2000) Connexin gene mutations in human genetic diseases Mutat Res, 462, pp. 197 - 207. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
4. Richard, G. (2001) Connexin disorders of the skin Adv Dermatol, 17, pp. 243 - 277. [PUBMED] [INFOTRIEVE] [CSA]
5. Lo, C. (1999) Genes, gene knockouts, and mutations in the analysis of gap junctions Dev Genet, 24, pp. 1 - 4. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
6. Mesnil, M. (2002) Connexins and cancer Biol Cell, 94, pp. 493 - 500. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
7. Trosko, J and Ruch, R. (1998) Cell-cell communication in carcinogenesis Frontiers in Bioscience, 3, pp. 208. [CSA]
8. King, T and Fukushima, L and Hieber, A and Shimabukuro, K and Sakr, W and Bertram, J. (2000) Reduced levels of connexin43 in cervical dysplasia: Inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression Carcinogenesis, 21, pp. 1097 - 1109. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
9. King, T and Fukushima, L and Yasui, Y and Lampe, P and Bertram, J. (2002) Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of ht-1080 human fibrosarcoma cells in vitro and in vivo Mol Carcinog, 35, pp. 29 - 41. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
10. Mehta, P and Perez-Stable, C and Nadji, M and Mian, M and Asotra, K and Roos, B. (1999) Suppression of human prostate cancer cell growth by forced expression of connexin genes Developmental Genetics, 24, pp. 91. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
11. Nelles, E and Butzler, C and Jung, D and Temme, A and Gabriel, H and Dahl, U and Traub, O and Stumpel, F and Jungermann, K and Zielasek, J and Toyka, K and Dermietzel, R and Willecke, K. (1996) Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice Proceedings of the National Academy of Sciences of the United States of America, 93, pp. 9565 - 9570. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
12. Temme, A and Stumpel, F and Sohl, G and Rieber, E and Jungermann, K and Willecke, K and Ott, T. (2001) Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liver Pflugers Arch, 442, pp. 961 - 966. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
13. Temme, A and Buchmann, A and Gabriel, H and Nelles, E and Schwarz, M and Willecke, K. (1997) High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32 Current Biology, 7, pp. 713 - 716. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
14. Evert, M and Ott, T and Temme, A and Willecke, K and Dombrowski, F. (2002) Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice Carcinogenesis, 23, pp. 697 - 703. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
15. Moennikes, O and Buchmann, A and Ott, T and Willecke, K and Schwarz, M. (1999) The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains Carcinogenesis, 20, pp. 1379 - 1382. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
16. King, T and Lampe, P. (2004b) Mice deficient for the gap junction protein connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/erk1, p42/ erk2) activation Carcinogenesis, 25, pp. 669 - 680. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
17. King, T and Lampe, P. (2004a) The gap junction protein connexin32 is a mouse lung tumor suppressor Cancer Res, 64, pp. 7191 - 7196. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
18. Sherr, C and Roberts, J. (1999) Cdk inhibitors: Positive and negative regulators of g1-phase progression Genes Dev, 13, pp. 1501 - 1512. [PUBMED] [INFOTRIEVE] [CSA]
19. Lloyd, R and Erickson, L and Jin, L and Kulig, E and Qian, X and Cheville, J and Scheithauer, B. (1999) P27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers Am J Pathol, 154, pp. 313 - 323. [PUBMED] [INFOTRIEVE] [CSA]
20. Fero, M and Randel, E and Gurley, K and Roberts, J and Kemp, C. (1998) The murine gene p27kip1 is haplo-insufficient for tumour suppression Nature, 396, pp. 177 - 180. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
21. Philipp-Staheli, J and Payne, S and Kemp, C. (2001) P27(kip1): Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer Exp Cell Res, 264, pp. 148 - 168. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
22. Hanna, E and Umhauer, S and Roshong, S and Piechocki, M and Fernstrom, M and Fanning, J and Ruch, R. (1999) Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro Carcinogenesis, 20, pp. 1369 - 1373. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
23. Koffler, L and Roshong, S and Kyu, Park and Cesen-Cummings, K and Thompson, D and Dwyer-Nield, L and Rice, P and Mamay, C and Malkinson, A and Ruch, R. (2000) Growth inhibition in g(1) and altered expression of cyclin d1 and p27(kip-1)after forced connexin expression in lung and liver carcinoma cells J Cell Biochem, 79, pp. 347 - 354. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
24. Zhang, Y and Morita, I and Ikeda, M and Ma, K and Murota, S. (2001) Connexin43 suppresses proliferation of osteosarcoma u2os cells through post-transcriptional regulation of p27 Oncogene, 20, pp. 4138 - 4149. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
25. Zhang, Y and Nakayama, K and Morita, I. (2003) A novel route for connexin 43 to inhibit cell proliferation: Negative regulation of s-phase kinase-associated protein (skp 2) Cancer Res, 63, pp. 1623 - 1630. [PUBMED] [INFOTRIEVE] [CSA]
26. Scherer, S and Xu, Y and Nelles, E and Fischbeck, K and Willecke, K and Bone, L. (1998) Connexin32-null mice develop demyelinating peripheral neuropathy Glia, 24, pp. 8 - 20. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
27. Fero, M and Rivkin, M and Tasch, M and Porter, P and Carow, C and Firpo, E and Polyak, K and Tsai, L and Broudy, V and Perlmutter, R and Kaushansky, K and Roberts, J. (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(kip1)-deficient mice Cell, 85, pp. 733 - 744. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
28. King, T and Gurley, K and Prunty, J and Shin, J and Kemp, C and Lampe, P. (2005) Deficiency in the gap junction protein connexin32 alters p27kip1 tumor suppression and mapk activation in a tissue-specific manner Oncogene, 24, pp. 1718 - 1726. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
29. Nikitin, A and Alcaraz, A and Anver, M and Bronson, R and Cardiff, R and Dixon, D and Fraire, A and Gabrielson, E and Gunning, W and Haines, D and Kaufman, M and Linnoila, R and Maronpot, R and Rabson, A and Reddick, R and Rehm, S and Rozengurt, N and Schuller, H and Shmidt, E and Travis, W and Ward, J and Jacks, T. (2004) Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium Cancer Res, 64, pp. 2307 - 2316. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
30. Hilger, R and Scheulen, M and Strumberg, D. (2002) The ras-raf-mek-erk pathway in the treatment of cancer Onkologie, 25, pp. 511 - 518. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
31. Ito, Y and Sasaki, Y and Horimoto, M and Wada, S and Tanaka, Y and Kasahara, A and Ueki, T and Hirano, T and Yamamoto, H and Fujimoto, J and Okamoto, E and Hayashi, N and Hori, M. (1998) Activation of mitogen-activated protein kinases/ extracellular signal-regulated kinases in human hepatocellular carcinoma Hepatology, 27, pp. 951 - 958. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
32. Ramakrishna, G and Perella, C and Birely, L and Diwan, B and Fornwald, L and Anderson, L. (2002) Decrease in k-ras p21 and increase in raf1 and activated erk 1 and 2 in murine lung tumors initiated by n-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol Appl Pharmacol, 179, pp. 21 - 34. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
33. Yano, T and Yano, Y and Nagashima, Y and Yuasa, M and Yajima, S and Horikawa, S and Hagiwara, K and Kishimoto, M and Ichikawa, T and Otani, S. (1999) Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen Life Sci, 64, pp. 229 - 236. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
34. Yao, R and Wang, Y and Lubet, R and You, M. (2003) Differential gene expression in chemically induced mouse lung adenomas Neoplasia, 5, pp. 41 - 52. [PUBMED] [INFOTRIEVE] [CSA]
35. Philipp-Staheli, J and Kim, K and Liggitt, D and Gurley, K and Longton, G and Kemp, C. (2004) Distinct roles for p53, p27kip1, and p21cip1 during tumor development Oncogene, 23, pp. 905 - 913. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
36. Philipp-Staheli, J and Kim, K and Payne, S and Gurley, K and Liggitt, D and Longton, G and Kemp, C. (2002) Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in apc mutant mice, but not in smad3 mutant mice Cancer Cell, 1, pp. 355 - 368. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
37. Muraoka, R and Lenferink, A and Simpson, J and Brantley, D and Roebuck, L and Yakes, F and Arteaga, C. (2001) Cyclin-dependent kinase inhibitor p27(kip1) is required for mouse mammary gland morphogenesis and function J Cell Biol, 153, pp. 917 - 932. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
38. Defamie, N and Berthaut, I and Mograbi, B and Chevallier, D and Dadoune, J and Fenichel, P and Segretain, D and Pointis, G. (2003) Impaired gap junction connexin43 in sertoli cells of patients with secretory azoospermia: A marker of undifferentiated sertoli cells Lab Invest, 83, pp. 449 - 456. [PUBMED] [INFOTRIEVE] [CSA]
39. Upham, B and Rummel, A and Carbone, J and Trosko, J and Ouyang, Y and Crawford, R and Kaminski, N. (2003) Cannabinoids inhibit gap junctional intercellular communication and activate erk in a rat liver epithelial cell line Int J Cancer, 104, pp. 12 - 18. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
40. Warn-Cramer, B and Cottrell, G and Burt, J and Lau, A. (1998) Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase J Biol Chem, 273, pp. 9188 - 9196. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
41. Warn-Cramer, B and Lampe, P and Kurata, W and Kanemitsu, M and Loo, L and Eckhart, W and Lau, A. (1996) Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein J Biol Chem, 271, pp. 3779 - 3786. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
42. Lumniczky, K and Antal, S and Unger, E and Wunderlich, L and Hidvegi, E and Safrany, G. (1998) Carcinogenic alterations in murine liver, lung, and uterine tumors induced by in utero exposure to ionizing radiation Mol Carcinog, 21, pp. 100 - 110. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
43. Schwarz, M and Wanke, I and Wulbrand, U and Moennikes, O and Buchmann, A. (2003) Role of connexin32 and beta-catenin in tumor promotion in mouse liver Toxicol Pathol, 31, pp. 99 - 102. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]