-
1
-
-
0029160940
-
Epidemiology of rheumatoid arthritis
-
G.S. Alarcon Epidemiology of rheumatoid arthritis Rheum Dis Clin North Am 21 1995 589 604
-
(1995)
Rheum Dis Clin North Am
, vol.21
, pp. 589-604
-
-
Alarcon, G.S.1
-
2
-
-
0036839553
-
Bone destruction in arthritis
-
E.M. Gravallese Bone destruction in arthritis Ann Rheum Dis 61 2002 284 286
-
(2002)
Ann Rheum Dis
, vol.61
, pp. 284-286
-
-
Gravallese, E.M.1
-
3
-
-
0021133558
-
Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion
-
M. Bromley, and D.E. Wooley Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion Arthritis Rheum 27 8 1984 857 863
-
(1984)
Arthritis Rheum
, vol.27
, Issue.8
, pp. 857-863
-
-
Bromley, M.1
Wooley, D.E.2
-
4
-
-
0035002353
-
Analysis of cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial specimens from the cartilage-pannus function in patients with RA
-
T.J. Smeets, M.C. Kraan, S. Galjaard, P.P. Yossef, M.D. Smith, and P.P. Tak Analysis of cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial specimens from the cartilage-pannus function in patients with RA Ann Rheum Dis 60 6 2001 561 565
-
(2001)
Ann Rheum Dis
, vol.60
, Issue.6
, pp. 561-565
-
-
Smeets, T.J.1
Kraan, M.C.2
Galjaard, S.3
Yossef, P.P.4
Smith, M.D.5
Tak, P.P.6
-
5
-
-
0036153347
-
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: Relationship with synovitis and steroid treatment
-
C. Ribbens, M. Martin y Porras, N. Frachimont, M.J. Kaiser, J.M. Jaspar, and P. Damas Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment Ann Rheum Dis 61 2 2002 161 166
-
(2002)
Ann Rheum Dis
, vol.61
, Issue.2
, pp. 161-166
-
-
Ribbens, C.1
Martin Porras, Y.M.2
Frachimont, N.3
Kaiser, M.J.4
Jaspar, J.M.5
Damas, P.6
-
6
-
-
0035932519
-
Cytokine pathways and joint inflammation in rheumatoid arthritis
-
E.H. Choy, and G.S. Panayi Cytokine pathways and joint inflammation in rheumatoid arthritis N Engl J Med 344 2001 907 916
-
(2001)
N Engl J Med
, vol.344
, pp. 907-916
-
-
Choy, E.H.1
Panayi, G.S.2
-
8
-
-
0030987746
-
Leflunomide and malononitrilamides
-
K. Silva, and R.E. Morris Leflunomide and malononitrilamides Am J Med Sci 313 1997 289 301
-
(1997)
Am J Med Sci
, vol.313
, pp. 289-301
-
-
Silva, K.1
Morris, R.E.2
-
9
-
-
0030032806
-
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
-
J.P. Davis, G.A. Cain, W.J. Pitts, R.L. Magolda, and R.A. Copeland The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase Biochemistry 35 1996 1270 1273
-
(1996)
Biochemistry
, vol.35
, pp. 1270-1273
-
-
Davis, J.P.1
Cain, G.A.2
Pitts, W.J.3
Magolda, R.L.4
Copeland, R.A.5
-
10
-
-
0029793899
-
Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme
-
W. Knecht, U. Bergiohann, B. Kitshbaum, and M. Loeffler Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme Eur J Biochem 240 1996 292 302
-
(1996)
Eur J Biochem
, vol.240
, pp. 292-302
-
-
Knecht, W.1
Bergiohann, U.2
Kitshbaum, B.3
Loeffler, M.4
-
11
-
-
0030014489
-
Two activities of the immunosuppressive metabolite of leflunomide, A77-1726: Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation
-
X. Xu, J.W. Williams, H. Gong, A. Finnegan, and A.S.F. Chong Two activities of the immunosuppressive metabolite of leflunomide, A77-1726: inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation Biochem Pharmacol 52 1996 527 534
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 527-534
-
-
Xu, X.1
Williams, J.W.2
Gong, H.3
Finnegan, A.4
Chong, A.S.F.5
-
12
-
-
0027501428
-
Inhibition of the epidermal growth receptor tyrosine kinase activity by leflunomide
-
T. Mattar, K. Kochhar, R. Barlett, E.G. Bremer, and A. Finnegan Inhibition of the epidermal growth receptor tyrosine kinase activity by leflunomide FEBS Lett 334 1993 161 164
-
(1993)
FEBS Lett
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Barlett, R.3
Bremer, E.G.4
Finnegan, A.5
-
13
-
-
0027238470
-
Effects of leflunomide on immune responses and models of inflammation
-
R.R. Barlett, H. Anagnostopulos, T. Zielinsky, T. Mattar, and R. Schleyerbach Effects of leflunomide on immune responses and models of inflammation Springer Semin Immunopathol 14 1993 381
-
(1993)
Springer Semin Immunopathol
, vol.14
, pp. 381
-
-
Barlett, R.R.1
Anagnostopulos, H.2
Zielinsky, T.3
Mattar, T.4
Schleyerbach, R.5
-
14
-
-
0033884087
-
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis
-
M.C. Kraan, R.J. Reece, E.C. Barg, T.J. Smeets, J. Farnell, and R. Rosenburg Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis Arthritis Rheum 43 2000 1820 1830
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1820-1830
-
-
Kraan, M.C.1
Reece, R.J.2
Barg, E.C.3
Smeets, T.J.4
Farnell, J.5
Rosenburg, R.6
-
15
-
-
0029044362
-
American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis
-
D.T. Felson, J.J. Anderson, M. Boers, C. Bombardier, D. Furst, and C. Goldsmith American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis Arthritis Rheum 38 1995 727 735
-
(1995)
Arthritis Rheum
, vol.38
, pp. 727-735
-
-
Felson, D.T.1
Anderson, J.J.2
Boers, M.3
Bombardier, C.4
Furst, D.5
Goldsmith, C.6
-
16
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
R.I. Fox, M.L. Hermann, C.G. Frangou, G.M. Wahl, R.E. Morris, and V. Strand Mechanism of action for leflunomide in rheumatoid arthritis Clin Immunol 93 1999 198 208
-
(1999)
Clin Immunol
, vol.93
, pp. 198-208
-
-
Fox, R.I.1
Hermann, M.L.2
Frangou, C.G.3
Wahl, G.M.4
Morris, R.E.5
Strand, V.6
-
17
-
-
0033764113
-
Leflunomide: Mode of action in the treatment of rheumatoid arthritis
-
F.C. Breedveld, and J.M. Dayer Leflunomide: mode of action in the treatment of rheumatoid arthritis Ann Rheum Dis 59 2000 841 849
-
(2000)
Ann Rheum Dis
, vol.59
, pp. 841-849
-
-
Breedveld, F.C.1
Dayer, J.M.2
-
18
-
-
0032692178
-
Leflunomide, mycophenolic acid and matrix metalloproteinase inhibitors
-
D.E. Furst Leflunomide, mycophenolic acid and matrix metalloproteinase inhibitors Rheumatology 38 Suppl. 2 1999 14 18
-
(1999)
Rheumatology
, vol.38
, Issue.2 SUPPL.
, pp. 14-18
-
-
Furst, D.E.1
-
19
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomized, multicentre trial. European leflunomide study group
-
J.S. Smolen, J.R. Kalden, D.L. Scott, B. Rozman, T.K. Kvein, and A. Larsen Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomized, multicentre trial. European leflunomide study group Lancet 353 1999 259 266
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
Rozman, B.4
Kvein, T.K.5
Larsen, A.6
-
20
-
-
0033596065
-
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide rheumatoid arthritis investigators group
-
V. Strand, S. Cohen, M. Schiff, A. Weaver, R. Fleischmann, and G. Cannon Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide rheumatoid arthritis investigators group Arch Intern Med 159 1999 2542 2550
-
(1999)
Arch Intern Med
, vol.159
, pp. 2542-2550
-
-
Strand, V.1
Cohen, S.2
Schiff, M.3
Weaver, A.4
Fleischmann, R.5
Cannon, G.6
-
21
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
P. Emery, F.C. Breedveld, E.M. Lemmel, J.P. Kaltwasser, P.T. Dawes, and B. Gomor A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis Rheumatology 39 2000 655 665
-
(2000)
Rheumatology
, vol.39
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
Kaltwasser, J.P.4
Dawes, P.T.5
Gomor, B.6
-
22
-
-
0036139929
-
Improved functional ability in patients with rheumatoid arthritis - Long-term treatment with leflunomide versus sulfasalazine. European leflunomide study group
-
J.R. Kalden, D.L. Scott, J.S. Smolen, M. Schattenkirchener, B. Rozman, and B.D. Williams Improved functional ability in patients with rheumatoid arthritis - long-term treatment with leflunomide versus sulfasalazine. European leflunomide study group J Rheumatol 29 2002 205
-
(2002)
J Rheumatol
, vol.29
, pp. 205
-
-
Kalden, J.R.1
Scott, D.L.2
Smolen, J.S.3
Schattenkirchener, M.4
Rozman, B.5
Williams, B.D.6
-
23
-
-
0036720662
-
Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: Clinical experience using a structured follow up programme in southern Sweden
-
P. Geborek, M. Crnkic, I.F. Petersson, and T. Saxne Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden Ann Rheum Dis 61 2002 793 798
-
(2002)
Ann Rheum Dis
, vol.61
, pp. 793-798
-
-
Geborek, P.1
Crnkic, M.2
Petersson, I.F.3
Saxne, T.4
-
24
-
-
0032926067
-
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1(TIMP-1) and MMP-1/TIMP-1 complex in rheumatic disease: Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers
-
G. Keyszer, I. Lambiri, R. Nagel, C. Keysser, M. Keysser, and E. Gromnica-Ihle Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1(TIMP-1) and MMP-1/TIMP-1 complex in rheumatic disease: correlation with clinical activity of rheumatoid arthritis versus other surrogate markers J Rheumatol 26 1999 251
-
(1999)
J Rheumatol
, vol.26
, pp. 251
-
-
Keyszer, G.1
Lambiri, I.2
Nagel, R.3
Keysser, C.4
Keysser, M.5
Gromnica-Ihle, E.6
-
25
-
-
0037242710
-
Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis
-
M.J. Green, A.K. Gough, J. Devlin, J. Smith, P. Astin, and D. Taylor Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis Rheumatology (Oxford) 42 2003 83 88
-
(2003)
Rheumatology (Oxford)
, vol.42
, pp. 83-88
-
-
Green, M.J.1
Gough, A.K.2
Devlin, J.3
Smith, J.4
Astin, P.5
Taylor, D.6
-
26
-
-
0037404259
-
Active leflunomide metabolite inhibits interleukin 1beta, tumor necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures
-
O. Elkayam, I. Yaron, I. Shirazi, R. Judovitch, D. Caspi, and M. Yaron Active leflunomide metabolite inhibits interleukin 1beta, tumor necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures Ann Rheum Dis 62 2003 440 443
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 440-443
-
-
Elkayam, O.1
Yaron, I.2
Shirazi, I.3
Judovitch, R.4
Caspi, D.5
Yaron, M.6
-
27
-
-
0037238591
-
The active metabolite of leflunomide, A77 1727, inhibits the production of prostaglandin E2, matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes
-
D. Burger, N. Begue-Pator, S. Benavet, L. Grauz, M.T. Kaufmann, and R. Chiccheportiche The active metabolite of leflunomide, A77 1727, inhibits the production of prostaglandin E2, matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes Rheumatology (Oxford) 42 2003 89 96
-
(2003)
Rheumatology (Oxford)
, vol.42
, pp. 89-96
-
-
Burger, D.1
Begue-Pator, N.2
Benavet, S.3
Grauz, L.4
Kaufmann, M.T.5
Chiccheportiche, R.6
-
28
-
-
8744233401
-
The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes
-
G. Palmer, D. Burger, F. Mezin, D. Magne, C. Gabay, and J.M. Dayer The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes Arthritis Res Ther 6 2004 R181 R189
-
(2004)
Arthritis Res Ther
, vol.6
-
-
Palmer, G.1
Burger, D.2
Mezin, F.3
Magne, D.4
Gabay, C.5
Dayer, J.M.6
-
29
-
-
0037378668
-
Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis
-
M. Cutolo, A. Sulli, P. Ghiorzo, C. Pizzorni, C. Craviotto, and B. Villaggio Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis Ann Rheum Dis 62 2003 297 302
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 297-302
-
-
Cutolo, M.1
Sulli, A.2
Ghiorzo, P.3
Pizzorni, C.4
Craviotto, C.5
Villaggio, B.6
-
30
-
-
0038667615
-
The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover
-
P.K. Wong, I.K. Campbell, P.J. Egan, M. Ernst, and I.P. Wicks The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover Arthritis Rheum 48 5 2003 1177 1189
-
(2003)
Arthritis Rheum
, vol.48
, Issue.5
, pp. 1177-1189
-
-
Wong, P.K.1
Campbell, I.K.2
Egan, P.J.3
Ernst, M.4
Wicks, I.P.5
-
31
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, blind, placebo-controlled, dose-escalation trial
-
E.H. Choy, D.A. Isenberg, T. Garrood, S. Farrow, Y. Ioannou, and H. Bird Therapeutic benefit of blocking interleukin-6 activity with anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, blind, placebo-controlled, dose-escalation trial Arthritis Rheum 46 12 2002 3143 3150
-
(2002)
Arthritis Rheum
, vol.46
, Issue.12
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
Farrow, S.4
Ioannou, Y.5
Bird, H.6
-
32
-
-
0038283161
-
Interleukin-10 therapy - Review of a new approach
-
K. Asadullah, W. Sterry, and H.D. Volk Interleukin-10 therapy - review of a new approach Pharmacol Rev 55 2 2003 241 269
-
(2003)
Pharmacol Rev
, vol.55
, Issue.2
, pp. 241-269
-
-
Asadullah, K.1
Sterry, W.2
Volk, H.D.3
-
33
-
-
0033179534
-
Regulation of cytokines, cytokine inhibitors, and acute phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis
-
P. Charles, M.J. Elliot, D. Davis, A. Potter, J.R. Kalden, and C. Antoni Regulation of cytokines, cytokine inhibitors, and acute phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis J Immunol 163 3 1999 1521 1528
-
(1999)
J Immunol
, vol.163
, Issue.3
, pp. 1521-1528
-
-
Charles, P.1
Elliot, M.J.2
Davis, D.3
Potter, A.4
Kalden, J.R.5
Antoni, C.6
-
34
-
-
0032950912
-
Combination of methotrexate and prednisone decreases circulating concentrations of interleukin-1 beta and interleukin-6 in patients with rheumatoid arthritis. Poor correlation of cytokine suppression with clinical improvement
-
D. Nowak, J. Lewandowicz, B. Dbkowska, and J. Marczak Combination of methotrexate and prednisone decreases circulating concentrations of interleukin-1 beta and interleukin-6 in patients with rheumatoid arthritis. Poor correlation of cytokine suppression with clinical improvement Int J Immunopathol Pharmacol 12 1 1999 13 21
-
(1999)
Int J Immunopathol Pharmacol
, vol.12
, Issue.1
, pp. 13-21
-
-
Nowak, D.1
Lewandowicz, J.2
Dbkowska, B.3
Marczak, J.4
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