Neurological recovery from closed head injury is impaired in diabetic rats

Journal of Neurotrauma

Volumn 17, Issue 11, 2000, Pages 1013-1027

  Elangovan, V ^a   Kohen, R ^a   Shohami, E ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Closed head injury; Diabetes; Low molecular weight antioxidants; Oxidative stress; Reactive oxygen species

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUCOSE; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN EDEMA; BRAIN FUNCTION; CONTROLLED STUDY; CONVALESCENCE; CYCLIC POTENTIOMETRY; DIABETES MELLITUS; ELECTROCHEMICAL DETECTION; GLUCOSE BLOOD LEVEL; HEAD INJURY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INJURY SCALE; LIPID PEROXIDATION; MALE; NEUROLOGIC EXAMINATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RAT;

EID: 0033748524     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2000.17.1013     Document Type: Article

References (53)

1. Changes of biological reducing activity in rat brain following closed head injury: A cyclic voltammetry study in normal and heat-acclimated rats
2. Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat
3. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
4. Microsomal lipid peroxidation
5. The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications
6. The role of oxygen radicals in brain injury and edema
7. Rivastigmine, a brain selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed head injury in the mouse
8. Lipid peroxidation induced 'in vivo' by iron-carbohydrate complex in the rat brain cortex
9. Effect of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats
10. Membrane lipid changes in laminectomized and traumatized cat spinal cord
11. The free radical pathology and the microcirculation in the major central nervous system disorders
12. Hypoxic neuropathy: Does hypoxia play a role in diabetic neuropathy?
13. Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides
14. An increase in the overall total liver lipid soluble antioxidants' capacity as compared to other organs of streptozotocin-induced diabetic rats: A cyclic voltammetry study
15. Changes in adrenocorticotropic hormone (ACTH) release from the cultured anterior pituitary cells of streptozotocin-induced diabetic rats
16. Central nervous system trauma and stroke. Physiological evidence for the involvement of oxygen radicals and lipid peroxidation
17. How to characterize a biological antioxidant
18. Free radicals and antioxidants; a personal view
19. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy
20. The use of cyclic voltammetry for the evaluation of oxidative damage in biological samples
21. Evaluation of the total low molecular weight antioxidant activity of plasma in health and disease: A new approach
22. Reducing equivalents in the aging process
23. Overall low molecular weight antioxidants activity of biological fluids and tissues by cyclic voltammetry
24. Effects of streptozotocin-induced hyperglycemia on brain damage following transient ischemia
25. Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas
26. Streptozotocin-induced pancreatic insulitis; a new model of diabetes mellitus
27. Hyperglycemia triggers massive neutrophil deposition in brain following transient ischemia in rats
28. Posttraumatic cerebral hemisphere swelling
29. Oxygen free radical effects in sciatic nerve in experimental diabetes
30. Neuropathological sequelae of traumatic brain injury: Relationship to neurochemical and biomechanical mechanisms
31. Effect of tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve
32. Increased susceptibility to ischemic damage in streptozotocin-diabetic nerve
33. Assay for lipid peroxides in animal tissues by thiobarbituric acid reactions
34. A 'radical' view of cerebral ischemia injury
35. Total antioxidant status in plasma and body fluids
36. Effect of methylprednisolone and the combination of alphatocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue
37. Experimental closed head injury in rats. Mechanical, pathophysiologic and neurologic properties
38. Head injury induces increased prostaglandin synthesis in rat brain
39. 2 is activated after experimental closed head injury in the rat
40. Closed head injury triggers early production of TNFα and IL-6 by brain tissue
41. Long term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory function after closed head injury in the rat brain
42. The effect of the adrenocortical axis upon recovery from closed head injury
43. Oxidative stress in closed head injury: Brain antioxidant capacity as an indicator of functional outcome
44. Closed head injury in the rat induces whole body oxidative stress: Overall reducing antioxidant profile
45. Mechanisms of ischemic brain damage
46. 1H-NMR analysis of nerve edema in the streptozotocin induced diabetic rat
47. Neurological recovery in diabetic rats following spinal cord injury
48. The pharmacology of diabetic neuropathy
49. The role of oxidative stress in neuropathy and other diabetic complications
50. Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke
51. Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes rat. Effects of insulin treatment
52. Protein glycation and oxidative stress in diabetes mellitus and aging
53. The molecular basis of brain injury and brain edema. The role of oxygen free radicals