-
2
-
-
0026589680
-
Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide
-
14312; note
-
(1992)
Immunopharmacology
, vol.23
, pp. 105-116
-
-
Glant, T.T.1
Mikecz, K.2
Bartlett, R.R.3
Deak, F.4
Thonar, E.J.5
Williams, J.M.6
Mattar, T.7
Kuettner, K.E.8
Schleyerbach, R.9
-
3
-
-
0026579123
-
3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, a new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
-
22559; note
-
(1992)
J Med Chem
, vol.35
, pp. 507-510
-
-
Patterson, J.W.1
Cheung, P.S.2
Ernest, M.J.3
-
6
-
-
0025234002
-
Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis
-
32268; note
-
(1990)
Agents Actions
, vol.29
, pp. 328-332
-
-
Hambleton, P.1
McMahon, S.2
-
9
-
-
0023554171
-
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery
-
78277; note
-
(1987)
Agents Actions
, vol.21
, Issue.3
, pp. 284-286
-
-
Popovic, S.1
Bartlett, R.R.2
-
10
-
-
0005919958
-
Hoechst's leflunomide licensed to Kyorin
-
159079
-
(1994)
Scrip
, vol.1926
, pp. 25
-
-
-
11
-
-
0027279125
-
Leflunomide, a novel immunosuppressive agent: The mechanism of inhibition of T cell proliferation
-
161099; note
-
(1993)
Transplantation
, vol.55
, Issue.6
, pp. 1361-1366
-
-
Chong, A.S.F.1
-
12
-
-
0028354267
-
Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporine
-
164042; note
-
(1994)
Transplantation
, vol.57
, Issue.8
, pp. 1223-1231
-
-
Williams, J.W.1
Xiao, F.2
Foster, P.3
Clardy, C.4
McChesney, L.5
Sankary, H.6
Chong, A.S.7
-
15
-
-
0005951953
-
Immunomodulatory activity of leflunomide on acute and chronic relapsing experimental allergic encephalomyelitis
-
187881; W03/05; note
-
(1995)
Inflamm Res
, vol.44
, Issue.SUPPL. 3
-
-
Schorlemmer, H.U.1
Bartlett, R.R.2
-
19
-
-
0028792355
-
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study
-
208027; note
-
(1995)
Arthritis Rheum
, vol.38
, Issue.11
, pp. 1595-1603
-
-
Mladenovic, V.1
Domljan, Z.2
Rozman, B.3
Jajic, I.4
Mihajlovic, D.5
Dordevic, J.6
Popovic, M.7
Dimitrijevic, M.8
Zivkovic, M.9
Campion, G.10
-
21
-
-
0003190181
-
HMR sets development priorities
-
221118
-
(1996)
Scrip
, vol.2166
, pp. 10
-
-
-
26
-
-
15644364861
-
A new rational hypothesis for the pharmacophore of the active metabolite of leflunomide, a potent immunosuppressive drug
-
253615
-
(1997)
J Med Chem
, vol.40
, Issue.13
, pp. 2011-2016
-
-
Bertolini, G.1
Aquino, M.2
Biffi, M.3
D'Atri, G.4
DiPierro, F.5
Ferrario, F.6
Mascagni, P.7
Somenzi, F.8
Zaliani, A.9
Leoni, F.10
-
27
-
-
0005998949
-
HMR filing arthritis drug in EC & US
-
279727
-
(1998)
Scrip
, vol.2312
, pp. 22
-
-
-
28
-
-
0005958215
-
Arava/Methotrexate combo may expand indication to refractory patients
-
296186
-
(1998)
FDC Reports Pink Sheet
, vol.60
, Issue.33
, pp. 20-21
-
-
-
29
-
-
0005920743
-
Hoechst Arava pregnancy registry recommended to track teratogenicity
-
296187
-
(1998)
FDC Reports Pink Sheet
, vol.60
, Issue.33
, pp. 21-22
-
-
-
30
-
-
0005951772
-
Hoechst Marion Roussel's Arava approved by FDA for treatment of adult rheumatoid arthritis (RA): First new disease-modifying agent developed specifically for RA in more than a decade
-
298204; September 11
-
(1998)
Hoechst Marion Roussel Inc Press Release
-
-
-
31
-
-
0005951773
-
FDA advisory committee meetings
-
299258
-
(1998)
FDC Reports Pink Sheet
, vol.60
, Issue.37
, pp. 26-26
-
-
-
33
-
-
0005959052
-
New study shows Arava (leflunomide) slowed progression of rheumatoid arthritis and improved physical function data supports use of new disease-modifying drug in adults with active rheumatoid arthritis
-
304501; November 10
-
(1998)
Hoechst Marion Roussel Inc Press Release
-
-
-
38
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-bind, randomised, multicentre trial. European Leflunomide Study Group
-
329522; note
-
(1999)
Lancet
, vol.353
, Issue.9149
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
Rozman, B.4
Kvien, T.K.5
Larsen, A.6
Loew-Friedrich, I.7
Oed, C.8
Rosenburg, R.9
-
39
-
-
0003189077
-
Hoechst Marion Roussel Amaryl sales reach $62 million in second quarter
-
337534
-
(1999)
FDC Reports Pink Sheet
, vol.61
, Issue.32
, pp. 20
-
-
-
41
-
-
0005957970
-
Aventis, new world leader in life sciences, launched today; Rhône-Poulenc shareholders overwhelmingly approve final steps of merger with Hoechst; Supervisory Board members appointed; full listing on world stock exchanges on December 20
-
350762; December 15
-
(1999)
Rhône Poulenc SA Press Release
-
-
-
43
-
-
0005980438
-
Methotrexate, leflunomide effective for RA, US trial results
-
354231; January 16-17
-
(2000)
Pharma JPN
, vol.1682
, Issue.31
-
-
-
46
-
-
0005920279
-
Aventis Pharma - New data indicate Arava significantly improves long-term functional ability in rheumatoid arthritis - Additional data presented this week suggest Arava improves function as early as four weeks in rheumatoid arthritis patients
-
371867; June 22
-
(2000)
Aventis Pharma AG Press Release
-
-
-
48
-
-
0034122123
-
Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
-
395018; note
-
(2000)
Immunopharmacology
, vol.47
, pp. 273-289
-
-
Hermann, M.L.1
-
52
-
-
19244384279
-
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days
-
395024
-
(2000)
Transplant Proc
, vol.32
, pp. 1061
-
-
Wennberg, L.1
Song, Z.2
Zhang, J.3
Bennet, W.4
Nava, S.5
Bari, S.6
Sunberg, B.7
Korsgren, O.8
Groth, C.G.9
-
53
-
-
4243991848
-
Arava™ leflunomide
-
395027; 2000 December 18; note
-
-
-
-
54
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
395028; note
-
(2000)
Rheumatology (Oxford)
, vol.39
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
Kaltwasser, J.P.4
Dawes, P.T.5
Gomor, B.6
Van Den Bosch, F.7
Nordstrom, D.8
Bjorneboe, O.9
Dahl, R.10
Horslev-Petersen, K.11
-
59
-
-
0005998951
-
Onset of effect and duration of response to leflunomide treatment of active rheumatoid arthritis (RA) compared to placebo or methotrexate
-
395035
-
(1998)
Arthritis Rheum
, Issue.SUPPL.
, pp. 734
-
-
Furst, D.1
Cannon, G.W.2
Fox, R.3
-
65
-
-
0031865023
-
Mechanism of action of leflunomide in rheumatoid arthritis
-
395043
-
(1998)
J Rheumatol
, vol.25
, Issue.SUPPL. 53
, pp. 20-26
-
-
Fox, R.I.1
-
69
-
-
0032197408
-
Leflunomide approved for rheumatoid arthritis; Other drugs nearing approval (news)
-
395056
-
(1998)
Am J Health-system Pharm
, vol.55
, pp. 2225-2226
-
-
-
70
-
-
0029162483
-
What is the best source of useful data on the treatment of rheumatoid arthritis: Clinical trials, clinical observations or clinical protocols?
-
395057
-
(1995)
J Rheumatol
, vol.22
, pp. 1611
-
-
Pincus, T.1
Stein, C.M.2
|