Sex differences in proinflammatory cytokine profiles of progressive patients in multiple sclerosis

Multiple Sclerosis

Volumn 11, Issue 5, 2005, Pages 520-523

  Eikelenboom, M J ^a   Killestein, J ^a   Uitdehaag, B M J ^a   Polman, C H ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cytokines; Gender differences; Multiple sclerosis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DATA ANALYSIS; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PROTEIN EXPRESSION; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; SEX CHARACTERISTICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 25844511726     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/1352458505ms1195oa     Document Type: Article

References (18)

1. Martino G, Hartung HP. Immunopathogenesis of multiple sclerosis: the role of T cells. Curr Opin Neurol 1999; 2: 1109-15.
2. Charlton B, Lafferty KJ. The Th1/Th2 balance in autoimmunity. Curr Opin Immunol 1995; 7: 793-98.
3. Duquette P, Girard M. Hormonal factors in susceptibility to multiple sclerosis. Curr Opin Neurol Neurosurg 1993; 6: 195-201.
4. Voskuhl RR. Gender issues and multiple sclerosis. Curr Neurol Neurosci Rep 2002; 2: 277-86.
5. Whitacre CC, Reingold SC, O'Looney PA. A gender gap in autoimmunity. Science 1999; 283: 1277-78.
6. Whitacre CC. Sex differences in autoimmune disease. Nat Immunol 2001; 2: 777-80.
7. Gilmore W, Weiner LP, Correale J. Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1997; 158: 446-51.
8. Verthelyi D, Klinman DM. Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 2000; 100: 384-90.
9. Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S. Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation. Arthritis Rheum 1988; 31: 1314-17.
10. Lahita RG, Bradlow HL, Kunkel HG, Fishman J. Increased 16 alpha-hydroxylation of estradiol in systemic lupus erythematosus. J Clin Endocrinol Metab. 1981; 53: 174-78.
11. Sicotte NL, Liva SM, Klutch R, Pfeiffer P, Bouvier S, Odesa S et al. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol 2002; 52: 421-28.
12. Pelfrey CM, Cotleur AC, Lee JC, Rudick RA. Sex differences in cytokine responses to myelin peptides in multiple sclerosis. J Neuroimmunol 2002; 130: 211-23.
13. Nguyen LT, Ramanathan M, Weinstock-Guttman B, Baier M, Brownscheidle C, Jacobs LD. Sex differences in in vitro proinflammatory cytokine production from peripheral blood of multiple sclerosis patients. J Neurol Sci 2003; 209: 93-99.
14. Killestein J, Den Drijver BF, Van der Graaff WL, Uitdehaag BM, Polman CH, Van Lier RA. Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease. Mult Scler 2001; 7: 145-50.
15. Killestein J, Eikelenboom MJ, Izeboud T, Kalkers NF, Ader HJ, Barkhof F et al. Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS. J Neuroimmuno] 2003; 142: 141-48.
16. Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann Neurol 2003; 53: 292-304.
17. Pozzilli C, Tomassini V, Marinelli F, Paolillo A, Gasperini C, Bastianello S. 'Gender gap' in multiple sclerosis: magnetic resonance imaging evidence. Eur J Neurol 2003; 10: 95-97.
18. Tomassini V, Onesti E, Mainero C, Giugni E, Paolillo A, Salvetti M et al. Sex hormones modulate brain damage in multiple sclerosis: MRI evidence. JNNP 2005; 76: 272-75.