Impairment of the ability of the injured aged brain in elevating urate and ascorbate

Experimental Gerontology

Volumn 41, Issue 3, 2006, Pages 303-311

  Moor, Eitan ^a   Shohami, Esther ^a   Kanevsky, Ester ^a   Grigoriadis, Nikolaos ^b   Symeonidou, Constantina ^c   Kohen, Ron ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b AHEPA UNIVERSITY HOSPITAL   (Greece)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Aging; Ascorbic acid; Axonal injury; Closed head injury; Low molecular weight antioxidants; Microdialysis; Traumatic brain injury; Uric acid

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; URATE; URIC ACID;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AXONAL INJURY; CELL LOSS; CONTROLLED STUDY; CORPUS CALLOSUM; GENETIC SUSCEPTIBILITY; HIPPOCAMPUS; HISTOPATHOLOGY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY; URIC ACID BLOOD LEVEL;

AGING; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; AXONS; BRAIN INJURIES; CORPUS CALLOSUM; EXTRACELLULAR MATRIX; HIPPOCAMPUS; MALE; MICRODIALYSIS; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; URIC ACID;

ANIMALIA;

EID: 33644966337     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.12.006     Document Type: Article

References (47)

1. B.N. Ames, R. Cathcart, E. Schwiers, and P. Hochstein Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis Proc. Natl Acad. Sci. USA 78 1981 6858 6862
2. W.M. Armstead Age dependent NMDA contribution to impaired hypotensive cerebral hemodynamics following brain injury Brain Res. Dev. Brain Res. 139 2002 19 28
3. T.R. Bashore, and K.R. Ridderinkhof Older age, traumatic brain injury, and cognitive slowing: some convergent and divergent findings Psychol. Bull. 128 2002 151 198
4. H. Bayir, V.E. Kagan, Y.Y. Tyurina, V. Turyn, R.A. Ruppel, P.D. Adelson, S.H. Graham, K. Janesko, R.S. Clark, and P.M. Kochanek Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children Pediatr. Res. 51 2002 571 578
5. B.F. Becker Towards the physiological function of uric acid Free Radic. Biol. Med. 14 1993 615 631
6. K.B. Beckman, and B.N. Ames The free radical theory of aging matures Physiol. Rev. 78 1998 547 551
7. E. Beit-Yannai, R. Kohen, M. Horowitz, V. Trembovler, and E. Shohami Changes of biological reducing activity in rat brain following closed head injury: a cyclic voltammetry study in normal and heat-acclimated rats J. Cerebr. Blood Fou Metal. 17 1997 273 279
8. L. Beni-Adani, I. Gozes, Y. Cohen, Y. Assaf, R. Steindart, D. Brenneman, O. Eizenberg, V. Trembovler, and E. Shohami Reduced mortality and improved recovery after treatment with a femtomolar-acting peptide in a mouse model of closed head injury J. Pharmacol. Exp. Ther. 296 2001 57 63
9. E.M. Berry, and R. Kohen Is the biological antioxidant system integrated and regulated? Med. Hypotheses 53 1999 397 401
10. D. Butterfield, J. Drake, C. Pocernich, and A. Castenga Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide Trends Mol. Med. 7 2001 548 554
11. Y. Chen, S. Constantini, V. Trembovler, M. Weinstock, and E. Shohami An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits J. Neurotrauma 13 1996 557 568
12. G. Cohen Enzymatic/nonenzymatic sources of oxyrdaicals and regulation of antioxidant defenses Ann. NY Acad. Sci. 738 1994 8 15
13. M. Davis, A.D. Mendelow, R.H. Perry, I.R. Chambers, and O.F. James Experimental stroke and neuroprotection in the aging rat brain Stroke 26 1995 1072 1078
14. V. Elangovan, R. Kohen, and E. Shohami Neurological recovery from closed head injury is impaired in diabetic rats J. Neurotrauma 17 2000 1013 1027
15. E. Esposito, E. Rotilio, V. Di Matteo, C. Di Giulio, M. Cacchio, and S. Algeri A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes Neurobiol. Aging 23 2002 719 735
16. P. Fan, T. Yamauchi, L.J. Noble, and D.M. Ferriero Age-dependent differences in glutathione peroxidase activity after traumatic brain injury J. Neurotrauma 20 2003 437 445
17. L. Glantz, A. Avramovich, V. Trembovler, V. Gurvitz, R. Kohen, L.A. Eidelman, and E. Shohami Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia Exp. Neurol. 192 2005 117 124
18. F.C. Goldstein, and H.S. Levin Cognitive outcome after mild and moderate traumatic brain injury in older adults J. Clin. Exp. Neuropsychol. 23 2001 739 753
19. E.D. Hall, P.G. Sullivan, T.R. Gibson, K.M. Pavel, B.M. Thompson, and S.W. Scheff Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury J. Neurotrauma 22 2005 252 265
20. B. Halliwell, and M. Grootveld The measurement of free radical reaction in humans FEBS Lett. 213 1987 9 14
21. B. Halliwell, and J.M.C. Gutteridge Free Radicals in Biology and Medicine third ed. 1999 Oxford University Press Oxford
22. D. Harman Aging: theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
23. L. Hillered, L. Persson, H.G. Bolander, A. Hallstrom, and U. Ungerstedt Increased extracellular levels of ascorbate in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis Neurosci. Lett. 95 1988 1 3
24. L. Hillered, P. Nilsson, U. Ungerstadt, and U. Ponten Trauma-induced increase of extracellular ascorbate in rat cerebral cortex Neurosci. Lett. 113 1990 328 332
25. E. Javouhey, A.C. Guerin, and M. Chiron Incidence and risk factors of severe traumatic brain injury resulting from road accidents: a population-based study Accident Anal. Prev. 2005 (Epub ahead of print)
26. J.A. Joseph, N.A. Denisova, D. Bielinski, D.R. Fisher, and B. Shukkit-Hale Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention Mech. Ageing & Dev. 116 2000 141 153
27. R. Kohen, and A. Niska Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions and methods for their quantification Toxicol. Pathol. 30 2002 620 650
28. R. Kohen, D. Fanberstein, and O. Tirosh Reducing equivalents in the aging brain Arch. Gerontol. Geriatr. 24 1997 103 123
29. S. Litchfield, and Z. Nagy New temperature modification makes the Bielschowsky silver stain reproducible Acta Neuropathol. (Berl.) 101 2001 17 21
30. L. Lomnitski, A. Nyska, E. Shohami, Y. Chen, and D.M. Michaelson Increased levels of intracellular iron in the brains of ApoE-deficient mice with closed head injury Exp. Toxicol. Pathol. 52 2000 177 183
31. C.M. Maier, and P.H. Chan Role of superoxide dismutases in oxidative damage and neurodegenerative disorders Neuroscientist 8 2002 323 334
32. J.L. Martindale, and N.J. Holbrook Cellular response to oxidative stress: signaling for suicide and survival J. Cell Physiol. 192 2002 1 15
33. M. Miele, and M. Fillenz In vivo determination of extracellular brain ascorbate J. Neurosci. Methods 70 1996 15 19
34. M. Miele, M.G. Boutelle, and M. Fillenz The physiologically induced release of ascorbate in rat brain is dependent on impulse traffic, calcium influx and glutamate uptake Neuroscience 62 1994 87 91
35. M. Miele, M.A. Mura, P. Enrico, G. Esposito, P.A. Serra, R. Migheli, D. Zangani, E. Miele, and M.S. Desole On the mechanism of d-amphetamine-induced changes in glutamate, ascorbic acid and uric acid release in the striatum of freely moving rats Br. J. Pharmacol. 129 2000 582 588
36. E. Moor, R. Kohen, R.J. Reiter, and E. Shohami Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: an adaptive mechanism? Neurosci. Lett. 316 2001 169 172
37. P.A. Motchnik, B. Frei, and B.N. Ames Measurements of antioxidants in human blood plasma Methods Enzymol. 234 1994 115 121
38. A. Sevanian, K.L. Davies, and P. Hochstein Serum urate as an antioxidant for ascorbic acid Am. J. Clin. Nutr. 54 6 Suppl 1991 1129S 1134S
39. Y. Shapira, E. Shohami, A. Sidi, D. Soffer, S. Freeman, and S. Cotev Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties Crit. Care Med. 16 1988 258 265
40. E. Shohami, E. Beit-Yannai, M. Horowits, and R. Kohen Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome J. Cerebr. Blood Flow Metab. 17 1997 1007 1019
41. L. Svensson, C. Wu, P. Hulthe, K. Johannessen, and J.A. Engel Effect of ageing on extracellular ascorbate concentration in rat brain Brain Res. 309 1993 36 40
42. E.C. Tayag, S.N. Nair, S. Wahhab, C. Katsetos, J.W. Lighthall, and J.C. Lehmann Cerebral uric acid increases following experimental traumatic brain injury in rat Brain Res. 733 1996 287 291
43. B. Van Der Loo, M. Bachschmid, V. Spitzer, L. Brey, V. Ullrich, and T.F. Luscher Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense Biocim. Biophys. Res. Commun. 303 2003 383 387
44. Y.H. Wei Oxidative stress and mitochondrial DNA mutations in human aging Proc. Soc. Exp. Biol. Med. 217 1998 53 63
45. Y.H. Wei, and H.C. Lee Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging Exp. Biol. Med. 227 2002 671 682
46. T. Yusa Continuous real-time measurement of extracellular ascorbate release in the rat striatum in vivo during ischemia-reperfusion Neurosci. Lett. 293 2000 123 126
47. T. Yusa Increased extracellular ascorbate release reflects glutamate re-uptake during the early stage of reperfusion after forebrain ischemia in rats Brain Res. 897 2001 104 113