Clinical Follow-Up in the Rat Experimental Model of African-Trypanosomiasis

Experimental Biology and Medicine

Volumn 228, Issue 11, 2003, Pages 1355-1362

  Darsaud, A ^a,b   Bourdon, L ^a   Chevrier, C ^a   Keita, M ^b,c   Bouteille, B ^b   Queyroy, A ^a   Canini, F ^a   Cespuglio, R ^d   Dumas, M ^b   Buguet, A ^a,e  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITÉ DE LIMOGES   (France)

^c UNIVERSITY OF LIMOGES   (France)

^d UNIVERSITÉ LYON 1   (France)

^e SERVICE DE SANTÉ DES ARMÉES   (France)

Author keywords

Body weight; Experimental African trypanosomiasis; Food consumption; Open field; Rat model

Indexed keywords

AFRICAN TRYPANOSOMIASIS; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; DEATH; FOLLOW UP; FOOD INTAKE; HEMATOCRIT; HEMOLYMPH; HISTOPATHOLOGY; INFESTATION; MALE; MENINGOENCEPHALITIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; OPEN FIELD TEST; RAT; RAT STRAIN; TRYPANOSOMA BRUCEI; WEIGHT REDUCTION;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 10744224104     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322801114     Document Type: Article

References (49)

1. Greenwood BM, Whittle HC. The pathogenesis of sleeping sickness. Trans R Soc Trop Med Hyg 74:716-723, 1980.
2. Molyneux DH, Pentreath V, Doua F. African Trypanosomiasis in man. In: Cook GC, Ed. Manson's Tropical Diseases. Vol. 63. pp1171-1196, 1996.
3. Smith DH, Pepin J, Stich AHR. Human African trypanosomiasis: an emerging public health crisis. Br Med Bull 54:341-355, 1998.
4. st ed. Paris: Springer Verlag, pp344, 1999.
5. Gibbons A. Researchers fret over neglect of 600 million patients. Science 256:1135, 1992.
6. Antoine P. Neurological and psychological studies of patients with sleeping sickness and their course. Ann Soc Belg Med Trop 57:227-248, 1977.
7. Dumas M, Boa Y. Human African trypanosomiasis. In: Harris AA, Ed. Handbook of Clinical Neurology 8:339-344, 1988.
8. Dumas M, Bisser S. Clinical aspects of human African trypanosomiasis. In: Dumas M, Bouteille B, Buguet A. Eds. Progress in Human African Trypanosomiasis, Sleeping Sickness. Paris: Springer Verlag, pp215-233, 1999.
9. Van Bogaert L. Experimental trypanosomal encephalitis. In: Innes JTM, Saunders LZ, Eds. Comparative Neuropathology. New York and London: Academic Press, pp465-481, 1962.
10. Jennings FW. The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis. Bull Soc Pathol Exot 81:595-607, 1988.
11. Losos GJ, Ikede BO. Review of pathology of diseases in domestic and laboratory animals caused by Trypanosoma congolense, T. vivax, T. brucei, T. rhodiesense and T. gambiense. Vet Path 9:1-71, 1972.
12. Grassi-Zucconi G, Harris JA, Mohammed AH, Ambrosini MV, Kristensson K, Bentivoglio M. Sleep fragmentation, and changes in locomotor activity and body temperature in Trypanosome-infected rats. Brain Res Bull 37:123-129, 1995.
13. Bouteille B, Darde ML, Pestre-Alexandre M. Action des médicaments testés en milieu acellulaire et chez la souris infectée par Trypanosoma brucei brucei. Bull Soc Pathol Exot Filiales 81:533-542, 1988.
14. Montmayeur A, Buguet A. Time-related changes in the sleep-wake cycle of rats infected with Trypanosoma brucei brucei. Neurosci Lett 168:172-174, 1994.
15. Beckers A, Wery M, Van Marck E, Gigase P. Experimental infections of laboratory rodents with recently isolated stocks of Trypanosoma brucei gambiense. 1. Parasitological Investigations. Z Parasitenkd 64:285-296, 1981.
16. Van Marck EAE, Gigase PLJ, Beckers A, Wery M. Experimental infections of laboratory rodents with recently isolated stocks of Trypanosoma brucei gambiense. 2. Histopathological investigations. Z Parasitenkd 64:187-193, 1981.
17. Jennings FW, Whitelaw DD, Urquhart GM. The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy. Parasitology 75:143-153, 1977.
18. Bouteille B, Darde ML, Pestre-Alexandre M. Trypanosomose à Trypanosoma brucei brucei: traitement par des associations. Bull Soc Fr Parasitol 6:15-20, 1990.
19. Keita M, Bouteille B, Enanga B, Vallat JM, Dumas M. Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis and neurological disorders. Exp Parasitol 85:183-192, 1997.
20. Mulenga C, Mhlanga JDM, Kristensson K, Robertson B. Trypanosoma brucei brucei crosses the blood-brain barrier while tight junction proteins are preserved in a rat chronic disease model. Neuropathol Appl Neurobiol 27:77-85, 2001.
21. Quan N, Mhlanga JDM, Whiteside MB, McCoy AN, Kristensson K, Herkenham M. Chronic over-expression of pro-inflammatory cytokines and histopathology in the brains of rats infected with Trypanosoma brucei. J Comp Neurol 44:114-130, 1999.
22. Kristensson K, Claustrat B, Mhlanga JDM, Moller M. African trypanosomiasis in the rat alters melatonin secretion and melatonin receptor binding in the suprachiasmatic nucleus. Brain Res Bull 47:265-269, 1998.
23. Nishimura K, Araki N, Ohnishi Y, Kozaki S. Effects of dietary polyamine deficiency on Trypanosoma gambiense infection in rats. Exp Parasitol 97:95-101, 2001.
24. Toth LA, Tolley EA, Broady R, Blakely B, Krueger JM. Sleep during experimental trypanosomiasis in rabbits. Proc Soc Exp Biol Med 205:174-181, 1994.
25. Igbokwe IO, Isa S, Aliyu UK, Hamza HG, Egbe-Nwiyi T. Increased severity of acute Trypanosoma brucei brucei infection in rats with alloxan-induced diabetes. Vet Res 29:573-578, 1998.
26. Schultzberg M, Ambatsis M, Samuelsson EB, Kristensson K, Van Meirvenne N. Spread of Trypanosoma brucei to the nervous system: early attack on the circumventricular organs and sensory ganglia. J Neurosci Res 21:51-61, 1988.
27. Pentreath VM, Baugh PJ, Lavin DR. Sleeping sickness and central nervous system. Onderstepoort J Vet Res 61:369-377, 1994.
28. Van Marck EAE, Le Ray D, Beckers A, Jacob W, Wery M, Gigase PLJ. Light and electron microscope studies on extravascular Trypanosoma brucei gambiense in the brain of chronically infected rodents. Ann Soc Belg Med Trop 61:57-78, 1981.
29. Rudin W, Poltera AA, Jenni L. An EM study on cerebral trypanosomiasis in rodents and primates. Contrib Microbiol Immunol 7:165-172, 1983.
30. Schmidt H. The pathogenesis of trypanosomiasis of the CNS. Studies on parasitological and neurohistological findings in Trypanosoma rhodiesense infected vervet monkeys. Virshows Arch 399:333-343, 1983.
31. Poltera AA, Hochmann A, Rudin W, Lambert PH. Trypanosoma brucei brucei: a model for cerebral trypanosomiasis in mice. An immunological, histological and electronmicroscopic study. Clin Exp Immunol 40:496-507, 1980.
32. Van Marck EAE, Le Ray D, Beckers A, Jacob W, Wery M, Gigase PL. Light and electron microscope studies on extravascular Trypanosoma brucei gambiense in the brain of chronically infected rodents. Ann Soc Belg Med Trop 61:57-78, 1981.
33. Chirimwami B, Van Marck EAE, Brucher JM, Wery M, Gigase PL. Progression of central nervous system lesions in the rat infected with Trypanosoma brucei gambiense. A light microscopic study. Ann Soc Belg Med Trop 68:205-218, 1988.
34. Philip KA, Dascombe MJ, Fraser PA, Pentreath VW. Blood-brain barrier damage in experimental African trypanosomiasis. Ann Trop Med Parasitol 88:607-616, 1994.
35. Nyakundi JN, Crawley B, Smith RA, Pentreath VW. The relationships between intestinal damage and circulating endotoxins in experimental Trypanosoma brucei brucei infections. Parasitology 124:589-595, 2002.
36. Rhind SG, Sabiston BH, Shek PN, Buguet A, Muanga G, Stanghellini A, Dumas M, Radomski MW. Effect of melarsoprol treatment on circulating IL-10 and TNF-α levels in human African trypanosomiasis. Clin Immunol Immunopathol 83:185-189, 1997.
37. Radomski MW, Buguet A, Bogui P, Doua F, Lonsdorfer A, Tapie P, Dumas M. Disruptions in the secretion of cortisol, prolactin, and certain cytokines in human African trypanosomiasis patients. Bull Soc Pathol Exot 87:376-379, 1994.
38. Reincke M, Heppner C, Petzke F, Allolio B, Arlt W, Mbulamberi D, Siekmann L, Vollmer D, Winkelmann W, Chrousos GP. Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in African trypanosomiasis. Neuroimmunomodulation 1:14-22, 1994.
39. Reincke M, Arlt W, Heppner C, Petzke F, Chrousos GP, Allolio B. Neuroendocrine dysfunction in African trypanosomiasis. The role of cytokines. Ann N Y Acad Sci 840:809-821, 1998.
40. Okomo-Assoumou M, Daulouede S, Lemesre JL, N'Sila-Mouanda A, Vincendeau P. Correlation of high levels of tumor necrosis factor-α with disease severity in human African trypanosomiasis. Am J Trop Med Hyg 53:539-543, 1995.
41. Magez S, Lucas R, Darji A, Songa B, Hamers R, De Baetselier P. Murine tumor necrosis factor plays a protective role during the phase of the experimental infection with Trypanosoma brucei brucei. Parasite Immunol 15:635-641, 1993.
42. Daulouede S, Bouteille B, Moynet D, De Baetselier P, Courtois P, Lemesre JL, Buguet A, Cespuglio R, Vincendeau P. Human macrophage tumor necrosis factor (TNF)-α production induced by Trypanosoma brucei gambiense and the role of TNF-α in parasite control. J Infect Dis 183:988-991, 2001.
43. Cerami A. Inflammatory cytokines. Clin Immunol Immunopathol 62:S3-S10, 1992.
44. Plata-Salaman CR, Oomura Y, Kai Y. Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Res 448:106-114, 1988.
45. Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA, O'Connor JV. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1. J Exp Med 163:1433-1450, 1986.
46. Uehara A, Sekiya C, Takasugi Y, Namiki M, Arimura A. Anorexia induced by interleukin-1: involvement of corticotropin-releasing factor. Am J Physiol 257:R613-R617, 1989.
47. Bianchi M, Sacerdote P, Ricciardi-Castagnoli P, Mantegazza P, Panerai PE. Central effects of TNFα and interleukin-1 (IL-1) a on nociceptive thresholds and spontaneous motor activity. Neurosci Lett 148:76-80, 1992.
48. Fiore M, Alleva E, Probert L, Kollias G, Angelucci F, Aloe L. Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNFα. Physiol Behav 63:571-576, 1998.
49. Bluthe RM, Pawlowski M, Suarez S, Parnet P, Pittman Q, Kelley KW, Dantzer R. Synergy between TNFα and IL-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology 19:197-207, 1994.